公开(公告)号：EP1933128A2

公开(公告)日：2008-06-18

申请号：EP08101757.6

申请日：1998-05-05

申请人： ChemoMetec A/S

发明人： Hansen, Frans Ejner Ravn ,  Glensbjerg, Martin ,  Arnvidarson, Börkur ,  Jeppesen, Jesper Myron

IPC分类号： G01N15/02 ,  G01N15/14

CPC分类号： G01N15/1459 ,  B01L3/5027 ,  G01N15/1463 ,  G01N21/31 ,  G01N21/59 ,  G01N21/6428 ,  G01N21/6458 ,  G01N21/76 ,  G01N33/04 ,  G01N2015/025 ,  G01N2015/1452 ,  G01N2015/1486 ,  G01N2021/5957 ,  G01N2021/6491

摘要： The present invention relates to a method and a device for the assessment of quantity and quality parameters of biological particles in a liquid analyte material. The method comprises applying a volume of a liquid sample to an exposing domain from which exposing domain electromagnetic signals from the sample in the domain can pass to the exterior, and exposing, onto an array of active detection elements such as CCD-elements, a spatial representation of electromagnetic signals having passed from the domain, the representation being detectable as an intensity by individual active detection elements, under conditions permitting processing of the intensities detected by the array of detection elements during the exposure in such a manner that representation of electromagnetic signals from the biological particles are identified as distinct from representations of electromagnetic signals from background signals. The light source is a LED and/or a laser diode, arranged to transmit light onto the sample.

摘要翻译： 本发明涉及用于评估液体分析物材料中生物颗粒的数量和质量参数的方法和装置。 该方法包括将一定体积的液体样品施加到曝光区域，从该区域中的样品暴露域电磁信号可以将该液体样品传递到外部，并且将活性检测元件阵列（例如CCD元件）暴露在曝光区域的空间 在允许在曝光期间处理由检测元件阵列检测到的强度的条件下，从该域通过的电磁信号的表示可以作为单个有源检测元件的强度来检测， 生物粒子被识别为不同于来自背景信号的电磁信号的表示。 光源是LED和/或激光二极管，被设置为将光透射到样品上。

公开(公告)号：EP0983378B1

公开(公告)日：2008-06-11

申请号：EP98921022.4

申请日：1998-05-05

申请人： ChemoMetec A/S

发明人： HANSEN, Frans, Ejner, Ravn ,  GLENSBJERG, Martin ,  ARNVIDARSON, Börkur ,  JEPPESEN, Jesper Myron

IPC分类号： C12Q1/06 ,  G01N33/483 ,  G01N33/04 ,  G01N24/00 ,  G01N21/00 ,  G01N15/06 ,  G06M11/00

CPC分类号： G01N15/1459 ,  B01L3/5027 ,  G01N15/1463 ,  G01N21/31 ,  G01N21/59 ,  G01N21/6428 ,  G01N21/6458 ,  G01N21/76 ,  G01N33/04 ,  G01N2015/025 ,  G01N2015/1452 ,  G01N2015/1486 ,  G01N2021/5957 ,  G01N2021/6491

摘要： Assessment of the number of somatic cells in a liquid milk or milk product analyte material comprises arranging a volume of a liquid sample representing the analyte material in a sample compartment and allowing electromagnetic signals from the sample in the compartment to pass through and be exposed to the exterior. There is exposed onto an array of active detection elements, an at least one-dimensional spatial representation of electromagnetic signals from the sample. The representation is detectable as an intensity by individual active detection elements. Representations of electromagnetic signs from the somatic cells are identified. The size of the volume of the liquid sample is sufficiently large to permit the assessement of the number of somatic cells to fulfill a predetermined requirement to the statistically quality of the assessment based on substantially one exposure.

公开(公告)号：EP1438582A1

公开(公告)日：2004-07-21

申请号：EP02798696.7

申请日：2002-09-16

申请人： ChemoMetec A/S

发明人： RASMUS DINES, Larsen

IPC分类号： G01N33/50 ,  G01N33/569 ,  G01N15/14

CPC分类号： G01N15/02 ,  G01N15/14 ,  G01N33/52 ,  G01N33/56911 ,  G01N33/56966 ,  G01N33/56972

摘要： The invention relates to the field of detecting and optionally collecting and isolating rare event particles. The method according to the invention is based on relatively simple optical equipment, which requires a few and uncomplicated decisions for the user of the system. The method is based on the acquisition of an image of relatively low resolution and magnification of a large volume of sample and detecting the presence or absence of the rare event particle. The method is then repeated with at least one further volume of sample. The method is particularly adapted for detection of white blood cells in leuko-depleted blood.

公开(公告)号：EP3571488A1

公开(公告)日：2019-11-27

申请号：EP18701712.4

申请日：2018-01-22

申请人： ChemoMetec A/S

发明人： PEDERSEN, Rune, Troelsgaard ,  KJÆRULFF, Søren

IPC分类号： G01N15/14 ,  G01N21/64

公开(公告)号：EP2350617B1

公开(公告)日：2018-01-10

申请号：EP09744320.4

申请日：2009-10-21

申请人： ChemoMetec A/S

发明人： KJÆRULFF, Søren ,  SKINDERSØ, Mette Elena ,  SØRENSEN, Helle Frobøse ,  RAVN, Frans ,  GLENSBJERG, Martin

IPC分类号： G01N21/64 ,  C12N15/00 ,  G01N33/50 ,  G02B21/06 ,  G02B27/09 ,  G01N1/30 ,  G01N33/58

CPC分类号： G01N21/64 ,  G01N21/6458 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2021/6478 ,  G01N2201/0631 ,  G02B27/0905 ,  G02B27/0961

摘要： According to an embodiment of the invention, an apparatus to detect fluorescence from a sample is disclosed. The apparatus comprises a sample plane onto which the sample is arranged, an excitation light unit including at least a light source to illuminate the sample, and a detection unit comprising at least a detector having at least 100,000 active detection elements to detect a fluorescence signal from the sample.

公开(公告)号：EP1947443A2

公开(公告)日：2008-07-23

申请号：EP08101764.2

申请日：1998-05-05

申请人： ChemoMetec A/S

发明人： Hansen, Frans Ejner Ravn ,  Glensbjerg, Martin ,  Arnvidarson, Börkur ,  Jeppesen, Jesper Myron

IPC分类号： G01N15/14 ,  G01N33/04

CPC分类号： G01N15/1459 ,  B01L3/5027 ,  G01N15/1463 ,  G01N21/31 ,  G01N21/59 ,  G01N21/6428 ,  G01N21/6458 ,  G01N21/76 ,  G01N33/04 ,  G01N2015/025 ,  G01N2015/1452 ,  G01N2015/1486 ,  G01N2021/5957 ,  G01N2021/6491

摘要： The present invention relates to a method for the assessment of quantity and quality parameters of biological particles in a liquid analyte material. The method comprises applying a volume of a liquid sample to an exposing domain from which exposing domain electromagnetic signals from the sample in the domain can pass to the exterior, and exposing, onto an array of active detection elements such as CCD-elements, a spatial representation of electromagnetic signals having passed from the domain, the representation being detectable as an intensity by individual active detection elements, under conditions permitting processing of the intensities detected by the array of detection elements during the exposure in such a manner that representation of electromagnetic signals from the biological particles are identified as distinct from representations of electromagnetic signals from background signals. The exposing domain has an average interior thickness of between 20 μm and 200 μm.

摘要翻译： 本发明涉及一种用于评估液体分析物质中生物颗粒的数量和质量参数的方法。 该方法包括将一定体积的液体样本施加到曝光区域，从该区域中的来自样品的区域电磁信号可以从该域暴露于外部，并将其暴露于诸如CCD元件的主动检测元件的阵列上， 在从曝光期间通过检测元件阵列检测到的强度处理的条件下，可以通过单独的有源检测元件作为强度检测该表示作为强度的表示，从而以这种方式表示电磁信号， 生物颗粒被识别为不同于来自背景信号的电磁信号的表示。 曝光区域的平均内部厚度在20¼m至200¼m之间。

公开(公告)号：EP1936351A2

公开(公告)日：2008-06-25

申请号：EP08101761.8

申请日：1998-05-05

申请人： ChemoMetec A/S

发明人： Hansen, Frans Ejner Ravn ,  Glensbjerg, Martin ,  Arnvidarson, Börkur ,  Jeppesen, Jesper Myron

IPC分类号： G01N15/02 ,  G01N15/14

CPC分类号： G01N15/1459 ,  B01L3/5027 ,  G01N15/1463 ,  G01N21/31 ,  G01N21/59 ,  G01N21/6428 ,  G01N21/6458 ,  G01N21/76 ,  G01N33/04 ,  G01N2015/025 ,  G01N2015/1452 ,  G01N2015/1486 ,  G01N2021/5957 ,  G01N2021/6491

摘要： The present invention relates to a method for the assessment of quantity and quality parameters of biological particles in a liquid analyte material. The method comprises applying a volume of a liquid sample to an exposing domain from which exposing domain electromagnetic signals from the sample in the domain can pass to the exterior, and exposing, onto an array of active detection elements such as CCD-elements, a spatial representation of electromagnetic signals having passed from the domain, the representation being detectable as an intensity by individual active detection elements, under conditions permitting processing of the intensities detected by the array of detection elements during the exposure in such a manner that representation of electromagnetic signals from the biological particles are identified as distinct from representations of electromagnetic signals from background signals. The light source is a thermal light source, such as a halogen lamp.

摘要翻译： 本发明涉及用于评估液体分析物材料中生物颗粒的数量和质量参数的方法。 该方法包括将一定体积的液体样品施加到曝光区域，从该区域中的样品暴露域电磁信号可以将该液体样品传递到外部，并且将活性检测元件阵列（例如CCD元件）暴露在曝光区域的空间 在允许在曝光期间处理由检测元件阵列检测到的强度的条件下，从该域通过的电磁信号的表示可以作为单个有源检测元件的强度来检测， 生物粒子被识别为不同于来自背景信号的电磁信号的表示。 光源是热光源，例如卤素灯。

公开(公告)号：EP1933128A3

公开(公告)日：2008-06-25

申请号：EP08101757.6

申请日：1998-05-05

申请人： ChemoMetec A/S

发明人： Hansen, Frans Ejner Ravn ,  Glensbjerg, Martin ,  Arnvidarson, Börkur ,  Jeppesen, Jesper Myron

IPC分类号： G01N15/02 ,  G01N15/14

CPC分类号： G01N15/1459 ,  B01L3/5027 ,  G01N15/1463 ,  G01N21/31 ,  G01N21/59 ,  G01N21/6428 ,  G01N21/6458 ,  G01N21/76 ,  G01N33/04 ,  G01N2015/025 ,  G01N2015/1452 ,  G01N2015/1486 ,  G01N2021/5957 ,  G01N2021/6491

摘要： The present invention relates to a method and a device for the assessment of quantity and quality parameters of biological particles in a liquid analyte material. The method comprises applying a volume of a liquid sample to an exposing domain from which exposing domain electromagnetic signals from the sample in the domain can pass to the exterior, and exposing, onto an array of active detection elements such as CCD-elements, a spatial representation of electromagnetic signals having passed from the domain, the representation being detectable as an intensity by individual active detection elements, under conditions permitting processing of the intensities detected by the array of detection elements during the exposure in such a manner that representation of electromagnetic signals from the biological particles are identified as distinct from representations of electromagnetic signals from background signals. The light source is a LED and/or a laser diode, arranged to transmit light onto the sample.

公开(公告)号：EP1360488A1

公开(公告)日：2003-11-12

申请号：EP01960173.1

申请日：2001-07-12

申请人： ChemoMetec A/S

发明人： GLENSBJERG, Martin

IPC分类号： G01N33/53 ,  C12Q1/68 ,  G01N21/64

CPC分类号： G01N33/536 ,  G01N33/56972

摘要： The present invention relates to a method of assessing at least one quality parameter and/or at least one quantity parameter of at lest one analyte wherein said at least one analyte is connected to a catalyst capable of catalysing a substrate into a product, whereby the analyte is assessed through detection of product produced around the analyte. More particularly the present invention relates to a method of assessing at least one quality parameter or at least one quantity parameter of at least one species of analytes in a sample comprising the steps of establishing a sample domain having at least one wall, arranging in the sample domain catalyst-analyte complexes between the at lest one species of analytes and at least one catalyst in a manner allowing the analytes to move relative to the wall(s) of the sample domain, arranging a substrate in the sample domain, said substrate being capable of being converted into a product through catalysation by said catalyst, contacting the substrate with the catalyst-analyte complexes of individual analytes allowing a detectable amount of product to be produced, recording an image of the product related to individual analytes in the sample domain, correlating the image to the at least one quality parameter or the at least one quantity parameter of the at least one species of analytes.

公开(公告)号：EP1126757B8

公开(公告)日：2003-03-26

申请号：EP99953734.3

申请日：1999-11-05

申请人： ChemoMetec A/S

发明人： ARNVIDARSON, Börkur

IPC分类号： A01J5/013

CPC分类号： A01J5/0135 ,  A01J5/0132

摘要： The present invention concerns a system and a method for regulating the handling of milk during the milking process in order to separate mastitis infected milk from milk for human consumption and apt to be applied in an automated milking process.