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公开(公告)号：EP4362026A1
公开(公告)日：2024-05-01
申请号：EP22203671.7
申请日：2022-10-25
发明人： Hummer, Prof. Dr. Gerhard , Sikora, Dr. Mateusz , Bülow, Sören von , Blanc, Dr. Florian , Beck, Dr. Martin , Covino, Dr. Roberto
摘要： The present invention relates to a computer-implemented method of predicting site-specific mutation activity of an antigen, said method comprising (a) providing in silico at least one three-dimensional structure of said antigen, preferably an ensemble of three-dimensional structures of said antigen; (b) providing in silico at least one three-dimensional structure of at least one antibody or fragment thereof capable of binding to or specific for said antigen, preferably an ensemble of three-dimensional structures of said antibody or fragment thereof; (c) determining in silico the accessibility of the structure(s) of (a) to the structure(s) of (b), wherein higher accessibility is indicative of higher mutation activity, in particular under selective pressure exerted by said antibody or fragment thereof; thereby predicting said site-specific mutation activity.
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公开(公告)号：EP4357343A1
公开(公告)日：2024-04-24
申请号：EP22202598.3
申请日：2022-10-19
发明人： WU, Peng , JIANG, Mao , LIU, Yang , BORGELT, Lydia
IPC分类号： C07D417/04 , C07D401/04 , C07D401/12 , C07D403/14 , C07D413/14 , C07D417/14 , C07D495/04 , A61K31/397 , A61P35/00 , A61K31/428 , A61K31/4439 , A61K31/506 , A61K31/496 , A61K31/4365 , C07D401/14
CPC分类号： C07D417/04 , C07D495/04 , C07D401/12 , C07D413/14 , C07D403/14 , C07D401/14 , C07D401/04 , C07D417/14 , A61P35/00
摘要： The present invention relates to novel RNA-binding azetidine compounds of general formula (I) and stereoisomeric forms, hydrates, solvates and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions containing said azetidine compound together with at least one pharmaceutically acceptable carrier, excipient and/or diluent. Said azetidine compounds are particularly useful for the treatment and/or prophylaxis of diseases caused by and/or associated with microRNA expression or microRNA misexpression, particularly cancer, tumor, virus infections, immune-related diseases, inflammatory diseases, diabetes, cardiovascular diseases, metabolic diseases, and neurodegenerative diseases.
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13.发明公开
公开(公告)号：EP4355725A1
公开(公告)日：2024-04-24
申请号：EP22734295.3
申请日：2022-06-16
IPC分类号： C07C69/716 , C07D319/06 , C07B59/00
CPC分类号： C07D319/06 , C07B2200/0520130101 , C07B59/001 , C07C69/716
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14.发明公开
公开(公告)号：EP4352556A1
公开(公告)日：2024-04-17
申请号：EP22731683.3
申请日：2022-06-03
IPC分类号： G02B6/134
CPC分类号： B82Y10/00 , B82Y20/00 , G02B2006/1206120130101 , G02B2006/120820130101 , G02B6/1223 , G02B6/1342
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公开(公告)号：EP4333822A1
公开(公告)日：2024-03-13
申请号：EP22727767.0
申请日：2022-05-02
发明人： BERGBREDE, Tim , UNGER, Anke , DI LUCREZIA, Raffaella , CHOIDAS, Axel , KLEBL, Bert , NUSSBAUMER, Peter , MENNINGER, Sascha , HABENBERGER, Peter , ZISCHINSKY, Gunther , KOCH, Uwe , SCHRÖDER, Peter , JESTRABOVÁ, Pavla , PALOVÁ-JELÍNKOVÁ, Lenka , DÁNOVÁ, Klára , FALKENBERG-GUSTAFSSON, Maria , ARABANIAN, Laleh , GUSTAFSSON, Claes , LARSSON, Nils-Göran , PALMQVIST, Lars
IPC分类号： A61K31/166 , A61K31/167 , A61K31/4184 , A61K31/437 , A61K31/4412 , A61K31/4439 , A61K31/4523 , A61K31/453 , A61K31/4709 , A61K31/496 , A61K31/502 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/5517 , A61P35/00
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16.发明公开
公开(公告)号：EP4331024A1
公开(公告)日：2024-03-06
申请号：EP22732506.5
申请日：2022-06-07
IPC分类号： H01M4/04 , H01M4/66 , H01M10/052
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17.发明公开
公开(公告)号：EP4314772A1
公开(公告)日：2024-02-07
申请号：EP21716983.8
申请日：2021-03-30
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公开(公告)号：EP4298650A1
公开(公告)日：2024-01-03
申请号：EP22711501.1
申请日：2022-02-21
发明人： FELSER, Claudia , HE, Yangkun
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公开(公告)号：EP4291865A1
公开(公告)日：2023-12-20
申请号：EP21705476.6
申请日：2021-02-11
发明人： BANZER, Peter , EISMANN, Jörg , NEUGEBAUER, Martin
IPC分类号： G01M11/02
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20.发明公开
公开(公告)号：EP4285183A1
公开(公告)日：2023-12-06
申请号：EP21702461.1
申请日：2021-01-28
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