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11.发明公开KV1.5-BLOCKER ZUR SELEKTIVEN STEIGERUNG DER VORHOFKONTRAKTILITÄT UND BEHANDLUNG DER HERZINSUFFIZIENZ 审中-公开对Kv1.5阻滞剂FOR THE选择性增加心房收缩力和治疗心力衰竭
公开(公告)号：EP1720549A1
公开(公告)日：2006-11-15
申请号：EP05707351.2
申请日：2005-02-12
发明人： WIRTH, Klaus
IPC分类号： A61K31/4406 , A61K31/166 , A61K31/44 , A61P9/04
CPC分类号： A61K31/4406 , A61K31/166 , A61K31/44
摘要： The invention relates to the contractility-increasing action of Kvl.5-blockers, especially phenylcarboxylic acid amides of formulae la and/or lb (I), (II) and/or pharmaceutically acceptable salts thereof, for treating reduced atrial contractility and cardiac insufficiency, especially cardiac insufficiency caused by diastolic dysfunction.
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12.发明授权
公开(公告)号：EP1255724B1
公开(公告)日：2006-08-30
申请号：EP00977604.8
申请日：2000-12-01
发明人： HEINELT, Uwe , LANG, Hans-Jochen , KLEEMANN, Heinz-Werner , SCHWARK, Jan-Robert , WIRTH, Klaus , JANSEN, Hans-Willi
IPC分类号： C07C211/38 , C07C217/56 , A61K31/137
CPC分类号： C07C317/32 , C07B2200/07 , C07C211/38 , C07C211/49 , C07C215/30 , C07C217/58 , C07C217/60 , C07C217/62 , C07C229/38 , C07C237/30 , C07C255/58 , C07C257/18 , C07C311/37 , C07C323/32 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/68
摘要： The invention relates to substituted norbornylamino derivatives containing exo-configured nitrogen and an endo-annellated pentacyclic ring of formula (I) and exo-configured nitrogen and an exo-annellated pentacyclic ring of formula (Ia), wherein R1, R2 R3, R4, R5, A, B, S1 and S2 have the meanings cited in the claims. Said derivatives are especially suitable as anti-hypertensive agents for reducing or preventing ischaemia-induced damage, as medicaments for use in surgical procedures for treating ischaemias of the nervous system, of a cerebrovascular accident and of a cerebral oedema. The derivatives are also suitable for treating shock, an impaired respiratory impulse, snoring, or for use as a laxative, as an agent against ectoparasites, in the prophylaxis of gall stones, as an anti-atherosclerotic agent, as an agent for treating late complications of diabetes, or for treating cancerous illnesses, fibrotic disorders, endothelial dysfunction and organ hypertrophies and hyperplasias. Said derivatives act as inhibitors of the cellular sodium-proton-antiporter. They also influence serum lipoproteins and can thus be used in the prophylaxis and reversal of atherosclerotic changes.
摘要翻译： 应用程序盘松动substituiertem降冰片衍生物，它们的制备方法，它们作为药物或诊断和药物，其包含具有外切构造氮气下式的内切稠合的五元环的和themSubstituted降冰片衍生物使用I，或具有外切构造氮 和下式的外切稠合的五元环的我泉其中R1，R2，R3，R4，R5，A，B，S1和S2是如在权利要求限定，是高度适合用作抗高血压剂，用于 减少或防止缺血性损伤，用作药物，用于神经系统的缺血的治疗外科手术中风和脑水肿，休克，受损的呼吸驱动的，对于打鼾的治疗，作为泻药，作为对抗剂 体外寄生虫，为防止形成胆结石，因为antiatherosclerotics的，因为对后期糖尿病并发症，癌性疾病，纤维变性疾病，药物恩 内皮功能障碍，和器官hypertrophies和hyperplasias.They是蜂窝钠/质子反向转运蛋白的抑制剂。 他们必须对血清脂蛋白的影响，可以为动脉粥样硬化的变化预防和回归了。所以使用。
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13.发明公开2-(BUTYL-1-SULFONYLAMINO)-N- 1(R)-(6-METHOXY-PYRIDIN-3-YL)-PROPYL -BENZAMID, DESSEN VERWENDUNG ALS MEDIKAMENT SOWIE DIESES ENTHALTENDE PHARMAZEUTISCHE ZUBEREITUNGEN 审中-公开2-（丁基-1-磺酰基氨基）-N- 1（R） - （6-甲氧基 - 吡啶-3-基） - 丙基 - 苯甲酰胺，及其用作药物和含有药物制剂
公开(公告)号：EP1606237A1
公开(公告)日：2005-12-21
申请号：EP04717628.4
申请日：2004-03-05
IPC分类号： C07C11/08 , C07D213/64 , A61K31/18 , A61P9/06
CPC分类号： C07D213/64
摘要： The invention relates to 2-(Butyl-1-sulfonylamino)-N-[1 (R)-(6-methoxy-pyridin-3-yl)-propyl]-benzamid of formula (I), and to the pharmaceutically acceptable salts thereof. Said invention also relates to the production and use of the inventive compound or the pharmaceutically acceptable salts thereof, in particular for treating and preventing auricular arrhythmia, for example auricular fibrillation (atrial fibrillation) or auricular flutter (atrial flutter).
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14.发明公开KOMBINATION VON PHENYLCARBONSÄUREAMIDEN MIT BLOCKERN DES IKR-KANALS UND DEREN VERWENDUNG ZUR BEHANDLUNG VON VORHOFARRHYTHMIEN 有权phenylcarboxamides与受体阻滞剂的IR通道与它们用于房性心律失常疗法相结合
公开(公告)号：EP1605976A1
公开(公告)日：2005-12-21
申请号：EP04717614.4
申请日：2004-03-05
发明人： BRENDEL, Joachim , WIRTH, Klaus , GOEGELEIN, Heinz , ALLESSIE, Maurits,Department of Physiology , BLAAUW, Yuri,Department of Physiology
CPC分类号： A61K31/18 , A61K31/165 , A61K31/44 , A61K45/06 , A61K2300/00
摘要： The invention relates to a combination of one or several IKr channel inhibitors and one or several Kv1.5 inhibitors, in particular phenylcarboxyl acid amides represented by the formula (Ia) and/or (Ib), and/or acceptable pharmaceutical salts thereof and to the use of the inventive combination for treating atrial arrhythmia.
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15.发明公开
公开(公告)号：EP1592669A2
公开(公告)日：2005-11-09
申请号：EP04703371.7
申请日：2004-01-20
IPC分类号： C07D233/50 , C07D235/30 , A61K31/4168 , A61K31/4184 , A61P1/10 , A61P9/12 , A61P11/16 , A61P13/12 , A61P33/02 , A61P39/00
CPC分类号： C07D233/50
摘要： The invention relates to compounds of formula (I) whose radicals R1-R8 are defined as in the claims. Compounds of this type are useful in the prevention or treatment of diverse disorders. They can be used, among other things, in the treatment of: kidney diseases such as acute or chronic kidney failure; failures in biliary function; breathing disturbances such as snoring or sleep apnea or; cerebrovascular accidents.
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16.发明授权SUBSTITUIERTE 4-PHENYLTETRAHYDROISOCHINOLINE, VERFAHREN ZU IHRER HERSTELLUNG, IHRE VERWENDUNG ALS MEDIKAMENT, SOWIE SIE ENTHALTENDES MEDIKAMENT 有权取代的4- PHENYLTETRAHYDROISOCHINOLINE，工艺所周之，它们作为药品和含药
公开(公告)号：EP1613600B1
公开(公告)日：2015-12-23
申请号：EP04719379.2
申请日：2004-03-11
发明人： HOFMEISTER, Armin , HEINELT, Uwe , LANG, Hans-Jochen , FRICK, Wendelin , BLEICH, Markus , WIRTH, Klaus
IPC分类号： C07D217/16 , C07D401/12 , A61K31/47 , A61P9/00 , A61P11/00 , A61P13/12
CPC分类号： C07D401/12 , C07D217/16
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17.发明授权SUBSTITUIERTE 4-PHENYLTETRAHYDROISOCHINOLINE, VERFAHREN ZU IHRER HERSTELLUNG, IHRE VERWENDUNG ALS MEDIKAMENT, SOWIE SIE ENTHALTENDES MEDIKAMENT 有权取代的4- PHENYLTETRAHYDROISOCHINOLINE，工艺所周之，它们作为药品和含药
公开(公告)号：EP1794128B1
公开(公告)日：2012-01-11
申请号：EP05784511.7
申请日：2005-09-08
IPC分类号： C07D217/22 , A61K31/47 , A61P9/12
CPC分类号： C07D405/12 , C07D217/14 , C07D401/12
摘要： The invention relates to compounds of formula (I) in which R1 to R10 have the meanings as described in the claims. Medicaments containing compounds of this type are useful in preventing or treating various diseases. The compounds can be used, among other things, for renal diseases such as acute or chronic renal failure, for defects of biliary function, for breathing disturbances such as snoring or sleep apnea or for stroke.
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18.发明公开SUBSTITUTED AMINOINDANES AND ANALOGS THEREOF, AND THE PHARMACEUTICAL USE THEREOF 有权取代的茚满及其类似物和它们的药物用途
公开(公告)号：EP2342178A1
公开(公告)日：2011-07-13
申请号：EP09778082.9
申请日：2009-08-25
申请人： Sanofi-Aventis
发明人： RACKELMANN, Nils , BIALY, Laurent , ENGLERT, Heinrich , WIRTH, Klaus , ARNDT, Petra , WESTON, John , HEINELT, Uwe , FOLLMANN, Markus
IPC分类号： C07D207/08 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , A61K31/4523 , A61P1/00 , A61P3/00 , A61P9/00
CPC分类号： C07D487/10 , C07D205/04 , C07D207/08 , C07D211/56 , C07D243/08 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D411/12 , C07D413/12 , C07D417/12 , C07D487/04 , C07D487/08
摘要： The invention relates to substituted aminoindanes and analogs thereof of formula (I) and the pharmaceutical use thereof. Medicaments which comprise compounds of this type are suitable for the prevention or treatment of diverse disorders such as, for example, of respiratory disorders, cystic fibrosis disorders, acute or chronic renal disorders or bowel disorders.
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公开(公告)号：EP2012758A2
公开(公告)日：2009-01-14
申请号：EP07724232.9
申请日：2007-04-13
发明人： BRENDEL, Joachim , GOEGELEIN, Heinz , WIRTH, Klaus , KAMM, Walter
IPC分类号： A61K31/00 , A61K31/166 , A61K31/18 , A61K31/341 , A61K31/381 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4418 , A61K31/444 , A61K31/47
CPC分类号： A61K31/00 , A61K31/166 , A61K31/18 , A61K31/341 , A61K31/381 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4418 , A61K31/444 , A61K31/47
摘要： The invention relates to the use of Kv1.5 inhibitors for producing a medicament for the therapy or prophylaxis of respiratory disorders, sleep-related respiratory disorders, central and obstructive sleep apneas, upper airway reisistance syndrome, Cheyne-Stokes respiration, snoring, disrupted central respiratory drive, sudden child death, postoperative hypoxia and apnea, muscle-related respiratory disorders, respiratory disorders after long-term ventilation, respiratory disorders during adaptation in high mountains, acute and chronic lung disorders with hypoxia and hypercapnia, neurodegenerative disorders, dementia, Alzheimer's disease, Parkinson's disease, Huntington's disease, cancer disorders, breast cancer, lung cancer, colon cancer and prostate cancer.
摘要翻译： 本发明涉及Kv1.5抑制剂用于治疗或预防呼吸系统疾病，睡眠相关呼吸障碍，中枢性和阻塞性睡眠呼吸暂停，上呼吸道阻力综合征，Cheyne-Stokes呼吸，打鼾，中枢呼吸驱动中断，突发 儿童死亡，术后缺氧和呼吸暂停，肌肉相关呼吸障碍，长期通气后的呼吸系统疾病，高山适应期间的呼吸障碍，缺氧和高碳酸血症的急性和慢性肺病，神经退行性疾病，痴呆，阿尔茨海默病，帕金森病 ，亨廷顿舞蹈病，癌症疾病，乳腺癌，肺癌，结肠癌和前列腺癌。
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20.发明公开SUBSTITUTED PYRR0LIDIN-2-0NES , PIPERIDIN-2-0NES AND ISOTHIAZOLIDINE-1, 1-DIOXIDES, THEIR USE AS KVl .5 POTASSIUM CHANNEL BLOCKERS AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM 有权取代的吡咯烷-2-酮，哌啶-2-酮和噻唑烷-1,1-二氧化物，它们作为Kv1.5的钾通道阻断剂和药物制剂含有它们的使用
公开(公告)号：EP1899320A1
公开(公告)日：2008-03-19
申请号：EP06754278.7
申请日：2006-06-10
申请人： Sanofi-Aventis
发明人： BRENDEL, Joachim , ENGLERT, Heinrich Christian , PEUKERT, Stefan , WIRTH, Klaus , WAGNER, Michael , RUXER, Jean-Marie , PILORGE, Fabienne
IPC分类号： C07D401/06 , C07D207/26 , C07D275/02 , C07D409/06 , C07D401/14 , C07D211/76 , A61K31/4015 , A61K31/4412 , A61P9/00 , A61P11/00 , A61P25/28 , A61P35/00
CPC分类号： C07D401/06 , C07D207/27 , C07D211/76 , C07D275/02 , C07D401/14 , C07D409/06
摘要： The invention relates to compounds of the formula (I), in which A, R1 , R2, R3, R4, R5, R6, R7 and n have the meanings stated in the claims. The compounds are particularly suitable as antiarrhythmic active ingredients, in particular for the treatment and prophylaxis of atrial arrhythmias, for example atrial fibrillation (AF) or atrial flutter.
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