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公开(公告)号：EP1945641A1
公开(公告)日：2008-07-23
申请号：EP06825976.1
申请日：2006-10-12
发明人： CARINI, David, J. , JOHNSON, Barry, L. , ZHENG, Zhizhen, Barbara , D'ANDREA, Stanley , SCOLA, Paul, Michael
IPC分类号： C07D487/04 , A61K31/407 , A61P31/12 , C07D498/04
CPC分类号： C07K5/0804 , C07D487/04 , C07K5/081 , C07K5/0815 , C07K5/0827
摘要： Hepatitis C virus inhibitors having the general formula (I): are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
摘要翻译： 公开了具有通式（I）的丙型肝炎病毒抑制剂： 还公开了包含所述化合物的组合物和使用所述化合物抑制HCV的方法。
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12.发明公开MACROCYCLIC ISOQUINOLINE PEPTIDE INHIBITORS OF HEPATITIS C VIRUS 有权大环ISOCHINOLINPEPTIDINHIBITOREN丙型肝炎病毒的
公开(公告)号：EP1629000A2
公开(公告)日：2006-03-01
申请号：EP04759941.0
申请日：2004-04-16
发明人： MCPHEE, Fiona , CAMPBELL, Jeffrey Allen , LI, Wenying , D'ANDREA, Stanley , ZHENG, Zhizhen Barbara , GOOD, Andrew Charles , CARINI, David J. , JOHNSON, Barry L. , SCOLA, Paul Michael
CPC分类号： C07K5/0804 , A61K38/00 , C12P7/62 , C12P13/04 , C12P41/005
摘要： Macrocyclic isoquinoline are disclosed having the general formula: A compound of formula 1: wherein R1 to R9, Q and W are described in the description. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
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公开(公告)号：EP2768831A1
公开(公告)日：2014-08-27
申请号：EP12783457.0
申请日：2012-10-17
IPC分类号： C07D487/04 , A61K31/55 , A61P31/14
CPC分类号： C07D487/04
摘要： The present invention provides (1a
R ,12b
S )-8-cyclohexyl-11-fluoro-
N -((1- methylcyclopropyl)sulfonyl)-1a-((3-methyl-3,8-diazabicyclo[3.2.1]oct-8- yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[
d ]indolo[2,1-
a ][2]benzazepine-5- carboxamide (formula I), including pharmaceutically acceptable salts, as well as compositions and methods of using the compound. The compound has activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.摘要翻译： 本发明提供了（1aR，12bS）-8-环己基-11-氟-N - （（1-甲基环丙基）磺酰基）-1a - （（3-甲基-3,8-二氮杂双环[3.2.1]辛基 -8-基）羰基）-1,1a，2,12b-四氢环丙并[d]吲哚并[2,1-a] [2]苯并氮杂-5-甲酰胺（式I），包括药学上可接受的盐， 和使用该化合物的方法。 该化合物具有抗丙型肝炎病毒（HCV）活性，可用于治疗感染HCV的患者。
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公开(公告)号：EP1945641B1
公开(公告)日：2014-03-19
申请号：EP06825976.1
申请日：2006-10-12
发明人： CARINI, David, J. , JOHNSON, Barry, L. , ZHENG, Zhizhen, Barbara , D'ANDREA, Stanley , SCOLA, Paul, Michael
IPC分类号： C07D487/04 , A61K31/407 , A61P31/12 , C07D498/04
CPC分类号： C07K5/0804 , C07D487/04 , C07K5/081 , C07K5/0815 , C07K5/0827
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公开(公告)号：EP2089020B1
公开(公告)日：2010-12-22
申请号：EP07864430.9
申请日：2007-11-15
发明人： WANG, Alan Xiangdong , ZHENG, Barbara Zhizhen , D'ANDREA, Stanley , MEANWELL, Nicholas A. , SCOLA, Paul Michael
IPC分类号： C07K5/08 , C07D487/04 , C07D498/04 , A61K31/407 , A61P31/12
CPC分类号： C07D498/04 , C07D487/04 , C07K5/0802 , C07K5/0815
摘要： Macrocyclic peptides having the general formula are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
摘要翻译： 公开了具有通式的大环肽。 还公开了包含所述化合物的组合物和使用所述化合物抑制HCV的方法。
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公开(公告)号：EP2089385A2
公开(公告)日：2009-08-19
申请号：EP07863696.6
申请日：2007-10-31
IPC分类号： C07D409/04 , C07D231/56 , C07D237/32 , C07D239/88 , C07D487/04 , C07D495/04 , C07D498/04
CPC分类号： C07K5/0804
摘要： Macrocyclic peptides are disclosed having the general formula: (I) wherein R3, R'3, R4, R6, R', X, Q and W are described. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
摘要翻译： 公开了具有以下通式的大环肽：其中描述了R3，R'3，R4，R6，R'，X，Q和W。 还公开了包含所述化合物的组合物和使用所述化合物抑制HCV的方法。
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公开(公告)号：EP2086995A1
公开(公告)日：2009-08-12
申请号：EP07864446.5
申请日：2007-11-15
发明人： WANG, Alan Xiangdong , ZHENG, Barbara Zhizhen , D'ANDREA, Stanley , ZHAO, Qian , SCOLA, Paul Michael
IPC分类号： C07K5/08 , A61K31/401 , A61P31/00
CPC分类号： C07K5/0827 , C07K5/0804 , C07K5/0812
摘要： Hepatitis C virus inhibitors having the general formula (I) are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
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公开(公告)号：EP2086994A2
公开(公告)日：2009-08-12
申请号：EP07863706.3
申请日：2007-10-31
CPC分类号： C07K5/0804
摘要： Macrocyclic peptides are disclosed having the general formula (I) wherein R3, R3', R4, R6, R', X, Q and W are described. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
摘要翻译： 公开了具有通式（I）的大环肽，其中描述了R3，R3'，R4，R6，R'，X，Q和W. 还公开了包含所述化合物的组合物和使用所述化合物抑制HCV的方法。
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公开(公告)号：EP1951743A1
公开(公告)日：2008-08-06
申请号：EP06836865.3
申请日：2006-11-02
发明人： D'ANDREA, Stanley , ZHENG, Zhizhen Barbara , CAMPBELL, Jeffrey Allen , MCPHEE, Fiona , GOOD, Andrew Charles , SCOLA, Paul Michael
CPC分类号： A61K38/204 , A61K38/2013 , A61K38/208 , A61K38/212 , C07K5/06139 , C07K5/0804 , A61K2300/00
摘要： Macrocyclic peptides are disclosed having the general formula: [I] , wherein R', R3, R3', R4, R6, X5 Q, and W are described. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
摘要翻译： 公开了具有通式[I]的大环肽，其中描述了R'，R3，R3'，R4，R6，X5Q和W. 还公开了包含所述化合物的组合物和使用所述化合物抑制HCV的方法。
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公开(公告)号：EP2888266A1
公开(公告)日：2015-07-01
申请号：EP13750479.1
申请日：2013-08-12
发明人： NAIDU, B. Narasimhulu , PATEL, Manoj , D'ANDREA, Stanley , ZHENG, Zhizhen Barbara , CONNOLLY, Timothy P. , LANGLEY, David R. , PEESE, Kevin , WANG, Zhongyu , WALKER, Michael A. , KADOW, John F.
IPC分类号： C07D487/16 , C07D498/16 , A61K31/519 , A61P31/18
CPC分类号： A61K31/5383 , A61K31/519 , A61K45/06 , C07D487/16 , C07D491/22 , C07D498/16 , C07D498/22
摘要： The disclosure generally relates to compounds of formula (I), including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.
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