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公开(公告)号：EP3783100A1
公开(公告)日：2021-02-24
申请号：EP19788373.9
申请日：2019-04-15
发明人： CHENG, Tong , WANG, Wei , YE, Xiangzhong , FU, Wenkun , PAN, Dequan , ZHANG, Jun , XIA, Ningshao
摘要： Provided are Coxsackie virus CVB1 or a modified form thereof, or a genomic sequence or cDNA sequence comprising CVB1 or the modified form thereof, or a nucleic acid molecule of a complement sequence of the genomic sequence or cDNA sequence, the use of same for treating tumors in subjects including humans, and the use of same in the preparation of a pharmaceutical composition for treating tumors in subjects including humans. Also provided is a method for treating tumors, comprising administering CVB1 or the modified form thereof, or the genomic sequence or cDNA sequence comprising CVB1 or the modified form thereof, or the nucleic acid molecule of the complement sequence of the genomic sequence or cDNA sequence to a subject in need thereof.
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公开(公告)号：EP2975052B1
公开(公告)日：2020-09-23
申请号：EP14765573.2
申请日：2014-03-17
申请人： Xiamen University , The United States of America, as represented by the Secretary, Department of Health and Human Services , Yang Sheng Tang Company, Ltd.
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公开(公告)号：EP3974446A1
公开(公告)日：2022-03-30
申请号：EP20808887.2
申请日：2020-05-22
发明人： LUO, Wenxin , JIANG, Yichao , YU, Chao , CHEN, Xiaoqing , TANG, Jixian , YUAN, Quan , ZHANG, Tianying , XIA, Ningshao
摘要： Antibodies (especially humanized antibodies) against the hepatitis B surface antigen (HBsAg), a nucleic acid molecule encoding same, a method for preparing same, and a pharmaceutical composition containing same. The anti-HBsAg antibodies have a higher binding affinity to HBsAg at a neutral pH than at an acidic pH, thereby significantly enhancing virus clearance efficiency and prolonging virus inhibition time. The antibodies and pharmaceutical composition may be used to prevent and/or treat HBV infections or diseases related to HBV infection (such as hepatitis B) for use in neutralizing the virulence of HBV in the body of a subject (such as a human) to reduce a serum level of HBV DNA and/or HBsAg in the body of the subject, or to activate a humoral immune response of a subject (such as a person infected with chronic HBV or a patient who has chronic hepatitis B) against HBV.
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公开(公告)号：EP3656854A1
公开(公告)日：2020-05-27
申请号：EP18835927.7
申请日：2018-07-18
发明人： CHENG, Tong , WANG, Wei , WAN, Junkai , FU, Wenkun , YE, Xiangzhong , ZHANG, Jun , XIA, Ningshao
摘要： Provided are an enterovirus D68 (EV-D68) or a modified form thereof, or a nucleic acid molecule comprising a genomic sequence or cDNA sequence of the EV-D68 or a modified form thereof, or a complementary sequence of the genomic sequence or cDNA sequence, or a pharmaceutical composition comprising the EV-D68 or a modified form thereof, or the nucleic acid molecule, and use of the EV-D68 or a modified form thereof, or the nucleic acid molecule in the manufacture of a pharmaceutical composition for treating a tumor.
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公开(公告)号：EP3617317A1
公开(公告)日：2020-03-04
申请号：EP18754095.0
申请日：2018-02-05
发明人： ZHANG, Tianying , YUAN, Quan , GUO, Xueran , WEI, Minxi , KANG, Xiaozhen , ZHANG, Jun , XIA, Ningshao
摘要： The invention relates to a polypeptide carrier for presenting a target polypeptide, and use thereof. In particular, the invention relates to a nucleic acid molecule, comprising a nucleotide sequence encoding a polypeptide carrier, and being used for insertion of a nucleotide sequence encoding a target polypeptide. In addition, the invention further relates to a recombinant protein comprising the polypeptide carrier and a target polypeptide. Furthermore, the invention further relates to use of the nucleic acid molecule and the recombinant protein. In addition, the invention further relates to a vaccine or a pharmaceutical composition useful for preventing, alleviating or treating HBV infection or a disease associated with HBV infection (e.g., hepatitis B), comprising a recombinant protein comprising the polypeptide carrier of the invention and an epitope from HBV.
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公开(公告)号：EP3594328A1
公开(公告)日：2020-01-15
申请号：EP18764074.3
申请日：2018-02-28
发明人： HUANG, Chenghao , LUO, Yong , YUAN, Quan , ZHANG, Jun , XIA, Ningshao
IPC分类号： C12N7/00 , C12N15/869 , C12N5/10 , A61K35/763 , A61P35/00
摘要： The invention relates to the field of virology and tumor therapy. In particular, the present invention provides a recombinant herpes simplex virus (HSV) capable of specifically replicating at a high level in a tumor cell and effectively killing the tumor cell, but replicating at low levels in normal cells, thereby the recombinant herpes simplex virus of the present invention not only has high lethality against tumor cells, but also has significantly decreased side effects (especially neurotoxicity). Further, the present invention relates to a viral vector constructed based on the recombinant herpes simplex virus, a pharmaceutical composition comprising the recombinant herpes simplex virus or the viral vector, and the use of the recombinant herpes simplex virus or the viral vector. The recombinant herpes simplex virus of the present invention can be used to infect and kill tumor cells, and can be used for gene drug delivery into tumor cells for gene therapy.
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公开(公告)号：EP4186505A1
公开(公告)日：2023-05-31
申请号：EP21821809.7
申请日：2021-06-01
发明人： ZHANG, Tianying , CAO, Jiali , SHI, Tianshu , MA, Jian , WANG, Shaojuan , YUAN, Quan , ZHANG, Jun , XIA, Ningshao
IPC分类号： A61K31/415 , A61P31/20
摘要： The present application relates to the field of antiviral treatment of hepatitis B, and specifically relates to the use of a compound represented by formula I in treatment against HBV virus.
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公开(公告)号：EP2860188B1
公开(公告)日：2020-10-21
申请号：EP13804161.1
申请日：2013-06-06
发明人： YUAN, Quan , ZHANG, Tianying , LUO, Wenxin , CHEN, Yixin , ZHANG, Jun , XIA, Ningshao
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公开(公告)号：EP3360896A1
公开(公告)日：2018-08-15
申请号：EP16853117.6
申请日：2016-10-09
发明人： LUO, Wenxin , ZHOU, Bing , ZHANG, Juan , YUAN, Quan , ZHANG, Tianying , ZHANG, Jun , XIA, Ningshao
CPC分类号： A61K39/395 , C07K16/10 , C12N5/10 , C12N15/63
摘要： The invention provides an antibody (in particular, a humanized antibody) against hepatitis B surface antigen (HBsAg), a nucleic acid molecule encoding the same, a method for preparing the same, and a pharmaceutical composition comprising the same. The invention also provides use of the antibody and pharmaceutical composition. The antibody and pharmaceutical composition according to the invention can be used for preventing and/or treating HBV infection or a disease associated with HBV infection (such as Hepatitis B), for neutralizing HBV virulence in a subject (such as human), or for reducing the serum level of HBV DNA and/or HBsAg in a subject.
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公开(公告)号：EP4190802A1
公开(公告)日：2023-06-07
申请号：EP21842399.4
申请日：2021-07-13
发明人： YUAN, Quan , WANG, Shaojuan , NIAN, Sheng , WEI, Min , ZHANG, Yali , WANG, Kai , CHEN, Yixin , ZHANG, Tianying , GE, Shengxiang , XIA, Ningshao
摘要： Provided is a cell-penetrating peptide, which can deliver a variety of biological macromolecules, such as proteins, antibodies, nucleic acids and so on into cells across a membrane. In addition, further provided are a fusion protein, conjugate and complex containing the cell-penetrating peptide, and a use of the cell-penetrating peptide.
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