公开(公告)号：EP2888285A4

公开(公告)日：2016-08-17

申请号：EP13830412

申请日：2013-08-20

申请人： ORTHO CLINICAL DIAGNOSTICS INC ,  JANSSEN PHARMACEUTICA NV

发明人： HRYHORENKO ERIC ,  SANKARAN BANUMATHI ,  DECORY THOMAS R ,  TUBBS THERESA ,  COLT LINDA ,  REMMERIE BART M ,  SALTER RHYS ,  LIN RONGHUI

IPC分类号： C07K16/44 ,  C07D487/04 ,  C07K14/00 ,  G01N33/94

CPC分类号： C07K16/44 ,  C07K2317/14 ,  G01N33/94 ,  G01N2800/302 ,  G01N2800/52

摘要： Disclosed is an antibody which binds to aripiprazole, which can be used to detect aripiprazole in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of aripiprazole, including multiplex detection of aripiprazole, olanzapine, quetiapine, and risperidone in a single lateral flow assay device.

公开(公告)号：EP2401678A4

公开(公告)日：2016-07-27

申请号：EP10746746

申请日：2010-02-24

申请人： ORTHO CLINICAL DIAGNOSTICS INC

发明人： JACOBS MERRIT N ,  DOODY CHRISTOPHER THOMAS ,  BASHAW EDWIN CRAIG ,  INDOVINA JOSEPH MICHAEL ,  ALTLAND OWEN ,  GOULD NICHOLAS JOHN

IPC分类号： G06F11/00 ,  G05B23/00 ,  G06F19/00

CPC分类号： G06F11/008 ,  G16H10/40 ,  G16H40/40

摘要： A method of detecting impending analytical failure in a networked diagnostic clinical analyzer is based upon detecting whether the operation of a particular analyzer is statistically distinguishable based on one or more thresholds. A failure occurs when one or more components or modules of the analyzer fails. A method to detect such an impending failure is disclosed. Baseline data on a pre-selected set of analyzer variables for a population of diagnostic clinical analyzers is used to generate an impending failure threshold. Subsequently, operational data comprising the same pre-selected set of analyzer variables allows generation of a time series of operational statistics. If the operational statistic exceeds the impeding failure threshold in a prescribed manner, an impending analytical failure is predicted. Such detection of impending analytical failures facilitates intelligent scheduling of service for the analyzer in question to maintain high assay throughput and accuracy.

公开(公告)号：EP2888593A4

公开(公告)日：2016-07-20

申请号：EP13831744

申请日：2013-08-20

申请人： ORTHO CLINICAL DIAGNOSTICS INC ,  JANSSEN PHARMACEUTICA NV

发明人： HRYHORENKO ERIC ,  SANKARAN BANUMATHI ,  DECORY THOMAS R ,  TUBBS THERESA ,  COLT LINDA ,  VLIEGEN MAARTEN ,  HASPESLAGH PIETER RIK

IPC分类号： G01N33/53 ,  C07K16/00 ,  C12P21/08

CPC分类号： G01N33/94 ,  C07K16/44 ,  C07K2317/56 ,  C07K2317/565 ,  G01N2800/302

摘要： Disclosed is an antibody which binds to risperidone, which can be used to detect risperidone in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of risperidone, including multiplex detection of aripiprazole, quetiapine, olanzapine, and risperidone in a single lateral flow assay device.

公开(公告)号：EP2888373A4

公开(公告)日：2016-05-11

申请号：EP13830375

申请日：2013-08-20

申请人： ORTHO CLINICAL DIAGNOSTICS INC ,  JANSSEN PHARMACEUTICA NV

发明人： HRYHORENKO ERIC ,  SANKARAN BANUMATHI ,  DECORY THOMAS R ,  TUBBS THERESA ,  COLT LINDA ,  REMMERIE BART M ,  SALTER RHYS ,  LIN RONGHUI

IPC分类号： C12Q1/68 ,  C07K14/00 ,  C07K16/44

CPC分类号： G01N33/94 ,  C07K16/44 ,  C07K2317/56 ,  C07K2317/565 ,  G01N2800/302 ,  G01N2800/52

摘要： Disclosed is an antibody which binds to aripiprazole, which can be used to detect aripiprazole in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of aripiprazole, including multiplex detection of aripiprazole, olanzapine, quetiapine, and risperidone in a single lateral flow assay device.

摘要翻译： 公开了结合阿立哌唑的抗体，其可以用于在样品中检测阿立哌唑，例如在竞争性免疫测定法中。 该抗体可用于侧流测定装置，用于阿立哌唑的护理点检测，包括在单个侧流测定装置中多次检测阿立哌唑，奥氮平，喹硫平和利培酮。

公开(公告)号：EP2888286A4

公开(公告)日：2016-03-23

申请号：EP13830990

申请日：2013-08-20

申请人： ORTHO CLINICAL DIAGNOSTICS INC ,  JANSSEN PHARMACEUTICA NV

发明人： HRYHORENKO ERIC ,  SANKARAN BANUMATHI ,  DECORY THOMAS R ,  TUBBS THERESA ,  COLT LINDA ,  REMMERIE BART M ,  SALTER RHYS ,  DONAHUE MATTHEW GARRETT ,  GONG YONG

IPC分类号： C07K16/44 ,  A61K31/551 ,  C07K14/00 ,  G01N33/94

CPC分类号： C07K16/44 ,  G01N33/94 ,  G01N33/9466

摘要： Disclosed is an antibody which binds to quetiapine, which can be used to detect quetiapine in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of quetiapine, including multiplex detection of aripiprazole, olanzapine, quetiapine, and risperidone in a single lateral flow assay device.

摘要翻译： 公开了结合喹硫平的抗体，其可用于检测样品中的喹硫平，例如在竞争性免疫测定法中。 该抗体可用于侧流测定装置，用于在喹诺酮治疗中进行点检测，包括在单个侧流测定装置中多次检测阿立哌唑，奥氮平，喹硫平和利培酮。

公开(公告)号：EP2888592A2

公开(公告)日：2015-07-01

申请号：EP13831507.2

申请日：2013-08-20

申请人： Ortho-Clinical Diagnostics, Inc. ,  Janssen Pharmaceutica, N.V.

发明人： HRYHORENKO, Eric ,  SANKARAN, Banumathi ,  DECORY, Thomas R. ,  TUBBS, Theresa ,  COLT, Linda ,  REMMERIE, Bart M. ,  SALTER, Rhys ,  DONAHUE, Matthew Garrett ,  GONG, Yong

IPC分类号： G01N33/53

CPC分类号： G01N33/9466 ,  C07K16/44 ,  C07K2317/56 ,  C07K2317/565 ,  G01N33/94

摘要： Disclosed is an antibody which binds to quetiapine, which can be used to detect quetiapine in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of quetiapine, including muitiplex detection of aripiprazole, quetiapine, olanzapine, and risperidone in a single lateral flow assay device.

公开(公告)号：EP2888277A2

公开(公告)日：2015-07-01

申请号：EP13831719.3

申请日：2013-08-20

申请人： ORTHO-CLINICAL DIAGNOSTICS, INC. ,  Janssen Pharmaceutica, N.V.

发明人： HRYHORENKO, Eric ,  SANKARAN, Banumathi ,  DECORY, Thomas R. ,  TUBBS, Theresa ,  COLT, Linda ,  VLIEGEN, Maarten ,  HASPESLAGH, Pieter Rik

IPC分类号： C07K16/00 ,  C12P21/08

CPC分类号： G01N33/9413 ,  C07K16/44 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  G01N33/9406

摘要： Disclosed is an antibody which binds to paliperidone, which can be used to detect paliperidone in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of paliperidone, including multiplex detection of aripiprazole, quetiapine, olanzapine, and risperidone/paliperidone in a single lateral flow assay device.

摘要翻译： 公开了与利培酮结合的抗体，其可以用于检测样品中的利培酮，例如在竞争性免疫测定法中。 该抗体可以用于侧流测定装置，用于帕立培酮的点护理检测，包括在单个侧流测定装置中多次检测阿立哌唑，喹硫平，奥氮平和利培酮/帕培培酮。

公开(公告)号：EP2888257A1

公开(公告)日：2015-07-01

申请号：EP13753777.5

申请日：2013-08-20

申请人： Janssen Pharmaceutica, N.V. ,  ORTHO-CLINICAL DIAGNOSTICS, INC.

发明人： DONAHUE, Matthew Garrett ,  GONG, Yong ,  SALTER, Rhys ,  HRYHORENKO, Eric ,  DECORY, Thomas R. ,  REMMERIE, Bart M. ,  SANKARAN, Banumathi

IPC分类号： C07D417/12 ,  C07D417/14 ,  C07D281/16 ,  G01N33/53 ,  A61K47/48 ,  A61K31/554 ,  A61P25/00

CPC分类号： G01N33/5308 ,  A61K47/64 ,  A61K47/643 ,  A61K47/646 ,  C07D281/16 ,  C07D417/12 ,  C07D417/14

摘要： The invention relates to compounds of Formula I, wherein R
1 , R
2 , and R
3 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from quetiapine. The invention also relates to conjugates of a quetiapine hapten and a protein.

摘要翻译： 本发明涉及式I化合物，其中R 1，R 2和R 3在本说明书中定义，可用于合成衍生自喹硫平的新缀合物和免疫原。 本发明还涉及喹硫平半抗原和蛋白质的缀合物。

公开(公告)号：EP2777499A1

公开(公告)日：2014-09-17

申请号：EP14159208.9

申请日：2014-03-12

申请人： Ortho-Clinical Diagnostics Inc

发明人： Gunnerson, Kory A. ,  Jakubowicz, Raymond F. ,  Kirsch, Andrew M. ,  Robinson, James Ellis ,  Salotto, Daniel P. ,  Tomasso, David A. ,  Ding, Zhong ,  Gottermeier, William Franklin ,  Swick, Aaron Michael

IPC分类号： A61B5/15 ,  A61B5/157

CPC分类号： G01N33/558 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150213 ,  A61B5/150267 ,  A61B5/150343 ,  A61B5/150755 ,  A61B5/150809 ,  A61B5/157 ,  A61B2562/0295 ,  B01L3/50273 ,  G01N33/5302 ,  G01N33/726 ,  Y10T436/25375

摘要： A sample collection device for a fluid sample includes: a body including a capillary channel having a first end and a second end, wherein the first end is adapted to draw the fluid into the channel by capillary action; an air vent located in the vicinity of the second end and in fluid communication with the capillary channel; a barrier positioned within the capillary channel to prevent flow of the fluid by capillary action thereacross; and features on opposing sides of the body to form an axis of rotation, which is substantially perpendicular to the overall direction of the capillary channel from the first end to the second end. In a preferred embodiment, the sample collection device is adapted to rotate about the axis of rotation within a cartridge having a sample manipulation device to bring the first end into position with the sample manipulation device.

公开(公告)号：EP2723065A3

公开(公告)日：2014-08-13

申请号：EP13189153.3

申请日：2013-10-17

申请人： ORTHO-CLINICAL DIAGNOSTICS, INC.

发明人： Jorgensen, Jens H. ,  Lacourt, Michael W. ,  Moran JR., Donald J. ,  Hawks, David J. ,  Wycallis, Joseph ,  Arnold, Stephen C.

IPC分类号： H04N5/235

CPC分类号： G06K9/00134 ,  G01N21/255 ,  G01N21/82 ,  G02B27/024 ,  G06K9/0014 ,  G06T7/0012 ,  G06T11/001 ,  G06T2207/10024 ,  G06T2207/10152 ,  G06T2207/20216 ,  G06T2207/30004 ,  H04N5/2256 ,  H04N5/2354

摘要： The invention relates generally to both a method and apparatus for the creation of full resolution color digital images of diagnostic cassettes or objects of interest using a gray-scale digital camera or sensor combined with time sequential illumination using additive primary colors followed by post exposure digital processing. Such procedures and equipment is of significant economic value when employed in situations such as diagnostic clinical analyzers where space is limited and image quality requirements are high.