公开(公告)号：EP2013172A1

公开(公告)日：2009-01-14

申请号：EP07748054.9

申请日：2007-04-23

申请人： AstraZeneca AB

发明人： BAILEY, Andrew ,  METE, Antonio ,  PAIRAUDEAU, Garry ,  STOCKS, Michael ,  WENLOCK, Mark

IPC分类号： C07D211/46 ,  A61K31/4409 ,  A61K31/4535 ,  A61K31/4545 ,  A61P11/00 ,  A61P13/10 ,  C07D401/12 ,  C07D409/12

CPC分类号： C07D211/48 ,  C07D409/12

摘要： The invention provides compounds of formula (I), wherein R1, R2, R3, R4, R5 and X are as defined in the specification, a process for their preparation, pharmaceutical compositions containing them, a process for preparing pharmaceutical compositions and their use in therapy (I).

公开(公告)号：EP1539731A1

公开(公告)日：2005-06-15

申请号：EP03738863.4

申请日：2003-07-15

申请人： AstraZeneca AB

发明人： METE, Antonio ,  WALTERS, Iain

IPC分类号： C07D333/34 ,  A61K31/381 ,  A61P29/00

CPC分类号： C07D333/38

摘要： There are provided novel compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, M, T, U, Y, V and W are as defined in the specification and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease and pain.

公开(公告)号：EP2121137A1

公开(公告)日：2009-11-25

申请号：EP07848557.0

申请日：2007-12-17

申请人： AstraZeneca AB

发明人： FORD, Rhonan ,  METE, Antonio ,  MILLICHIP, Ian ,  TEOBALD, Barry

IPC分类号： A61P11/12 ,  A61K31/439 ,  C07D205/04 ,  C07D409/06 ,  C07D453/02 ,  C07D295/037

CPC分类号： C07D453/02 ,  C07D519/00

摘要： The invention provides compounds of formula (I) wherein R5 is a group of formula (II) or (III) and R1, R2, R3, R4, R6, a, b, Z, Y and X are as defined in the specification, a process for their preparation, pharmaceutical compositions containing them, a process for preparing pharmaceutical compositions, their use in therapy and intermediates of use in their preparation.

公开(公告)号：EP2094694A1

公开(公告)日：2009-09-02

申请号：EP07824574.3

申请日：2007-11-13

申请人： AstraZeneca AB

发明人： FORD, Rhonan ,  MATHER, Andrew ,  METE, Antonio

IPC分类号： C07D453/02 ,  A61K31/439

CPC分类号： C07D453/02

摘要： The invention provides compounds of formula (I) wherein R4 is a group of formula (II) or (IIIa) or (IIIb) and R1, R2, R3, R5, a, b and X are as defined in the specification, a process for their preparation, pharmaceutical compositions containing them, a process for preparing pharmaceutical compositions, their use in therapy and intermediates of use in their preparation (I), (II), (IIIa), (IIIb).

摘要翻译： 本发明提供了其中R 4为式（II）或（IIIa）或（IIIb）的基团且R 1，R 2，R 3，R 5，a，b和X如说明书中所定义的式 它们的制备，含有它们的药物组合物，制备药物组合物的方法，它们在治疗中的用途以及在其制备（I），（II），（IIIa），（IIIb）中使用的中间体。

公开(公告)号：EP1539731B9

公开(公告)日：2008-08-20

申请号：EP03738863.4

申请日：2003-07-15

申请人： AstraZeneca AB

发明人： METE, Antonio ,  WALTERS, Iain

IPC分类号： C07D333/34 ,  A61K31/381 ,  A61P29/00

CPC分类号： C07D333/38

摘要： There are provided novel compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, M, T, U, Y, V and W are as defined in the specification and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease and pain.

公开(公告)号：EP1414802A1

公开(公告)日：2004-05-06

申请号：EP02749497.0

申请日：2002-07-26

申请人： AstraZeneca AB

发明人： BIRKINSHAW, Timothy ,  CHESHIRE, David ,  CONNOLLY, Stephen ,  LUKER, Timothy ,  METE, Antonio

IPC分类号： C07D213/85 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  A61K31/44 ,  A61K31/4427 ,  A61P29/00 ,  A61P25/00

CPC分类号： C07D409/12 ,  A61K31/44 ,  A61K31/4427 ,  C07D213/85 ,  C07D413/12 ,  C07D417/12

摘要： There are provided novel compounds of formula (I). wherein R?1, R2, R3¿, Q, T, U, X, Y, V and W are as defined in the specification, and pharmaceutically acceptable salts thereof, and enantiomers and racemates thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease and pain.

公开(公告)号：EP1263714B1

公开(公告)日：2004-04-28

申请号：EP01906490.6

申请日：2001-02-20

申请人： AstraZeneca AB

发明人： BIRKINSHAW, Tim ,  CHESHIRE, David ,  METE, Antonio

IPC分类号： C07C255/50 ,  C07C323/31 ,  C07C317/32 ,  C07C217/54 ,  C07C211/49 ,  C07D295/04 ,  A61K31/00 ,  A61P29/00

CPC分类号： C07D233/64 ,  C07C217/48 ,  C07C255/54 ,  C07D213/38 ,  C07D277/32 ,  C07D295/088 ,  C07D333/32

摘要： There are provided novel compounds of formula (I), wherein R1, R2, X, Y, V, W and Z are as defined in the specification, and pharmaceutically acceptable salts thereof, and enantiomers and racemates thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease and pain.

公开(公告)号：EP1263714A1

公开(公告)日：2002-12-11

申请号：EP01906490.6

申请日：2001-02-20

申请人： AstraZeneca AB

发明人： BIRKINSHAW, Tim ,  CHESHIRE, David ,  METE, Antonio

IPC分类号： C07C255/50 ,  C07C323/31 ,  C07C317/32 ,  C07C217/54 ,  C07C211/49 ,  C07D295/04 ,  A61K31/00 ,  A61P29/00

CPC分类号： C07D233/64 ,  C07C217/48 ,  C07C255/54 ,  C07D213/38 ,  C07D277/32 ,  C07D295/088 ,  C07D333/32

摘要： There are provided novel compounds of formula (I), wherein R1, R2, X, Y, V, W and Z are as defined in the specification, and pharmaceutically acceptable salts thereof, and enantiomers and racemates thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease and pain.

摘要翻译： 提供了式（I）的新化合物，其中R 1，R 2，X，Y，V，W和Z如说明书中所定义，及其药学上可接受的盐，以及其对映体和外消旋体; 以及它们的制备方法，含有它们的组合物以及它们在治疗中的用途。 这些化合物是一氧化氮合酶的抑制剂，因此特别适用于治疗或预防炎性疾病和疼痛。

公开(公告)号：EP1135377A1

公开(公告)日：2001-09-26

申请号：EP99963777.0

申请日：1999-11-30

申请人： AstraZeneca AB

发明人： CONNOLLY, Stephen ,  METE, Antonio

IPC分类号： C07D277/20 ,  C07D277/62 ,  C07D263/54 ,  C07D233/54 ,  C07D235/04 ,  C07D213/04 ,  A61K31/426 ,  A61K31/41 ,  A61K31/44 ,  A61P29/00 ,  A61P11/06

CPC分类号： C07D233/64 ,  C07D213/50 ,  C07D235/12 ,  C07D263/56 ,  C07D277/24 ,  C07D277/64

摘要： Compounds of formula (I) are disclosed, processes for their preparation, pharmaceutical compositions containing the compounds and the use of the compounds as pharmaceuticals. There are also provided chemical intermediates useful for the preparation of the compounds. The compounds are useful as pharmaceuticals, especially for the treatment of inflammatory disease.

摘要翻译： 公开了式（I）化合物，其制备方法，含有该化合物的药物组合物以及该化合物作为药物的用途。 还提供可用于制备化合物的化学中间体。 这些化合物可用作药物，特别是用于治疗炎性疾病。