公开(公告)号：EP1356046A2

公开(公告)日：2003-10-29

申请号：EP01988203.4

申请日：2001-11-28

申请人： ZymoGenetics, Inc.

发明人： PRESNELL, Scott, R. ,  XU, Wenfeng ,  NOVAK, Julia, E. ,  WHITMORE, Theodore, E. ,  GRANT, Francis, J.

IPC分类号： C12N15/12 ,  C07K14/715 ,  C12N15/62 ,  C07K16/28 ,  G01N33/68 ,  C12Q1/68 ,  C12N5/10 ,  C12N1/21

CPC分类号： C07K14/47 ,  C07K14/715 ,  C07K2319/00 ,  Y10T436/143333

摘要： Novel polypeptide4s, polynuecleotides encoding the polpeptids, and related compositions and methos are disclosed for zcytor19, a novel class II cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or developement of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polpeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor19, are located on chromosome 1p36.11, and can be used to identify a region of the genome associated with human disease states. The present invetion also includes methods, for producing the protein, uses therefor and antibodies thereto.

公开(公告)号：EP1328638A2

公开(公告)日：2003-07-23

申请号：EP01988513.6

申请日：2001-10-19

申请人： ZymoGenetics, Inc.

发明人： CONKLIN, Darrell, C. ,  GAO, Zeren ,  LOFTON-DAY, Catherine, E. ,  WHITMORE, Theodore, E.

IPC分类号： C12N15/24 ,  C07K14/52

CPC分类号： C07K14/52 ,  C07K2319/00

摘要： The present invention relates to zlmda24 polynucleotide and polypeptide molecules. Zlmda24 is a novel cytokine-like polypeptide with an anti-parallel alphahelical structure. The polypeptides may be used within methods for stimulating the proliferation and/or development of hematopoietic cells in vitro and in vivo. Moreover, zlmda24 polynucleotides, polypeptides and antibodies can be used as a diagnostic to detect the presence of human testis tissue. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

公开(公告)号：EP1325115A2

公开(公告)日：2003-07-09

申请号：EP01952259.8

申请日：2001-06-26

申请人： ZymoGenetics, Inc.

发明人： SPRECHER, Cindy, A. ,  PRESNELL, Scott, R. ,  GAO, Zeren ,  WHITMORE, Theodore, E. ,  KUIJPER, Joseph, L. ,  MAURER, Mark, F.

IPC分类号： C12N15/00 ,  C07K14/715

CPC分类号： C07K14/715

摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor17, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.