公开(公告)号：EP1978944B1

公开(公告)日：2012-08-15

申请号：EP07707560.4

申请日：2007-01-23

申请人： R-Tech Ueno, Ltd. ,  Sucampo AG

发明人： HASHITERA, Yukiko ,  HIRATA, Ryu ,  HARADA, Yasuhiro ,  UENO, Ryuji

IPC分类号： A61K9/48 ,  A61K31/5575

CPC分类号： A61K31/352 ,  A61K9/4816 ,  A61K9/4825 ,  A61K9/4858 ,  A61K31/557 ,  A61K31/5575

摘要： The present invention discloses a soft gelatin capsule formulation of a 15-keto-prostaglandin compound, which comprises: a soft gelatin capsule shell comprising gelatin and sugar alcohol as a plasticizer, and a mixture comprising a 15-keto-prostaglandin compound and a pharmaceutically acceptable vehicle which is filled in the shell. By encapsulating the 15-keto-prostaglandin compound in the specified soft gelatin capsule shell, stability of the compound is significantly improved.

摘要翻译： 本发明公开了15-酮 - 前列腺素化合物的软明胶胶囊制剂，其包含：包含明胶和糖醇作为增塑剂的软明胶胶囊壳，以及包含15-酮 - 前列腺素化合物和药学上可接受的 填充在壳体中的车辆。 通过将15-酮 - 前列腺素化合物包封在特定的软明胶胶囊壳中，化合物的稳定性显着提高。

公开(公告)号：EP1994933A4

公开(公告)日：2012-04-11

申请号：EP07738306

申请日：2007-03-12

申请人： R TECH UENO LTD ,  SUCAMPO AG

发明人： HIRATA RYU ,  HARADA YASUHIRO ,  UENO RYUJI

IPC分类号： A61K31/5575 ,  A61K9/00 ,  A61K9/08 ,  A61K47/18 ,  A61K47/44 ,  A61P27/02

CPC分类号： A61K9/0048 ,  A61K9/08 ,  A61K9/48 ,  A61K31/5575 ,  A61K47/44

公开(公告)号：EP2384790A3

公开(公告)日：2011-12-28

申请号：EP11170921.8

申请日：2006-03-22

申请人： Sucampo AG ,  NORTH CAROLINA STATE UNIVERSITY

发明人： Ryuji, Ueno ,  Kuno, Sachiko ,  Blikslager, Anthony T. ,  Moeser, Adam J.

IPC分类号： A61P1/04 ,  A61P35/00 ,  A61K31/557 ,  C07C405/00

CPC分类号： C07C405/00 ,  A61K31/557

摘要： Provided is a method and composition for treating mucosal disorders using a specific prostaglandin compound. The prostaglandin compound induces a conformational change in the tight junction that results in recovery of mucosal barrier function. Accordingly, the prostaglandin compound used herein is useful for the treatment of mucosal disorders.

公开(公告)号：EP2341894A2

公开(公告)日：2011-07-13

申请号：EP09788094.2

申请日：2009-10-02

申请人： R-Tech Ueno, Ltd. ,  Sucampo AG

发明人： HARADA, Yasuhiro ,  KAWASAKI, Junichi ,  HAYASHI, Tadashi ,  UENO, Ryuji

IPC分类号： A61K9/00 ,  A61K47/10 ,  A61K47/26

CPC分类号： A61K9/0048 ,  A61K31/557 ,  A61K47/10 ,  A61K47/26

摘要： Provided is a pharmaceutical composition comprising: a) a prostaglandin compound; (b) a sugar alcohol; (c) a polyol; and (d) a pharmaceutically acceptable carrier. The composition of the present invention can be stored stably even in a polyethylene container. In addition, the composition of the present invention can be stored stably for a long term even if it comprises only a small amount of a preserving agent.

公开(公告)号：EP2308495A1

公开(公告)日：2011-04-13

申请号：EP10191488.5

申请日：2006-03-03

申请人： Sucampo AG

发明人： Ueno, Ryuji

IPC分类号： A61K31/5575 ,  A61P9/02 ,  A61P9/10

CPC分类号： A61K31/5575 ,  A61K31/557

摘要： The present invention provides a method for treating peripheral vascular diseases in a mammalian subject, which comprises administering to the patient in need thereof an effective amount of 11-deoxy-prostaglandin compound.

摘要翻译： 本发明提供了用于治疗哺乳动物受试者的外周血管疾病的方法，该方法包括给有此需要的患者施用有效量的11-脱氧 - 前列腺素化合物。

公开(公告)号：EP2175861A1

公开(公告)日：2010-04-21

申请号：EP08778018.5

申请日：2008-07-03

申请人： Sucampo AG

发明人： UENO, Ryuji

IPC分类号： A61K31/557 ,  A61K45/06 ,  A61P1/04 ,  A61P29/00 ,  A61P35/00 ,  A61P25/28 ,  C07C405/00

CPC分类号： A61K31/192 ,  A61K31/20 ,  A61K31/557 ,  A61K45/06 ,  A61K2300/00

摘要： Provided is a method for treating a condition or disease which is one of the indications for NSAID use, which comprises administering a combination of: (a) a pharmaceutically effective amount of a NSAID, and (b) a pharmaceutically effective amount of a prostaglandin (PG) compound represented by the formula (I): to a subject in need thereof.

公开(公告)号：EP1661573A4

公开(公告)日：2009-05-06

申请号：EP04720157

申请日：2004-03-12

申请人： SUCAMPO AG ,  R TECH UENO LTD

发明人： UENO RYUJI

IPC分类号： A61K31/5575 ,  A61K9/00 ,  A61K31/557 ,  A61K47/10 ,  A61K47/32 ,  A61K47/38 ,  A61P27/00 ,  A61P43/00

CPC分类号： A61K47/32 ,  A61K9/0048 ,  A61K31/557 ,  A61K31/5575 ,  A61K47/10 ,  A61K47/38

摘要： An ophthalmic composition comprising a prostaglandin compound and a thickening compound. This composition, by virtue of the addition of a thickening compound, realizes stabler exertion of the activity and effect of prostaglandin compound and further enhances the continuity of the activity and effect and achieves intensified exertion of the activity and effect.

摘要翻译： 包含前列腺素化合物和增稠化合物的眼科用组合物。 该组合物通过添加增稠化合物，实现了前列腺素化合物的活性和效果的更稳定的发挥，进一步提高了活性和效果的连续性，并且实现了活性和效果的强化发挥。

公开(公告)号：EP1857105A2

公开(公告)日：2007-11-21

申请号：EP07016834.9

申请日：2001-09-04

申请人： Sucampo AG

发明人： Ueno, Ryuji

IPC分类号： A61K31/35

CPC分类号： C07C405/00 ,  A61K31/335 ,  A61K31/35 ,  A61K31/352 ,  A61K31/4741 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/559 ,  C07D221/04 ,  C07D335/04 ,  Y10S514/892 ,  A61K2300/00

摘要： An object of the present invention is to provide an anti-constipation composition containing a halogenated-bi-cyclic compound as an active ingredient in a ratio of bi-cyclic/monocyclic structure of at least 1 : 1. The halogenated-bi-cyclic compound is represented by Formula (I):

where X 1 and X 2 are preferably both fluorine atoms. The composition can be used to treat constipation without substantive side-effects, such as stomachache.

摘要翻译： 本发明的目的是提供一种含有卤代双环化合物作为活性成分的抗 - 便秘组合物，其双环/单环结构比至少为1:1。卤代双环化合物 由式（I）表示：其中X 1和X 2优选为氟原子。 该组合物可用于治疗便秘，而没有实质的副作用，如胃痛。

公开(公告)号：EP1791545A1

公开(公告)日：2007-06-06

申请号：EP05782157.1

申请日：2005-09-01

申请人： Sucampo AG

发明人： UENO, Ryuji

IPC分类号： A61K31/557 ,  A61K31/558 ,  A61P1/04 ,  A61P1/08 ,  A61P1/14

CPC分类号： C07D311/94 ,  A61K31/557 ,  A61K31/558

摘要： The present invention relates to a method for the long term treatment of gastrointestinal disorders in a human subject, which comprises administering an effective amount of a halogenated prostaglandin compound and/or its tautomer to the subject. The method induces substantially no electrolyte shifting during the term of the treatment. The compound used in the present invention can improve quality of life in the human subjects with gastrointestinal disorders, are similarly effective in treating male and female human subjects, and also effective in a human subject aged even 65 years and older.

公开(公告)号：EP1673058A1

公开(公告)日：2006-06-28

申请号：EP04771825.9

申请日：2004-08-12

申请人： Sucampo AG

发明人： UENO, Ryuji ,  HABE, Tsuyoshi ,  SEKIDA, Takashi

IPC分类号： A61K8/18 ,  A61P17/14 ,  A61K31/22 ,  A61K31/357 ,  C07D317/30 ,  C07D319/06

CPC分类号： A61K8/4973 ,  A61K8/37 ,  A61K8/498 ,  A61K31/22 ,  A61K31/357 ,  A61Q7/00 ,  C07C405/00 ,  C07D317/30 ,  C07D319/06

摘要： The present invention provides a method and composition for promoting hair growth in a mammal which comprises a prostaglandin compound having two hetero atoms at the 15 position as an active ingredient thereof.