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    METHOD AND APPARATUS FOR DETERMINING A PROBABILITY OF COLORECTAL CANCER IN A SUBJECT
    102.
    发明公开
    METHOD AND APPARATUS FOR DETERMINING A PROBABILITY OF COLORECTAL CANCER IN A SUBJECT 有权
    确定受试者中大肠癌概率的方法和装置

    公开(公告)号：EP2281059A2

    公开(公告)日：2011-02-09

    申请号：EP09730647.6

    申请日：2009-04-10

    申请人： Genenews Corporation

    发明人： LIEW, Choong-Chin ,  CHAO, Samuel

    IPC分类号： C12Q1/68 ,  C40B30/02 ,  C40B30/04 ,  G06F19/00 ,  C07H21/00 ,  C40B40/06

    CPC分类号： C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2600/166 ,  G01N33/57419 ,  G01N2800/50 ,  G01N2800/56 ,  G06F19/12 ,  G06F19/20 ,  G06F19/24

    摘要： A method of determining a probability that a human test subject has colorectal cancer as opposed to not having colorectal cancer is disclosed. The method comprises, for each gene of a set of one or more genes selected from the group consisting of ANXA3, CLEC4D, IL2RB, LMNB1, PRRG4, TNFAIP6 and VNN1: determining a level of RNA encoded by the gene in blood of the test subject, thereby generating test data; providing positive control data representing levels of RNA encoded by the gene in blood of human control subjects having colorectal cancer, and providing negative control data representing levels of RNA encoded by the gene in blood of human control subjects not having colorectal cancer; and determining a probability that the test data corresponds to the positive control data and not to the negative control data, where the probability that the test data corresponds to the positive control data and not to the negative control data represents the probability that the test subject has colorectal cancer as opposed to not having colorectal cancer.

    摘要翻译： 公开了确定人类受试者患有结肠直肠癌而不患有结肠直肠癌的概率的方法。 对于选自由ANXA3，CLEC4D，IL2RB，LMNB1，PRRG4，TNFAIP6和VNN1组成的组的一组一种或多种基因的每个基因，该方法包括：确定受试者血液中基因编码的RNA的水平 从而生成测试数据; 提供代表具有结肠直肠癌的人类对照受试者的血液中基因编码的RNA的水平的阳性对照数据，并且提供代表没有结肠直肠癌的人类对照受试者的血液中基因编码的RNA的水平的阴性对照数据; 并且确定测试数据对应于阳性对照数据而不是阴性对照数据的概率，其中测试数据对应于阳性对照数据而不是阴性对照数据的概率表示测试对象具有 结肠直肠癌，而不是没有结肠直肠癌。

    Ligational encoding of small molecules
    106.
    发明公开
    Ligational encoding of small molecules 有权
    小分子的介导结扎编码

    公开(公告)号：EP2236606A3

    公开(公告)日：2010-10-20

    申请号：EP09154197.9

    申请日：2004-03-22

    申请人： Nuevolution A/S

    发明人： Franch, Thomas ,  Jacobsen, Søren Nyboe ,  Rasmussen, Torben ,  Neve, Søren ,  Pedersen, Henrik ,  Gouliaev, Alex Haahr

    IPC分类号： C12N15/10 ,  C40B50/04 ,  C40B40/06 ,  C40B50/14

    CPC分类号： C07H21/04 ,  C12N15/1068 ,  C12P21/02 ,  C40B40/06 ,  C40B50/04

    摘要： The invention relates to a method for synthesising a bifunctional complex comprising an encoded molecule and an identifier polynucleotide identifying the chemical entities having participated in the synthesis of the encoded molecule, said method comprising the steps of
    i) providing
    a) at least one template comprising one or more codons capable of hybridising to an anti-codon, wherein said template is optionally associated with one or more chemical entities, and
    b) a plurality of building blocks each comprising an anti-codon associated with one or more chemical entities, and

    ii) hybridising the anti-codon of one or more of the provided building blocks to the template,
    iii) covalently linking said anti-codons and/or linking the at least one template with the anti-codon of at least one building block, thereby generating an identifier polynucleotide capable of identifying chemical entities having participated in the synthesis of the encoded molecule,
    iv) separating the template from one or more of the anti-codons hybridised thereto, thereby generating an at least partly single stranded identifier polynucleotide associated with a plurality of chemical entities,
    v) generating a bifunctional complex comprising an encoded molecule and an identifier polynucleotide identifying the chemical entities having participated in the synthesis of the encoded molecule,

    wherein said encoded molecule is generated by reacting at least two of said plurality of chemical entities associated with the identifier polynucleotide, and
    wherein said at least two chemical entities are provided by separate building blocks.