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1.发明授权
公开(公告)号：EP1664058B1
公开(公告)日：2007-11-14
申请号：EP04764791.2
申请日：2004-09-03
发明人： LANG, Hans-Jochen , HEINELT, Uwe , WIRTH, Klaus , LICHER, Thomas
IPC分类号： C07D495/04 , A61K31/4188 , A61P1/00 , A61P11/00
CPC分类号： C07D495/04
摘要： The invention relates to substituted thienoimidazoles of formula (I) or (II), where R1 to R4 have the meanings given in the claims. Medicaments comprising compounds of this type are useful for the prevention or treatment of diverse diseases. The compounds find application, amongst other things, for the treatment of breathing disorders and snoring, to improve the breathing process, for treatment of chronic and acute diseases of the kidney and the intestine, diseases caused by ischaemic and/or reperfusion events, proliferative or fibrotic diseases, for the treatment or prophylaxis of diseases of the central nervous system, lipometabolism, diabetes, blood clotting and parasitic attack.
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2.发明公开
公开(公告)号：EP1664058A1
公开(公告)日：2006-06-07
申请号：EP04764791.2
申请日：2004-09-03
发明人： LANG, Hans-Jochen , HEINELT, Uwe , WIRTH, Klaus , LICHER, Thomas
IPC分类号： C07D495/04 , A61K31/4188 , A61P1/00 , A61P11/00
CPC分类号： C07D495/04
摘要： The invention relates to substituted thienoimidazoles of formula (I) or (II), where R1 to R4 have the meanings given in the claims. Medicaments comprising compounds of this type are useful for the prevention or treatment of diverse diseases. The compounds find application, amongst other things, for the treatment of breathing disorders and snoring, to improve the breathing process, for treatment of chronic and acute diseases of the kidney and the intestine, diseases caused by ischaemic and/or reperfusion events, proliferative or fibrotic diseases, for the treatment or prophylaxis of diseases of the central nervous system, lipometabolism, diabetes, blood clotting and parasitic attack.
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3.发明授权SUBSTITUIERTE 4-PHENYLTETRAHYDROISOCHINOLINE, VERFAHREN ZU IHRER HERSTELLUNG, IHRE VERWENDUNG ALS MEDIKAMENT, SOWIE SIE ENTHALTENDES MEDIKAMENT 有权取代的4- PHENYLTETRAHYDROISOCHINOLINE，工艺所周之，它们作为药品和含药
公开(公告)号：EP1453810B1
公开(公告)日：2009-03-18
申请号：EP02804183.8
申请日：2002-11-20
发明人： HOFMEISTER, Armin , HEINELT, Uwe , LANG, Hans-Jochen , BLEICH, Markus , WIRTH, Klaus , GEKLE, Michael
IPC分类号： C07D217/22 , C07D401/12 , C07D403/12 , C07D417/12 , C07D409/12 , A61K31/47 , A61P9/12
CPC分类号： C07D401/12 , C07D217/18 , C07D405/12 , C07D409/12 , C07D417/12
摘要： The invention relates to compounds of formula (I), wherein R1 - R9 which have the meaning as cited in the claims, are extremely suitable as antihypertensives for reducing or preventing ischemically induced injuries, as medicaments for operative intervention for the treatment of ischemics of the nervous system, strokes and swelling of the brain, shocks, disturbed respiratory functions, for the treatment of snorers, as a laxative, as agents against ectopic parasites, for the prevention of gallstones, as antiatherosclerotic agents, agents against diabetic late complications, cancer, fibrotic diseases, endothelial dysfunctions, organ hypertrophia and hyperplasia. Said compounds are also inhibitors of the cellular sodium-proton-antiporters, they influence serum lipoproteins and can be used in the prophylaxis of and for the regression of atherosclerotic alterations.
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4.发明授权N-SUBSTITUIERTE (BENZOIMIDAZOL-2-YL)-PHENYL-AMINE, VERFAHREN ZU IHRER HERSTELLUNG, IHRE VERWENDUNG ALS MEDIKAMENT ODER DIAGNOSTIKUM SOWIE SIE ENTHALTENDES MEDIKAMENT 有权的N-取代的（苯并咪唑-2-基）苯基胺，METHOD FOR THE PRODUCTION，它们作为药物或诊断和药物含
公开(公告)号：EP1592671B1
公开(公告)日：2008-04-09
申请号：EP04703374.1
申请日：2004-01-20
IPC分类号： C07D235/30 , A61K31/4184 , A61P11/00
CPC分类号： C07D235/30
摘要： The invention relates to compounds of formula (I), in which R1 to R7 are defined as cited in the claims. Medicaments containing compounds of this type are used to prevent or treat diverse diseases. Said compounds are used to treat renal diseases such as acute or chronic renal failure, gall-bladder dysfunction, respiratory disorders such as snoring or sleep apnoea, or to treat strokes.
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5.发明公开SUBSTITUTED HETEROCYCLES, THEIR USE AS MEDICAMENT, AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM 有权取代的杂环，及其作为药物的用途和药物制剂含有它们的
公开(公告)号：EP1896416A1
公开(公告)日：2008-03-12
申请号：EP06754277.9
申请日：2006-06-10
申请人： sanofi-aventis
发明人： BRENDEL, Joachim , ENGLERT, Heinrich, Christian , WIRTH, Klaus , WAGNER, Michael , RUXER, Jean-Marie c/o Aventis Pharma , PILORGE, Fabienne c/o Aventis Pharma
IPC分类号： C07D213/64 , C07D237/14 , A61K31/4412 , A61K31/50 , A61P9/00 , A61P11/00 , A61P25/00 , A61P35/00
CPC分类号： C07D213/64 , C07D237/14
摘要： The invention relates to compounds of the formula (I), in which R1 , R2, R3, R4, R5, R6 and X have the meanings stated in the claims. The compounds are particularly suitable as antiarrhythmic active ingredients, in particular for the treatment and prophylaxis of atrial arrhythmias, for example atrial fibrillation (AF) or atrial flutter.
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6.发明公开SUBSTITUIERTE 4-PHENYLTETRAHYDROISOCHINOLINE, VERFAHREN ZU IHRER HERSTELLUNG, IHRE VERWENDUNG ALS MEDIKAMENT, SOWIE SIE ENTHALTENDES MEDIKAMENT 有权SUBSTITUIERTE 4-苯基四氢异喹啉，VERFAHREN ZU IHRER HERSTELLUNG，IHRE VERWENDUNG ALS MEDIKAMENT，SOWIE SIE ENTHALTENDES MEDIKAMENT
公开(公告)号：EP1838315A1
公开(公告)日：2007-10-03
申请号：EP05823573.0
申请日：2005-12-30
申请人： sanofi-aventis
IPC分类号： A61K31/47 , A61P9/12 , C07D217/14
CPC分类号： C07D401/10 , C07D217/18
摘要： The invention relates to the compounds of formula (I), wherein R1 to R8, W, X and Z are defined as in the claims. Drugs that contain compounds of this type are suitable for use in the prevention or treatment of various diseases. The inventive compounds can be used, inter alia, for renal diseases such as acute or chronic renal failure, for biliary dysfunction and for respiratory disorders such as snoring or sleep apnoea.
摘要翻译： 本发明涉及式（I）的化合物，其中R 1至R 8，W，X和Z如权利要求中所定义。 含有这种化合物的药物适用于预防或治疗各种疾病。 本发明的化合物尤其可用于肾疾病如急性或慢性肾衰竭，胆道功能障碍和呼吸障碍如打鼾或睡眠呼吸暂停。
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7.发明公开SUBSTITUIERTE 4-PHENYLTETRAHYDROISOCHINOLINE, VERFAHREN ZU IHRER HERSTELLUNG, IHRE VERWENDUNG ALS MEDIKAMENT, SOWIE SIE ENTHALTENDES MEDIKAMENT 有权取代的4- PHENYLTETRAHYDROISOCHINOLINE，工艺所周之，它们作为药品和含药
公开(公告)号：EP1794128A1
公开(公告)日：2007-06-13
申请号：EP05784511.7
申请日：2005-09-08
IPC分类号： C07D217/22 , A61K31/47 , A61P9/12
CPC分类号： C07D405/12 , C07D217/14 , C07D401/12
摘要： The invention relates to compounds of formula (I) in which R1 to R10 have the meanings as described in the claims. Medicaments containing compounds of this type are useful in preventing or treating various diseases. The compounds can be used, among other things, for renal diseases such as acute or chronic renal failure, for defects of biliary function, for breathing disturbances such as snoring or sleep apnea or for stroke.
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8.发明公开SUBSTITUIERTE 4-PHENYLTETRAHYDROISOCHINOLINE, VERFAHREN ZU IHRER HERSTELLUNG, IHRE VERWENDUNG ALS MEDIKAMENT, SOWIE SIE ENTHALTENDES MEDIKAMENT 有权取代的4- PHENYLTETRAHYDROISOCHINOLINE，工艺所周之，它们作为药品和含药
公开(公告)号：EP1613600A1
公开(公告)日：2006-01-11
申请号：EP04719379.2
申请日：2004-03-11
发明人： HOFMEISTER, Armin , HEINELT, Uwe , LANG, Hans-Jochen , FRICK, Wendelin , BLEICH, Markus , WIRTH, Klaus
IPC分类号： C07D217/16
CPC分类号： C07D401/12 , C07D217/16
摘要： The invention relates to compounds of formula I wherein R1 to R9 have the designations cited in the patent claims. Medicaments containing this type of compound can be used in the prevention or treatment of various illnesses. Said compounds can be used, inter alia, for renal diseases such as acute or chronic kidney failure, for disturbances of the biliary function, for respiratory disturbances such as snoring or sleep apnoea, or for apoplexy.
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9.发明公开N-SUBSTITUIERTE (BENZOIMIDAZOL-2-YL)-PHENYL-AMINE, VERFAHREN ZU IHRER HERSTELLUNG, IHRE VERWENDUNG ALS MEDIKAMENT ODER DIAGNOSTIKUM SOWIE SIE ENTHALTENDES MEDIKAMENT 有权的N-取代的（苯并咪唑-2-基）苯基胺，METHOD FOR THE PRODUCTION，它们作为药物或诊断和药物含
公开(公告)号：EP1592671A1
公开(公告)日：2005-11-09
申请号：EP04703374.1
申请日：2004-01-20
IPC分类号： C07D235/30 , A61K31/4184 , A61P11/00
CPC分类号： C07D235/30
摘要： The invention relates to compounds of formula (I), in which R1 to R7 are defined as cited in the claims. Medicaments containing compounds of this type are used to prevent or treat diverse diseases. Said compounds are used to treat renal diseases such as acute or chronic renal failure, gall-bladder dysfunction, respiratory disorders such as snoring or sleep apnoea, or to treat strokes.
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10.发明授权KOMBINATION VON PHENYLCARBONSÄUREAMIDEN MIT BLOCKERN DES IKR-KANALS UND DEREN VERWENDUNG ZUR BEHANDLUNG VON VORHOFARRHYTHMIEN 有权phenylcarboxamides与受体阻滞剂的IR通道与它们用于房性心律失常疗法相结合
公开(公告)号：EP1605976B1
公开(公告)日：2010-02-24
申请号：EP04717614.4
申请日：2004-03-05
发明人： BRENDEL, Joachim , WIRTH, Klaus , GOEGELEIN, Heinz , ALLESSIE, Maurits, Department of Physiology , BLAAUW, Yuri, Department of Physiology
IPC分类号： A61K31/4406 , A61K31/18 , A61P9/06
CPC分类号： A61K31/18 , A61K31/165 , A61K31/44 , A61K45/06 , A61K2300/00
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