公开(公告)号：EP3383890A1

公开(公告)日：2018-10-10

申请号：EP16808969.6

申请日：2016-12-02

申请人： SANOFI

发明人： SOMMERFELD, Mark ,  LANGER, Thomas ,  BOSCHEINEN, Oliver ,  DREYER, Matthias ,  DITTRICH, Werner ,  HABERMANN, Paul

IPC分类号： C07K14/50 ,  A61K38/18 ,  A61K38/26 ,  A61K38/28

CPC分类号： C07K14/50 ,  A61K38/00

摘要： The present invention relates to polypeptide variants of human fibroblast growth factor 21 (FGF21) and fusion molecules thereof, as well as to nucleic acid molecules encoding the same. It further relates to their use as medicaments, in particularfor the treatment of obesity, overweight, metabolic syndrome, diabetes mellitus, hyperglycemia, dyslipidemia, non-alcoholic steatohepatitis (NASH) and/or atherosclerosis.

公开(公告)号：EP3289095A1

公开(公告)日：2018-03-07

申请号：EP16719856.3

申请日：2016-04-29

申请人： miRdetect GmbH

发明人： SPIEKERMANN, Meike ,  WINTER, Nina ,  FLOR, Inga ,  BELGE, Gazanfer

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6851 ,  C12Q1/686 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/158 ,  C12Q2600/178 ,  C12Q2545/114 ,  C12Q2531/113

摘要： The present invention relates to methods for the detection of nucleic acid molecules at the lower detection limit.

公开(公告)号：EP3218676A1

公开(公告)日：2017-09-20

申请号：EP15859317.8

申请日：2015-11-10

申请人： In-situ Inc.

发明人： MCKEE, Duane B.

IPC分类号： G01F1/00

CPC分类号： G01N33/1886

摘要： Provided are multi-parameter sonde systems having a unique integrated user interface for ease of set-up and control, service and maintenance, even in the field and without accessory controllers. The necessary components, such as central processing unit, display and accelerometer are positioned in a water-tight housing, with the display configured for convenient observability and readability. A plurality of sensors provide electronic signals to the CPU, such as by a measurement subsystem. Upon a controlled change in orientation or a force application to the sonde, the display via the accelerometer provides a desired output display configuration.

摘要翻译： 提供的多参数探测器系统具有独特的集成用户界面，便于设置和控制，维修和维护，即使在现场且无需配件控制器。 必要的组件，如中央处理器，显示屏和加速度传感器位于防水外壳内，显示屏配置便于观察和读取。 多个传感器例如通过测量子系统向CPU提供电子信号。 通过受控的方向改变或向探测器施加力，通过加速度计的显示提供了所需的输出显示配置。

公开(公告)号：EP3033623A2

公开(公告)日：2016-06-22

申请号：EP14755023.0

申请日：2014-08-13

申请人： Technische Universität München

发明人： GERHARD, Markus ,  KALALI, Behnam ,  FORMICHELLA, Luca ,  KHALIFE-GHOLI, Mohammad

IPC分类号： G01N33/569 ,  C07K16/12 ,  C12Q1/68

CPC分类号： G01N33/56922 ,  C07K16/121 ,  G01N2469/20

摘要： The present invention is related to a method for detecting H. pylori infection in a subject, wherein the method comprises detecting in a sample from the subject an immune response against FliD, wherein the immune response comprises an anti-FliD antibody.

摘要翻译： 本发明涉及用于检测受试者中幽门螺杆菌感染的方法，其中所述方法包括在受试者的样品中检测针对FliD的免疫应答，其中所述免疫应答包含抗FliD抗体。

公开(公告)号：EP2959021A1

公开(公告)日：2015-12-30

申请号：EP14755642.7

申请日：2014-08-19

申请人： BioNTech Diagnostics GmbH ,  STRATIFYER Molecular Pathology GmbH

发明人： WIRTZ, Ralph ,  KNEIP, Christoph

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886

摘要： The present invention relates to an in vitro method of identifying a molecular subtype of a tumor in a cancer patient and to a method of stratifying a cancer patient for tumor treatment. The present invention further relates to kits that are useful for identifying a molecular subtype of a tumor in a cancer patient.

公开(公告)号：EP2902038A1

公开(公告)日：2015-08-05

申请号：EP14003585.8

申请日：2007-10-19

申请人： ImevaX GmbH

发明人： Gerhard, Markus ,  Schmees, Christian ,  Prinz, Christian

IPC分类号： A61K39/106 ,  G01N33/50 ,  A61K38/00 ,  C12N9/10

CPC分类号： A61K39/105 ,  A61K39/00 ,  C07K16/121 ,  C07K16/40 ,  C12N9/104 ,  C12Q1/48 ,  C12Y203/02002 ,  G01N2333/91074 ,  Y02A50/472

摘要： The present invention concerns methods and compositions for an immunogenic composition comprising an enzymatically inactive form of H. pylori gamma-glutamyl transpeptidase (HPGGT) or an enzymatically inactive fragment of HPGGT. H. H,..

摘要翻译： 本发明涉及包含幽门螺杆菌γ-谷氨酰转肽酶（HPGGT）的酶促失活形式或HPGGT酶促无活性片段的免疫原性组合物的方法和组合物。 H. H，..

公开(公告)号：EP3594337A1

公开(公告)日：2020-01-15

申请号：EP19180818.7

申请日：2015-07-06

申请人： BioNTech RNA Pharmaceuticals GmbH ,  TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH

发明人： EBERLE, Florian ,  SAHIN, Ugur ,  KUHN, Andreas ,  VALLAZZA, Britta ,  DIKEN, Mustafa

IPC分类号： C12N15/09 ,  C12N15/67 ,  C12N15/68

摘要： The present invention relates to nucleic acid molecules containing poly(dA:dT) regions which are stabilized in E.coli, methods of propagating such nucleic acid molecules in E.coli, methods of obtaining RNA, peptides or proteins using such nucleic acid molecules and to RNA which is obtained from such nucleic acid molecules and its use. In particular, the poly(dA:dT) regions contain at least one disruption by a sequence not encoding a sequence solely composed of A residues.

公开(公告)号：EP3357503B1

公开(公告)日：2019-10-30

申请号：EP18162214.3

申请日：2011-01-21

申请人： Sanofi

发明人： Sommerfeld, Mark ,  Schaefer, Hans-Ludwig ,  Boscheinen, Oliver ,  Habermann, Paul ,  Rao, Ercole ,  Dreyer, Matthias

IPC分类号： A61K38/18 ,  A61K38/26 ,  A61P3/00

公开(公告)号：EP3552627A1

公开(公告)日：2019-10-16

申请号：EP19157022.5

申请日：2004-05-06

申请人： Bioverativ Therapeutics Inc.

发明人： RIVERA, Daniel S. ,  PETERS, Robert T. ,  BITONTI, Alan J.

IPC分类号： A61K39/395 ,  C12P21/08 ,  A61K38/36 ,  C07K14/745 ,  C07K16/18 ,  A61K45/06 ,  C12N9/64 ,  A61K39/00 ,  A61K38/48

摘要： A pharmaceutical composition, for treatment of a hemostatic disorder, comprises a chimeric protein and a pharmaceutically acceptable carrier or excipient, wherein said chimeric protein comprises at least a portion of an immunoglobulin constant region which is an FcRn binding partner, a clotting factor selected from Factor VII, a Factor VII analog, Factor VIIa and a Factor VIIa analog, and optionally at least one linker.

公开(公告)号：EP3473267A1

公开(公告)日：2019-04-24

申请号：EP18199105.0

申请日：2012-05-23

申请人： BioNTech RNA Pharmaceuticals GmbH ,  TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH

发明人： SAHIN, Ugur ,  KREITER, Sebastian ,  DIKEN, Mustafa ,  DIEKMANN, Jan ,  KOSLOWSKI, Michael ,  BRITTEN, Cedrik ,  CASTLE, John ,  LÖWER, Martin ,  RENARD, Bernhard ,  OMOKOKO, Tana ,  DE GRAAF, Johannes Hendrikus

IPC分类号： A61K39/00 ,  C12Q1/68 ,  A61P35/00 ,  G01N33/50

摘要： The present invention relates to the provision of vaccines which are specific for a patient's tumor and are potentially useful for immunotherapy of the primary tumor as well as tumor metastases. In one aspect, the present invention relates to a method for providing an individualized cancer vaccine comprising the steps: (a) identifying cancer specific somatic mutations in a tumor specimen of a cancer patient to provide a cancer mutation signature of the patient; and (b) providing a vaccine featuring the cancer mutation signature obtained in step (a). In a further aspect, the present invention relates to vaccines which are obtainable by said method.