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公开(公告)号：EP1385870A2
公开(公告)日：2004-02-04
申请号：EP01954764.5
申请日：2001-07-19
发明人： SAKSENA, Anil, K. , GIRIJAVALLABHAN, Viyyoor, Moopil , LOVEY, Raymond, G. , JAO, Edwin, E. , BENNETT, Frank , MC CORMICK, Jinping, L. , WANG, Haiyan , PIKE, Russell, E. , BOGEN, Stephane, L. , CHAN, Tin-Yau , LIU, Yi-Tsung , ZHU, Zhaoning , NJOROGE, F., George , ARASAPPAN, Ashok , PAREKH, Tejal, N. , GANGULY, Ashit, K. , CHEN, Kevin, X. , VENKATRAMAN, Srikanth , VACCARO, Henry, A. , PINTO, Patrick A. , SANTHANAM, Bama , WU, Wanli , HENDRATA, Siska , HUANG, Yuhua , KEMP, Scott Jeffrey , LEVY, ODILE ESTHER , LIM-WILBY, Marguetita , TAMURA, Susan Y.
IPC分类号： C07K1/00
CPC分类号： C07K5/0202 , A61K38/00 , C07K5/0812 , C07K5/0827 , C07K7/02
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
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12.发明公开
公开(公告)号：EP1301528A2
公开(公告)日：2003-04-16
申请号：EP01959046.2
申请日：2001-07-19
发明人： SAKSENA, Anil, K. , GIRIJAVALLABHAN, Viyyoor, Moopil , LOVEY, Raymond, G. , JAO, Edwin, E. , BENNETT, Frank , MCCORMICK, Jinping , WANG, Haiyan , PIKE, Russell, E. , BOGEN, Stephane, L. , LIU, Yi-Tsung , ARASAPPAN, Ashok , PAREKH, Tejal , PINTO, Patrick, A. , NJOROGE, F., George , GANGULY, Ashit, K. , BRUNCK, Terence, K. , KEMP, Scott, Jeffrey , LEVY, Odile, Esther , LIM-WILBY, Marguerita
摘要： The present invention discloses novel peptide compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such peptides as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型肽化合物以及制备该化合物的方法。 在另一个实施方案中，本发明公开了包含此类肽的药物组合物以及使用它们治疗与HCV蛋白酶相关的病症的方法。
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13.发明公开RIBAVIRIN-INTERFERON ALFA COMBINATION THERAPY FOR ERADICATING DETECTABLE HCV-RNA IN PATIENTS HAVING CHRONIC HEPATITIS C INFECTION 审中-公开利巴韦林干扰素-α-组合销毁检测的HCV-RNA慢性丙型肝炎治疗的感染的患者
公开(公告)号：EP1121370A1
公开(公告)日：2001-08-08
申请号：EP99970663.3
申请日：1999-10-14
申请人： SCHERING CORPORATION
发明人： GANGULY, Ashit, K. , McCORMICK, Jinping , LOVEY, Raymond, G. , BENNETT, Frank , SAKSENA, Anil, K. , GIRIJAVALLABHAN, Viyyoor, M.
IPC分类号： C07H19/056 , A61K31/70
CPC分类号： C07H19/056 , Y10S514/894
摘要： Ribavirin derivatives represented by formula (I) wherein at least one of R?2, R3 or R5¿ is a straight or branched chain polyalkylene oxide polymer conjugate, and pharmaceutical compositions containing them as well as their use to treat patients having susceptible viral infections, alone and in combination with a therapeutically effective amount of interferon-alpha are disclosed.
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公开(公告)号：EP0773941A1
公开(公告)日：1997-05-21
申请号：EP96916574.0
申请日：1996-05-30
申请人： SCHERING CORPORATION
发明人： SAKSENA, Anil, K. , GIRIJAVALLABHAN, Viyyoor, M. , LOVEY, Raymond, G. , PIKE, Russell, E. , WANG, Haiyan , LIU, Yi-Tsung , GANGULY, Ashit, K. , BENNETT, Frank
IPC分类号： C07D521
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56
摘要： A compound represented by formula (I), wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl; R1 is a straight or branched chain (C4 to C5) alkyl group substituted by one or two amino acid ester grou ps convertible in vivo into a hydroxy group or a pharmaceutically acceptable salt thereof and pharmaceutical compositions thereof useful for treating and/or preventing fungal infections are disclosed.
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公开(公告)号：EP0736030A1
公开(公告)日：1996-10-09
申请号：EP95906620.0
申请日：1994-12-20
申请人： SCHERING CORPORATION
发明人： SAKSENA, Anil, K. , GIRIJAVALLABHAN, Viyyoor, M. , LOVEY, Raymond, G. , PIKE, Russell, E. , WANG, Haiyan , LIU, Yi-Tsung , GANGULY, Ashit, K. , BENNETT, Frank
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07F9/65586
摘要： A compound represented by formula (I) wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl; R1 is a straight or branched chain (C3 to C8) alkyl group substituted by one or two hydroxy moieties, an ether or ester (e.g., a polyestherester or phosphate ester) thereof a pharmaceutically acceptable salt thereof and pharmaceutical compositions thereof useful for treating and/or preventing fungal infections are disclosed.
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16.发明公开
公开(公告)号：EP0696282A1
公开(公告)日：1996-02-14
申请号：EP94915399.0
申请日：1994-04-28
申请人： SCHERING CORPORATION
发明人： SAKSENA, Anil, K. , GIRIJAVALLABHAN, Viyyoor, M. , PIKE, Russell E. , WANG, Haiyan , LOVEY, Raymond, G. , LIU, Yi-Tsung , GANGULY, Ashit, K. , MORGAN, William, Brian , ZAKS, Aleksey
CPC分类号： C07D249/08 , C07C69/63 , C07C69/65 , C07D231/12 , C07D233/56 , C07D263/26 , C07D307/12 , C07D405/06 , C07D413/06 , C07D417/06 , C12P7/62 , C12P41/004 , Y02P20/55
摘要： Disclosed is a process for preparing chiral compounds of formula (I) wherein: X?1 and X2¿ are independently F or Cl; and E is -SO¿2R?2, wherein R2 is C1-C6 alkyl, -C6H4CH3 or -CF3; its enantiomer and racemates thereof, useful in the synthesis of tetrahydrofuran azole antifungals. Novel compounds of formula (II) or (III) wherein: X?1 and X2¿ are independently F or Cl; B represents -C(O)Q* or -CH¿2?OR'; Q* represents a chiral auxiliary group; R' represents a hydroxy protecting group; and A represents Cl, Br, I, triazolyl or imidazolyl; are also disclosed.
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公开(公告)号：EP1385870B1
公开(公告)日：2010-03-17
申请号：EP01954764.5
申请日：2001-07-19
发明人： SAKSENA, Anil, K. , GIRIJAVALLABHAN, Viyyoor, Moopil , LOVEY, Raymond, G. , JAO, Edwin, E. , BENNETT, Frank , MC CORMICK, Jinping, L. , WANG, Haiyan , PIKE, Russell, E. , BOGEN, Stephane, L. , CHAN, Tin-Yau , LIU, Yi-Tsung , ZHU, Zhaoning , NJOROGE, F., George , ARASAPPAN, Ashok , PAREKH, Tejal, N. , GANGULY, Ashit, K. , CHEN, Kevin, X. , VENKATRAMAN, Srikanth , VACCARO, Henry, A. , PINTO, Patrick A. , SANTHANAM, Bama , WU, Wanli , HENDRATA, Siska , HUANG, Yuhua , KEMP, Scott Jeffrey , LEVY, Odile Esther , LIM-WILBY, Marguerita , TAMURA, Susan Y.
IPC分类号： C07K1/00
CPC分类号： C07K5/0202 , A61K38/00 , C07K5/0812 , C07K5/0827 , C07K7/02
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
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18.发明授权RIBAVIRIN-INTERFERON ALFA COMBINATION THERAPY FOR ERADICATING DETECTABLE HCV-RNA IN PATIENTS HAVING CHRONIC HEPATITIS C INFECTION 有权利巴韦林干扰素-α-组合销毁检测的HCV-RNA慢性丙型肝炎治疗的感染的患者
公开(公告)号：EP1121369B1
公开(公告)日：2004-12-08
申请号：EP99970662.5
申请日：1999-10-14
申请人： SCHERING CORPORATION
发明人： GANGULY, Ashit, K. , MCCORMICK, Jinping , LOVEY, Raymond, G. , BENNETT, Frank , SAKSENA, Anil, K. , GIRIJAVALLABHAN, Viyyoor, M.
IPC分类号： C07H19/056 , A61K31/70
CPC分类号： C07H19/056
摘要： A method for treating a patient having chronic hepatitis C infection to eradicate detectable HCV-RNA involving a combination therapy using a therapeutically effective amount of ribavirin derivative of formula (I) and a therapeutically effective amount of interferon-alpha for a time period of from 20 up to 80 weeks.
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19.发明公开
公开(公告)号：EP1481000A2
公开(公告)日：2004-12-01
申请号：EP03731956.3
申请日：2003-01-16
发明人： SAKSENA, Anil, K. , GIRIJAVALLABHN, Viyyoor, M. , LOVEY, Raymond, G. , JAO, Edwin , BENNETT, Frank , MC CORMICK, Jinping, L. , WANG, Haiyan , PIKE, Russell, E. , BOGEN, Stephane, L. , CHAN, Tin-Yau , LIU, Yi-Tsung , ZHU, Zhaoning , NJOROGE, George, F. , ARASAPPAN, Ashok , PAREKH, Tejal , GANGULY, Ashit, K. , CHEN, Kevin, X. , VENKATRAMAN, Srikanth , VACCARO, Henry, A. , PINTO, Patrick A. , SANTHANAM, Bama , KEMP, Scott Jeffrey , LEVY, Odile Esther , LIM-WILBY, Marguerita , TAMURA, Susan Y. , WU, Wanli , HENDRATA, Siska , HUANG, Yuhua , WONG, Jesse K. , NAIR, Latha G.
CPC分类号： C07K5/0804 , A61K38/00 , C07K5/0202 , C07K5/0812 , C07K5/0827 , C07K7/02
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
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公开(公告)号：EP0837859B1
公开(公告)日：2003-08-13
申请号：EP96921326.3
申请日：1996-06-17
申请人： SCHERING CORPORATION
发明人： LOVEY, Raymond, G. , GIRIJAVALLABHAN, Viyyoor, M. , SAKSENA, Anil, K. , PIKE, Russell, E. , BENNET, Frank
IPC分类号： C07D405/14 , A61K31/41
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56
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