公开(公告)号：EP1311261A4

公开(公告)日：2004-06-02

申请号：EP01954627

申请日：2001-07-10

申请人： PHOTOGEN INC

发明人： DEES H CRAIG ,  SCOTT TIMOTHY

IPC分类号： C07D311/82 ,  A61B17/22 ,  A61F7/00 ,  A61K9/00 ,  A61K9/06 ,  A61K9/08 ,  A61K9/12 ,  A61K31/352 ,  A61K41/00 ,  A61K47/10 ,  A61K47/12 ,  A61K47/20 ,  A61K47/48 ,  A61N5/06 ,  A61P31/00 ,  A61P35/00 ,  A61P43/00 ,  A61P17/06

CPC分类号： A61K41/0057 ,  A61B2017/22062 ,  A61B2017/22087 ,  A61F7/00 ,  A61K9/0014 ,  A61K9/0019 ,  A61K31/352 ,  A61K41/0071 ,  A61K47/10 ,  A61K47/12 ,  A61K47/20 ,  A61N5/0601 ,  A61N5/062 ,  C07D311/82 ,  Y10T436/193333

摘要： New chemotherapeutic medicaments and certain medical uses and methods for use of such chemotherapeutic medicaments for treatment of disease in human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. Preferably, the halogenated xanthene is Rose Bengal or a functional derivative of Rose Bengal. The halogenated xanthenes constitute a family of useful chemotherapeutic agents that afford selective, persistent accumulation in certain tissues. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection. In another preferred embodiment, such medicaments are produced in various formulations useful for intracorporeal or topical administration, including in liquid, semisolid, solid or aerosol delivery vehicles.

公开(公告)号：EP1126782A4

公开(公告)日：2003-06-04

申请号：EP99971283

申请日：1999-10-26

申请人： PHOTOGEN INC

发明人： DEES H CRAIG ,  SCOTT TIMOTHY

IPC分类号： G01R33/28 ,  A61B5/055 ,  A61B6/00 ,  A61B6/03 ,  A61K31/352 ,  A61K41/00 ,  A61K49/00 ,  A61K49/04 ,  A61N5/06 ,  A61P35/00 ,  A61B5/00

CPC分类号： A61K49/0041 ,  A61K41/0057 ,  A61K41/008 ,  A61N5/0601 ,  A61N5/062

摘要： The present invention is directed to an apparatus and method of imaging and treatment using at least one photodynamic therapy ('PDT') agent. The method includes administering a photoactive agent to a patient (56), imaging the patient to locate the diseased tissue or tumors (54) in the patient using an imaging device (52) such as CAT scan or MRI, and treating the imaged diseased tissue with light (60) sufficient to photo-activate the agent in the tissue.

公开(公告)号：EP1284727A1

公开(公告)日：2003-02-26

申请号：EP01920579.8

申请日：2001-03-20

申请人： Photogen, Inc.

发明人： DEES, H, Craig ,  SCOTT, Timothy ,  WACHTER, Eric ,  FISHER, Walter ,  SMOLIK, John

IPC分类号： A61K31/35

CPC分类号： A61K31/352 ,  A61B2017/00057 ,  A61B2017/22062 ,  A61B2017/22087 ,  A61F7/00 ,  A61K9/0019 ,  A61K41/0038 ,  A61K41/0057 ,  A61K41/0071 ,  A61K41/008 ,  A61K47/10 ,  A61K47/12 ,  A61K47/20 ,  A61K47/6803 ,  A61K49/0041 ,  A61K49/0433 ,  A61N5/0601 ,  A61N5/062 ,  C07D311/82 ,  Y02A50/473 ,  Y10T436/153333 ,  Y10T436/19 ,  Y10T436/193333

摘要： New intracorporeal photodynamic medicaments and certain medical uses and methods for use of such photodynamic medicaments for treatment of disease in human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection. In another preferred embodiment, such medicaments are produced in various formulations including liquid, semisolid, solid or aerosol delivery vehicles.

公开(公告)号：EP1265546A1

公开(公告)日：2002-12-18

申请号：EP01916441.7

申请日：2001-03-07

申请人： Photogen, Inc.

发明人： FISHER, Walter ,  WACHTER, Eric

IPC分类号： A61B19/00

CPC分类号： A61K41/008 ,  A61B5/0059 ,  A61B5/0066 ,  A61B5/0068 ,  A61B2017/00053 ,  A61B2017/00057 ,  A61B2017/00243 ,  A61B2017/00867 ,  A61K49/0017 ,  A61M25/0041 ,  A61M25/0133 ,  A61N1/056 ,  A61N5/062 ,  A61N2005/0644 ,  B23K26/0624 ,  B82Y15/00 ,  G01N21/4795

摘要： Methods and apparatus directed to using modulation to substantially improve detection limits in optical imaging, and to substantially improve the performance of various optical imaging systems. Such modulation is achieved using a modulated light source (40), a modulation frequency reference (42), a detector (10), and a demodulator (46). The modulated light source may comprise a light source emitting an inherently modulated output; or, this modulated light source may comprise a separate optical modulator and a continuous wave, modulated, or pulsed light source configured to impose a modulation in the output of light source. Methods for imaging are also disclosed.

公开(公告)号：EP1100394A4

公开(公告)日：2005-03-16

申请号：EP99940828

申请日：1999-07-29

申请人： PHOTOGEN INC

发明人： DEES H CRAIG ,  WACHTER ERIC A

IPC分类号： A61B18/20 ,  A61K41/00 ,  A61N5/06 ,  A61B19/00

CPC分类号： A61B18/203 ,  A61B2017/00769 ,  A61B2018/00452 ,  A61B2018/00458 ,  A61B2018/0047 ,  A61B2018/00476 ,  A61N5/062

摘要： This invention is a method, and apparatus for selectively photo-bleaching or killing pigmented tissues by photochemically converting pigments in the tissues using light (82), and specifically two photon excitation. Photo-toxic products thereby produced then kill pigmented cells. Hyperthermia or an exogenous agent can also be added to augment efficacy. The present invention is also directed to selective thermal destruction of pigmented tissues using related optical means.

公开(公告)号：EP1187841A4

公开(公告)日：2004-12-08

申请号：EP00930813

申请日：2000-05-18

申请人： PHOTOGEN INC

发明人： DEES H CRAIG ,  SMOLIK JOHN

IPC分类号： C12N15/09 ,  C07K14/005 ,  C07K14/47 ,  C12N1/15 ,  C12N1/19 ,  C12N5/02 ,  C12N5/08 ,  C12N5/10 ,  C12N7/00 ,  C12N7/01 ,  C12P21/02 ,  C12P21/04 ,  C07H21/02 ,  C12P19/34 ,  C12P21/06 ,  H01J5/48 ,  H01J5/50 ,  H01J29/10

CPC分类号： C07K14/47 ,  C12N7/00 ,  C12N2760/18451

公开(公告)号：EP1311261A1

公开(公告)日：2003-05-21

申请号：EP01954627.4

申请日：2001-07-10

申请人： Photogen, Inc.

发明人： DEES, H., Craig ,  SCOTT, Timothy

IPC分类号： A61K31/352

CPC分类号： A61K41/0057 ,  A61B2017/22062 ,  A61B2017/22087 ,  A61F7/00 ,  A61K9/0014 ,  A61K9/0019 ,  A61K31/352 ,  A61K41/0071 ,  A61K47/10 ,  A61K47/12 ,  A61K47/20 ,  A61N5/0601 ,  A61N5/062 ,  C07D311/82 ,  Y02A50/473 ,  Y10T436/193333

摘要： New chemotherapeutic medicaments and certain medical uses and methods for use of such chemotherapeutic medicaments for treatment of disease in human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. Preferably, the halogenated xanthene is Rose Bengal or a functional derivative of Rose Bengal. The halogenated xanthenes constitute a family of useful chemotherapeutic agents that afford selective, persistent accumulation in certain tissues. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection. In another preferred embodiment, such medicaments are produced in various formulations useful for intracorporeal or topical administration, including in liquid, semisolid, solid or aerosol delivery vehicles.

公开(公告)号：EP1192450A4

公开(公告)日：2003-05-21

申请号：EP99967402

申请日：1999-12-16

申请人： PHOTOGEN INC

发明人： DEES H CRAIG ,  SCOTT TIMOTHY ,  SMOLIK JOHN ,  WACHTER ERIC

IPC分类号： A61N5/10 ,  A61K31/352 ,  A61K41/00 ,  A61K49/04 ,  A61P35/00 ,  A61P43/00 ,  G01N23/00 ,  A61K51/00

CPC分类号： A61K41/0038 ,  A61K49/0433 ,  Y10S436/813 ,  Y10S436/819

摘要： A high energy phototherapeutic agents or radiosensitizer agent comprised of a halogenated xanthene, or an agent that exhibits a preference for concentration in biologically sensitive structures in diseased tissue, and methods of treating and imaging using radiosensitizer agents in diseased tissue.

公开(公告)号：EP1187555A1

公开(公告)日：2002-03-20

申请号：EP00937691.4

申请日：2000-05-23

申请人： Photogen, Inc.

发明人： FISHER, Walter ,  SMOLIK, John ,  DEES, H, Craig ,  WACHTER, Eric

IPC分类号： A61B6/00

CPC分类号： A61B5/444 ,  A61B5/0059 ,  A61B5/0091

摘要： A method and apparatus for diagnosis or imaging of a particular volume of material, including the steps of treating the particular volume of material with light sufficient to promote a multi-photon excitation of at least one photo-active agent contained on or within the particular volume of the material, wherein the at least one photo-active agent becomes active in the particular volume of the material, thereby resulting in the production of an optical signal, and wherein such optical signal is captured in electronic form for diagnosis or imaging of the particular volume of material.

公开(公告)号：EP1109506A1

公开(公告)日：2001-06-27

申请号：EP99939669.0

申请日：1999-08-02

申请人： Photogen, Inc.

发明人： DEES, H., Craig ,  SCOTT, Timothy ,  SMOLIK, John ,  WACHTER, Eric, A. ,  FISHER, Walter

IPC分类号： A61B19/00

CPC分类号： A61K41/0057 ,  A61B2017/22062 ,  A61B2017/22069 ,  A61B2017/22087 ,  A61F7/00 ,  A61M25/104 ,  A61N5/0601

摘要： A method and apparatus for topical treatment of diseased tissue, including topical or systemic application of a PDT agent to diseased tissue, followed by topical application of light (24).