公开(公告)号：EP2441779A1

公开(公告)日：2012-04-18

申请号：EP11195666.0

申请日：2007-08-31

申请人： USV Limited

发明人： Hedge, Deepak Anant ,  Choudhary, Varsha Shashank ,  Tarur, Radhakrishnan Venkatasubramanian ,  Sathe, Dhananjay Govind ,  Mondkar, Harish Kashinath ,  Patil, Samadhan Daulat ,  Thoovara, Sasikumar Mohan ,  Bhide, Yogesh Sharad

IPC分类号： C08F8/00 ,  C08F26/02 ,  A61K31/785 ,  A61K9/20 ,  A61K47/00 ,  A61P13/12 ,  A61K9/28 ,  C08F8/44

CPC分类号： A61K31/785 ,  A61K9/284 ,  A61K9/2846 ,  A61K9/2866 ,  C08F8/02 ,  C08F8/08 ,  C08F126/02

摘要： Disclosed herein is an improved process for preparation of Sevelamer hydrochloride having phosphate binding capacity of 4.7 to 6.4mmol/g. Further, the invention discloses Sevelamer hydrochloride compositions and a novel process for preparation of said compositions comprising high shear non-aqueous granulation.

摘要翻译： 本文公开了一种改进的具有4.7至6.4mmol / g的磷酸盐结合能力的盐酸司维拉姆的制备方法。 此外，本发明公开了盐酸司维拉姆组合物和用于制备包含高剪切非水性造粒物的所述组合物的新方法。

公开(公告)号：EP2389168A2

公开(公告)日：2011-11-30

申请号：EP10719783.2

申请日：2010-01-22

申请人： USV Limited

发明人： OMRAY, Ashok ,  CHOUDHARY, Varsha, Shashank ,  BHIDE, Yogesh, Sharad

IPC分类号： A61K9/20 ,  A61K47/38 ,  A61K31/785

CPC分类号： A61K9/2866 ,  A61K9/2018 ,  A61K31/785

摘要： The present invention discloses pharmaceutical composition comprising phosphate binding polymers such as Sevelamer carbonate substantially free of monovalent anion other than bicarbonate anion. Particularly, monovalent anion content is less than about 0.05% (w/w). Disclosed are compositions comprising wet granulated Sevelamer carbonate free of added metal ions and/or added monovalent anion source.

公开(公告)号：EP2356240A2

公开(公告)日：2011-08-17

申请号：EP09810850.9

申请日：2009-10-28

申请人： USV Limited

发明人： RAO, Laxmi Srinivas ,  MISHRA, Shrikant ,  NIPHADKAR, Milind ,  THAKUR, Priti ,  NAZARETH, Genevieve

IPC分类号： C12N15/70 ,  C12R1/19

CPC分类号： C12N15/70

摘要： An expression vehicle comprising an isolated nucleic acid as shown in Seq ID No. 1 comprising of a synthetic hybrid promoter wherein the hybrid promoter comprises of an inducible arabinose promoter derived from E. coli and a synthetic stretch of 8-35 nucleotides from pHO regulon introduced in the region between −55 to −10 and ribosome binding site from the transcription initiation site.

公开(公告)号：EP2187874A2

公开(公告)日：2010-05-26

申请号：EP08852448.3

申请日：2008-08-07

申请人： USV Limited

发明人： HEGDE, Deepak, Anant ,  SHENOY, Sandhya, Rajendra ,  BHATT, Harish, Tulsidutt ,  OMRAY, Ashok

IPC分类号： A61K9/22

CPC分类号： A61K9/2031 ,  A61K9/2009 ,  A61K9/2027 ,  A61K9/205 ,  A61K31/495

摘要： Disclosed herein are sustained release pharmaceutical compositions comprising Trimetazidine or a pharmaceutically acceptable salt thereof and release modifying agents together with suitable pharmaceutically acceptable excipients. The sustained release pharmaceutical compositions of the present invention are characterized by the absence of cellulose and/or their derivatives as release modifying agents.

公开(公告)号：EP2150528A2

公开(公告)日：2010-02-10

申请号：EP09721132.0

申请日：2009-01-13

申请人： USV Limited

发明人： SATHE, Dhananjay, Govind ,  MONDKAR, Harish, Kashinath ,  JADHAV, Tanaji, Shamrao ,  HAGAVANE, Nitin, Nivrutti

IPC分类号： C07C279/26

CPC分类号： C07C279/26

摘要： Disclosed herein is the process for the preparation of 1-(4-chlorophenyl)-5- isopropyl-biguanide hydrochloride (Proguanil hydrochloride), Formula (I), an antimalarial agent.

公开(公告)号：EP1904033B1

公开(公告)日：2009-09-09

申请号：EP06762653.1

申请日：2006-07-17

申请人： Alfred E. Tiefenbacher GmbH & Co. KG ,  USV Limited

发明人： SINGNURKAR, Prurushottam, S. ,  TEWARI, Prashant, Kumar ,  KORITKE, Claudia ,  STARK, Georg

IPC分类号： A61K9/16 ,  A61K31/64

CPC分类号： A61K9/2077 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2059 ,  A61K31/64

摘要： The invention relates to a method for producing solid oral pharmaceutical compositions containing glimepiride. The compositions produced according to the inventive method are characterized by a high stability.

公开(公告)号：EP1706113B1

公开(公告)日：2008-12-10

申请号：EP04806731.8

申请日：2004-07-16

申请人： USV Limited

发明人： TARUR, Venkatasubramanian Radhakrishnan ,  SATHE, Dhananjay Govind ,  MONDKAR, Harish Kashinath ,  BHOPALKAR, Rajesh Ganpat ,  PATIL, Samadhan Daulat

IPC分类号： A61K31/4035 ,  C07D209/48 ,  C07D403/06 ,  C07D209/34 ,  A61K31/4045 ,  A61P25/16

CPC分类号： C07D209/48 ,  C07D209/34

摘要： The present invention discloses a novel process and novel intermediates for the Preparation of 4-[2-(di -n-propyl amino) ethyl]-1,3-dihydro-2H-indol-2-one, commonly known as Ropinirole (I) and pharmaceutical composition comprising the same. Further the present invention also discloses a method of treatment for cardiovascular disorders and Parkinson’s disease.

公开(公告)号：EP1809664B1

公开(公告)日：2008-05-14

申请号：EP04821383.9

申请日：2004-11-09

申请人： USV Limited

发明人： BORBHUIYA, Ahmed Monsur ,  RAO, Yada Madhava ,  RAO, Laxmi Srinivas ,  MAITI, Dipanwita ,  NIPHADKAR, Prabhakar Milind ,  MISHRA, Shrikant

IPC分类号： C07K14/61 ,  C07K1/20

CPC分类号： C07K14/61 ,  C07K1/20

摘要： The present invention relates to a commercial process for purification of human Growth hormone obtained by DNA recombinant technique using hydrophobic interactive chromatography, efficient to separate clipped molecules of human growth hormone present as an impurity arising due to clipping positions present on the megamolecule of human growth hormone from the target human growth hormone molecule using a phenyl column, mixture of aqueous buffers and organic solvents as an eluant, followed by desalting, lypholization and the invention also relates to the process wherein the elution of clipped molecules of human growth hormone precedes the elution of target human growth hormone to obtain hGH of purity > 99.5%.

公开(公告)号：EP1863759A1

公开(公告)日：2007-12-12

申请号：EP05784693.3

申请日：2005-05-10

申请人： USV LIMITED

发明人： TARUR, Venkatasubramanian, Radhakrishnan ,  KADAM, Suresh, Mahadev Room No 12 NL-4, Sec. 1 ,  JOSHI, Anil, Purushottam 406, Sonal Co-oper. Housing Soc ,  GAVHANE, Sachin, Baban

IPC分类号： C07C315/02 ,  C07C315/06 ,  C07D317/46

CPC分类号： C07C315/06 ,  C07B2200/13 ,  C07C315/02 ,  C07C317/46

摘要： The present invention discloses a process for the synthesis of N-[4-Cyano-3-(trifluoromethyl) phenyl]-3-[(4-fluorophenyl) sulphonyl]-2-hydroxy-2-methyl propanamide (Form I). The invention discloses a reagent for oxidation of N-[4-Cyano-3-(trifluoromethyl) phenyl]-3-[(4-fluorophenyl) thio]-2-hydroxy-2-methyl propanamide to N-[4-Cyano-3-(trifluoromethyl) phenyl]-3-[(4-fluorophenyl) sulphonyl]-2-hydroxy-2-methyl propanamide. More particularly, the invention discloses a method of purification of N-[4-Cyano-3-(trifluoromethyl) phenyl]-3-[(4-fluorophenyl) sulphonyl]-2-hydroxy-2-methyl propanamide in a mixture of methylethyl ketone and hexane giving form (I). This form (I) is useful as an active pharmaceutical and has antiandrogenic activity.

公开(公告)号：EP1531151B1

公开(公告)日：2007-03-07

申请号：EP04016772.8

申请日：2004-07-15

申请人： USV Limited

发明人： Tarur, Venkatasubramanian Radhakrishnan ,  Sathe, Dhananjay Govind ,  Naidu, Avinash Venkataraman

IPC分类号： C07D211/32

CPC分类号： C07D211/22 ,  C07D211/32