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29 条记录 (耗时 0.018 秒)

    HEMATOPOIETIC STEM CELL PROLIFERATION REGULATORS AND POLYNUCLEOTIDES ENCODING THE SAME
    16.
    发明公开
    HEMATOPOIETIC STEM CELL PROLIFERATION REGULATORS AND POLYNUCLEOTIDES ENCODING THE SAME 审中-公开
    调节剂增加食品添加剂STAMMZELLEN DIESE CODIERENDE POLYNUKLEOTIDE

    公开(公告)号：EP1428881A1

    公开(公告)日：2004-06-16

    申请号：EP02760698.7

    申请日：2002-08-22

    申请人： Japan Science and Technology Agency ,  JAPAN as represented by PRESIDENT OF NATIONAL CANCER CENTER

    发明人： UENO, Hiroo

    IPC分类号： C12N15/12 ,  C12P21/02 ,  C12N5/10 ,  C07K16/18

    CPC分类号： C07K14/705 ,  C07K14/475

    摘要： By analyzing hematopoietic stem cell proliferation regulators produced by stroma cells, a cDNA library is constructed and novel hematopoiesis-associated genes are isolated. Genes encoding the proteins as specified in the following (a) or (b): (a) having an amino acid sequence represented by one of SEQ ID NOS selected from the group consisting of SEQ ID NOS: 2, 4, 6, 8, 10 and 12; or (b) having an amino acid sequence derived from the amino acid sequence as defined in the above (a) by deletion, substitution or addition of one to several amino acids andhaving an activity of regulation hematopoietic stem cell proliferation.

    摘要翻译： 通过分析由间质细胞产生的造血干细胞增殖调节因子，构建cDNA文库，分离出新的造血相关基因。 编码如以下（a）或（b）中所指定的蛋白质的基因：（a）具有由选自SEQ ID NO：2,4,6,8或8的SEQ ID NOS之一表示的氨基酸序列， 10和12; 或（b）通过缺失，取代或添加一至数个氨基酸并具有调节造血干细胞增殖活性的方式具有源自上述（a）所定义的氨基酸序列的氨基酸序列。

    hst-2 Mutein, DNA coding for the same and preparation thereof
    17.
    发明公开
    hst-2 Mutein, DNA coding for the same and preparation thereof 失效
    HST-2 Mutein，dafürkodierende DNS和Herstellung。

    公开(公告)号：EP0613946A2

    公开(公告)日：1994-09-07

    申请号：EP94102093.5

    申请日：1994-02-11

    申请人： TAKEDA CHEMICAL INDUSTRIES, LTD. ,  PRESIDENT OF NATIONAL CANCER CENTER

    发明人： Yoshimura, Koji ,  Ishimaru, Kaori ,  Igarashi, Koichi ,  Tereda, Masaaki

    IPC分类号： C12N15/16 ,  C07K13/00 ,  A61K37/24 ,  C12N1/21

    CPC分类号： C07K14/50 ,  A61K38/00

    摘要： The present invention provides a polypeptide represented by the following amino acid sequence:
    wherein n is 0 or 1 and X represents
    or a fragment thereof (n = 0: SEQ ID NO:1, n = 1: SEQ ID NO:2), a recombinant DNA coding for the polypeptide, a vector containing the recombinant DNA, the preparation of a transformant carrying the vector, and the production of the polypeptide with the transformant.
    The invention also provides a method for promoting an increase in the number of platelets in a mammal using a polypeptide having a heparin binding secretory transforming factor 2 (hst-2) activity.
    The polypeptide can be produced in large amounts, and has hst-2 activity, so that it can be advantageously used as drugs for promoting treatment of burns, wounds, etc., and therapeutic agents for gastrointestinal ulcers. Further, it can be utilized as platelet-increasing agents.

    摘要翻译： 本发明提供由以下氨基酸序列表示的多肽：其中n为0或1，X代表其片段（n = 0：SEQ ID NO：1，n = 1：SEQ ID NO： NO：2），编码该多肽的重组DNA，含有该重组DNA的载体，携带该载体的转化体的制备以及与转化体的多肽的产生。 本发明还提供使用具有肝素结合分泌转化因子2（hst-2）活性的多肽促进哺乳动物血小板数量增加的方法。 该多肽可以大量生产，并具有hst-2活性，因此可有利地用作促进烧伤，伤口等治疗药物和胃肠溃疡治疗剂的药物。 此外，它可以用作血小板递增剂。