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    ALPHA-ALKOXYIMINOBENZYL DERIVATIVES AND AGRICULTURAL CHEMICALS CONTAINING THEM AS ACTIVE INGREDIENTS
    13.
    发明公开
    ALPHA-ALKOXYIMINOBENZYL DERIVATIVES AND AGRICULTURAL CHEMICALS CONTAINING THEM AS ACTIVE INGREDIENTS 失效
    AL-ALOXOXYIMINOBENZYL衍生物和含有它们作为活性成分的农用化学品

    公开(公告)号：EP0893433A1

    公开(公告)日：1999-01-27

    申请号：EP97914602.4

    申请日：1997-04-04

    申请人： SHIONOGI & CO., LTD.

    发明人： KAI, Hiroyuki ,  MASUI, Moriyasu

    IPC分类号： C07C251/50 ,  C07C251/62 ,  C07C251/74 ,  C07C251/88 ,  C07C255/63 ,  C07D233/61 ,  C07D249/08 ,  C07D261/08 ,  C07D271/10 ,  C07D277/38 ,  C07D307/52

    CPC分类号： C07D271/10 ,  A01N35/10 ,  A01N37/50 ,  A01N43/08 ,  A01N43/50 ,  A01N43/653 ,  A01N43/74 ,  A01N43/80 ,  A01N43/82 ,  C07C251/58 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D261/04 ,  C07D261/08 ,  C07D263/32 ,  C07D277/04 ,  C07D307/52

    摘要： A compound represented by the formula(I):
    wherein R 1 is a heterocyclic group, CHO or CH 2 OR 6 ; R 2 is an alkyl group; R 3 is hydrogen atom, an alkyl group, an alkoxy group, a halogen atom, nitro, cyano or a halogen-substituted alkyl group; R 4 is hydrogen atom, an alkyl group, a cycloalkyl group, an alkoxyalkyl group, an alkoxycarbonyl group, cyano, a halogen-substituted alkyl group, an aryl group or a heterocyclic group; R 5 is hydrogen atom, an alkyl group, a cycloalkyl group, an alkenyl group, an alkynyl group, an alkanoyl group, an aroyl group, an alkoxycarbonyl group, an aryl group or a heterocyclic group; A is (1) - CH 2 ON=C(R 7 )-, (2) -CH 2 N(R 8 )-N=C(R 7 )-, (3) -CH=NOC(R 9 )(R 10 )- or (4)-CH=NN=C(R 7 )-; B is oxygen atom or NR 11 ; the wary line: ∼ indicates E isomer, Z isomer or a mixture of them, has a broad spectrum of fungicidal activity, and therefore, is excellent as fungicides.

    摘要翻译： 由式（I）表示的化合物：其中R1是杂环基，CHO或CH2OR6; R2是烷基; R3是氢原子，烷基，烷氧基，卤原子，硝基，氰基或卤素取代的烷基; R4是氢原子，烷基，环烷基，烷氧基烷基，烷氧羰基，氰基，卤素取代的烷基，芳基或杂环基; R5为氢原子，烷基，环烷基，烯基，炔基，烷酰基，芳酰基，烷氧基羰基，芳基或杂环基; （1）-CH2ON = C（R7） - ，（2）-CH2N（R8）-N = C（R7） - ，（3）-CH = NOC（R9）（R10） - 或（4） CH = NN = C（R 7） - ; B是氧原子或NR11; 警戒线：〜表示E异构体，Z异构体或它们的混合物，具有广谱的杀真菌活性，因此作为杀真菌剂是优异的。

    PROCESS FOR PRODUCING CARBOXYLIC ACID DERIVATIVE
    19.
    发明授权
    PROCESS FOR PRODUCING CARBOXYLIC ACID DERIVATIVE 失效
    用于生产羧酸衍生物

    公开(公告)号：EP0658541B1

    公开(公告)日：1998-05-20

    申请号：EP94919838.6

    申请日：1994-07-01

    申请人： SHIONOGI & CO., LTD. ,  SUMITOMO CHEMICAL COMPANY LIMITED

    发明人： TAKASE, Akira ,  KAI, Hiroyuki ,  MASUI, Moriyasu ,  MASUMOTO, Katuhisa ,  NAKAMURA, Akihiko ,  KIYOSHIMA, Yujiro ,  SASAKI, Mikio

    IPC分类号： C07C251/48 ,  C07C249/12

    CPC分类号： C07C249/12 ,  C07C251/48

    摘要： A process for producing a carboxylic acid derivative represented by general formula [VIII], (wherein R , R , R and L are each as defined in the specification), which comprises reacting a benzyl halide with a cyano compound to give a phenylacetonitrile, reacting the nitrile with an alkyl nitrite in the presence of a base to give an alpha -hydroxyiminophenylacetonitrile, reacting the hydroxy nitrile with an alkylating agent to give an alpha -alkoxyiminophenylacetonitrile, hydrolyzing the alkoxy nitrile in the presence of a base, optionally after hydration and acid treatment, to give an alpha -alkoxyiminophenylacetic acid, and finally reacting the acid with a halogenating agent, or converting the acid into a corresponding metal salt and reacting the salt with an alkylating agent, or reacting the acid with a lower alcohol in the presence of an acidic catalyst. According to this process, the reactions can be advanced through the respective steps under mild conditions, and the target derivative [VIII] can be produced even without resort to high-pressure steam equipment, high-temperature heat medium equipment, refrigerator, and so forth. Further, this process is advantageous in that only a single solvent will suffice without the necessity for using various solvents according to the respective steps.

    PROCESS FOR PRODUCING CARBOXYLIC ACID DERIVATIVE
    20.
    发明公开
    PROCESS FOR PRODUCING CARBOXYLIC ACID DERIVATIVE 失效
    VERFAHREN ZUR HERSTELLUNG VONCARBONSÄURE-DERIVATEN。

    公开(公告)号：EP0658541A1

    公开(公告)日：1995-06-21

    申请号：EP94919838.6

    申请日：1994-07-01

    申请人： SHIONOGI & CO., LTD. ,  SUMITOMO CHEMICAL COMPANY LIMITED

    发明人： TAKASE, Akira ,  KAI, Hiroyuki ,  MASUI, Moriyasu ,  MASUMOTO, Katuhisa ,  NAKAMURA, Akihiko ,  KIYOSHIMA, Yujiro ,  SASAKI, Mikio

    IPC分类号： C07C251/48 ,  C07C249/12

    CPC分类号： C07C249/12 ,  C07C251/48

    摘要： A process for producing a carboxylic acid derivative represented by general formula [VIII], (wherein R¹, R², R³ and L are each as defined in the specification), which comprises reacting a benzyl halide with a cyano compound to give a phenylacetonitrile, reacting the nitrile with an alkyl nitrite in the presence of a base to give an α-hydroxyiminophenylacetonitrile, reacting the hydroxy nitrile with an alkylating agent to give an α-alkoxyiminophenylacetonitrile, hydrolyzing the alkoxy nitrile in the presence of a base, optionally after hydration and acid treatment, to give an α-alkoxyiminophenylacetic acid, and finally reacting the acid with a halogenating agent, or converting the acid into a corresponding metal salt and reacting the salt with an alkylating agent, or reacting the acid with a lower alcohol in the presence of an acidic catalyst. According to this process, the reactions can be advanced through the respective steps under mild conditions, and the target derivative [VIII] can be produced even without resort to high-pressure steam equipment, high-temperature heat medium equipment, refrigerator, and so forth. Further, this process is advantageous in that only a single solvent will suffice without the necessity for using various solvents according to the respective steps.

    摘要翻译： 制备由通式[Ⅷ]表示的羧酸衍生物的方法，其中R 1，R 2，R 3和L各自如说明书中所定义），其中包括使苄基卤与 氰基化合物，得到苯基乙腈，在碱的存在下使腈与亚硝酸烷基酯反应，得到α-羟基亚氨基苯基乙腈，使羟基腈与烷基化剂反应，得到α-烷氧基亚氨基苯基乙腈，在存在下水解烷氧基腈 的碱，任选地在水合和酸处理之后，得到α-烷氧基亚氨基苯基乙酸，最后使酸与卤化剂反应，或将酸转化成相应的金属盐，并使该盐与烷基化剂反应，或使 在酸性催化剂存在下用低级醇酸。 根据该方法，可以在温和条件下通过各个步骤进行反应，即使不使用高压蒸汽设备，高温热介质设备，冰箱等，也可以生产目标衍生物[Ⅷ] 。 此外，该方法的优点在于，只要单一的溶剂即可，而不需要根据各个步骤使用各种溶剂。