-
11.发明公开SUBSTITUTED HETEROCYCLIC AMINE COMPOUNDS AS CHOLESTRYL ESTER-TRANSFER PROTEIN (CETP) INHIBITORS 审中-公开替代性杂交氨基转移蛋白（CETP）-INHIBITOREN
公开(公告)号：EP2744803A2
公开(公告)日：2014-06-25
申请号：EP12787075.6
申请日：2012-08-17
发明人： BORUAH, Anima , ALIKUNJU, Shanavas
IPC分类号： C07D401/12 , C07D401/14 , C07D413/12 , C07D413/14 , A61K31/4709 , A61K31/435 , A61P3/06
CPC分类号： A61K31/4709 , A61K31/435 , A61K31/506 , A61K31/5377 , C07D401/12 , C07D401/14 , C07D413/12 , C07D413/14
摘要： The present application relates to cycloalkylpyridin-2-amines derivates of formula (1) or stereoisomers thereof or pharmaceutically acceptable salts thereof. The present application also relates to the process for the preparation of compounds of formula (I). The present application further describes the compounds of formula (1) as cholesteryl ester-transfer protein (CETP) inhibitors. The present application further relates to pharmaceutical compositions comprising compounds of formula (1) or stereoisomers thereof or pharmaceutically acceptable salts thereof.
摘要翻译： 本申请涉及式（1）的环烷基吡啶-2-胺衍生物或其立体异构体或其药学上可接受的盐。 本申请还涉及制备式（I）化合物的方法。 本申请进一步描述了式（1）化合物作为胆固醇酯转移蛋白（CETP）抑制剂。 本申请还涉及包含式（1）化合物或其立体异构体或其药学上可接受的盐的药物组合物。
-
12.发明公开
公开(公告)号：EP2743255A1
公开(公告)日：2014-06-18
申请号：EP13197519.5
申请日：2013-12-16
发明人： Kumar, Vujjini Satish , Rao, Badarla Venkata Krishna , Charyulu, Kandala Sreenadha , Praveen, Cherukupally , Reddy, Yerraguntla Sesha , Dey, Archan
IPC分类号： C07C233/18 , A61P25/24 , A61K31/165
CPC分类号： C07C233/18 , C07B2200/13
摘要： The present application relates to cocrystal of agomelatine with phosphoric acid and its method of preparation. Another aspect of the application relates to process for the preparation of crystalline Form I of agomelatine.
摘要翻译： 本申请涉及与磷酸一起使用的阿莫西拉坦共晶体及其制备方法。 本申请的另一方面涉及制备阿格美拉汀的晶型I的方法。
-
13.发明公开Processes for the preparation of sitagliptin and pharmaceutically acceptable salts thereof 审中-公开一种用于西他列汀及其药学上可接受的盐的制备方法
公开(公告)号：EP2599781A1
公开(公告)日：2013-06-05
申请号：EP12193141.4
申请日：2008-12-18
发明人： Padi, Pratap, Reddy , Ireni, Babu , Polavarapu, Srinivas , Nerella, Kavitha , Ramasamy, Vijaya, Anand , Vangala, Ranga, Reddy , Padamata, Shailaja
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： There is provided salts and polymorphs of sitagliptin, processes for the preparation thereof, and pharmaceutical compositions comprising the same.
摘要翻译： 有用于制备所提供的盐和西他列汀的多晶型物，它们的处理，和药物组合物，其包括相同的。
-
公开(公告)号：EP2598510A2
公开(公告)日：2013-06-05
申请号：EP11813250.5
申请日：2011-07-29
IPC分类号： C07F9/6571 , B01J31/18 , C07C45/50 , C07C253/30 , C07C67/313
CPC分类号： C07C45/505 , B01J31/185 , B01J31/2495 , B01J2231/321 , B01J2531/0261 , B01J2531/822 , C07B2200/07 , C07C67/293 , C07C231/12 , C07C253/30 , C07F9/65683 , C07F9/6571 , C07C47/228 , C07C69/14 , C07C47/24 , C07C47/02 , C07C255/17 , C07C235/16
摘要： In an aspect, the invention provides compounds of the formula 4: wherein the constituent variables are defined herein.
-
公开(公告)号：EP2582704A2
公开(公告)日：2013-04-24
申请号：EP11796436.1
申请日：2011-06-16
发明人： KATKAM, Srinivas , POLAVARAPU, Srinivas , YADDANAPUDI, Venkata Madhavi , VINIGARI, Krishna , PAGADALA, Narasimha Rao , SAGYAM, Rajeshwar Reddy
IPC分类号： C07D491/044 , A61K31/407 , A61P25/18
CPC分类号： C07D491/04 , C07D491/044
摘要： Aspects of the present application relate to a microcrystalline monoclinic form of asenapine maleate represented by structural Formula (I); processes for its preparation; and pharmaceutically acceptable dosage forms thereof.
-
公开(公告)号：EP2521787A2
公开(公告)日：2012-11-14
申请号：EP11732140.6
申请日：2011-01-06
CPC分类号： C07K16/00 , C07K16/22 , C07K2317/14 , C12P21/00
摘要： The application describes methods to enhance protein production using mammalian cells. Increased production of heterologous protein can be obtained by increasing osmolality and lowering temperature. The method maintains the cell growth rate and provides high product yield.
摘要翻译： 该应用描述了使用哺乳动物细胞增强蛋白质生产的方法。 通过增加重量克分子渗透浓度和降低温度可以获得增加的异源蛋白质的产生。 该方法保持细胞生长速率并提供高产率。
-
公开(公告)号：EP2473161A2
公开(公告)日：2012-07-11
申请号：EP10812737.4
申请日：2010-08-31
发明人： UBAIDULLA, Udhumansha , KANDAVILLI, Sateesh , VAIRALE, Ajay Sunil , WAYNE, Jeffrey, A. , NALAMOTHU, Vijendra , MEGHAL, Mistry , PAKUNLU, Refika Isil
CPC分类号： A61K31/573 , A61K9/0014 , A61K9/107 , A61K9/7015 , A61K31/56 , A61K31/575 , A61K31/58 , A61K47/10 , A61K47/14 , A61K47/22 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38 , A61K47/44 , B05B1/02 , B05B1/30 , B05B11/3045 , B05B15/30
摘要： The application provides formulations for the topical administration of an active agent comprising at least one steroid, in the form of topical sprays that are propellant-free, and/or substantially non-foaming, and/or alcohol-free. The present application also provides processes for preparing such compositions and methods of using them in management of skin diseases or disorders such as psoriasis, dermatoses, and other associated skin diseases or disorders.
-
18.发明公开PRODUCTION OF TRANS-4-AMINOCYCLOPENT-2-ENE-1-CARBOXYLIC ACID DERIVATIVES 有权HERSTELLUNG VON TRANS-4-AMINOCYCLOPENTAN-2-EN-1-CARBOXYLSAUREDERIVATEN
公开(公告)号：EP2448916A2
公开(公告)日：2012-05-09
申请号：EP10794811.9
申请日：2010-07-02
IPC分类号： C07C231/16 , C07C233/52 , C07C231/20 , C07C231/24
CPC分类号： C07C231/20 , C07B2200/09 , C07C231/24 , C07C233/52 , C07C269/06 , C07C2601/10 , C07C271/24
摘要： Methods of producing compositions of trans-4-amino-2-cyclopentene-1-carboxylic acid derivatives are described. Also described is an amine salt of a compound having formula A, having components present in both
cis and
trans structures.摘要翻译： 描述了制备反式-4-氨基-2-环戊烯-1-羧酸衍生物的组合物的方法。 还描述了具有式A的化合物的胺盐，其具有以顺式和反式结构两者存在的成分。
-
公开(公告)号：EP2358693A2
公开(公告)日：2011-08-24
申请号：EP09828277.5
申请日：2009-11-20
发明人： KADABOINA, Rajasekhar , NARIYAM, Sekhar Munaswamy , MATTI, Lankeshwara Rao , VASAM, Sridhar , MAKIREDDY, Siva Reddy , KOMATI, Shravan Kumar
IPC分类号： C07D305/14 , A61K31/337 , A61P35/00
CPC分类号： C07D413/12 , C07D305/14
摘要： The present invention relates to docetaxel and processes for preparing docetaxel, including process-related intermediates. The present invention also relates to processes for preparing substantially pure docetaxel and intermediates.
-
公开(公告)号：EP2334685A2
公开(公告)日：2011-06-22
申请号：EP09812196.5
申请日：2009-09-03
发明人： KADABOINA, Rajasekhar , NARIYAM, Sekhar Munaswamy , RAMAKRISHNAN, Srividya , PEDDIREDDY, Subbareddy , BAIG, Mohammed, Azeezulla , DUGGIRALA, Nagakiran
IPC分类号： C07D487/04 , C07F1/04
CPC分类号： C07D487/04
摘要： Processes for the preparation of amorphous pemetrexed disodium, and removal of residual solvents from amorphous pemetrexed disodium.
摘要翻译： 制备无定形培美曲塞二钠的方法，以及从无定形培美曲塞二钠中除去残余溶剂的方法。
-
-
-
-
-
-
-
-
-
搜索结果
248 条记录 (耗时 0.025 秒)
