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73 条记录 (耗时 0.024 秒)

    TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS
    13.
    发明公开
    TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS 失效
    宫缩催产素受体拮抗剂

    公开(公告)号：EP0805681A1

    公开(公告)日：1997-11-12

    申请号：EP96903618.0

    申请日：1996-01-19

    申请人： MERCK & CO., INC.

    发明人： WILLIAMS, Peter, D. ,  FREIDINGER, Roger, M.

    IPC分类号： C07D401 ,  C07D413

    CPC分类号： C07D413/04 ,  C07D401/14 ,  C07D413/14

    摘要： Compounds of formula (I) wherein X is selected from CH2 or O; provided that when R?1 and R3¿ are both simultaneously hydrogen then (a) R8 is C¿1-5? alkyl or halogen, and R?2¿ is C¿1-5? alkoxy, or (b) R?4¿ is (II); and the pharmaceutically acceptable salts thereof. Such compounds are useful in mammals as oxytocin receptor antagonists for the treatment of preterm labor, dysmenorrhea and stopping labor prior to cesarean delivery.

    CHILD RESISTANT BLISTER PACKAGE
    17.
    发明公开
    CHILD RESISTANT BLISTER PACKAGE 失效
    防止儿童使用吸

    公开(公告)号：EP0757653A1

    公开(公告)日：1997-02-12

    申请号：EP95917818.0

    申请日：1995-05-05

    申请人： Merck & Co., Inc. (a New Jersey corp.)

    发明人： LATAIX, Gilbert

    IPC分类号： B65D83 ,  A61J1 ,  B65D75

    CPC分类号： B65D75/22 ,  B65D75/323 ,  B65D75/327 ,  B65D2215/00

    摘要： There is disclosed a child resistant blister package comprising a conventional blister package (10) having cavities (12) containing unit doses of medication. The blister package is adapted to receive a locking member (22) which is slidably secured to the blister package (10) to effectively prevent children from accessing the medication therein and yet is readily, slidably removed from the blister package (10) by an adult to access medication therefrom.

    REGIOSPECIFIC PROCESSES TO MAKE CIS-1-AMINO-2-ALKANOL FROM DIOL OR HALOHYDRIN
    18.
    发明公开
    REGIOSPECIFIC PROCESSES TO MAKE CIS-1-AMINO-2-ALKANOL FROM DIOL OR HALOHYDRIN 失效
    REGIOSPECIFISCHE工艺的生产顺1-氨基-2-烷醇OFF二醇或卤代醇和

    公开(公告)号：EP0749410A1

    公开(公告)日：1996-12-27

    申请号：EP95912769.0

    申请日：1995-03-07

    申请人： Merck & Co., Inc.

    发明人： VERHOEVEN, Thomas, R. ,  ROBERTS, F., Edward ,  SENANAYAKE, Chris, H. ,  RYAN, Kenneth. M.

    IPC分类号： C07C5 ,  C07C213 ,  C07C215

    CPC分类号： C07C213/02 ,  C07C2602/08

    摘要： A regioselective process for synthesizing any enantiomer of cis-1-amino-2-indanol, or mixture of said enantiomers, from 1,2-indane diol, or 2-halo-1-indanol wherein the process comprises the steps of (a) mixing one equivalent of 1,2-indane diol in a solvent, said solvent selected from an alkyl nitrile or aryl nitrile; (b) adding to the mixture at least about 1,5 equivalents of an acid, said acid selected from a strong protic acid or a Lewis acid or an organic acid, and maintaining thereafter the temperature of the resulting mixture between about -70 °C and about 30 °C for a time period of between about 0.25 hours to about 6.0 hours; and (c) adding excess water to effect hydrolysis, and stirring for a time period of between about 0.5 hour and about 8.0 hours, at a temperature of between about 25 °C and about 80 °C, to give substantially cis-1-amino-2-indanol.

    摘要翻译： 甲个区域选择性方法是光盘为游离缺失（1R，1S） - 氨基 - （2 S，2 R）链烷醇，特别是（1R，1S） - 氨基 - （2 S，2R） - 茚满醇的合成。