公开(公告)号：EP1205186A1

公开(公告)日：2002-05-15

申请号：EP00940830.3

申请日：2000-06-23

申请人： SHIONOGI & CO., LTD.

发明人： YANAGITA, Toshihiko

IPC分类号： A61K38/17 ,  A61P21/02 ,  A61P13/02

CPC分类号： A61K38/22

摘要： A composition for promoting extension of bladder smooth muscle, comprising adrenomedullin. The composition of the present invention may be used to ameliorate a urination disorder. The urination disorder may be a urinary incontinence selected from the group consisting of urge incontinence, reflex incontinence, and overflow incontinence. According to the present invention, a method is provided for ameliorating a urination disorder using a composition comprising adrenomedullin. Further, use of adrenomedullin in production of a drug for ameliorating a urination disorder is provided.

摘要翻译： 一种促进膀胱平滑肌延伸的组合物，包括肾上腺髓质素。 本发明的组合物可用于改善排尿障碍。 排尿障碍可以是选自急迫性尿失禁，反射性尿失禁和溢流性尿失禁的尿失禁。 根据本发明，提供了使用包含肾上腺髓外素的组合物来改善排尿障碍的方法。 此外，提供了在制备用于改善排尿障碍的药物中使用肾上腺髓质素。

公开(公告)号：EP1185274A1

公开(公告)日：2002-03-13

申请号：EP00901264.2

申请日：2000-02-01

申请人： AstraZeneca AB ,  SHIONOGI & CO., LTD.

发明人： RAZA, Ali ,  PEARS, John Stuart ,  HUTCHINSON, Howard Gerard ,  SCHNECK, Dennis ,  BABA, Takahiko ,  TOUCHI, Akira ,  YAMAGUCHI, Yoshitaka

IPC分类号： A61K31/505 ,  A61P3/06

CPC分类号： A61K45/06 ,  A61K31/365

摘要： The invention concerns safe non-interacting drug combinations of a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, which is (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl] (3R,5S)-3,5-dihydroxyhept-6-enoic acid or a pharmaceutically acceptable salt thereof (the Agent) and a drug which is either an inducer, inhibitor or a substrate of cytochrome P450, in particular cytochrome P450 isoenzyme 3A4. Particular combinations are useful in treating hyperlipidaemia in humans who are receiving immunosuppressive chemotherapy. A preferred combination is the Agent and a fibrate drug, the use of such a combination in treating hyperlipidaemia in mammals, and medicaments containing such a combination for use in such treatments.

公开(公告)号：EP1169992A3

公开(公告)日：2002-03-13

申请号：EP01123736.9

申请日：1997-08-29

申请人： Shionogi & Co., Ltd.

发明人： Furuya, Yoshihiro ,  Enomoto, Takao ,  Sato, Koji ,  Mizuta, Taiichi

IPC分类号： A61J3/07

CPC分类号： A61J3/072 ,  Y10S53/90

摘要： A method of producing a capsule including forming a band seal between a cap and a body of the filled capsule when the cap has been fitted onto the body, by one or more applications of gelatin-based sealant in the form of a band spanning the cap surface and body surface across the edge of the cap, to form one or more corresponding band seal layers securing between the cap and body; characterised in that for said application of sealant, or for at least the first application where there are more than one, the gelatin-based sealant is one whose viscosity at 50°C is from 50 to 200 mPa.s (centipoise)..

摘要翻译： 一种制造胶囊的方法，该方法包括：通过一次或多次施加基于明胶的密封剂的形式，在盖子已经被装配到主体上时，在盖子和被填充的胶囊的主体之间形成带式密封件， 表面和身体表面穿过帽的边缘，以形成固定在帽和身体之间的一个或多个对应的带密封层; 其特征在于，对于所述密封剂的应用，或者对于至少多于一个的第一应用，明胶基密封剂是其在50℃下的粘度为50-200mPa.s（厘泊）的密封剂。

公开(公告)号：EP1176139A1

公开(公告)日：2002-01-30

申请号：EP00906622.6

申请日：2000-03-02

申请人： SHIONOGI & CO., LTD.

发明人： HONMA, Tsunetoshi, Shionogi & Co., Ltd. ,  HIRAMATSU, Yoshiharu, Shionogi & Co., Ltd. ,  ARIMURA, Akinori, Shionogi & Co., Ltd.

IPC分类号： C07C233/85 ,  C07C323/62 ,  C07C311/21 ,  C07C317/44 ,  C07D409/12 ,  C07D333/38 ,  C07D295/02 ,  C07D333/36 ,  C07D417/00 ,  C07D513/00 ,  A61K31/196 ,  A61K31/381 ,  A61K31/40 ,  A61K31/404 ,  A61K31/426 ,  A61K31/4025 ,  A61K31/435 ,  A61K31/4155 ,  A61K31/4164 ,  A61K31/4188

CPC分类号： C07D207/323 ,  A61K31/00 ,  A61K31/201 ,  A61K31/381 ,  A61K31/40 ,  A61K31/402 ,  A61K31/4025 ,  A61K31/404 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/4188 ,  A61K31/422 ,  A61K31/423 ,  A61K31/426 ,  A61K31/427 ,  A61K31/428 ,  A61K31/4402 ,  A61K31/4725 ,  C07C311/21 ,  C07C317/44 ,  C07C323/62 ,  C07C2602/42 ,  C07D207/48 ,  C07D209/08 ,  C07D213/75 ,  C07D277/46 ,  C07D277/52 ,  C07D307/68 ,  C07D307/84 ,  C07D333/34 ,  C07D333/38 ,  C07D333/54 ,  C07D333/68 ,  C07D333/76 ,  C07D333/78 ,  C07D409/06 ,  C07D409/12 ,  C07D413/06 ,  C07D417/06 ,  C07D495/04

摘要： The present invention provides novel compounds having a dual antagonistic activity against thromboxane A 2 receptor and prostaglandin D 2 receptor and pharmaceutical compositions comprising them.
A compound of the formula (I):
wherein R 1 is -CH 2 -CH=CH-CH 2 -CH 2 -CH 2 -COOR 2 or -CH=CH-CH 2 -CH 2 -CH 2 -COOR 2 ; R 2 is hydrogen or alkyl; m is 0 or 1; p is 0 or 1; X 1 and X 3 each is independently optionally substituted aryl or optionally substituted heteroaryl; X 2 is a bond, -CH 2 -, -S-, -SO 2 -, -CH 2 -O-, -O-CH 2 -, -CH 2 -S-, -S-CH 2 -, or the like; X 4 is -CH 2 -, -CH 2 -CH 2 -, -C(=O)-, or the like, have a dual antagonistic activity against both a thromboxane A 2 receptor and a prostaglandin D 2 receptor.

公开(公告)号：EP1172097A1

公开(公告)日：2002-01-16

申请号：EP00915360.2

申请日：2000-04-06

申请人： SHIONOGI & CO., LTD.

发明人： SHODAI, Hidekazu, Shionogi & Co., Ltd. ,  NAGAFUJI, Noboru, Shionogi & Co., Ltd. ,  MATSUDA, Shuichi, Shionogi & Co., Ltd. ,  SUZUKI, Yusuke, Shionogi & Co., Ltd.

IPC分类号： A61K9/00

CPC分类号： A61K9/1688

摘要： The present invention provides a method for preparation of a pharmaceutical composition which comprises suspending a hydrophobic medical compound without generating foams.
The present inventors have directed attention to properties of a hydrophobic medical compound and found a method for preparation of a pharmaceutical composition which comprises suspending and dispersing a basic hydrophobic medical compound, and neutralizing with a basic aqueous solution.

摘要翻译： 本发明提供了一种制剂，其包含悬浮，而不会产生泡沫的疏水性医疗化合物的药物组合物的方法。 本发明人把注意力转向的疏水性医疗化合物的性质，并发现为制剂，其包含悬浮和碱性疏水医疗化合物分散，并用碱性溶液wässrige中和的药物组合物的方法。

公开(公告)号：EP1169993A2

公开(公告)日：2002-01-09

申请号：EP01123737.7

申请日：1997-08-29

申请人： Shionogi & Co., Ltd.

发明人： Furuya, Yoshihiro ,  Enomoto, Takao ,  Sato, Koji ,  Mizuta, Taiichi

IPC分类号： A61J3/07

CPC分类号： A61J3/072 ,  Y10S53/90

摘要： A method of producing a capsule including forming a band seal between a cap and a body of the filled capsule when the cap has been fitted onto the body, by one or more applications of gelatin-based sealant in the form of a band spanning the cap surface and body surface across the edge of the cap, to form one or more corresponding band seal layers securing between the cap and body; characterised by
a preliminary application of gelatin-based sealant around the cap surface alone, adjacent its edge.

摘要翻译： 一种制造胶囊的方法，该方法包括：通过一次或多次施加基于明胶的密封剂的形式，在盖子已经被装配到主体上时，在盖子和被填充的胶囊的主体之间形成带式密封件， 表面和身体表面穿过帽的边缘，以形成固定在帽和身体之间的一个或多个对应的带密封层; 其特征在于在其边缘附近单独在盖表面周围初步施加明胶基密封剂。

公开(公告)号：EP0623678B1

公开(公告)日：2001-10-04

申请号：EP94302834.0

申请日：1994-04-21

申请人： SHIONOGI & CO., LTD.

发明人： Kageyama, Bunji ,  Nakae, Masanori ,  Yagi, Shigeo

IPC分类号： C12N15/55 ,  C12N9/16 ,  C12N1/21 ,  C12P41/00 ,  C12P7/02

CPC分类号： C12P7/02 ,  C12N9/16 ,  C12P41/004 ,  Y10S435/823

公开(公告)号：EP1134222A1

公开(公告)日：2001-09-19

申请号：EP99973033.6

申请日：1999-11-25

申请人： SHIONOGI & CO., LTD.

发明人： NISHITANI, Yasuhiro-Shionogi & Co., Ltd. ,  ITANI, Hikaru-Shionogi & Co., Ltd. ,  IRIE, Tadashi-Shionogi & Co., Ltd.

IPC分类号： C07D519/00 ,  C07D471/04 ,  A61K31/546 ,  A61P31/04

CPC分类号： C07D501/00

摘要： A cefem compound of the formula (I) shows wide antibacterial spectrum against various pathogenic bacteria including MRSA.
wherein, X is N or CY and Y is H or halogen; R 1 is amino or protected amino; R 2 is hydrogen or optionally substituted lower alkyl etc.; R 3 is hydrogen etc.; R 4 is hydrogen, optionally substituted lower alkyl, or optionally substituted N-containing heterocyclic group etc.; R 5 is hydrogen etc.; and a wavy line means syn- or anti-isomerism or a mixture thereof.

公开(公告)号：EP1132094A1

公开(公告)日：2001-09-12

申请号：EP99972107.9

申请日：1999-11-12

申请人： SHIONOGI & CO., LTD.

发明人： SUGITA, Katsuji ,  NISHIHARA, Yoshitaka ,  YOSHIKAWA, Takanori ,  KIHARA, Tsuyoshi

IPC分类号： A61K45/00 ,  A61K31/44 ,  A61K47/10 ,  A61K47/14

CPC分类号： A61K47/14 ,  A61K9/0014 ,  A61K31/437 ,  A61K47/10

摘要： Percutaneously administrable preparations which each comprise either an aqueous base comprising 1-menthol, a lower alcohol, and an acidic buffer or water, or an oily base comprising 1-menthol, a lower alcohol, and isopropyl myristate, and a cerebral function activator selected from among, e.g., 2-(3-isoxazolyl)-3,6,7,9-tetrahydroimidazo[4,5-d]pyrano[4,3-b]pyridine, salts of the same, and hydrates of both.

摘要翻译： 包含1-薄荷醇，低级醇和酸性缓冲液或水的水性基质或包含1-薄荷醇，低级醇和肉豆蔻酸异丙酯的油性基质的经皮给药的制剂和选自以下的大脑功能活化剂 例如2-（3-异恶唑基）-3,6,7,9-四氢咪唑并[4,5-d“吡喃并[4,3-b]吡啶，其盐和两者的水合物。

公开(公告)号：EP1099690A1

公开(公告)日：2001-05-16

申请号：EP99929887.0

申请日：1999-07-16

申请人： SHIONOGI & CO., LTD.

发明人： UENAKA, Masaaki ,  KII, Makoto ,  NAKAJIMA, Masatoshi

IPC分类号： C07D205/08 ,  C07D401/12 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  A61K31/395 ,  A61K31/40 ,  A61K31/44 ,  A61K31/445 ,  A61K31/495 ,  A61K31/505 ,  A61K31/535

CPC分类号： C07D405/06 ,  C07D205/08 ,  C07D205/09 ,  C07D405/12

摘要： Chymase inhibitors and cytokine production inhibitors containing compounds represented by general formula (I), prodrugs of the same, pharmaceutically acceptable salts thereof or hydrates of them, wherein A is -CO-, -CONH- or the like; R 1 is optionally substituted lower alkyl, optionally substituted aryl or the like; R 2 and R 3 are each independently hydrogen, optionally substituted lower alkyl or the like; B is -S-, -O- or the like; and R 4 is optionally substituted aryl or the like.

摘要翻译： 含有通式（I）表示的化合物的酪氨酸酶抑制剂和细胞因子产生抑制剂，其前药，药学上可接受的盐或它们的水合物，其中A为-CO-，-CONH-等; R 1是任选取代的低级烷基，任选取代的芳基等; R 2和R 3各自独立地为氢，任选取代的低级烷基等; B是-S-，-O-等; 和R 4是任选取代的芳基等。