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公开(公告)号：EP1430142B1
公开(公告)日：2006-12-06
申请号：EP02731594.4
申请日：2002-05-02
申请人： Agentase, LLC
CPC分类号： C12Q1/001 , G01N33/5438 , G01N33/94 , Y10S435/963
摘要： A sensor for detecting an analyte in an environment includes a first reaction system including a first enzyme and a substrate for the first enzyme. The analyte inhibits the reaction of the substrate catalyzed by the first enzyme. The sensor further includes at least a second reaction system that reacts to produce a first detectable state when the first enzyme is inhibited. In some embodiments, the reaction of the first reaction system can produce a second detectible state, different from the first detectible state. Another sensor for detecting an analyte in an environment includes a first reaction system including a first enzyme or a first substrate for the first enzyme. In this embodiment, the analyte is either a substrate for the first enzyme or the first enzyme if the first reaction system includes the first substrate. Figure (1) illustrates reaction schematics of one embodiment of a sensor of the present invention for detecting nerve agents.
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12.发明公开BUFFER POLYMERS, CO-IMMOBILE BUFFER AND ENZYME POLYMERS AND METHODS OF SYNTHESIS THEREOF 有权与IMMBOBILISIERTEM缓冲器和固定化酶和合成方法THEREFOR BUFFER聚合物聚合物
公开(公告)号：EP1543051A1
公开(公告)日：2005-06-22
申请号：EP03784929.6
申请日：2003-08-06
申请人： Agentase, LLC
IPC分类号： C08G18/00
CPC分类号： C12N11/08 , C08G18/10 , C08G18/6446 , C08G18/64 , C08G18/302
摘要： A polyurethane polymer includes at least one buffer selected to adjust pH to a pH within a desired range. The buffer compound is immobilized within the polymer, and the polymer has a buffer capacity in excess of 3 micromoles of acid or base per gram polymer. A polymer includes at least one enzyme that is selected to catalyze a reaction of a substance. The enzyme is immobilized within the polymer. The polymer also includes at least one buffer selected to adjust the pH in the vicinity of the enzyme to a pH within a desired range. The buffer compound is also immobilized within the polymer. The polymer preferably has enzyme activity and a buffer capacity in excess of 3 micromoles acids or base per gram polymer. In one embodiment, each of the enzymes(s) and the buffer(s) are covalently bonded to the polymer.
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公开(公告)号：EP1430142A2
公开(公告)日：2004-06-23
申请号：EP02731594.4
申请日：2002-05-02
申请人： Agentase, LLC
CPC分类号： C12Q1/001 , G01N33/5438 , G01N33/94 , Y10S435/963
摘要： A sensor for detecting an analyte in an environment includes a first reaction system including a first enzyme and a substrate for the first enzyme. The analyte inhibits the reaction of the substrate catalyzed by the first enzyme. The sensor further includes at least a second reaction system that reacts to produce a first detectable state when the first enzyme is inhibited. In some embodiments, the reaction of the first reaction system can produce a second detectible state, different from the first detectible state. Another sensor for detecting an analyte in an environment includes a first reaction system including a first enzyme or a first substrate for the first enzyme. In this embodiment, the analyte is either a substrate for the first enzyme or the first enzyme if the first reaction system includes the first substrate. Figure (1) illustrates reaction schematics of one embodiment of a sensor of the present invention for detecting nerve agents.
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14.发明公开A SMART, SELF-DECONTAMINATING POLYMER AND METHOD FOR INHIBITING THE GROWTH OF A BACTERIA AND FUNGUS 审中-公开智能化，SELBSTDEKONTAMINIERENDE聚合物和方法的生长抑制细菌和蘑菇的
公开(公告)号：EP2861267A4
公开(公告)日：2016-01-20
申请号：EP13804843
申请日：2013-06-12
申请人： AGENTASE LLC
CPC分类号： A61L15/38 , A61F13/00059 , A61F13/00063 , A61K9/06 , A61K9/7007 , A61K38/443 , A61L15/26 , A61L15/425 , A61L15/44 , A61L15/46 , A61L2300/404 , A61L2300/434 , A61L2420/06 , C08L75/04
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15.发明授权ENZYME CONTAINING LIQUID AND DELIVERY SYSTEM FOR DETECTION OF ANALYTES ON SURFACES 有权含酶液体和蔓延SYSTEM FOR检测分析物的物体表面
公开(公告)号：EP2069522B1
公开(公告)日：2015-05-27
申请号：EP07870735.3
申请日：2007-08-07
申请人： Agentase, LLC
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16.发明公开ENZYME CONTAINING LIQUID AND DELIVERY SYSTEM FOR DETECTION OF ANALYTES ON SURFACES 有权与液体和OUTPUT SYSTEM FOR分析物的物体表面检测酶
公开(公告)号：EP2069522A4
公开(公告)日：2010-06-09
申请号：EP07870735
申请日：2007-08-07
申请人： AGENTASE LLC
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17.发明公开ENZYME CONTAINING LIQUID AND DELIVERY SYSTEM FOR DETECTION OF ANALYTES ON SURFACES 有权含酶液体和蔓延SYSTEM FOR检测分析物的物体表面
公开(公告)号：EP2069522A2
公开(公告)日：2009-06-17
申请号：EP07870735.3
申请日：2007-08-07
申请人： Agentase, LLC
发明人： LEJEUNE, Keith E. , BACIOR, Jennifer A. , BERBERICH, Jason A. , ERBELDINGER, Markus , LELE, Bhalchandra Shripad
摘要： An aqueous enzyme based sensor comprising one or more enzymes and at least one indicator compound capable of indicating a reaction of at least one of the enzymes with at least one target analyte, wherein the enzyme and the indicator are capable of being delivered, preferably by being sprayed, to a surface having the target analyte without sampling the surface. An aqueous enzyme based sensor is provided that is capable of detecting an enzyme specific substrate as the analyte. This aqueous enzyme based sensor further comprises of one or more enzyme specific substrates in which the sensor detects enzyme inhibition. The aqueous enzyme based sensor optionally comprises one or more of a light scattering additive(s), an adhesive polymer(s), a protein stabilizer(s), a protein stabilizing sugar(s), a surfactant(s), and a solvent(s), and combinations thereof. A dispensing system and a method of detecting a target chemical on a surface without sampling the surface is provided.
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公开(公告)号：EP1430142A4
公开(公告)日：2005-07-27
申请号：EP02731594
申请日：2002-05-02
申请人： AGENTASE LLC
IPC分类号： C12Q1/00 , G01N33/543 , G01N33/94
CPC分类号： C12Q1/001 , G01N33/5438 , G01N33/94 , Y10S435/963
摘要： A sensor for detecting an analyte in an environment includes a first reaction system including a first enzyme and a substrate for the first enzyme. The analyte inhibits the reaction of the substrate catalyzed by the first enzyme. The sensor further includes at least a second reaction system that reacts to produce a first detectable state when the first enzyme is inhibited. In some embodiments, the reaction of the first reaction system can produce a second detectible state, different from the first detectible state. Another sensor for detecting an analyte in an environment includes a first reaction system including a first enzyme or a first substrate for the first enzyme. In this embodiment, the analyte is either a substrate for the first enzyme or the first enzyme if the first reaction system includes the first substrate. Figure (1) illustrates reaction schematics of one embodiment of a sensor of the present invention for detecting nerve agents.
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公开(公告)号：EP1234051A4
公开(公告)日：2003-03-12
申请号：EP00990989
申请日：2000-11-10
申请人： AGENTASE LLC
发明人： LEJEUNE KEITH E , RUSSELL ALAN J
CPC分类号： C12Q1/58 , C12Q1/34 , C12Q1/46 , G01N33/521
摘要： A sensor for detecting the presence of at least one analyte includes at least one enzyme that is selected to either (i) catalyze a reaction of the analyte to chemically convert the analyte to a product compound or (ii) be inhibited by the analyte in the presence of a substrate compound. The sensor also includes at least one indicator compound selected to produce a measurable change of state as a result of the interaction of the analyte and the enzyme. Each of the enzyme and the indicator compound are incorporated within a single polymer. The figure illustrates an embodiment of a reaction schematic for biopolymer synthesis.
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