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公开(公告)号：EP1488236B1
公开(公告)日：2012-10-31
申请号：EP02798611.6
申请日：2002-12-27
发明人： SEUL, Michael , CHAU, Chiu, Wo , HUANG, Hui , BANERJEE, Sukanta , HONG, Ye , YANG, Jiacheng
IPC分类号： G01N33/543 , G01N33/533 , C07H1/00 , C07H21/00 , C12Q1/68
CPC分类号： C12Q1/6837 , B01J19/0046 , B01J2219/00274 , B01J2219/00317 , B01J2219/00466 , B01J2219/00468 , B01J2219/005 , B01J2219/00545 , B01J2219/00648 , B01J2219/00662 , G01N33/54306 , C12Q2563/149
摘要： The present invention provides methods for quality control of biochip manufacture, preferably where the substrate is a semiconductor and the biochip carries bio-functionalized microbeads.
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12.发明公开AUTOMATED ANALYSIS OF MULTIPLEXED PROBE-TRAGET INTERACTION PATTERNS: PATTERN MATCHING AND ALLELE IDENTIFICATION 有权AUTOMATED交互模式分析复用器样品取样目标和比较ALLELIDENTIFIKATION
公开(公告)号：EP1774323A2
公开(公告)日：2007-04-18
申请号：EP05789862.9
申请日：2005-08-02
发明人： XIONGWU, Xia , SEUL, Michael
CPC分类号： C12Q1/6827 , G06F19/18 , G06F19/22
摘要： Disclosed are methods and algorithms (and their implementation) supporting the automated analysis and interactive review and refinement ('redaction') of the analysis within an integrated software environment, for automated allele assignments. The implementation, preferably with a software system and a program referred to as the Automated Allele Assignment ('AAA') program, provides a multiplicity of functionalities including: data management by way of an integrated interface to a portal a database to permit visualizing, importing, exporting and creating customizable summery reports; system configuration ('Set-up') including user authorization, training set analysis and probe masking; Pattern Analysis including string matching and probe flipping; and Interactive Redaction combining real-time database computations and 'cut-andpaste' editing, generating 'warning' statements and supporting annotation. It also includes a thresholding function, a method of setting thresholds, a method of refining thresholds by matching an experimental binary string ('reaction pattern') setting for that probe, probe masking of signals produced by probes which do not contribute significantly to discriminating among alleles.
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公开(公告)号：EP1543163A2
公开(公告)日：2005-06-22
申请号：EP03794568.0
申请日：2003-09-04
发明人： HASHMI, Ghazala , SEUL, Michael , MESSING, Joachim
CPC分类号： C12Q1/6827 , B82Y5/00 , B82Y10/00 , B82Y20/00 , C12Q1/6837 , C12Q2565/102 , C12Q2563/149 , C12Q2537/143
摘要： This invention provides compositions and methods for genetic testing of an organism and for correlating the results of the genetic testing with a unique marker that unambiguously identifies the organism. The marders may be internal markers, such as for example single nucleotide polymorphisms (SNPs), short tandem repeats (STRs), or other sites within a genomic locus. Alternatively, the markers may be external, such that they are separately added to the genetic sample before testing.
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14.发明公开
公开(公告)号：EP1463825A2
公开(公告)日：2004-10-06
申请号：EP02801745.7
申请日：2002-10-15
发明人： LI, Alice, Xiang , HASHMI, Ghazala , SEUL, Michael
CPC分类号： C12Q1/6827 , C12Q1/6837 , C12Q1/6858 , C12Q1/6883 , C12Q2600/156 , C12Q2600/16 , C12Q2565/537 , C12Q2535/125 , C12Q2527/107
摘要： The invention provides methods and processes for the identification of polymorphisms at one or more designated sites, without interference from non-designated sites located within proximity of such designated sites. Probes are provided capable of interrogation of such designated sites in order to determine the composition of each such designated site. By the methods of this invention, one or more mutations within the CFTR gene and the HLA gene complex can be identified.
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15.发明授权A METHOD OF NUCLEIC ACID TYPING FOR SELECTING REGISTERED DONORS FOR CROSS-MATCHING TO TRANSFUSION RECIPIENTS 有权对于核酸分型方法的选择登记捐助者CROSS样本输血RECEIVERS
公开(公告)号：EP1805326B1
公开(公告)日：2014-12-17
申请号：EP05816073.0
申请日：2005-10-24
CPC分类号： C12Q1/6881 , C12Q2600/156 , C12Q2600/16
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公开(公告)号：EP2013801A2
公开(公告)日：2009-01-14
申请号：EP07761283.6
申请日：2007-04-25
发明人： ZHANG, Yi , SEUL, Michael
CPC分类号： G06F19/327 , G06F19/00 , G06Q30/02 , G06Q30/0202 , G06Q50/22 , G06Q50/24 , G16H40/20
摘要： Disclosed is a registry for candidate transfusion donors, which invokes an inventory management policy to create and actively manage lists of candidate donors in order to minimize imbalances between demand and supply across multiple regions and across multiple categories of donors and recipients. Together with a genotyping laboratory, the registry does targeted recruitment of prospective donors who are typed for a set of genetic markers relating to clinically relevant antigens including mutations of Human Erythrocyte Antigens (HEA), genetic variants of Rh, and possibly additional antigens such as HLA and HPA. The registry monitors incoming demand for transfusion antigen genotypes, preferably stratify the demand into a set of categories representing stable subpopulations, and will apply strategies, disclosed herein, to tune the composition of candidate donor lists to match the demand, thereby avoiding excess, and unnecessary, typing of candidate donors.
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17.发明公开SELECTION OF GENOTYPED TRANSFUSION DONORS BY CROSS-MATCHING TO GENOTYPED RECIPIENTS 审中-公开基因分型，输血献血者用CROSS基因型RECEIVERS比较选择
公开(公告)号：EP1941414A2
公开(公告)日：2008-07-09
申请号：EP06826464.7
申请日：2006-10-23
发明人： ZHANG, Yi , SEUL, Michael
IPC分类号： G06F19/00
CPC分类号： G06F19/3456 , G06F19/00 , G06F19/18 , G06F19/20 , G06F19/22 , G06F19/24 , G06F19/3481 , G16H10/60 , G16H50/70
摘要： Disclosed are methods for establishing the compatibility between two bloodtypes on the basis of cross-matching (under a designated rule of stringency) the minor blood group genotypes of recipient and prospective donors. To determine compatibility, the blood group genotypes are mapped to corresponding phenotypes according to the expression states associated with a set of underlying haplotypes, and compatibility is established by establishing the compatibility of bloodtypes constructed as a combination of constituent phenotypes. The bit strings are matched, preferably using an algorithm expression. Where ambiguity in mapping genotypes to haplotypes exists, it can be reduced based on frequency of occurrence of the haplotypes in the sample population, or resolved by gametic phasing. Such reduction or resolution of ambiguity is particularly desirable where mismatches in the antigens expressed by the constituent haplotypes have greater clinical significance.
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18.发明公开MESSAGE ABUNDANCE AND ALLELE COPY NUMBER DETERMINATION USING IVT WITH SINGLE-STRANDED PRIMER-PROMOTER-SELECTOR CONSTRUCTS 有权发布频率的决心，通过单链引物启动子选择器构建ALLELKOPIENZAHL使用IVT
公开(公告)号：EP1926835A2
公开(公告)日：2008-06-04
申请号：EP06815137.2
申请日：2006-09-21
发明人： SEUL, Michael , KORZHEVA, Nataliya
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12N15/1096 , C12Q1/6858 , C12Q1/6865 , C12Q1/6876 , C12Q2521/107 , C12Q2525/143 , C12Q2563/179 , C12Q2565/137 , C12Q2545/114 , C12Q2531/113
摘要： Disclosed is a single stranded primer-pronioter-selector construct comprising (in 3' to 5' orientation) a primer subsequence annealing to the target, a T7 or other promoter subsequence (the template strand), and a selector subsequence. The primer can be extended by template mediated elongation, including reverse transcription, or ligation to another oligonucleotide. The promoter sequence is oriented to direct the in-vitro transcription (IVT) opposite to that of primer extension, where the selector subsequence serves as a template for IVT. The selector is associated with the target subsequence of interest and it, and the amplified product are unique subsequences, dissimilar to other sequence present in the sample. The constructs is useful for determination of the presence and relative abundance of designated subsequences in the sample, multiplex gene expression analysis, multiplex allele counting, determination of polymorphic/mutation site, and loss of heterozygosity.
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19.发明公开
公开(公告)号：EP1692298A2
公开(公告)日：2006-08-23
申请号：EP04817449.4
申请日：2004-10-26
IPC分类号： C12Q1/00
CPC分类号： C12Q1/6832 , B01J2219/00459 , B01J2219/00576 , B01J2219/00608 , B01J2219/00648 , B01J2219/00722 , C12Q1/6809 , C12Q1/6834 , C12Q1/6837 , C12Q2537/143 , C12Q2565/501 , C12Q2565/507 , C12Q2533/101 , C12Q2565/514 , C12Q2565/519
摘要： Disclosed are methods of multiplexed analysis of oligonucleotides in a sample, including: methods of probe and target “engineering”, as well as methods of assay signal analysis relating to the modulation of the probe-target affinity constant, K by a variety of factors including the elastic properties of target strands and layers of immobilized (“grafted”) probes; and assay methodologies relating to: the tuning of assay signal intensities including dynamic range compression and on-chip signal amplification; the combination of hybridization-mediated and elongation-mediated detection for the quantitative determination of abundance of messages displaying a high degree of sequence similarity, including, for example, the simultaneous determination of the relative expression levels, and identification of the specific class of, untranslated AU-rich subsequences located near the 3′ terminus of mRNA; and a new method of subtractive differential gene expression analysis which requires only a single color label.
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公开(公告)号：EP1488236A2
公开(公告)日：2004-12-22
申请号：EP02798611.6
申请日：2002-12-27
发明人： SEUL, Michael , CHAU, Chiu, Wo , HUANG, Hui , BANERJEE, Sukanta , HONG, Ye , YANG, Jiacheng
IPC分类号： G01N33/543 , G01N33/533 , C07H1/00 , C07H21/00 , C12Q1/68
CPC分类号： C12Q1/6837 , B01J19/0046 , B01J2219/00274 , B01J2219/00317 , B01J2219/00466 , B01J2219/00468 , B01J2219/005 , B01J2219/00545 , B01J2219/00648 , B01J2219/00662 , G01N33/54306 , C12Q2563/149
摘要： The present invention provides methods for quality control of biochip manufacture, preferably where the substrate is a semiconductor and the biochip carries bio-functionalized microbeads.
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