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11.发明公开
公开(公告)号：EP3704236A1
公开(公告)日：2020-09-09
申请号：EP18830543.7
申请日：2018-10-29
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公开(公告)号：EP3186362B1
公开(公告)日：2019-05-15
申请号：EP15797403.1
申请日：2015-08-31
申请人： Instytut Biochemii I Biofizyki Polskiej Akademii Nauk , Instytut Immunologii I Terapii Doswiadczalnej Polskiej Akademii
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公开(公告)号：EP3384289A1
公开(公告)日：2018-10-10
申请号：EP16823045.6
申请日：2016-12-01
发明人： GRZESIUK, Elzbieta , PIWOWARSKI, Jan , PILZYS, Tomasz , WISNIOWSKA, Iga , MARCINKOWSKI, Michal , GARBICZ, Damian , LISIK, Wojciech , KOSIERADZKI, Maciej , PACZEK, Leszek , KRASOWSKI, Pawel
IPC分类号： G01N33/561 , G01N33/68
CPC分类号： G01N33/6854 , G01N33/561 , G01N2800/245
摘要： The invention relates to a method of protein analysis in a urine sample, including preparation of the urine sample and protein detection, wherein the step of preparation of the urine sample for analysis includes mixing the sample without centrifugation and protein detection is performed for the whole urine.
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14.发明公开STAPHYLOCOCCUS AUREUS STRAINS FOR PRODUCTION OF MONOCLONAL PHAGE PREPARATIONS DEPRIVED OF CONTAMINATION WITH PLASMID DNA 审中-公开用于制备用质粒DNA污染的单克隆制备物的金黄色葡萄球菌菌株
公开(公告)号：EP3186362A1
公开(公告)日：2017-07-05
申请号：EP15797403.1
申请日：2015-08-31
申请人： Instytut Biochemii I Biofizyki Polskiej Akademii Nauk , Instytut Immunologii I Terapii Do Wiadczalnej Polskiej Akademii Nauk
发明人： LOBOCKA, Malgorzata , HEJNOWICZ, Monika , DABROWSKI, Kamil , IZAK, Dariusz , GOZDEK, Agnieszka , GLOWACKA, Aleksandra , GAWOR, Jan , KOSAKOWSKI, Jaroslaw , GROMADKA, Robert , WEBER-DABROWSKA, Beata , GÓRSKI, Andrzej
CPC分类号： C12R1/445 , C12N1/20 , C12N7/00 , C12N2795/00051
摘要： Disclosed are Staphylococcus aureus strains for obtaining monoclonal preparations of lytic bacteriophages with high titer, devoid of contamination with undesired bacteriophages and plasmid DNA, which guarantee the production of safe to use bacteriophage preparations, not being a source of dissemination of genes associated with bacterial virulence.
摘要翻译： 公开了金黄色葡萄球菌菌株用于获得高滴度的溶解性噬菌体的单克隆制备物，其不含不希望的噬菌体和质粒DNA的污染，其保证产生安全使用的噬菌体制剂，而不是与细菌毒力相关的基因传播的来源。
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15.发明公开Compounds as modulators of a mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction 审中-公开化合物作为突变CFTR蛋白的调节剂和其用于治疗疾病与CFTR蛋白故障相关联的治疗用途
公开(公告)号：EP2816034A3
公开(公告)日：2015-03-04
申请号：EP14185332.5
申请日：2011-06-20
发明人： Odolczyk, Norbert , Zielenkiewicz, Piotr , Wieczorek, Grzegorz , Edelman, Aleksander , Tondelier, Danielle , Fritsch, Janine
IPC分类号： C07D219/10 , C07D473/30 , C07F9/30 , C07C233/65 , A61K31/663 , A61K31/435 , A61K31/522 , A61K31/194 , A61P11/00 , C07D473/22 , C07D401/12 , C07C235/84
CPC分类号： A61K31/194 , A61K31/496 , A61K31/52 , A61K31/663 , C07C233/65 , C07C235/84 , C07C2603/18 , C07D219/10 , C07D401/12 , C07D473/22 , C07D473/30 , C07F9/304 , C07F9/305
摘要： The present invention relates to novel protein modulators capable of altering function of the mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction. The invention provides compositions, pharmaceutical preparations and methods of correcting the cellular alteration of a mutant CFTR protein wherein the CFTR mutation is a mutation ΔF508-CFTR, or another mutation of class II.
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16.发明公开Compounds as modulators of a mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction 审中-公开化合物作为突变CFTR蛋白的调节剂及其对疾病与CFTR蛋白功能障碍相关的治疗用途
公开(公告)号：EP2826771A3
公开(公告)日：2015-02-18
申请号：EP14185330.9
申请日：2011-06-20
发明人： Odolczyk, Norbert , Zielenkiewicz, Piotr , Wieczorek, Grzegorz , Edelman, Aleksander , Tondelier, Danielle , Fritsch, Janine
IPC分类号： C07D219/10 , C07D473/30 , C07F9/30 , C07C233/65 , A61K31/663 , A61K31/435 , A61K31/522 , A61K31/194 , A61P11/00 , C07D401/12 , C07C235/84 , C07D473/22
CPC分类号： A61K31/194 , A61K31/496 , A61K31/52 , A61K31/663 , C07C233/65 , C07C235/84 , C07C2603/18 , C07D219/10 , C07D401/12 , C07D473/22 , C07D473/30 , C07F9/304 , C07F9/305
摘要： The present invention relates to novel protein modulators capable of altering function of the mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction. The invention provides compositions, pharmaceutical preparations and methods of correcting the cellular alteration of a mutant CFTR protein wherein the CFTR mutation is a mutation ΔF508-CFTR, or another mutation of class II.
摘要翻译： 本发明涉及一种能够改变突变体CFTR蛋白的功能和它们用于治疗与CFTR蛋白故障有关的疾病的使用新颖蛋白调节剂。 本发明提供了组合物，药物制剂和校正的突变CFTR蛋白worin的CFTR突变的细胞改变是突变“F508-CFTR，或II类的另一突变的方法。
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17.发明公开Compounds as modulators of a mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction 审中-公开化合物作为突变CFTR蛋白调制器和它们用于疾病治疗的蛋白质CFTR障碍有关
公开(公告)号：EP2816035A2
公开(公告)日：2014-12-24
申请号：EP14185333.3
申请日：2011-06-20
发明人： Odolczyk, Norbert , Zielenkiewicz, Piotr , Wieczorek, Grzegorz , Edelman, Aleksander , Tondelier, Danielle , Fritsch, Janine
IPC分类号： C07D219/10 , C07D473/30 , C07F9/30 , C07C233/65 , A61K31/663 , A61K31/435 , A61K31/522 , A61K31/194 , A61P11/00 , C07D401/12 , C07C235/84 , C07D473/22
CPC分类号： A61K31/194 , A61K31/496 , A61K31/52 , A61K31/663 , C07C233/65 , C07C235/84 , C07C2603/18 , C07D219/10 , C07D401/12 , C07D473/22 , C07D473/30 , C07F9/304 , C07F9/305
摘要： The present invention relates to novel protein modulators capable of altering function of the mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction. The invention provides compositions, pharmaceutical preparations and methods of correcting the cellular alteration of a mutant CFTR protein wherein the CFTR mutation is a mutation ΔF508-CFTR, or another mutation of class II.
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公开(公告)号：EP3469372B1
公开(公告)日：2023-03-08
申请号：EP17736762.0
申请日：2017-06-12
发明人： MUCHA, Krzysztof , PACZEK, Leszek , ZAGOZDZON, Radoslaw , FORONCEWICZ, Bartosz , DADLEZ, Michal , BAKUN, Magdalena , PIWOWARSKI, Jan , PILZYS, Tomas , MARCINKOWSKI, Michal , GARBICZ, Damian , GRZESIUK, Elzbieta , FLORCZAK, Michal
IPC分类号： G01N33/68
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公开(公告)号：EP3460048B1
公开(公告)日：2021-04-28
申请号：EP18195142.7
申请日：2015-08-31
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公开(公告)号：EP3186370B1
公开(公告)日：2020-01-01
申请号：EP15780935.1
申请日：2015-08-27
申请人： Instytut Biochemii I Biofizyki Polskiej Akademii Nauk , Instytut Immunologii i Terapii Doswiadczalnej Polskiej Akademii Nauk
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