公开(公告)号：EP2125711A1

公开(公告)日：2009-12-02

申请号：EP08724206.1

申请日：2008-03-07

申请人： Albireo Ab

发明人： BROO, Anders ,  GOTTFRIES, Johan ,  KOSSENJANS, Michael ,  LANNA, Li ,  LINDSTEDT-ALSTERMARK, Eva-Lotte ,  NILSSON, Kristina A ,  OHLSSON, Bengt ,  THORSTENSSON, Maria

IPC分类号： C07C321/20 ,  A61K31/216 ,  A61K31/421 ,  A61K31/4402 ,  A61K31/495 ,  A61P1/00 ,  C07C271/26 ,  C07C309/70 ,  C07C317/24 ,  C07C327/28 ,  C07D213/46 ,  C07D263/32 ,  C07D277/30

CPC分类号： C07C323/56 ,  C07C271/28 ,  C07C309/66 ,  C07C317/44 ,  C07C323/62 ,  C07C327/28 ,  C07D213/55 ,  C07D231/12 ,  C07D263/32 ,  C07D263/34 ,  C07D277/24 ,  C07D277/30 ,  C07D295/04

摘要： The present invention relates to 2-(substituted sulphur, sulphone or sulphoxide)-3-(substituted phenyl) propionic acid derivatives, 2-(substituted oxygen)-3-(substituted phenyl) propionic acid derivatives, benzoic acid derivatives, and derivatives of 2-methyl-2-(phenoxy or phenylthio)propanoic acid and 2-(methylor ethyl)-2-(phenoxy or phenylthio)butanoic acid, to processes for preparing such compounds, to their use in the treatment of inflammatory conditions, and to pharmaceutical compositions containing them.

公开(公告)号：EP1797021A1

公开(公告)日：2007-06-20

申请号：EP05782778.4

申请日：2005-09-13

申请人： CEPHALON, INC.

发明人： HAUCK, Wilhelm ,  LUDEMANN-HOMBOURGER, Olivier ,  RULAND, Y. Novasep Asia/Applexion-Orelis-Novasep ,  LANDMESSER, Nelson ,  MALLAMO, John

IPC分类号： C07B57/00 ,  C07C317/24

CPC分类号： C07B57/00

摘要： The present invention is directed to a process for the isolation of the enantiomeric forms of modafinil with high enantiomeric purity and high overall yields by means of a continuous chromatographic process.

公开(公告)号：EP1740534A1

公开(公告)日：2007-01-10

申请号：EP05707695.2

申请日：2005-03-03

申请人： Syngenta Participations AG

发明人： BENKE, Alan, Henry ,  WICHERT, Julie, Marie

IPC分类号： C07C315/06 ,  C07C317/24

CPC分类号： C07C315/06 ,  C07C317/24

摘要： A method for reducing the cyanide levels in a mesotrione sample, said method comprising: (i) taking an aqueous solution of the mesotrione sample in an aqueous solvent, (ii) adjusting the pH of said aqueous solution to a value of 9.5 or higher, and (iii) crystallising the mesotrione out of solution is disclosed.

公开(公告)号：EP1692101A1

公开(公告)日：2006-08-23

申请号：EP03780487.9

申请日：2003-12-23

申请人： COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH

发明人： SANGITA ,  KUMAR, Atul ,  SINGH, Man Mohan ,  JAIN, Girish Kumar ,  MURTHY, Puvvada Sri Ramchandra ,  RAY, Suprabhat

IPC分类号： C07C317/22 ,  C07C317/24 ,  C07C323/19 ,  C07C323/22 ,  C07C323/25 ,  C07D295/088 ,  A61K31/10 ,  A61K31/12 ,  A61K31/145 ,  A61K31/222 ,  A61K31/40 ,  A61K31/4453 ,  A61P5/30

CPC分类号： C07D295/088 ,  C07C317/22 ,  C07C317/24 ,  C07C323/19 ,  C07C323/22 ,  C07C323/25

摘要： The present invention relates to the field of pharmaceuticals and organic chemistry and provides novel mercapto phenyl naphthyl methane derivatives, their pharmaceutically acceptable salts and compositions and preparation thereof, that are useful for the prevention or treatment of various medical indications associated with estrogen dependent diseases or syndromes related to osteoporosis, bone loss, bone formation, cardiovascular disorders, neurodegenerative disorders, menopausal disorders, physiological disorders, diabetes disorders, prostatic carcinoma, cancer of breast, cancer of uterus, cancer of the cervix and cancer of the colon, threatened or habitual abortion, obesity, ovarian development or function, post-partum lactation and depression.

公开(公告)号：EP1634861A1

公开(公告)日：2006-03-15

申请号：EP04292199.9

申请日：2004-09-13

申请人： CEPHALON, INC.

发明人： Hauck, Wilhelm ,  Ludemann-Hombourger, Olivier ,  Ruland, Yvan

IPC分类号： C07B57/00 ,  C07C317/24

CPC分类号： C07B57/00

摘要： The present invention is directed to a process for the isolation of the enantiomeric forms of modafinil with high enantiomeric purity and high overall yields by means of a continuous chromatographic process.

摘要翻译： 本发明涉及通过连续色谱法分离具有高对映体纯度和高总产率的莫非非尼的对映体形式的方法。

公开(公告)号：EP1515951A1

公开(公告)日：2005-03-23

申请号：EP03742193.0

申请日：2003-06-25

申请人： Pharmacia Corporation

发明人： CHEN, Yiyuan ,  FRESKOS, John, N. ,  GASIECKI, Alan, F. ,  GRAPPERHAUS, Margaret, L. ,  HANSEN, Donald, W., Jr. ,  HEINTZ, Robert, M. ,  KHANNA, Ish, K. ,  KOLODZIEJ, Steve, A. ,  MANTEGANI, Sergio ,  MASSA, Mark, A. ,  MCDONALD, Joseph, J. ,  MISCHKE, Deborah, A. ,  NAGY, Mark, A. ,  PERRONE, Ettore ,  SCHMIDT, Michelle, A. ,  SPANGLER, Dale, P. ,  TALLEY, John, J. ,  TRIVEDI, Mahima ,  WYNN, Thomas, A. ,  RICO, Joseph, G.

IPC分类号： C07D213/34 ,  C07D211/66 ,  C07D335/02 ,  C07D309/08 ,  C07D405/12 ,  A61K31/33 ,  C07C317/24 ,  A61K31/16

CPC分类号： C07D241/12 ,  C07C317/46 ,  C07D211/66 ,  C07D213/34 ,  C07D309/08 ,  C07D335/02 ,  C07D401/12 ,  C07D405/12 ,  C07D405/14 ,  C07D407/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

摘要： This invention is directed generally to hydroxamic acid and amide compounds (including salts of such compounds), and, more particularly, to aryl- and heteroaryl-­arylsulfonylmethyl hydroxamic acids and amides that, inter alia, inhibit protease activity, particularly matrix metalloproteinase (also known as 'matrix metalloprotease' or 'MMP') activity and/or aggrecanase activity. These compounds generally correspond in structure to formula (I): wherein Al, A2, A3, El, E2, E3, and E4 are as defined in this patent. This invention also is directed to compositions of such compounds, intermediates for the syntheses of such compounds, methods for making such compounds, and methods for treating conditions associated with MMP activity and/or aggrecanase activity, particularly pathological conditions.

公开(公告)号：EP1480944A2

公开(公告)日：2004-12-01

申请号：EP03706551.3

申请日：2003-02-21

申请人： Bayer CropScience Aktiengesellschaft

发明人： HOISCHEN, Dorothee ,  HERMANN, Stefan ,  KATHER, Kristian ,  MÜLLER, Klaus-Helmut ,  SCHWARZ, Hans-Georg ,  SCHALLNER, Otto ,  DREWES, Mark, Wilhelm ,  DAHMEN, Peter ,  FEUCHT, Dieter ,  PONTZEN, Rolf

IPC分类号： C07C239/20 ,  C07C311/04 ,  C07C311/17 ,  C07C317/24 ,  C07D409/12 ,  C07D333/34 ,  C07D233/80 ,  C07D213/30 ,  C07D335/02 ,  A01N33/08

CPC分类号： A01N35/06 ,  A01N41/06 ,  A01N43/56 ,  C07C239/20 ,  C07C311/04 ,  C07C311/17 ,  C07C317/24 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07D213/55

摘要： The invention relates to novel aryl ketones of formula (I), in which Z represents groupings (II) and (III) and A1, A2, A3, R1, R2, R3, R4, R5, R6, R7, X, Y, and m have the meaning indicated in the description, the use thereof as plant treating agents, particularly as herbicides, and methods and intermediate products for the production thereof.

摘要翻译： （II）和（III）以及A1，A2，A3，R1，R2，R3，R4，R5，R6，R7，X，Y， 和m具有说明书中所指的含义，其作为植物处理剂，特别是作为除草剂的用途，以及用于其生产的方法和中间产物。

公开(公告)号：EP1406626A2

公开(公告)日：2004-04-14

申请号：EP02761148.2

申请日：2002-07-19

申请人： Pharmacia Corporation

发明人： MCDONALD, Joseph, J. ,  BARTA, Thomas, E. ,  BECKER, Daniel, P. ,  BEDELL, Louis, J. ,  RAO, Shashidhar, N. ,  FRESKOS, John, N. ,  DE CRESCENZO, Gary, A. ,  MISCHKE, Brent, V. ,  GETMAN, Daniel, P. ,  VILLAMIL, Clara, I.

IPC分类号： A61K31/445 ,  A61K31/40 ,  A61K31/4409 ,  A61K31/485 ,  A61K31/18 ,  C07D211/96 ,  C07C317/24 ,  C07D207/48 ,  C07D401/12 ,  C07D235/22 ,  C07D401/04 ,  C07D405/12 ,  C07D409/12 ,  A61P1/16 ,  A61P19/02 ,  A61P19/00

CPC分类号： C07D295/26 ,  C07C311/16 ,  C07C311/21 ,  C07C317/22 ,  C07C317/44 ,  C07C323/65 ,  C07D207/14 ,  C07D207/16 ,  C07D207/48 ,  C07D211/16 ,  C07D211/18 ,  C07D211/46 ,  C07D211/54 ,  C07D211/62 ,  C07D211/96 ,  C07D213/30 ,  C07D213/82 ,  C07D295/15 ,  C07D309/12 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12

摘要： The invention is directed to sulfonyl aromatic hydroxamic acid compounds and salts thereof that, inter alia, inhibit matrix metalloprotease (MMP) activity and/or aggrecanase activity. In some particularly preferred embodiments, the compound corresponds in structure to one of the following formulas: (I) (II) wherein W2, the R groups, and -A-R-E-Y are described in more detail in Applicants'specification. This invention also is directed to a process that comprises administering such a compound or pharmaceutically acceptable salt thereof to a host animal having a condition associated with MMP activity.

公开(公告)号：EP1140791A4

公开(公告)日：2001-10-10

申请号：EP98947093

申请日：1998-09-17

申请人： SQUIBB BRISTOL MYERS CO

发明人： BANVILLE JACQUES ,  GAI YONGHUA ,  JOHNSON GRAHAM ,  ZUSI FRED CHRISTOPHER ,  BURKE JAMES R

IPC分类号： C07C17/269 ,  C07C25/18 ,  C07C45/51 ,  C07C45/67 ,  C07C45/74 ,  C07C49/245 ,  C07C49/248 ,  C07C49/255 ,  C07C69/63 ,  C07C69/712 ,  C07C69/738 ,  C07C217/22 ,  C07C229/12 ,  C07C233/18 ,  C07C235/20 ,  C07C311/04 ,  C07C317/18 ,  C07C323/12 ,  C07D207/08 ,  C07D207/12 ,  C07D207/16 ,  C07D211/14 ,  C07D211/46 ,  C07D215/14 ,  C07D231/12 ,  C07D271/06 ,  C07D277/04 ,  C07D311/20 ,  C07D313/08 ,  C07D317/34 ,  C07F7/18 ,  C07F9/113 ,  C07F9/24 ,  C07C217/54 ,  A61K31/135 ,  A61K31/165 ,  A61K31/18 ,  A61K31/215 ,  A61K31/40 ,  C07C237/20 ,  C07C317/24 ,  C07F9/02

CPC分类号： C07D207/08 ,  C07C17/269 ,  C07C25/18 ,  C07C45/515 ,  C07C45/673 ,  C07C45/74 ,  C07C49/245 ,  C07C49/248 ,  C07C49/255 ,  C07C69/63 ,  C07C69/712 ,  C07C69/738 ,  C07C217/22 ,  C07C229/12 ,  C07C233/18 ,  C07C235/20 ,  C07C311/04 ,  C07C317/18 ,  C07C323/12 ,  C07D207/12 ,  C07D207/16 ,  C07D211/14 ,  C07D211/46 ,  C07D215/14 ,  C07D231/12 ,  C07D271/06 ,  C07D277/04 ,  C07D311/20 ,  C07D313/08 ,  C07D317/34 ,  C07F7/1852 ,  C07F9/113 ,  C07F9/2458

公开(公告)号：EP0863870B1

公开(公告)日：2001-06-13

申请号：EP96939627.4

申请日：1996-11-08

申请人： THE PROCTER & GAMBLE COMPANY

发明人： MATTHEWS, Randall, Stryker

IPC分类号： C07C317/24 ,  A61K31/12

CPC分类号： C07C317/24

摘要： The subject invention relates to compounds having structure (I), wherein (a) x is from 1 to 5; (b) y is from 1 to 2; and (c) z is from 0 to 5. The subject invention also relates to the pharmaceutical compositions comprising the above compounds, and methods of treating inflammation using the compounds.