公开(公告)号：EP4190802A1

公开(公告)日：2023-06-07

申请号：EP21842399.4

申请日：2021-07-13

申请人： Yang Sheng Tang Company, Ltd. ,  Xiamen University

发明人： YUAN, Quan ,  WANG, Shaojuan ,  NIAN, Sheng ,  WEI, Min ,  ZHANG, Yali ,  WANG, Kai ,  CHEN, Yixin ,  ZHANG, Tianying ,  GE, Shengxiang ,  XIA, Ningshao

IPC分类号： C07K14/02 ,  C07K19/00 ,  A61K38/16 ,  A61K47/42 ,  A61K47/64

摘要： Provided is a cell-penetrating peptide, which can deliver a variety of biological macromolecules, such as proteins, antibodies, nucleic acids and so on into cells across a membrane. In addition, further provided are a fusion protein, conjugate and complex containing the cell-penetrating peptide, and a use of the cell-penetrating peptide.

公开(公告)号：EP3299384A1

公开(公告)日：2018-03-28

申请号：EP16795912.1

申请日：2016-05-20

申请人： Xiamen University

发明人： GE, Shengxiang ,  LI, Tingdong ,  JIA, Lianzhi ,  LI, Yijian ,  XUE, Miaoge ,  ZENG, Yuanjun ,  ZHANG, Jun ,  XIA, Ningshao

IPC分类号： C07K14/14 ,  C12N15/46 ,  A61K39/15 ,  A61P31/14

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/15 ,  A61K2039/552 ,  A61K2039/55505 ,  A61K2039/575 ,  A61P1/00 ,  A61P1/12 ,  A61P29/00 ,  A61P31/14 ,  C12N7/00 ,  C12N2720/12322 ,  C12N2720/12334 ,  C12N2720/12351

摘要： The invention relates to a truncated rotavirus VP4 protein, a sequence encoding the same, a method for preparing the same, and a pharmaceutical composition and a vaccine comprising the protein, wherein the protein, the pharmaceutical composition and the vaccine are useful for preventing, alleviating or treating rotavirus infection and a disease caused by rotavirus infection, such as rotavirus gastroenteritis and diarrhea. The invention further relates to use of the protein in the manufacture of a pharmaceutical composition or a vaccine for preventing, alleviating or treating rotavirus infection and a disease caused by rotavirus infection, such as rotavirus gastroenteritis and diarrhea.

摘要翻译： 本发明涉及截短的轮状病毒VP4蛋白，编码它的序列，其制备方法，以及包含该蛋白的药物组合物和疫苗，其中该蛋白，该药物组合物和疫苗可用于预防，缓解 或治疗轮状病毒感染和轮状病毒感染引起的疾病，如轮状病毒胃肠炎和腹泻。 本发明进一步涉及该蛋白质在制备用于预防，减轻或治疗轮状病毒感染和由轮状病毒感染引起的疾病（例如轮状病毒胃肠炎和腹泻）的药物组合物或疫苗中的用途。

公开(公告)号：EP4086275A1

公开(公告)日：2022-11-09

申请号：EP20910955.2

申请日：2020-11-09

申请人： Xiamen University ,  Xiamen Innovax Biotech Co., Ltd.

发明人： GE, Shengxiang ,  YU, Siyuan ,  YANG, Han ,  PAN, Haifeng ,  REN, Shuling ,  LI, Tingdong ,  GUO, Qingshun ,  XIONG, Junhui ,  ZHANG, Jun ,  XIA, Ningshao

IPC分类号： C07K14/47 ,  A61K9/00

摘要： A multimerization delivery system that can be used to deliver a cargo molecule intracellularly. The multimerization delivery system can achieve high-efficiency endocytosis of a cargo molecule and high-efficiency release thereof from an endocytic vesicle, significantly improving the cytoplasmic delivery efficiency of the cargo molecule. Once the cargo molecule is available in the cytoplasm, the cargo molecule can play any role related thereto. The multimerization delivery system provides an effective means for affecting the biological mechanisms and pathways of cells, and can be used in various fields such as research, treatment, and diagnosis.

公开(公告)号：EP3885363A1

公开(公告)日：2021-09-29

申请号：EP19888178.1

申请日：2019-11-06

申请人： Xiamen Innodx Biotech Co., Ltd ,  Xiamen University

发明人： XIONG, Junhui ,  CHEN, Zimin ,  XU, Weiling ,  WANG, Long ,  KE, Qishen ,  LI, Lihua ,  SONG, Liuwei ,  SUN, Xudong ,  GE, Shengxiang

IPC分类号： C07K16/26 ,  C12N5/20 ,  G01N33/74 ,  G01N33/577

摘要： The present invention belongs to the field of biomedical laboratory science, and provides a specific antibody for AMH and uses thereof.

公开(公告)号：EP2805729A1

公开(公告)日：2014-11-26

申请号：EP13738450.9

申请日：2013-01-17

申请人： Xiamen University ,  Xiamen Innovax Biotech Co., Ltd.

发明人： YUAN, Quan ,  SONG, Liuwei ,  ZHOU, Wenbin ,  WENG, Zuxing ,  XU, Feihai ,  GE, Shengxiang ,  ZHANG, Jun ,  XIA, Ningshao

IPC分类号： A61K39/29 ,  A61P1/16

CPC分类号： G01N33/56983 ,  G01N33/5762 ,  G01N2333/02 ,  G01N2469/20 ,  G01N2800/52 ,  G01N2800/56

摘要： The present invention relates to a method for quantitative detection of anti-HBc and its use in monitoring disease progression of chronic hepatitis B patients and predicting therapeutic effects. By quantitative detection of antibodies against hepatitis B core protein (Anti-HBc), it is able to monitor disease progression of chronic hepatitis B patients, effectively predict therapeutic effects in chronic hepatitis B patients who accept a therapy against hepatitis B virus (especially, a therapy based on interferon and a therapy based on nucleoside/nucleotide analogue anti-HBV drug), and thus guide the patients to reasonably choose drugs.

摘要翻译： 本发明涉及用于抗-HBc的定量检测及其在监测慢性乙型肝炎患者的疾病进展和预测治疗效果的使用的方法。 通过对乙型肝炎核心蛋白（抗-HBc）抗体的定量检测，它能够监测慢性乙型肝炎患者的疾病进展，有效地预测谁接受抗乙肝病毒治疗（尤其是慢性乙肝患者的治疗效果，一 治疗基于干扰素和基于核苷/核苷酸类似物的抗HBV药物治疗），因而指导患者合理选择药物。

公开(公告)号：EP4006057A1

公开(公告)日：2022-06-01

申请号：EP20837897.6

申请日：2020-07-10

申请人： Xiamen University ,  Xiamen Innovax Biotech Co., Ltd.

发明人： GE, Shengxiang ,  YU, Siyuan ,  YANG, Han ,  PAN, Haifeng ,  REN, Shuling ,  LI, Tingdong ,  GUO, Qingshun ,  XIONG, Junhui ,  ZHANG, Jun ,  XIA, Ningshao

IPC分类号： C07K19/00 ,  A61K47/50 ,  A61K38/00 ,  C12N15/11 ,  C12N15/63

摘要： A fusion protein and a complex containing same, capable of being used for the intracellular delivery of cargo molecules. The fusion protein and complex can implement the efficient release of cargo molecules from endocytic vesicles, thereby significantly improving the cytoplasmic delivery efficiency of the cargo molecules. One cargo molecules can be obtained in cytoplasms, they can exert any function related thereto. The fusion protein and complex provide effective means for affecting biological mechanisms and pathways of cells, and can be used in various fields such as research, treatment, and diagnosis.

公开(公告)号：EP3981782A1

公开(公告)日：2022-04-13

申请号：EP21194967.2

申请日：2016-05-20

申请人： Xiamen University ,  Xiamen Innovax Biotech Co., Ltd.

发明人： GE, Shengxiang ,  LI, Tingdong ,  JIA, Lianzhi ,  LI, Yijian ,  XUE, Miaoge ,  ZENG, Yuanjun ,  ZHANG, Jun ,  XIA, Ningshao ,  PAN, Huirong

IPC分类号： C07K14/14 ,  C12N15/46 ,  A61K39/15 ,  A61P31/14 ,  A61K39/12

摘要： The invention relates to a truncated rotavirus VP4 protein, a sequence encoding the same, a method for preparing the same, and a pharmaceutical composition and a vaccine comprising the protein, wherein the protein, the pharmaceutical composition and the vaccine are useful for preventing, alleviating or treating rotavirus infection and a disease caused by rotavirus infection, such as rotavirus gastroenteritis and diarrhea. The invention further relates to use of the protein in the manufacture of a pharmaceutical composition or a vaccine for preventing, alleviating or treating rotavirus infection and a disease caused by rotavirus infection, such as rotavirus gastroenteritis and diarrhea.

公开(公告)号：EP3812771A1

公开(公告)日：2021-04-28

申请号：EP19823488.2

申请日：2019-05-29

申请人： Xiamen Innodx Biotech Co., Ltd ,  Xiamen University

发明人： CHEN, Zimin ,  XIONG, Junhui ,  XU, Weiling ,  WENG, Zuxing ,  WANG, Long ,  ZHENG, Xiaohong ,  SUN, Xudong ,  GE, Shengxiang

IPC分类号： G01N33/68

摘要： The invention provides a kit for full-range detection of C-reactive protein based on chemiluminescence immunoassay and a method for full-range detection of C-reactive protein. The kit comprises an R1 reagent, an M reagent, an R2 reagent, a pre-excitation solution and an excitation solution. The R1 reagent, that is a sample treatment solution, is a 0.5M citric acid solution (pH 3.0-3.5, which is adjusted by disodium hydrogen phosphate dodecahydrate). The present invention also provides a kit for full-range detection of C-reactive protein, which comprises a flat-bottomed plate-type chemiluminescence plate coated with a first antibody, a sample treatment solution, a second antibody labeled with horseradish peroxidase (HRP) or alkaline phosphatase (AP), a color developing solution. The invention also provides a method for full-range detection of C-reactive protein using the kit. Both the first antibody and the second antibody are monoclonal antibodies that can specifically react with C-reactive protein.

公开(公告)号：EP2899267A1

公开(公告)日：2015-07-29

申请号：EP13838213.0

申请日：2013-06-24

申请人： Xiamen University ,  Xiamen Innovax Biotech Co., Ltd.

发明人： GE, Shengxiang ,  LI, Tingdong ,  GUO, Qingshun ,  XU, Feihai ,  ZHANG, Jun ,  XIA, Ningshao

IPC分类号： C12N7/04 ,  C12P21/02 ,  C07K1/16 ,  C07K1/14 ,  C12R1/19

CPC分类号： C12N7/00 ,  A61K38/162 ,  A61K39/00 ,  C12N7/04 ,  C12N2720/12322 ,  C12N2720/12323 ,  C12N2720/12333 ,  C12N2720/12334 ,  C12N2720/12352

摘要： The invention relates to a method for preparing double-layered virus-like particles of rotavirus in vitro. The method comprises the following steps: purifying rotavirus VP6 proteins from a lysis supernatant, and in vitro assembling double-layered virus-like particles consisting of VP2 proteins and VP6 proteins, wherein the proteins and the virus-like particles can be used for preventing or reducing the clinical symptoms caused by rotavirus infection.

摘要翻译： 本发明涉及体外制备轮状病毒双层病毒样颗粒的方法。 该方法包括以下步骤：从裂解上清液中纯化轮状病毒VP6蛋白，以及体外组装由VP2蛋白和VP6蛋白组成的双层病毒样颗粒，其中蛋白质和病毒样颗粒可用于预防或 减少轮状病毒感染引起的临床症状。

公开(公告)号：EP4086274A1

公开(公告)日：2022-11-09

申请号：EP20909593.4

申请日：2020-12-25

申请人： Xiamen University ,  Xiamen Innodx Biotech Co., Ltd

发明人： LI, Tingdong ,  GE, Shengxiang ,  GUO, Xiaoyi ,  HONG, Congming ,  SONG, Liuwei ,  WEN, Shunhua ,  TANG, Jiabao ,  ZHANG, Jun ,  XIA, Ningshao

IPC分类号： C07K14/435 ,  C07K14/00 ,  G01N33/68 ,  G01N33/574 ,  G01N33/569

摘要： Provided are a method for diagnosing nasopharyngeal carcinoma on the basis of the anti-EB virus (EBV) antibody level and a kit used for the method. Also provided are a polypeptide encoded by a BNLF2b gene in EB virus used for the above-mentioned diagnosis and the use thereof for diagnosing nasopharyngeal carcinoma.