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公开(公告)号：EP1817276A1
公开(公告)日：2007-08-15
申请号：EP05808098.7
申请日：2005-11-18
IPC分类号： C07C255/46 , A61K31/275
CPC分类号： C07C255/46 , C07C2601/02
摘要： This invention relates to a novel class of compounds, diagrammed below, wherein R1, R2, R3, R4, R5, R6, R7, D and n are defined therein, which are cysteine protein inhibitors, including, but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone reportion is indicated, such as osteoporosis.
摘要翻译： 本发明涉及一类新化合物，如下图所示，其中R1，R2，R3，R4，R5，R6，R7，D和n定义为半胱氨酸蛋白抑制剂，包括但不限于 组织蛋白酶K，L，S和B.这些化合物可用于治疗其中显示抑制骨病的疾病，如骨质疏松症。
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162.发明公开DIASTEREOSELECTIVE REDUCTIVE AMINATION PROCESS 有权DIASTEREOSELEKTIVES REDUKTIVES AMINIERUNGSVERFAHREN
公开(公告)号：EP1789379A2
公开(公告)日：2007-05-30
申请号：EP05777430.9
申请日：2005-07-29
IPC分类号： C07C227/00
CPC分类号： C07C227/32 , C07B2200/07 , C07C227/04 , C07C227/18 , C07C229/14 , C07C229/20 , C07C229/36 , C07C249/02 , C07C315/04 , C07C317/32 , C07C251/24
摘要： This invention describes a reductive amination process whereby perfluorinated ketones or ketals are combined with α-aminoesters under basic conditions to form metal carboxylates. Diastereoselective reductions of the metal carboxylates enable access to two diastereomers, depending on the reducing conditions.
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公开(公告)号：EP1517895B1
公开(公告)日：2007-03-14
申请号：EP03760540.9
申请日：2003-06-23
发明人： DESCHENES, Denis , DUBE, Daniel , DUBE, Laurence , GALLANT, Michel , GIRARD, Yves , LACOMBE, Patrick , MACDONALD, Dwight
IPC分类号： C07D215/04 , C07D215/12 , C07D409/10 , C07D407/10 , C07D401/10 , C07D413/10 , C07D413/14 , C07D471/04 , C07D401/04 , C07D403/10 , C07D417/10 , A61K31/4709 , A61K31/47 , A61K31/497 , A61P29/00
CPC分类号： C07D215/04 , C07D215/06 , C07D215/12 , C07D215/14 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/10 , C07D405/10 , C07D407/10 , C07D409/10 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/12 , C07D471/04 , C07F7/0812 , C07F9/60
摘要： 8-(biaryl) quinolines wherein the bi-aryl group at the 8-position is in a meta relationship to the quinoline group, are PDE4 inhibitors useful in the treatment of asthma, chronic bronchitis, chronic obstructive pulmonary disease, eosinophilic granuloma, psoriasis and other benign or malignant proliferative skin diseases, endotoxic shock, laminitis in horses, colic in horses, septic shock, ulcerative colitis, Crohn's disease, reperfusion injury of the myocardium and brain, inflammatory arthritis, chronic glomerulonephritis, atopic dermatitis, urticaria, adult respiratory distress syndrome, chronic obstructive pulmonary disease in animals, diabetes insipidus, allergic rhinitis, allergic conjunctivitis, vernal conjunctivitis, arterial restenosis, ortherosclerosis, atherosclerosis, neurogenic inflammation, pain, cough, rheumatoid arthritis, ankylosing spondylitis, transplant rejection, graft versus host disease, hypersecretion of gastric acid, bacterial, fungal induced sepsis, viral induced sepsis, fungal induced septic shock, viral induced septic shock, inflammation-mediated chronic tissue degeneration, cytokine-mediated chronic tissue degeneration, osteoarthritis, cancer, cachexia, muscle wasting, depression, memory impairment, tumour growth, or cancerous invasion of normal tissues.In another aspect, the present invention is directed to a method of enhancing cognition in a healthy subject comprising administering a safe cognition enhancing amount of phosphodiesterase-4 inhibitor. In particular, this invention is directed to a method of enhancing memory, learning, retention, recall, awareness and judgement in health subjects comprising administering a safe and cognition enhancing amount of a phosphodiesterase-4 inhibitor.
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公开(公告)号：EP1758865A1
公开(公告)日：2007-03-07
申请号：EP05754860.4
申请日：2005-06-07
发明人： LACHANCE, Nicolas , ROY, Patrick , LEBLANC, Yves
IPC分类号： C07D221/04 , C07D215/48 , A61K31/435 , A61K31/47 , A61P37/00 , C07D241/40 , C07D239/70 , A61K31/498 , A61K31/517
CPC分类号： C07D221/04 , C07D215/48
摘要： The present invention provides novel compounds of Formula I which are antagonists of the C5a receptor. Compounds of the present invention are useful for the treatment of various C5a-mediated diseases and disorders; accordingly the present invention provides a method for the treatment of C5a-mediated diseases using the novel compounds described herein, as well as pharmaceutical compositions containing them.
摘要翻译： 本发明提供了作为C5a受体拮抗剂的式I的新化合物。 本发明的化合物可用于治疗各种C5a介导的疾病和病症; 因此本发明提供了使用本文所述新化合物治疗C5a介导的疾病的方法，以及含有它们的药物组合物。
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公开(公告)号：EP1458718B1
公开(公告)日：2006-10-25
申请号：EP02784961.1
申请日：2002-12-11
发明人： DUBE, Daniel , DESCHENES, Denis , FORTIN, Rejean , GIRARD, Yves
IPC分类号： C07D471/06 , A61K31/47 , C07D215/22
CPC分类号： C07D215/22 , A61K31/00 , A61K31/47 , A61K31/4706 , A61K31/4745 , C07D215/42 , C07D401/04 , C07D401/10 , C07D401/12 , C07D409/10 , C07D409/12 , C07D471/06
摘要： This invention encompasses a method for treating a prostaglandin E mediated disease or condition comprising administering to a mammalian patient in need of such treatment a compound of Formula (A) in an amount that is effective to treat the prostaglandin E mediated disease or condition.
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166.发明公开
公开(公告)号：EP1697322A1
公开(公告)日：2006-09-06
申请号：EP04802298.2
申请日：2004-12-13
IPC分类号： C07D209/88 , A61K31/403 , A61P11/06 , A61P11/02 , A61P29/00
CPC分类号： C07D209/94 , C07D209/88
摘要： The present invention provides substituted tetrahydrocarbazole and cyclopentanoindole derivatives as antagonists of DP receptor, and as such are useful for the treatment of prostaglandin D2 mediated diseases such as rhinitis, asthma and nasal congestion.
摘要翻译： 本发明提供取代的四氢咔唑和环戊烷吲哚衍生物作为DP受体的拮抗剂，因此可用于治疗前列腺素D2介导的疾病，如鼻炎，哮喘和鼻充血。
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公开(公告)号：EP1660436A1
公开(公告)日：2006-05-31
申请号：EP04761741.0
申请日：2004-08-23
IPC分类号： C07C255/29 , C07C317/22 , C07C317/40 , C07D241/04 , C07D333/10
CPC分类号： C07D295/108 , C07C255/24 , C07C255/29 , C07C255/46 , C07C323/41 , C07C2601/02 , C07D223/08 , C07D295/135 , C07D307/33 , C07D333/20 , C07D333/24 , C07D401/12 , C07K5/06191
摘要： This invention relates to a novel class of compounds, represented by the formula (I) below, wherein the meanings of R1, R2, R3 and R4 are indicated therein, which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis, osteoarthritis and rheumatoid arthritis.
摘要翻译： 本发明涉及由下式（I）表示的一类新化合物，其中R 1，R 2，R 3和R 4的含义在其中表示，它们是半胱氨酸蛋白酶抑制剂，包括但不限于组织蛋白酶K ，L，S和B.这些化合物可用于治疗其中指示抑制骨吸收的疾病，如骨质疏松症，骨关节炎和类风湿性关节炎。
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168.发明公开FLAVORED TASTE-MASKED PHARMACEUTICAL FORMULATION MADE USING A ONE-STEP COATING PROCESS 审中-公开利用生产的味药物一次涂敷工序配方味道掩盖
公开(公告)号：EP1656117A1
公开(公告)日：2006-05-17
申请号：EP04761647.9
申请日：2004-08-10
发明人： DUMONT, Hubert , THIBERT, Roch
CPC分类号： A61K31/415 , A61K9/5015 , A61K9/5026 , A61K9/5042
摘要： The present invention encompasses a flavored and taste-masked pharmaceutical composition comprising a plurality of pharmaceutically acceptable cores, such as microspheres, said pharmaceutically acceptable cores comprising etoricoxib, wherein the pharmaceutically acceptable cores are coated with a flavored taste-masking coating solution in a convenient one-step process.
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169.发明公开DIPHENYL SUBSTITUTED CYCLOALKANES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE 审中-公开联苯环烷烃取代的，含有它们的组合物及其使用方法
公开(公告)号：EP1651231A2
公开(公告)日：2006-05-03
申请号：EP04778708.0
申请日：2004-07-20
发明人： CHU, Lin , GOULET, Mark, T. , UJJAINWALLA, Feroze , FRENETTE, Richard , GIRARD, Yves , THERIEN, Michel , MACDONALD, Dwight , HUTCHINSON, John, H. , CHANG, Linda
IPC分类号： A61K31/535 , C07D221/02 , C07D231/02 , C07D263/02
CPC分类号： C07D215/14 , C07D215/12 , C07D237/28 , C07D277/64 , C07D401/12 , C07D413/12 , C07D417/12 , C07D471/02
摘要： The instant invention provides compounds of formula: (I) which are 5-lipoxygenase activating protein inhibitors: formula (I). Compounds of formula (I) are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.
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170.发明公开7-[(1,3-THIAZOL-2-YL)THIO]-COUMARIN DERIVATIVES AND THEIR USE AS LEUKOTRIENE BIOSYNTHESIS INHIBITORS 审中-公开7 - [（1,3-噻唑-2-基）硫代] -COUMARINDERIVATIVE及其作为白三烯生物合成的抑制剂
公开(公告)号：EP1636222A1
公开(公告)日：2006-03-22
申请号：EP04737802.1
申请日：2004-06-08
发明人： GAREAU, Yves , JUTEAU, Helene , MACKAY, Bruce, D. , FRIESEN, Richard , GRIMM, Erich, L. , BLOUIN, Marc , LALIBERTE, Sebastien
IPC分类号： C07D417/12 , A61K31/427 , C07D417/14
CPC分类号： C07D417/12 , C07D277/36 , C07D417/14
摘要： The instant invention provides compounds of Formula (I) which are leukotriene biosynthesis inhibitors. Compounds of formula (I) are useful as anti-asthmatic, anti-allergic, anti-inflammatory, cytoprotective and anti-artherosclerotic agents.
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