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公开(公告)号：EP1288297A4
公开(公告)日：2004-11-17
申请号：EP01930205
申请日：2001-05-18
发明人： SEIKI MOTOHARU , OBATA KEN-ICHI
IPC分类号： A61K38/00 , A61K48/00 , A61P35/00 , A61P43/00 , C12N9/64 , C12N15/12 , C12Q1/37 , G01N33/50 , G01N33/573 , A61K38/46 , A61K39/395 , C07K14/81 , C07K16/38 , C12N5/10 , C12P21/02 , C12Q1/02
CPC分类号： C12N9/6491 , A61K38/00 , A61K48/00 , C12Q1/37 , G01N33/5011 , G01N33/573 , G01N2333/96486 , G01N2500/00 , G01N2500/02
摘要： It is considered that the activation of pro-MMP-2 by MT1-MMP is one of the important steps of tumor cell infiltration such as cancer. However, the detailed mechanism of the expression of this activity still remains unknown. It is therefore required to clarify the mechanism of the activation of pro-MMP-2 by MT1-MMP and thus clarify not only the infiltration and metastasis of cancer but also various phenomena in which MT1-MMP seemingly participates, thereby contributing to the prevention and treatment of various diseases. In the activation of pro-MMP-2 by MT1-MMP, it is essentially required to form complexes consisting of plural MT1-MMPs, in particular, an MT1-MMP homodimer. The formation of this dimer is based on the function of the PEX region in MT1-MMP. By using these findings, it is intended to inhibit the formation of the MT1-MMP homodimer and inhibit the activation of pro-MMP-2, thereby regulating the infiltration and metastasis of cancer, etc.
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公开(公告)号：EP1273665A4
公开(公告)日：2006-04-05
申请号：EP01908255
申请日：2001-03-02
发明人： SAKAMOTO KEIJI , KITA SHINJI , TSUZAKI KAZUYA , MORIKAWA TADANORI , SHIMIZU SAKAYU , KATAOKA MICHIHIKO
IPC分类号： C12P13/00 , C12P41/00 , C12R1/01 , C12R1/22 , C12R1/32 , C12R1/40 , C12R1/43 , C12R1/64 , C12R1/645
CPC分类号： C12P13/001 , C12P13/008 , C12P41/002 , Y10S435/822 , Y10S435/865 , Y10S435/877 , Y10S435/911 , Y10S435/914 , Y10S435/917 , Y10S435/918
摘要： A process for producing an optical active beta -amino alcohol, the method comprising the step of allowing at least one microorganism selected from the group consisting of microorganisms belonging to the genus Morganella and others, to act on an enantiomeric mixture of an alpha -aminoketone or a salt thereof having the general formula (I): to produce an optical active beta -amino alcohol with the desired optical activity having the general formula (II) described below in a high yield as well as in a highly selective manner:
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公开(公告)号：EP1101492A4
公开(公告)日：2002-09-25
申请号：EP99929875
申请日：1999-07-16
发明人： IGETA KATSUHIRO , TOBETTO KENJI , SAIKI IKUO , ODAKE SHINJIRO , FUJISAWA TETSUNORI , MATSUO TETSU , OKU TOHRU
IPC分类号： A61K31/16 , A61K31/165 , A61K31/215 , A61K31/35 , A61K31/415 , A61K31/66 , A61K31/70 , A61P37/00
CPC分类号： A61K31/70 , A61K31/16 , A61K31/165 , A61K31/215 , A61K31/35 , A61K31/415 , A61K31/66
摘要： Drugs characterized by containing hydroxamic acid derivatives as the active ingredient which are efficacious in treating and/or preventing allergies, in particular, type I and/or type II allergies, etc. These drugs exert therapeutic and/or preventive effects on inflammation, rhinitis, conjunctivitis, bronchial asthma, atopic dermatitis (dermatitis, enteritis, etc.) and allergic digestive inflammation. Use of these drugs achieves the effects of: (A) inhibiting the proliferation of colonies of blood cells (lymphocytes, etc.) in an affected part; and/or (B) relieving inflammation caused by the migration, infiltration, accumulation, etc. of blood cells (lymphocytes, etc.) into an affected part; and/or (C) regulating the pathophysiological functions of cells such as blood cells (lymphocytes, etc.), Langerhans cells and dendritic cells; and/or (D) regulating the production of antibodies, in particular, IgE in the plasma, thus being useful in treating and/or preventing diseases or pathological conditions in the affected parts.
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公开(公告)号：EP0870826A4
公开(公告)日：2002-05-02
申请号：EP96923081
申请日：1996-07-12
发明人： SEIKI MOTOHARU , SATO HIROSHI , SHINAGAWA AKIRA
CPC分类号： C12N9/6491 , A61K38/00 , C07K16/40
摘要： A novel protein which is useful as diagnostic means for the studies relating to the diagnosis and treatment of cancer (detection of cancer cells, estimation of the malignity, etc.) and in other medicinal and physiological purposes; a gene encoding the same; and an antibody, in particular, a monoclonal antibody specific to the protein. MT-MMP-3, which is a pro MMP-2 activator having the ability to activate pro MMP-2 which is under expression specifically on the surface layer of a human cancer cell and falling within the category of MMP but being different from MT-MMP-1; a DNA containing the base sequence encoding the same; host cells transformed by the DNA; a process for producing a matrix metalloproteinase protein by using the host cells; a monoclonal antibody binding specifically to the matrix metalloproteinase protein; and use of the protein and antibody.
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公开(公告)号：EP2476408A4
公开(公告)日：2013-03-06
申请号：EP10815324
申请日：2010-09-06
发明人： WADA KOICHI , SUMI KOICHI , SHIMOMURA SHIHOKO
CPC分类号： A61K31/661 , A61K8/55 , A61Q1/02 , A61Q5/02 , A61Q19/02
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公开(公告)号：EP1679316A4
公开(公告)日：2010-05-26
申请号：EP04773642
申请日：2004-09-30
发明人： SAKAMOTO KEIJI , WADA KOICHI , ITO HAJIME , TAKE NOBUHIRO , MORIMOTO HIROSHI , MANIWA FUMIO , SHIMMOTO YUKIKO
IPC分类号： C07H17/02 , A23K1/16 , A23L1/302 , A61K31/66 , A61K31/706 , A61P1/02 , A61P1/04 , A61P3/02 , A61P5/16 , A61P7/06 , A61P17/00 , A61P17/04 , A61P21/02 , A61P25/08 , A61P25/32 , A61P29/00 , C07F9/02
CPC分类号： A61K8/673 , A23K20/174 , A23L33/15 , A61K31/66 , A61K31/706 , A61Q5/02 , A61Q19/00 , A61Q19/004 , A61Q19/005 , A61Q19/02 , A61Q19/08 , C07F9/582 , C07H17/02
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公开(公告)号：EP1688491A4
公开(公告)日：2008-04-02
申请号：EP04793212
申请日：2004-10-29
发明人： YAMAMURA EITORA , FUJIMOTO NOBORU
IPC分类号： C12N15/09 , C12N9/04 , C12N13/00 , C12N15/31 , C12N15/63 , C12N15/70 , C12N15/74 , C12P7/02 , C12P13/00
CPC分类号： C12P13/008 , C12N9/0006 , C12N15/70 , C12N15/74 , C12P13/001
摘要： A shuttle vector is constructed by preparing a DNA region replicable in a microorganism belonging to the genus Rhodococcus from a Rhodococcus-origin plasmid having the base sequence represented by SEQ ID NO:73 and a plasmid having the base sequence represented by SEQ ID NO:74, DNA fragments thereof or the like and further preparing a DNA region replicable in Escherichia coli from an E. coli-origin plasmid or its DNA fragment. Then an aminoketone asymmetric reductase gene is inserted into the shuttle vector to form a vector. Next, a transformant having this vector is constructed to thereby produce aminoketone asymmetric reductase and an optically active aminoalcohol.
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公开(公告)号：EP1600499A4
公开(公告)日：2006-08-30
申请号：EP04716788
申请日：2004-03-03
CPC分类号： C12P41/003 , C12N9/18 , C12P17/04
摘要： It has been required to economically produce a large amount of an optically active gamma-lactone derivative (for example, pantolactone) which is useful as an intermediate in synthesizing a useful substance such as a drug. To achieve this object, it is advantageous to employ a technique of enzymatic asymmetric hydrolysis with the use of an enzyme lactonase. However, it remains troublesome to prepare the enzyme or utilize a microorganism capable of producing the enzyme. Also, it is difficult to obtain a sufficient and stable enzymatic activity in the case of using recombination techniques. In producing lactonase, which asymmetrically hydrolyzes a gamma-lactone derivative such as racemic pantolactone selectively, by a recombination technique, maturation lactonase DNA and signal peptide region DNA are both transferred into a host. Thus, a stable activity comparable to that of natural lactonase can be achieved and a transformant having a high enzyme activity and sustaining it in a stable state can be obtained. As a result, it becomes possible to efficiently and industrially advantageously perform the asymmetric synthesis of a gamma-lactone derivative.
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公开(公告)号：EP1371731A4
公开(公告)日：2005-12-14
申请号：EP02701683
申请日：2002-03-01
发明人： SAKAMOTO K , KITA S , TSUZAKI K , MORIKAWA T , SHIMIZU S , KATAOKA M
IPC分类号： C12N1/15 , C12N1/19 , C12N1/21 , C12N9/04 , C12N15/53 , C12P13/00 , C12N5/10 , C12N9/02 , C12P7/02
CPC分类号： C12N9/0006 , C12P13/001 , C12P13/008
摘要： A protein which is an aminoketone asymmetric reductase acting on 1-2-methylaminopropiophenone to form d-pseudoephedrine and having the following physicochemical properties; and a nucleic acid encoding this protein: substrate: 1-2-methylaminopropiophenone; optimum pH value: 8.1; optimum temperature: 55 °C; coenzyme: NADP; and molecular weight: homotetramer of about 28500 Da.
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公开(公告)号：EP1293497A4
公开(公告)日：2005-04-27
申请号：EP01943812
申请日：2001-06-22
IPC分类号： A61P3/02 , A61P17/00 , A61P29/00 , C07C231/24 , C07C235/12 , A61K31/197
CPC分类号： C07C235/12 , C07C231/24
摘要： A process for the production of crystalline calcium pantothenate which comprises subjecting a homogeneous mixture containing both crystalline calcium pantothenate and amorphous calcium pantothenate to moisture absorption. This process comprises, e.g., the following steps of: (1) mixing crystalline calcium pantothenate with amorphous calcium pantothenate to form a homogeneous mixture and (2) making the obtained homogeneous mixture absorb moisture, and permits efficient production of extremely lowly hygroscopic crystalline calcium pantothenate.
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