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公开(公告)号：EP2318430A2
公开(公告)日：2011-05-11
申请号：EP09806982.6
申请日：2009-08-14
申请人： Los Alamos National Security, LLC , Beth Israel Deaconess Medical Center , Duke University , The University of Alabama at Birmingham Research Foundation
发明人： KORBER, Bette, T. , FISCHER, William , LETVIN, Norman , LIAO, Hua-xin , HAYNES, Barton, F. , HAHN, Beatrice, H.
IPC分类号： C07K14/155 , C12N15/49 , A61K39/21
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/53 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2710/24143 , C12N2740/16022 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16234 , C12N2740/16334
摘要： The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.
摘要翻译： 本发明涉及马赛克进化枝M HIV-1 Env多肽和包含其的组合物。 本发明的多肽适用于诱导人体对HIV-1的免疫应答。
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公开(公告)号：EP2358757B1
公开(公告)日：2018-09-12
申请号：EP09828172.8
申请日：2009-11-18
IPC分类号： C07K17/00 , C07K14/005 , A61K39/12 , A61K39/235 , A61K39/21 , A61K39/275 , A61K39/00 , C12N7/00
CPC分类号： A61K39/21 , A61K39/12 , A61K39/235 , A61K39/275 , A61K2039/53 , C07K14/005 , C12N7/00 , C12N2710/10043 , C12N2710/10343 , C12N2710/24043 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171 , C12N2740/16222 , C12N2740/16234 , C12N2740/16271 , C12N2740/16322 , C12N2740/16334 , Y02A50/467
摘要： The invention provides compositions, methods, and kits for the treatment or prevention of viral infections. The polyvalent (e.g., 2-valent) vaccines described herein incorporate computationally-optimized viral polypeptides that can increase the diversity or breadth and depth of cellular immune response in vaccinated subjects.
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公开(公告)号：EP3470437A1
公开(公告)日：2019-04-17
申请号：EP18191558.8
申请日：2009-11-18
IPC分类号： C07K17/00 , C07K14/005 , C12N7/00 , A61K39/21 , A61K39/12 , A61K39/235 , A61K39/275 , A61K39/00
摘要： The invention provides compositions, methods, and kits for the treatment or prevention of viral infections. The polyvalent (e.g., 2-valent) vaccines described herein incorporate computationally-optimized viral polypeptides that can increase the diversity or breadth and depth of cellular immune response in vaccinated subjects.
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公开(公告)号：EP2129395A2
公开(公告)日：2009-12-09
申请号：EP08799657.5
申请日：2008-03-27
申请人： The Regents of the University of California , Duke University , THE UNIVERSITY OF ALABAMA AT BIRMINGHAM , UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
发明人： HAYNES, Barton, F. , KORBER, Bette, T. , HAHN, Beatrice, H. , BHATTACHARYA, Tanmoy , GNANAKARAN, Gnana, S. , GAO, Feng , SWANSTROM, Ron , SHAW, George
IPC分类号： A61K39/21
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , C12N2740/16122 , C12N2740/16134
摘要： The present invention relates, in general, to human immunodeficiency virus (HIV) and, in particular, to a method of inducing an immune response to HIV in a patient and to immunogens suitable for use in such a method. The invention also relates to diagnostic test kits and methods of using same.
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公开(公告)号：EP4415752A2
公开(公告)日：2024-08-21
申请号：EP22881744.1
申请日：2022-10-12
申请人： Duke University , The Trustees of the University of Pennsylvania , Korber, Bette, T. , Wagh, Kshitij, G. , Shaw, George, M. , Weissman, Drew , Alameh, Mohamad-Gabriel
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公开(公告)号：EP1917040A2
公开(公告)日：2008-05-07
申请号：EP06802155.9
申请日：2006-08-23
申请人： The Regents of the University of California , Beth Israel Deaconess Medical Center , Duke University , University of Alabama at Birmingham Research Foundation
发明人： KORBER, Bette, T. , PERKINS, Simon , BHATTACHARYA, Tanmoy , FISCHER, William, M. , THEILER, James , LETVIN, Norman , HAYNES, Barton, F. , HAHN, Beatrice, H. , YUSIM, Karina , KUIKEN, Carla
IPC分类号： A61K48/00
CPC分类号： A61K39/21 , A61K39/00 , A61K39/12 , C12N2740/16034
摘要： The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.
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公开(公告)号：EP1461077A2
公开(公告)日：2004-09-29
申请号：EP02799181.9
申请日：2002-11-07
申请人： Duke University
发明人： HAYNES, Barton, F.,c/o Duke University , KORBER, Bette, T. , DELORIMIER, Robert, M.,c/o Duke University
IPC分类号： A61K39/00 , A61K39/21 , A61K39/385
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/57 , C07K2319/00 , C12N2740/16122 , C12N2740/16222 , Y10S530/826
摘要： The present invention relates, generally, to a polyvalent immunogen and, more particularly, to a method of inducing neutralizing antibodies against HIV and to a polyvalent immunogen suitable for use in such a method.
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公开(公告)号：EP1667714B1
公开(公告)日：2018-01-03
申请号：EP04784298.4
申请日：2004-09-17
申请人： Duke University , The University of Alabama at Birmingham Research Foundation , The Regents of the University of California
发明人： HAYNES, Barton, F. , GAO, Feng , KORBER, Bette, T. , HAHN, Beatrice, H. , SHAW, George, M. , KOTHE, Denise , LI, Ying Ying , DECKER, Julie , LIAO, Hua-Xin
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/53 , A61K2039/57 , C07K14/005 , C07K16/4225 , C12N2740/15022 , C12N2740/15034 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16322
摘要： The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralize a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.
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公开(公告)号：EP4229070A1
公开(公告)日：2023-08-23
申请号：EP21883746.6
申请日：2021-10-19
IPC分类号： C07K14/005 , C07K14/155 , A61K39/12 , C07K14/08
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公开(公告)号：EP1667714A2
公开(公告)日：2006-06-14
申请号：EP04784298.4
申请日：2004-09-17
申请人： Duke University , The University of Alabama at Birmingham Research Foundation , The Regents of the University of California
发明人： HAYNES, Barton, F. , GAO, Feng , KORBER, Bette, T. , HAHN, Beatrice, H. , SHAW, George, M. , KOTHE, Denise , LI, Ying Ying , DECKER, Julie , LIAO, Hua-Xin
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/53 , A61K2039/57 , C07K14/005 , C07K16/4225 , C12N2740/15022 , C12N2740/15034 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16322
摘要： The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralize a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.
摘要翻译： 本发明一般涉及免疫原，特别涉及用于诱导中和广谱HIV原发分离株和/或诱导T细胞免疫应答的免疫原的抗体的免疫原。 本发明还涉及使用这种免疫原诱导抗HIV抗体的方法，和/或诱导T细胞免疫应答的方法。 本发明还涉及编码本发明免疫原的核酸序列。
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