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11.发明公开DEVICE AND METHOD FOR ELECTROPORATION-BASED DELIVERY OF MOECULES INTO CELLS AND DYNAMIC MONITORING OF CELL RESPONSES 有权DEVICE AND METHOD FOR分子的ON ELEKTROPORATIONSBASIS细胞和细胞应答动态监测摄食
公开(公告)号：EP1815025A4
公开(公告)日：2011-10-12
申请号：EP05852157
申请日：2005-11-23
Applicant: ACEA BIOSCIENCES INC
Inventor： ABASSI YAMA A , WANG XIAOBO , ATIENZA JOSEPHINE , XU XIAO , XU JUNQUAN
CPC classification number: G01N33/5008 , C12M35/02 , C12N15/87 , G01N15/12 , G01N33/48728
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公开(公告)号：EP1742635A4
公开(公告)日：2010-03-17
申请号：EP05779301
申请日：2005-04-20
Applicant: ACEA BIOSCIENCES INC
Inventor： XU XIAO , AN HAOYUN , WANG XIAOBO
IPC: C07C321/20 , A61K31/095 , A61K31/381 , A61K31/444 , A61K31/513 , C07C323/07 , C07C323/16 , C07C323/20 , C07D213/52 , C07D333/54
CPC classification number: C07C323/07 , C07C321/20 , C07C323/16 , C07C323/20
Abstract: The present invention provides substituted di-, tri-, tetra- and penta-sulfide compounds and compositions, and methods of using the same for the treatment and/or prevention of a cell proliferative disorder. The present invention also provides methods for preparing trisulfide compounds and compositions.
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13.发明授权
公开(公告)号：EP1527328B1
公开(公告)日：2009-09-09
申请号：EP03751801.6
申请日：2003-07-18
Applicant: Acea Biosciences, Inc.
Inventor： WANG, Xiaobo , XU, Xiao
CPC classification number: G01N33/5005 , G01N15/12 , G01N33/54366 , G01N33/5438
Abstract: A device for monitoring the migration or invasion of a biological particle such as a cell is disclosed. The device includes an upper chamber adapted to receive and retain a cell sample, a lower chamber having at least two electrodes, and a biocompatible porous membrane having a porosity sufficient to allow cells to migrate therethrough. The membrane is disposed in the device so as to separate the upper and lower chambers from one another. Migration of cells through the porous membrane permits contact between the migrating cells and one or more electrodes of the lower chamber. The contact provides a detectable change in impedance between or among the electrodes.
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14.发明授权DYNAMIC MONITORING OF ACTIVATION OF G-PROTEIN (GPCR) IN LIVING CELLS USING REAL-TIME MICROELECTRONIC CELL SENSING TECHNOLOGY 有权动态监测G蛋白（GPCR）在活细胞中使用微电子REAL-TIME CELL探测技术的活化
公开(公告)号：EP1773979B1
公开(公告)日：2016-06-29
申请号：EP05786773.1
申请日：2005-08-04
Applicant: Acea Biosciences, Inc.
Inventor： Abassi, Yama A. , Yu, Naichen , Atienza, Josephine , Xu, Xiao , Wang, Xiaobo
CPC classification number: G01N33/4836
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公开(公告)号：EP3019496A2
公开(公告)日：2016-05-18
申请号：EP14748351.5
申请日：2014-07-11
Applicant: ACEA Biosciences, Inc.
Inventor： XU, Xiao , WANG, Xiaobo , MAO, Long , ZHAO, Li , XI, Biao
IPC: C07D417/12 , C07D473/18 , C07D487/04 , C07D519/00 , A61K31/506 , A61P35/00 , C07D239/553 , C07D239/545 , C07D403/12
CPC classification number: C07D239/545 , C07D239/553 , C07D403/12 , C07D417/12 , C07D473/18 , C07D487/04 , C07D519/00
Abstract: The present invention relates to pharmaceutical compounds, compositions and methods, especially as they are related to compositions and methods for the treatment and/or prevention of a proliferation disorder, a cancer, a tumor, an inflammatory disease, an autoimmune disease, psoriasis, dry eye or an immunologically related disease, and in some embodiments diseases or disorders related to the dysregulation of kinase such as, but not limited to, EGFR (including HER), Alk, PDGFR, BLK, BMX/ETK, FLT3(D835Y), ITK, TEC, TXK, BTK, or JAK, and the respective pathways.
Abstract translation: 本发明涉及药物化合物，组合物和方法，尤其涉及用于治疗和/或预防增殖性疾病，癌症，肿瘤，炎性疾病，自身免疫性疾病，牛皮癣，干燥的组合物和方法 （包括但不限于）EGFR（包括HER），Alk，PDGFR，BLK，BMX / ETK，FLT3（D835Y），ITK ，TEC，TXK，BTK或JAK，以及各自的途径。
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Patent Agency Ranking16.发明授权Real-time electronic cell sensing system and applications for cytotoxicity profiling and compound assays 有权电子实时细胞识别系统，为Zytotoxizitätsprofil和连接试验应用
公开(公告)号：EP2450698B1
公开(公告)日：2014-10-29
申请号：EP11193882.5
申请日：2005-02-09
Applicant: ACEA Biosciences, Inc.
Inventor： Xu, Xiao , Abassi, Yama , Wang, Xiaobo
IPC: G01N27/02 , G01N33/487 , G01N33/543 , C12M1/34
CPC classification number: C12M25/08 , C12M41/36 , G01N27/021 , G01N33/4836 , G01N33/5005
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17.发明公开DEVICE FOR SPLITTING LIGHT INTO COMPONENTS HAVING DIFFERENT WAVELENGTH RANGES AND METHODS OF USE 审中-公开装置上使用不同波长的分配和使用的方法在分量的光列
公开(公告)号：EP2769260A1
公开(公告)日：2014-08-27
申请号：EP12845835.3
申请日：2012-10-19
Applicant: Acea Biosciences, Inc.
Inventor： LI, Nan , CHEN, Ye , WANG, Xiaobo
IPC: G02B27/10
CPC classification number: G02B27/1006 , G01J3/14 , G01J3/36 , G01J3/443 , G02B5/04 , G02B5/285 , G02B27/141 , G02B27/142
Abstract: A prism including a substrate faceted to provide a plurality of flat surfaces, wherein at least two of the plurality of surfaces, each including a filter coating, form at least two filter surfaces, wherein each filter surface selectively permits passage of a predetermined wavelength and reflects remaining wavelengths along an optical path towards another of the plurality of surfaces, optionally another filter surface, wherein an angle of incidence of each of the plurality of surfaces along the optical path is equal or nearly equal. An apparatus incorporating the prism and its use for splitting a light spectrum into a plurality of wavelengths or wavelength ranges.
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18.发明公开LABEL-FREE MONITORING OF EXCITATION-CONTRACTION COUPLING AND EXCITABLE CELLS USING IMPEDANCE BASED SYSTEMS WITH MILLISECOND TIME RESOLUTION 有权MARK免费监测机电耦合和兴奋细胞系统研究基地阻抗MILLISECONDS时间分辨率BASIS
公开(公告)号：EP2291645A4
公开(公告)日：2013-12-25
申请号：EP09743426
申请日：2009-05-05
Applicant: ACEA BIOSCIENCES INC
Inventor： WANG XIAOBO , ABASSI YAMA , XI BIAO , ZHANG WEN FU , XU XIAO
IPC: C12M1/34 , G01N33/483
CPC classification number: G01N33/4836
Abstract: Systems and methods for improved monitoring of excitation-contraction coupling and excitable cells are provided, which provide millisecond time resolution. The system is capable of continuously monitoring excitation-contraction coupling in a relatively high-throughput manner. The system includes a device for monitoring cell-substrate impedance, an impedance analyzer capable of impedance measurements at millisecond time resolution, electronic circuitry that can engage the device and selectively connect two or more electrode arrays of the device to the impedance analyzer and a software program that controls the electronic circuitry and records and analyzes data obtained from the impedance analyzer.
Abstract translation: 提供了用于改进的兴奋 - 收缩偶联和可兴奋细胞的监测系统和方法，其提供毫秒的时间分辨率。 该系统能够监视连续兴奋 - 收缩偶联的在相对高通量方式进行。 该系统包括用于监测细胞 - 基底阻抗在毫秒时间分辨率到阻抗能够阻抗测量仪，电子电路也可接合设备和选择性地将所述装置的两个或多个电极阵列连接到阻抗分析仪和软件程序的装置 确实控制电子电路和记录和分析从阻抗分析仪获得的数据。
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19.发明公开DYNAMIC MONITORING OF ACTIVATION OF G-PROTEIN (GPCR) AND RECEPTOR TYROSINE KINASE (RTK) IN LIVING CELLS USING REAL-TIME MICROELECTRONIC CELL SENSING TECHNOLOGY 有权动态监测G蛋白（GPCR）与受体酪氨酸激酶（RTK）在活使用微电子REAL-TIME CELL探测技术活化细胞
公开(公告)号：EP1773979A4
公开(公告)日：2013-04-24
申请号：EP05786773
申请日：2005-08-04
Applicant: ACEA BIOSCIENCES INC
Inventor： ABASSI YAMA A , YU NAICHEN , ATIENZA JOSEPHINE , XU XIAO , WANG XIAOBO
CPC classification number: G01N33/4836
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20.发明公开METHOD FOR ASSAYING FOR NATURAL KILLER, CYTOTOXIC T- LYMPHOCYTE AND NEUTROPHIL-MEDIATED KILLING OF TARGET CELLS USING REAL-TIME MICROELECTRONIC CELL SENSING TECHNOLOGY 有权程序对自然杀伤细胞，细胞毒性T淋巴细胞和NEUTROPHILVERMITTELTES杀伤靶细胞中使用微电子ZELLENABTASTTECHNOLOGIE实时
公开(公告)号：EP1773980A4
公开(公告)日：2013-04-17
申请号：EP05804409
申请日：2005-08-04
Applicant: ACEA BIOSCIENCES INC
Inventor： XU XIAO , ABASSI YAMA , WANG XIAOBO
CPC classification number: G01N33/4836
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