公开(公告)号：EP2379599A1

公开(公告)日：2011-10-26

申请号：EP09793538.1

申请日：2009-12-18

申请人： Novo Nordisk A/S

发明人： HILDEN, Ida ,  CLAUSEN, Jes Thorn

IPC分类号： C07K16/38 ,  A61P7/04

CPC分类号： C07K16/18 ,  C07K16/38 ,  C07K2317/565 ,  C07K2317/76

摘要： The invention relates to antibodies that specifically bind to tissue factor pathway inhibitor (TFPI) and that reduce clotting time in (a) human FVIII-deficient plasma and/or (b) human whole blood. Such antibodies have utility in the treatment of bleeding disorders and in the stimulation of blood clotting.

公开(公告)号：EP2209810A1

公开(公告)日：2010-07-28

申请号：EP08806603.0

申请日：2008-10-15

申请人： King's College London ,  Baylor College Of Medicine

发明人： VYAKARNAM, Annapurna ,  ROWLEY, David, R.

IPC分类号： C07K16/38 ,  A61K39/395 ,  A61K31/7088 ,  C07K14/81 ,  A61P31/16 ,  A61P31/18 ,  C07K14/705

CPC分类号： C07K16/38 ,  A61K31/7088 ,  A61K2039/505 ,  C07K14/47 ,  C07K14/705 ,  C07K2317/76 ,  G01N33/56988

摘要： The invention provides a method of inhibiting viral infection of a mammalian cell, said method comprising reducing or inhibiting ps20 polypeptide expressed by said cell. Suitably ps20 is inhibited by contacting said cell with an antibody capable of binding to ps20 polypeptide. Suitably said antibody is ps20 neutralising antibody. The invention also provides antibody capable of binding ps20 polypeptide, siRNA targeted to a transcript encoding ps20 polypeptide, or antisense ps20 polynucleotide for use as a medicament for viral infection. The invention also provides a method of identifying an agent for inhibiting a viral infection, comprising determining level of ps20 expression in first and second samples, the first contacted with test agent; and comparing the level of ps20 expression in said first and second samples; wherein lower level of ps20 expression in said first sample relative to said second sample identifies test agent as an agent for inhibiting a viral infection.

公开(公告)号：EP2094832A4

公开(公告)日：2010-05-12

申请号：EP07840067

申请日：2007-11-15

申请人： DAVID GLADSTONE INST

发明人： GAN LI ,  MUCKE LENNART

IPC分类号： A61K38/57 ,  A61K38/55 ,  C07K14/81 ,  C07K16/38

CPC分类号： C12Q1/37 ,  A61K31/7052 ,  A61K38/00 ,  A61K38/55 ,  A61K39/3955 ,  C07K16/38 ,  C12N15/1136 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2330/51 ,  C12Q1/68 ,  G01N33/6896

公开(公告)号：EP1319669B1

公开(公告)日：2008-10-29

申请号：EP03005363.1

申请日：1994-10-04

申请人： Amgen Inc.,

发明人： Silbiger, Scott M. ,  Koski, Raymond A.

IPC分类号： C12N15/15 ,  C07K14/81 ,  C12N1/21 ,  C12N5/10 ,  A61K48/00 ,  A61K38/57 ,  A61K38/43 ,  A61K38/17 ,  A61K38/48 ,  C07K16/38

CPC分类号： A61K38/57 ,  C07K14/8146

公开(公告)号：EP1572864A4

公开(公告)日：2008-02-13

申请号：EP02721328

申请日：2002-03-08

申请人： IMMUNEX CORP

发明人： CLARKE HOWARD R G ,  DUBOSE ROBERT F ,  WILEY STEVEN R

IPC分类号： G01N33/50 ,  A61K38/00 ,  A61K38/55 ,  A61P1/16 ,  A61P7/02 ,  A61P11/00 ,  A61P17/00 ,  A61P17/06 ,  A61P17/08 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  A61P37/08 ,  A61P43/00 ,  C07K14/47 ,  C07K14/81 ,  C07K16/18 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C12P21/08 ,  G01N33/15 ,  G01N33/566 ,  A61K39/00 ,  A61K39/395 ,  C07K16/38 ,  C12N15/15

CPC分类号： C07K14/8121 ,  A61K38/00 ,  C07K2317/24 ,  G01N2333/8121

公开(公告)号：EP1483407A4

公开(公告)日：2006-11-15

申请号：EP03709107

申请日：2003-02-14

申请人： NUVELO INC

发明人： EMTAGE PETER ,  DEDERA DOUGLAS A ,  BOYLE BRYAN J ,  WANG JIAN-RUI ,  CHEN HUANG-TSU ,  WAN CHING-YI ,  YAMAZAKI VICTORIA ,  ASUNDI VINOD ,  LIU CHENGHUA ,  TANG Y TOM ,  DRMANAC RADOJE T

IPC分类号： C07K16/18 ,  C07K16/28 ,  C07K16/38 ,  G01N33/574 ,  C12Q1/68

CPC分类号： G01N33/57492 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/28 ,  C07K16/2896 ,  C07K16/38 ,  G01N33/57407

公开(公告)号：EP1519192A3

公开(公告)日：2005-06-08

申请号：EP04022393.5

申请日：2004-09-21

申请人： Roche Diagnostics GmbH ,  F.HOFFMANN-LA ROCHE AG

发明人： Sigler, Gerald F. ,  Hui, Raymond A. ,  Deras, Ina ,  Root, Richard Terry ,  Ghoshal, Mitali ,  Huber, Erasmus ,  Von der Eltz, Herbert ,  Metz, Sigrun ,  Kern, Peter

IPC分类号： G01N33/53 ,  C07K16/38 ,  C07D401/12 ,  C07D493/04 ,  C12N5/16

CPC分类号： C07K16/38 ,  C07K16/44

摘要： Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for HIV protease inhibitors. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group common to all HIV protease inhibitors, e.g., saquinavir, nelfinavir, indinavir, amprenavir, ritonavir, lopinavir, and atazanavir.

公开(公告)号：EP1227842A4

公开(公告)日：2005-06-08

申请号：EP00980341

申请日：2000-11-10

申请人： UNIV TEMPLE ,  BRISTOL MYERS SQUIBB PHARMA CO

发明人： COLMAN ROBERT W ,  MOUSA SHAKER A

IPC分类号： A61K39/395 ,  C07K16/38 ,  A61K39/40 ,  A61K39/42

CPC分类号： C07K16/38 ,  A61K2039/505

公开(公告)号：EP1288297A4

公开(公告)日：2004-11-17

申请号：EP01930205

申请日：2001-05-18

申请人： DAIICHI FINE CHEM CO LTD

发明人： SEIKI MOTOHARU ,  OBATA KEN-ICHI

IPC分类号： A61K38/00 ,  A61K48/00 ,  A61P35/00 ,  A61P43/00 ,  C12N9/64 ,  C12N15/12 ,  C12Q1/37 ,  G01N33/50 ,  G01N33/573 ,  A61K38/46 ,  A61K39/395 ,  C07K14/81 ,  C07K16/38 ,  C12N5/10 ,  C12P21/02 ,  C12Q1/02

CPC分类号： C12N9/6491 ,  A61K38/00 ,  A61K48/00 ,  C12Q1/37 ,  G01N33/5011 ,  G01N33/573 ,  G01N2333/96486 ,  G01N2500/00 ,  G01N2500/02

摘要： It is considered that the activation of pro-MMP-2 by MT1-MMP is one of the important steps of tumor cell infiltration such as cancer. However, the detailed mechanism of the expression of this activity still remains unknown. It is therefore required to clarify the mechanism of the activation of pro-MMP-2 by MT1-MMP and thus clarify not only the infiltration and metastasis of cancer but also various phenomena in which MT1-MMP seemingly participates, thereby contributing to the prevention and treatment of various diseases. In the activation of pro-MMP-2 by MT1-MMP, it is essentially required to form complexes consisting of plural MT1-MMPs, in particular, an MT1-MMP homodimer. The formation of this dimer is based on the function of the PEX region in MT1-MMP. By using these findings, it is intended to inhibit the formation of the MT1-MMP homodimer and inhibit the activation of pro-MMP-2, thereby regulating the infiltration and metastasis of cancer, etc.

公开(公告)号：EP1433848A1

公开(公告)日：2004-06-30

申请号：EP02762987.2

申请日：2002-09-03

申请人： MOCHIDA PHARMACEUTICAL CO., LTD.

发明人： SHINOZAKI, Mikihiko, MOCHIDA PHARMACEUTICAL CO. ,  HOSAKA, Yoshitaka, MOCHIDA PHARMACEUTICAL CO. ,  NANBA, Mutsuo, MOCHIDA PHARMACEUTICAL CO.

IPC分类号： C12N15/12 ,  C12N9/99 ,  C12N5/10 ,  C12Q1/68 ,  C12Q1/02 ,  C07K16/38

CPC分类号： C12Q1/37 ,  C07K14/811 ,  G01N33/6893 ,  G01N2500/00

摘要： A gene and a protein participating in the control of serine protease activity and a method of efficiently evaluating an activity controlling agent for the protein are provided.
A DNA comprising the nucleotide sequence represented by SEQ ID NO:1; a serine protease inhibitory protein encoded by the DNA; a method of screening for an agent capable of binding to the protein with the use of the protein; an antisense nucleic acid to the DNA; and an antibody specific for the protein.

摘要翻译： 提供参与丝氨酸蛋白酶活性控制的基因和蛋白质以及有效评估蛋白质活性控制剂的方法。 包含由SEQ ID NO：1表示的核苷酸序列的DNA; 由DNA编码的丝氨酸蛋白酶抑制蛋白; 使用蛋白质筛选能够结合蛋白质的试剂的方法; DNA的反义核酸; 和对蛋白质特异性的抗体。