公开(公告)号：EP1826549A3

公开(公告)日：2008-09-10

申请号：EP07102943.3

申请日：2007-02-23

申请人： CEM Corporation

发明人： Revesz, Robert N.

IPC分类号： G01N1/40 ,  G01N22/00 ,  B01D29/085

CPC分类号： G01N1/40 ,  B01L3/50255 ,  B01L2300/0803 ,  B01L2300/1866 ,  B01L2400/0478 ,  G01N1/4044 ,  G01N1/44 ,  G01N22/00 ,  Y10T436/25

摘要： A method and apparatus are disclosed that are useful in bench top sample preparation and filtration techniques, including those related to microwave assisted extraction and partial digestion. In one aspect the method includes the steps of positioning a microwave-transparent matrix removal tool (40) in a microwave transparent reaction vessel (37) adding a matrix-based composition to the microwave reaction vessel containing the removal tool, applying microwave radiation to the reaction vessel, the matrix-based composition, and the matrix removal tool, and removing the matrix based composition from the reaction vessel using the matrix removal too1. In another aspect the method includes the steps of positioning a matrix based composition that includes at least some liquid in a filter vessel, and applying a moderate over-pressure to the composition upstream of the filter to accelerate the movement of liquid through the filter.

公开(公告)号：EP1079923B1

公开(公告)日：2007-02-21

申请号：EP99918741.2

申请日：1999-04-20

申请人： CEM Corporation

发明人： HARGETT, Wyatt, Price, Jr. ,  THOMAS, James, Edward ,  BARRETT, Matthew, Donald

IPC分类号： B01J19/12 ,  B01J19/00 ,  B01J19/02

CPC分类号： H05B6/806 ,  B01J19/0073 ,  B01J19/02 ,  B01J19/126 ,  B01J2219/0218 ,  B01J2219/0295 ,  B01J2219/1209 ,  B01J2219/1215 ,  B01J2219/1218 ,  B01J2219/1239 ,  G01N1/44 ,  H05B6/6402

摘要： A self venting sealable vessel system for microwave assisted chemistry is disclosed. The system includes a vessel (11) formed of a microwave-transparent material, one end of which forms an opening for placing materials inside the vessel, a lid (13) for being seated against the opening, a flexible frame (14) surrounding the vessel (11) and lid (13) and formed of a microwave-transparent material, and means for urging the frame (14) against the vessel and seated lid with a predetermined force to seal the vessel at low pressures and so that the frame refrains from flexing until the pressure inside the vessel exceeds the predetermined force, after which the frame flexes sufficiently to allow the lid (13) to unseat and gases to vent safely from the vessel without rupturing the vessel (11) or the frame (14).

公开(公告)号：EP1547681A2

公开(公告)日：2005-06-29

申请号：EP04255177.0

申请日：2004-08-27

申请人： CEM Corporation

发明人： Collins Jr, Michael John ,  King, Edward Earl ,  Thomas, James Edward ,  Hargett Jr., Wyatt Price ,  Lambert, Joseph Joshua

IPC分类号： B01J19/12

CPC分类号： B01J19/126 ,  B01J4/02 ,  B01J2219/00164 ,  B01J2219/1218 ,  B01J2219/1239 ,  B01J2219/126 ,  H05B6/6408 ,  H05B6/806

摘要： A controlled-flow microwave instrument is disclosed for chemical synthesis using heterogeneous or highly viscous starting materials. The instrument includes a microwave source (10) for generating electromagnetic radiation in the microwave frequencies, a microwave cavity (11) in wave communication with the source for exposing compositions placed therein to microwave radiation, a microwave-transparent pressure resistant reaction vessel (13) in the cavity, a source reservoir (15) for starting materials and related compositions, a pump (17) in communication with the source reservoir for pumping heterogeneous or highly viscous materials from the source reservoir to the reaction vessel, and a pressure-resistant valve (34) between the pump and the reaction vessel for isolating the reaction vessel from the pump and the source reservoir during application of microwave energy to compositions in the vessel and from any resulting high pressures generated therein.

摘要翻译： 公开了一种控制流动的微波仪器，用于使用不均匀或高粘度起始材料进行化学合成。 该仪器包括用于产生微波频率中的电磁辐射的微波源（10），与该源波形连通的微波腔（11），用于将放置在其中的组合物暴露于微波辐射，微波透明耐压反应容器（13） 在腔体中，用于起始材料和相关组合物的源储存器（15），与源储存器连通的泵（17），用于将不均匀或高粘度材料从源储存器泵送到反应容器，以及耐压阀 （34），用于在向容器中的组合物施加微波能量期间从反应容器与泵和源储存器隔离，以及从其中产生的任何产生的高压中分离反应容器。

公开(公告)号：EP1533025A2

公开(公告)日：2005-05-25

申请号：EP05101287.0

申请日：2004-06-23

申请人： CEM Corporation

发明人： Collins, Jonathan Mckinnon ,  Collins, Michael John ,  Lambert, Joseph Joshua

IPC分类号： B01J19/12 ,  C07K1/04

CPC分类号： B01J19/126 ,  B01J19/087 ,  B01J2219/0871 ,  B01J2219/0879 ,  B01J2219/1206 ,  B01J2219/1209 ,  B01J2219/1215 ,  B01J2219/1218 ,  B01J2219/1221 ,  B01J2219/1254 ,  B01J2219/126 ,  B01J2219/1272 ,  B01J2219/1293 ,  C07K1/045 ,  C07K1/063 ,  C07K5/08 ,  C07K7/06

摘要： A vessel system for accelerating the solid phase synthesis of peptides comprises a vessel system for the accelerated synthesis of peptides by the solid phase method, said vessel system comprising:

a reaction cell or vessel (45) that is transparent to microwave radiation;
a first passageway (46) in fluid communication with said cell (45) for transferring solid phase resin between a resin source external to said cell and said cell;
a second passageway (47) in fluid communication between at least one amino acid source and said cell (45) for adding amino acids to said cell;
a third passageway (50) in gaseous communication with an inert gas source (70) and with a vent (71) for applying gas pressure to and releasing gas pressure from said cell (45) so that the controlled flow of gases to and from said cell can be used to add and remove fluids and flowing solids to and from said cell (45).

摘要翻译： 用于加速肽的固相合成的容器系统包括用于通过固相方法加速合成肽的容器系统，所述容器系统包括：对微波辐射透明的反应池或容器（45）; 与所述电池（45）流体连通的第一通道（46），用于在所述电池外部的树脂源和所述电池之间输送固相树脂; 至少一个氨基酸源和所述细胞（45）之间流体连通的第二通道（47），用于向所述细胞添加氨基酸; 与惰性气体源（70）气态连通的第三通道（50）和用于向所述电池（45）施加气体压力并释放气体压力的通气口（71），以使所述气体与所述气体源 细胞可用于添加和去除流体并将固体流入和从所述细胞（45）流出。

公开(公告)号：EP1515799A1

公开(公告)日：2005-03-23

申请号：EP03736565.7

申请日：2003-05-07

申请人： CEM Corporation

发明人： HAYES, Brittany, L. ,  COLLINS, Michael, J.

IPC分类号： B01J19/12 ,  H05B6/80

CPC分类号： H05B6/806 ,  B01J19/126 ,  B01J2219/0006 ,  B01J2219/00094 ,  B01J2219/002 ,  B01J2219/00213 ,  B01J2219/0024 ,  B01J2219/00306 ,  B01J2219/00495 ,  B01J2219/00601 ,  B01J2219/00698 ,  B01J2219/00716 ,  B01J2219/1275 ,  C07B61/00 ,  C40B60/14

摘要： A method is disclosed for carrying out microwave assisted chemical reactions. The method includes the steps of placing reactants in a microwave-transparent vessel, placing the vessel and its contents into a microwave cavity, applying microwave radiation within the cavity and to the vessel and its contents while concurrently externally cooling the vessel conductively.

公开(公告)号：EP1358007A1

公开(公告)日：2003-11-05

申请号：EP02749916.9

申请日：2002-01-24

申请人： CEM Corporation

发明人： JENNINGS, William, Edward ,  HARGETT, Wyatt, Price, Jr. ,  THOMAS, James, Edward

IPC分类号： B01J19/12

CPC分类号： H05B6/806 ,  B01J19/126 ,  B01J2219/1233 ,  B01J2219/1269 ,  G01L19/0007 ,  G01M3/3272 ,  H05B6/6408

摘要： A pressure-measuring vessel system for microwave assisted chemical processes is disclosed. The vessel system includes a pressure resistant vessel that is otherwise transparent to microwave radiation, a pressure-resistant closure for the mouth of the vessel, with portions of the closure including a pressure resistant synthetic membrane, a pressure transducer external to the vessel, and a tube extending from the transducer, through the membrane and into the vessel for permitting the pressure inside the vessel to be applied against the transducer while the closure and membrane otherwise maintain the pressure resistant characteristics of the vessel.

公开(公告)号：EP1110432B1

公开(公告)日：2003-07-02

申请号：EP99945481.2

申请日：1999-09-03

申请人： CEM Corporation

发明人： GREENE, Gary, Roger ,  JASSIE, Lois, B. ,  KING, Edward, Earl ,  COLLINS, Michael, J.

IPC分类号： H05B6/72

CPC分类号： H05B6/806 ,  H05B6/70 ,  H05B6/72

摘要： A microwave heating system is disclosed for enhancing physical and chemical processes. The system includes a microwave source, an antenna having a cable, a receiver for receiving microwaves generated by the source, with the receiver being connected to a first end of the cable, and a transmitter for transmitting microwaves generated by the source, and with the transmitter being connected to an opposite end of the cable. The system also includes a reaction vessel with the transmitter inside the reaction vessel; and microwave shield surrounding the transmitter for preventing microwaves emitted from the transmitter from extending substantially beyond the reaction vessel.

公开(公告)号：EP1214582A2

公开(公告)日：2002-06-19

申请号：EP00965009.4

申请日：2000-09-16

申请人： CEM Corporation

发明人： JENNINGS, William, Edward ,  BARRETT, Matthew, Donald ,  KING, Edward, Earl

IPC分类号： G01N22/00 ,  G01N22/04 ,  G01N22/02 ,  H05B6/64 ,  H01P7/06

CPC分类号： G01N5/045 ,  G01N1/44 ,  G01N22/00 ,  G01N22/04 ,  G01N2001/4027

摘要： A volatiles analyzer is disclosed that includes a source of microwave radiation that can selectively produce at least one predetermined frequency of microwave radiation. A cavity is in communication with the source. The analyzer includes an analytical pan balance with at least its balance pan in the cavity. The walls of the cavity form a polyhedron that focuses microwave energy of the predetermined frequency on the balance pan while supporting a plurality of TM and TE modes in the cavity.

公开(公告)号：EP1181093A1

公开(公告)日：2002-02-27

申请号：EP00930793.5

申请日：2000-05-17

申请人： CEM Corporation

发明人： HARGETT, Wyatt, Price, Jr.

IPC分类号： B01J19/12 ,  H05B6/76 ,  B01J19/02

CPC分类号： H05B6/806 ,  B01J19/0073 ,  B01J19/02 ,  B01J19/126 ,  B01J2219/0245 ,  B01J2219/1209 ,  B01J2219/1218 ,  G01N1/44 ,  H05B6/763

摘要： A dynamic sealing structure for pressure vessels used in microwave assisted chemistry is disclosed. The structure includes a cylindrical vessel liner (11) and a removable liner cap (12), each formed of a microwave transparent material. The liner (11) has a circular mouth (26) with a lip (31) formed of respective first and second beveled edges (32, 33), with the first beveled edge (32) forming an interior edge of the circular mouth (26) and the second beveled edge (33) forming an exterior edge of the circular mouth (26). The cap (12) includes respective interior and exterior faces (27, 30) with a sleeve (24) depending from the interior face (27) and having a circumference that engages the interior surface of the vessel liner (11) for being urged under pressure against the interior surface of the vessel liner. The interior face of the cap comprising a circular channel (25) outward of the sleeve (24) and having a circumference that engages the lip (31) of the vessel liner (11), and with the channel (25) comprising two beveled edges (34, 35) that respectively engage both beveled edges of the lip (31) of the liner (11).

公开(公告)号：EP1079922A1

公开(公告)日：2001-03-07

申请号：EP99918740.4

申请日：1999-04-20

申请人： CEM Corporation

发明人： MUTTERER, James, Nelson, Jr. ,  HARGETT, Wyatt, Price, Jr.

IPC分类号： B01J19/12

CPC分类号： B01J19/126 ,  B01J2219/00056 ,  B01J2219/00058 ,  B01J2219/00065 ,  B01J2219/1218

摘要： A system for carrying out microwave assisted chemical reactions is disclosed. The system includes a source of microwave radiation (11); a cavity (12) in communication with the source (11), an attenuator (13) in communication with the cavity (12) for providing access to the cavity while preventing microwaves from escaping through the attenuator (13), and a vessel (16) positioned in the cavity (12) and the attenuator (13) and extending externally of the attenuator for holding materials in the cavity while microwaves from the source are applied thereto. The vessel (16) includes a reaction chamber (23) and a venting portion (22). The chamber (23) portion is positioned entirely within the cavity (12), and the venting portion (22) extends from the cavity (12) and through the attenuator (13) and externally of the attenuator and has a gas passage (24) for permitting gases to flow to or from the reaction portion from gas sources external to the cavity, the attenuator, and the vessel.