公开(公告)号：EP1613958A2

公开(公告)日：2006-01-11

申请号：EP04724084.1

申请日：2004-03-29

申请人： INSTITUT PASTEUR ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

发明人： SANSONETTI, Philippe ,  GIRARDIN, Stephen ,  PHILPOTT, Dana ,  BONECA, Ivo

IPC分类号： G01N33/53 ,  G01N33/567 ,  G01N33/68 ,  C07K14/47 ,  C07K5/02

CPC分类号： G01N33/502 ,  A61K38/04 ,  A61K38/05 ,  C07K5/0215 ,  C07K9/005 ,  C07K14/4702 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/5017 ,  G01N33/5041 ,  G01N33/56911 ,  G01N2510/00 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/481

摘要： A method for modulating Nod1 activity wherein said method comprises the steps of providing cells expressing a functional Nod1: and bringing said cells into contact with a molecule related to compositions comprising a molecule related to MTP and use of a molecule related to MTP for modulating inflammation and/or apoptosis.

公开(公告)号：EP3502239A1

公开(公告)日：2019-06-26

申请号：EP19157000.1

申请日：2015-03-09

申请人： Institut Pasteur ,  Institut National de la Santé et de la Recherche Médicale

发明人： MARTEYN, Benoît ,  SANSONETTI, Philippe ,  MONCEAUX, Valérie ,  UNGEHEUER, Marie-Noëlle

IPC分类号： C12N5/0787

摘要： A method for keeping leukocytes alive ex vivo or in vitro, comprising maintaining the leukocytes in a medium comprising from 3 to 10 mM of glucose, in hypoxic conditions with P(O 2 ) ≤ 10 mM Hg.

公开(公告)号：EP3237602A1

公开(公告)日：2017-11-01

申请号：EP15830866.8

申请日：2015-12-23

申请人： Institut Pasteur ,  Fondation Imagine ,  Assistance Publique-Hôpitaux de Paris ,  Université Paris Descartes ,  Institut National de la Santé et de la Recherche Médicale (INSERM)

发明人： EBERL, Gérard ,  BIKARD, David ,  SCHNUPF, Pamela ,  CERF BENSUSSAN, Nadine ,  GABORIAU-ROUTHIAU, Valérie ,  SANSONETTI, Philippe

IPC分类号： C12N1/20

CPC分类号： C12N1/20 ,  C12N13/00 ,  C12N15/74 ,  C12N2502/23

摘要： The present invention relates to an in vitro method of culturing a segmented filamentous bacterium strain, comprising co-culturing said segmented filamentous bacterium strain with a eukaryotic host cell, wherein the culture is performed at an O2 level inferior to 5% in a rich tissue culture liquid medium containing bacterial medium components including iron. The present invention also relates to methods for genetically modifying a segmented filamentous bacterium strain comprising a step a culturing the strain in vitro.

摘要翻译： 本发明涉及培养分段丝状细菌菌株的体外方法，其包括将所述分段丝状细菌菌株与真核宿主细胞共培养，其中所述培养物在富含组织中以低于5％的O 2水平进行 含有含铁细菌培养基成分的培养液培养基。 本发明还涉及用于遗传修饰分段丝状细菌菌株的方法，其包括在体外培养菌株的步骤。

公开(公告)号：EP2083853B1

公开(公告)日：2013-06-12

申请号：EP07859250.8

申请日：2007-10-12

申请人： Institut Pasteur ,  Institut National de la Santé et de la Recherche Médicale ,  Université Libre de Bruxelles ,  Rijksuniversiteit Groningen

发明人： ALLAOUI, Adbelmounaaïm ,  SANSONETTI, Philippe ,  SANI, Musa ,  BOTTEAUX, Anne ,  PARSOT, Claude ,  BOEKEMA, Egbert, J.

IPC分类号： A61K39/02

CPC分类号： A61K39/0283 ,  Y02A50/476

摘要： The present invention relates to compositions and methods for blocking entry of Shigella into a cell of an animal, to therefore providing protection against, or reduce the severity of Shigella infections. More particularly it relates to the use of the IpaD protein obtained from natural sources and/or through synthesis or recombinant technology, and conjugates thereof to induce neutralizing antibodies having protective activity against several serotypes of Shigella, in particular S. flexneri. The composition of the invention is useful to prevent and/or treat shigellosis caused by a bacterium of the Shigella family.

公开(公告)号：EP2195457A1

公开(公告)日：2010-06-16

申请号：EP08804165.2

申请日：2008-09-12

申请人： Institut Pasteur

发明人： MHLANGA, MUSA ,  ENNINGA, Jost ,  SANSONETTI, Philippe ,  NEHRBASS, Ulf

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6897 ,  C12Q2563/179 ,  C12Q2525/301 ,  C12Q2565/1015

摘要： The invention relates to a double-stranded polynucleotide comprising on its positive strand considered from its 5' end to its 3' end, (i) a promoter of a gene of interest or several promoters of various genes of interest selected among genes which are endogenous to a determined cell, and, (ii) one or several barcode(s) wherein each barcode contains at least one barcode unit formed of at least one, especially of multiple, recognition binding sites each binding site being composed of a nucleotide sequence, and wherein each of said barcode(s) is under the control of at least one of said promoter(s) for transcription. It further concerns use of said polynucleotide to monitor gene expression patterns in living cells, especially in single cells, with a rapid and high spatio-temporal resolution.

摘要翻译： 本发明涉及双链多核苷酸，包括在其正海滩从其5考虑“末端到3”末端，（i）目标或基因中选择的感兴趣的各种基因的几个启动子的基因，其是内源性的启动子 于确定性的开采细胞，和，（ii）一个或多个条形码（或多个）worin每个条形码含有至少一个条形码单元形成的至少一个，爱的特别每个结合位点是由具有核苷酸序列的多个，识别结合位点，和 worin每个所述条形码（多个）是所述启动子（一个或多个），用于转录的至少一个的控制下。 它涉及进一步使用所述多核苷酸来监测活细胞中的基因表达模式，尤其是在单细胞爱，具有快速和高时空分辨率。