摘要:
A Hepatitis C virus (HCV) protein such as a non-structured protein 4 (NS4) or a non-structured protein 3 (NS3) or a derivative or fragment or variant or peptide thereof or product of cells activated by the agent is useful in the treatment and/or prophylaxis of an inflammatory and/or an immune-mediated disorder. The agent can also be used as a vaccine adjuvant.
摘要:
Biological assays using various constructions of biochips are disclosed to mirror in vivo situations. The biochip 50 comprises a microchannel 51 having a liquid outlet port 1, bubble release port 2 and a liquid outlet port 3 with an associated bubble release port 4. A multiplicity of tests can be performed often by coating the bore of the microchannel 50 with various adhesion mediating proteins or the use of chemoattractants. The assay assembly 60 comprises a syringe pump feeding the biochip 50. An inverted microscope 65, digital camera 66 and recorder 67 are provided. A sample liquid containing cells in suspension is injected slowly through the biochip and the effect of the assay recorded over a long period of time.
摘要:
A method for the quantitative determination of human acute phase serum amyloid A protein (A-SAA) comprises contacting a sample of a biological fluid with antibody specific for A-SAA, the sample being reacted with an organic solvent prior to or simultaneous with antibody contact. The organic solvent is suitably a C1-C4 alcohol and the antibody can be used on the solid phase and as a component of the detection system of an enzyme linked immunosorbant assay. The method provides a sensitive and reliable measure of A-SAA and inflammatory status which can be used for the diagnosis and clinical management of both acute and chronic inflammatory conditions.
摘要:
A method for the quantitative determination of human acute phase serum amyloid A protein (A-SAA) comprises contacting a sample of a biological fluid with antibody specific for A-SAA, the sample being reacted with an organic solvent prior to or simultaneous with antibody contact. The organic solvent is suitably a C1-C4 alcohol and the antibody can be used on the solid phase and as a component of the detection system of an enzyme linked immunosorbant assay. The method provides a sensitive and reliable measure of A-SAA and inflammatory status which can be used for the diagnosis and clinical management of both acute and chronic inflammatory conditions.
摘要:
A case base system (1) does not need a decision structure such as a rule base as it uses both automatic (46) and interactive steps (47-48) which are carried out in real time to retrieve the most appropriate case. Case filtering (5) is carried out to immediately provide an initial candidate set by elimination of incompatible case records according to received free features. The free features are addressable as such in the case records. A primary processor (6) carries out pattern matching operations (46) correlating feature values and solutions in case records (10) of a candidate set. By doing this, it automatically identifies the most discriminating feature for the candidate set. The primary processor (6) interactively provides feedback (47-48) and receives a value for the most discriminating feature and further reduces the candidate set. The automatic and interactive steps are repeated in cycles until all remaining case records have the same solution (45).
摘要:
A new magnetic material of the general formula: R x Fe y X′ a Z b is derived from an intermetallic compound of rhomohedral or hexagonal crystal structure wherein R is one or more rare earth elements, X′ is an element of groups IIIA, IIIB, IVA or IVB of the periodic table, Z is one or more elements of group VA of the periodic table, x is a value from 1 to 2, y is a value from 11 to 19, a is a value from 0 to 3, b is a value from 0.5 to 3 and Fe is unsubstituted or partly, substitued with the proviso that if the component Z is antimony or bismuth the element X′ is not boron. These new materials exhibit increased Curie temperatures, magnetic strength and easy uniaxial anisotropy and are therefore suitable for fabricating into permanent magnets. Processes for preparing materials R x Fe y X′ a Z b are also described.
摘要:
A new magnetic material of the general formula:
R x Fe y X′ a Z b
is derived from an intermetallic compound of rhomohedral or hexagonal crystal structure wherein R is one or more rare earth elements, X′ is an element of groups IIIA, IIIB, IVA or IVB of the periodic table, Z is one or more elements of group VA of the periodic table, x is a value from 1 to 2, y is a value from 11 to 19, a is a value from 0 to 3, b is a value from 0.5 to 3 and Fe is unsubstituted or partly, substitued with the proviso that if the component Z is antimony or bismuth the element X′ is not boron. These new materials exhibit increased Curie temperatures, magnetic strength and easy uniaxial anisotropy and are therefore suitable for fabricating into permanent magnets. Processes for preparing materials R x Fe y X′ a Z b are also described.
摘要翻译:一种新的磁性材料,其通式为:RxFeyX min aZb衍生自菱方晶或六方晶体结构的金属间化合物,其中R是一种或多种稀土元素,X min是IIIA,IIIB,IVA或IVB族的元素 周期表Z是周期表的组VA的一个或多个元素,x是1至2的值,y是11至19的值,a是0至3的值,b是0.5的值 至3且Fe是未取代的或部分取代的,条件是如果组分Z是锑或铋,则元素X min不是硼。 这些新材料表现出居里温度,磁强度和容易的单轴各向异性的增加,因此适用于制造成永磁体。 还描述了制备材料的方法RxFeyX min aZb。
摘要:
Polyclonal and monoclonal antibodies which are cross-reactive to both coagulase-positive staphylococcus bacteria, such as S. (hemolyticus), are provided which can recognize surface proteins from both coagulase-positive and coagulase negative staph bacteria. The antibodies may be generated from surface proteins that have been isolated on the basis of characteristics that may be common between S. (aureus) and coagulase-negative staphylococci, and these recombinant surface proteins are used to generate the antibodies of the invention. There is also provided vaccines and methods which utilize these proteins and antibodies for the treatment or protection against a wide variety of staphylococcal infections.