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20 条记录 (耗时 0.02 秒)

    METHOD FOR ASSESSING RISK OF HUMAN CYTOMEGALOVIRUS ACTIVE INFECTION IN BODY AND RELATED KIT
    16.
    发明公开
    METHOD FOR ASSESSING RISK OF HUMAN CYTOMEGALOVIRUS ACTIVE INFECTION IN BODY AND RELATED KIT 审中-公开
    评估体内和相关试剂盒中人巨细胞病毒活性感染风险的方法

    公开(公告)号：EP3258265A1

    公开(公告)日：2017-12-20

    申请号：EP16748586.1

    申请日：2016-01-26

    申请人： Xiamen University

    发明人： GE, Shengxiang ,  LI, Jinjie ,  HUANG, Xi ,  LI, Tingdong ,  ZHANG, Jun ,  XIA, Ningshao

    IPC分类号： G01N33/53 ,  G01N33/569 ,  G01N33/543

    CPC分类号： G01N33/56983 ,  G01N33/53 ,  G01N33/543 ,  G01N33/569 ,  G01N33/56994 ,  G01N2333/045 ,  G01N2469/20 ,  G01N2800/50 ,  G01N2800/52

    摘要： The invention belongs to the fields of medicine and immunology, particularly, the field of immunological diagnosis. In particular, the invention discloses a method for assessing whether a subject is at risk of developing human cytomegalovirus (HCMV) active infection and a kit therefor. The method comprises the steps of: (1) determining the level of an antibody against a HCMV protein in a body fluid sample from the subject; and (2) comparing the level with a predetermined reference value, wherein if the level is below the predetermined reference value, the subject is determined to be at risk of developing HCMV active infection. In addition, the invention also discloses a method for screening a candidate drug which is capable of improving the ability of a subject to resist human cytomegalovirus (HCMV) active infection, and a kit therefor.

    摘要翻译： 本发明属于医学和免疫学领域，特别是免疫学诊断领域。 特别地，本发明公开了评估受试者是否有发生人巨细胞病毒（HCMV）活性感染风险的方法及其试剂盒。 该方法包括以下步骤：（1）确定来自受试者的体液样品中针对HCMV蛋白的抗体水平; 和（2）将该水平与预定参考值进行比较，其中如果该水平低于预定参考值，则确定该受试者处于发生HCMV活动性感染的风险中。 此外，本发明还公开了用于筛选能够改善受试者抵抗人巨细胞病毒（HCMV）活性感染的能力的候选药物的方法及其试剂盒。

    RNA REVERSE TRANSCRIPTION AMPLIFICATION METHOD
    19.
    发明公开
    RNA REVERSE TRANSCRIPTION AMPLIFICATION METHOD 审中-公开

    公开(公告)号：EP3498861A1

    公开(公告)日：2019-06-19

    申请号：EP17819301.7

    申请日：2017-06-29

    申请人： Xiamen University

    发明人： ZHANG, Shiyin ,  GE, Shengxiang ,  WANG, Jin ,  ZHANG, Jun ,  XIA, Ningshao

    IPC分类号： C12Q1/68

    摘要： A ribonucleic acid (RNA) reverse transcription amplification method, comprising the steps of reverse transcription of RNA into cDNA and immediate amplification of cDNA, characterized in that the process of reverse transcription of RNA into cDNA is completed during the process that a cDNA amplification reaction system is heated to reach the reaction condition for cDNA amplification. The RNA reverse transcription amplification method can combine the reaction condition for reverse transcription of RNA into cDNA with the reaction condition for cDNA amplification, thereby significantly shorten the time required for RNA reverse transcription amplification. And in the whole process of RNA reverse transcription amplification, there is no need to change the instrument temperature, and thus, it is possible to achieve detection at any time.