公开(公告)号：EP1298131A4

公开(公告)日：2004-09-08

申请号：EP01917706

申请日：2001-03-30

申请人： DAIICHI SEIYAKU CO

发明人： TAKEMURA MAKOTO ,  TAKAHASHI HISASHI ,  KAWAKAMI KATSUHIRO ,  ITOH MASAO ,  SUZUKI TETSUYA ,  OHTANI TSUYOSHI ,  SEKIGUCHI MASAYASU ,  MIYAUCHI RIE ,  HAYAKAWA ISAO

IPC分类号： A61K31/4709 ,  A61P31/04 ,  C07D401/04 ,  C07M7/00

CPC分类号： C07D401/04 ,  A61K31/4709

摘要： (-)-7-[(7S)-7-Amino-5-azaspiro[2.4]heptan-5-yl]-6-fluoro-1-[(1R,2S)-2-fluoro-1-cyclopropyl]-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid monohydrochloride monohydrate and antibacterial agents containing the same. This compound is excellent in antibacterial activity and safety and highly stable to light and humidity, which makes it useful as an antibacterial agent.

公开(公告)号：EP1249456A4

公开(公告)日：2004-09-08

申请号：EP01900751

申请日：2001-01-15

申请人： DAIICHI SEIYAKU CO

发明人： WASHIDA NAOHIRO ,  TAKAHASHI KEN ,  SATAKE TOSHIKO ,  FUJISE NOBUAKI ,  TANAKA HIDEKI ,  KURIYAMA MASAYOSHI

IPC分类号： A61P37/08 ,  C07K7/08 ,  C07K16/42 ,  C12N1/21 ,  C12N15/13 ,  C12P21/08 ,  A61K39/395 ,  C12N5/10

CPC分类号： C07K7/08 ,  A61K2039/505 ,  C07K16/4291 ,  C07K2317/21

摘要： A novel peptide; a screening method by using this peptide; and an antibody obtained by this screening method. A novel peptide consisting of 18 amino acids represented by SEQ ID NO:1 in Sequence Listing; a method of screening human type antihuman IgE monoclonal antibody by using this peptide; and human type antihuman IgE monoclonal antibody obtained by this screening method. The antibody thus obtained is useful as a preventive and/or a remedy for allergic diseases.

公开(公告)号：EP1167344A4

公开(公告)日：2004-06-16

申请号：EP00909655

申请日：2000-03-15

申请人： DAIICHI SEIYAKU CO

发明人： TAKEMURA MAKOTO ,  TAKAHASHI HISASHI

IPC分类号： C07C229/34 ,  C07D215/56 ,  C07C227/16 ,  C07C227/18

CPC分类号： C07D215/56 ,  C07C229/34

摘要： A process for producing intermediates of antibacterial agents in accordance with the schema (I), (III), (IV), (V), (VI) and (VII) and intermediates in the production thereof, wherein R1 represents hydrogen or nitro; R2 represents C¿1-6? alkyl; R?3 and R4¿ represent each C¿1-6? alkyl, or R?3 and R4¿ may form together with the nitrogen atom to which they are bonded a 5- or 6-membered cyclic structure optionally containing oxygen, nitrogen, sulfinyl or sulfonyl as a ring-constituting element; R6 represents C¿3-6? halogenocycloalkyl; X?1¿ represents halogeno or hydrogen; X?2 and X3¿ represent each a leaving group; and Y represents C¿1-6? alkyl or C2-6 alkenyl.

公开(公告)号：EP0950416A4

公开(公告)日：2004-06-16

申请号：EP98907159

申请日：1998-03-11

申请人： DAIICHI SEIYAKU CO

发明人： KOJIRO MASAMICHI ,  YANO HIROHISA ,  IEMURA AKIHIRO

IPC分类号： A61K38/22 ,  A61K38/18

CPC分类号： A61K38/1833

摘要： A preventive and/or therapeutic agent for cachexia, containing tumor cytotoxic factor II (TCF-II) as the active ingredient. This agent is excellently effective in the prevention and/or therapy of cachexia caused by cancer, acquired immunodeficiency syndrome (AIDS), heart diseases, infectious diseases, shock, burn, endotoxemia, organ inflammation, surgical operation, diabetes, collagen disease, radiation therapy or chemotherapy, thus being useful as a drug.

公开(公告)号：EP0925791A4

公开(公告)日：2004-06-16

申请号：EP98909799

申请日：1998-03-20

申请人： DAIICHI SEIYAKU CO

发明人： KINOSAKI MASAHIKO ,  OGAWA HIROMI ,  MASUNAGA HIROAKI ,  KOBAYASHI FUMIE ,  YAMAGUCHI KYOJI ,  HIGASHIO KANJI

IPC分类号： A61K38/00 ,  A61K38/22 ,  A61P13/02 ,  A61P13/12 ,  A61P15/00 ,  C07K14/47 ,  C07K14/475 ,  C07K14/52 ,  A61K38/18

CPC分类号： C07K14/4753 ,  A61K38/00 ,  C07K14/52

摘要： A preventive and/or therapeutic agent for kidney diseases, containing as the active ingredient a tumor cytotoxic factor II (TCF-II) mutant which has undergone point mutation. The mutant is TCF-II wherein the Arg-Lys-Arg-Arg amino acid sequence beginning at the second position from the N-terminal is replaced by Ala-Ala-Ala-Ala or the Lys-Ile-Lys-Thr-Lys-Lys amino acid sequence beginning at the 27th position therefrom is replaced by Ala-Ile-Ala-Thr-Ala-Ala.

公开(公告)号：EP0914829A4

公开(公告)日：2004-06-16

申请号：EP98907158

申请日：1998-03-11

申请人： DAIICHI SEIYAKU CO

发明人： ARISAWA HIROHIKO ,  MASUNAGA HIROAKI ,  OGAWA HIROMI ,  HIGASHIO KANJI

IPC分类号： A61K38/00 ,  A61K38/18 ,  A61K38/27 ,  A61P43/00 ,  C07K14/475 ,  C07K14/525 ,  A61K38/22

CPC分类号： A61K38/1833 ,  Y10S514/97

摘要： Preventives and/or remedies for multiple organ failure containing as the active ingredient tumor cytotoxic factor-II (TCF-II) or hepatocyte growth factor (HGF). These drugs are useful in preventing and/or treating deterioration in the general status due to burn, disseminated intravascular coagulation (DIC), circularity failure, hemorrhagis shock, infectious diseases, acute pancreatitis, ischemic injury, hepatorenal syndrome, hemorrhage of digestive tract, nutritional metabolic failure, cancer at the terminal stage, acquired immunodeficiency syndrome (AIDS), radiation injury, etc. and the progression from cachexy, etc. to multiple organ failure.

公开(公告)号：EP1103261A4

公开(公告)日：2003-03-12

申请号：EP99935091

申请日：1999-08-06

申请人： DAIICHI SEIYAKU CO

发明人： TANAKA TATSUYA ,  TAKAZAWA AKIRA ,  YOSHII MITSUNOBU ,  MURASHIMA YOSHIYA

IPC分类号： A61K31/40 ,  A61K31/4015 ,  A61K31/44 ,  A61K31/4439 ,  C07D207/26 ,  C07D207/27 ,  C07D401/12

CPC分类号： C07D207/27 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/44 ,  A61K31/4439 ,  C07D401/12

摘要： Remedies and preventives for intractable epilepsy which contain as the active ingredient compounds represented by the general formula (I): R2-CH2-CONH-R1 wherein R1 represents optionally substituted pyridyl or phenyl; and R2 represents optionally substituted 2-oxo-1-pyrrolidinyl.

公开(公告)号：EP0947513A4

公开(公告)日：2002-10-02

申请号：EP97909605

申请日：1997-10-23

申请人： DAIICHI SEIYAKU CO

发明人： TAKEMURA MAKOTO ,  TAKAHASHI HISASHI ,  KIMURA KENICHI ,  MIYAUCHI RIE ,  OHKI HITOSHI ,  KAWAKAMI KATSUHIRO

IPC分类号： C07D401/04 ,  C07D455/02 ,  C07D471/04 ,  C07D491/16 ,  C07D498/04 ,  C07D498/06 ,  C07D513/04 ,  A61K31/47 ,  C07D209/94 ,  C07D455/06

CPC分类号： C07D401/04 ,  C07D455/02 ,  C07D471/04 ,  C07D513/04

摘要： Compounds represented by general formula (I) carrying a tricylic amine substituent optionally having various substituents, their salts, hydrates thereof or drugs containing these compounds as the active ingredient. Because of having favorable antibacterial activities on gram-negative and gram-positive bacteria and being excellent both in the dynamics in vivo and safety, these compounds are useful in treating infectious diseases. In said formula (I), Q represents a partial structure which is preferably represented by formula (a); or (b) and may have various substituents.

摘要翻译： 由通式（I）表示的带有任选具有各种取代基的三取代胺取代基的化合物，其盐，其水合物或含有这些化合物的药物作为活性成分。 由于对革兰氏阴性菌和革兰氏阳性菌具有良好的抗菌活性，并且在体内动力学和安全性方面均优异，所以这些化合物可用于治疗感染性疾病。 在所述式（I）中，Q表示优选由式（a）表示的部分结构; 或（b）并可具有各种取代基。

公开(公告)号：EP1188760A4

公开(公告)日：2002-08-07

申请号：EP00929862

申请日：2000-05-25

申请人： DAIICHI SEIYAKU CO ,  NAGANO TESTUO

发明人： NAGANO TETSUO ,  KIKUCHI KAZUYA ,  INOUE TAKANARI ,  IINO MASAMITSU ,  HIROSE KENZO

IPC分类号： A61P43/00 ,  C07F9/117 ,  C07F9/655 ,  C07F9/6561 ,  C07F9/144 ,  A61K31/661 ,  A61K41/00 ,  C07D493/10

CPC分类号： C07F9/6561 ,  C07F9/117 ,  C07F9/65522

摘要： Compounds of general formula (I) or salts thereof, useful as ligands to inositol 1,4,5-trisphosphate (IP3) receptor, wherein R is a group represented by general formula (A), (B) or (C) (wherein R and R are each independently C1-6 alkyl; R is amino, mono(C1-6 alkyl)amino, di(C1-6 alkyl)amino, or C1-6 alkoxy; and X is an anion); and n is an integer of 2 to 5.

公开(公告)号：EP1182202A4

公开(公告)日：2002-03-27

申请号：EP00907973

申请日：2000-03-09

申请人： DAIICHI SEIYAKU CO

发明人： TAKEMURA MAKOTO ,  TAKAHASHI HISASHI ,  KAWAKAMI KATSUHIRO ,  TAKEDA TOSHIYUKI ,  MIYAUCHI RIE

IPC分类号： C07D401/14 ,  A61K31/4709 ,  A61P31/04 ,  C07D401/04 ,  C07D405/14 ,  C07D417/14 ,  C07D498/06 ,  A61K31/435 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/519 ,  A61K31/5383 ,  C07D455/02 ,  C07D471/04

CPC分类号： C07D401/04 ,  C07D405/14

摘要： Quinolone derivatives having potent antibacterial effects on various bacteria including insensible bacilli, which are compounds represented by general formula (1), salts of the same, or hydrates of both: wherein R1 is an optionally substituted aromatic group; R?2 and R3¿ are each hydrogen or alkyl; R?4, R5 and R6¿ are each hydrogen, hydroxyl, halogeno, or the like; R?7 and R8¿ are each hydrogen or alkyl; R9 is alkyl, alkenyl, halogenoalkyl, or the like; R10 is hydrogen or alkylthio; R11 is hydrogen, amino, hydroxyl, or the like; X1 is halogeno or hydrogen; A1 is nitrogen or C-X2; X2 is hydrogen, amino, halogeno, or the like; A?2 and A3¿ are each ⊃C=C(-A?1=)-N(-R9¿)- or ⊃N-C(-A?1=)=C(-R9)-; R10 and R9 or R9 and X2¿ may be united to form a ring structure; and Y is hydrogen or an ester-forming group.