公开(公告)号：EP1857542A1

公开(公告)日：2007-11-21

申请号：EP06714933.6

申请日：2006-02-22

申请人： Foundation for Biomedical Research and Innovation ,  TOKAI UNIVERSITY EDUCATIONAL SYSTEM

发明人： ASAHARA, Takayuki, Institute of Biomedical R & I ,  ISHIKAWA, Tetsuya, c/o Tokai University

IPC分类号： C12N5/00 ,  C12N1/00 ,  C12N5/06

CPC分类号： C12N5/0647 ,  C12N5/0692 ,  C12N2500/36 ,  C12N2500/90 ,  C12N2501/23

摘要： The present invention provides a method of efficiently expanding non-adhesive adult stem cells in vitro. More specifically, the present invention provides a method of expanding non-adhesive adult stem cells, comprising culturing non-adhesive adult stem cells in the co-presence of adhesive feeder cells and non-adhesive non-stem cells in serum-free medium, wherein the ratio of non-adhesive adult stem cell count to total cell count in the medium is kept low; non-adhesive adult stem cells obtained by the expansion method and differentiated cells thereof, and a composition comprising them; and a serum-free medium comprising a specified factor, and a kit for its preparation and the like.

摘要翻译： 本发明提供了一种在体外有效扩张非粘性成体干细胞的方法。 更具体地，本发明提供了扩展非粘性成体干细胞的方法，包括在无血清培养基中的粘合剂喂养细胞和非粘性非干细胞的共存下培养非粘性成体干细胞，其中 培养基中非粘性成体干细胞计数与总细胞计数的比例保持不变; 通过膨胀法和分化细胞获得的非粘性成体干细胞和包含它们的组合物; 和包含特定因子的无血清培养基，以及其制备用试剂盒等。

公开(公告)号：EP1413252A1

公开(公告)日：2004-04-28

申请号：EP03256639.0

申请日：2003-10-22

申请人： TOKAI UNIVERSITY EDUCATIONAL SYSTEM ,  Medico's Hirata Inc.

发明人： Shimura, Takaki Tokai University ,  Nimura, Yasuhara Medico's Hirata Inc. ,  Yoshioka, Wataru Medico's Hirata Inc.

IPC分类号： A61B8/08

CPC分类号： A61B5/02007 ,  A61B5/489 ,  A61B8/08 ,  A61B8/4209 ,  A61B8/463

摘要： The present invention aims to provide a puncture difficulty evaluating device (10) which can readily evaluate the difficulty of puncture in a measuring point. To this end, a puncture difficulty device (10,103) receives (12) the ultrasound backscattered at the measurement point, determines (16) an integral of the power of the ultrasound over a predetermined angle range, and generates (17) a parameter indicating the difficulty of puncture in the measurement point based on the determined integral.

摘要翻译： 发射器（102）用超声波脉冲照射样本的测量点。 接收器（12）在测量点处接收反向散射的超声波，并且确定超声波在预定角度范围内的积分。 发电机（17）基于确定的积分产生指示测量点的穿刺难度的参数。

公开(公告)号：EP1205146A3

公开(公告)日：2004-01-02

申请号：EP01309569.0

申请日：2001-11-13

申请人： TOKAI UNIVERSITY EDUCATIONAL SYSTEM

发明人： Shimura, Takaki, c/o Tokai University ,  Shimizu, Sohta, c/o Tokai University ,  Iguchi, Yuichi, c/o Tokai University ,  Kaneko, Mitsuo

IPC分类号： A61B5/16

CPC分类号： A61B5/16 ,  A61B5/4088

摘要： The present invention relates to a dementia test system and the like for testing the degree of dementia of a subject, and provides a dementia test system which is effective for preventing and finding, at an early stage, an initial sign (initial dementia) of senile dementia. A dementia test apparatus comprising an answer obtaining section (131) for obtaining an answer of a subject to both a dementia degree test chart which requires the subject to exercise a plurality of judgements at the same time and obtain an answer in such a form that correction of judgement is objectively determined, and a dementia factor degree test chart comprising a combination of multiple questions concerning sensibility and a multiplicity of answers alternatively selected from questions prepared for each of the former questions, and a dementia degree test section (132) for testing a dementia degree indicative of the current degree of dementia of the subject based on an answer obtained by the answer obtaining section, and for estimating a future dementia degree of the subject.

公开(公告)号：EP1205146A2

公开(公告)日：2002-05-15

申请号：EP01309569.0

申请日：2001-11-13

申请人： TOKAI UNIVERSITY EDUCATIONAL SYSTEM

发明人： Shimura, Takaki, c/o Tokai University ,  Shimizu, Sohta, c/o Tokai University ,  Iguchi, Yuichi, c/o Tokai University ,  Kaneko, Mitsuo

IPC分类号： A61B5/16

CPC分类号： A61B5/16 ,  A61B5/4088

摘要： The present invention relates to a dementia test system and the like for testing the degree of dementia of a subject, and provides a dementia test system which is effective for preventing and finding, at an early stage, an initial sign (initial dementia) of senile dementia. A dementia test apparatus comprising an answer obtaining section (131) for obtaining an answer of a subject to both a dementia degree test chart which requires the subject to exercise a plurality of judgements at the same time and obtain an answer in such a form that correction of judgement is objectively determined, and a dementia factor degree test chart comprising a combination of multiple questions concerning sensibility and a multiplicity of answers alternatively selected from questions prepared for each of the former questions, and a dementia degree test section (132) for testing a dementia degree indicative of the current degree of dementia of the subject based on an answer obtained by the answer obtaining section, and for estimating a future dementia degree of the subject.

摘要翻译： 本发明涉及一种用于测试受试者痴呆程度的痴呆试验系统等，并且提供了一种有效预防和发现老年人的初始痴呆（初始痴呆）的痴呆试验系统 痴呆。 一种痴呆试验装置，包括：答案获取部（131），用于获得要求受试者同时行使多个判断的痴呆程度测试图的对象的答案，并以这样的形式获得答案： 判断的客观判定，以及痴呆因子度测试图，其包含关于感知性的多个问题的组合，以及交替地从针对每个前述问题准备的问题中选择的多个答案的组合，以及用于测试 基于由答案获得部分获得的答案表示受试者目前的痴呆程度的痴呆程度，以及用于估计受试者的未来痴呆程度。

公开(公告)号：EP0980695A3

公开(公告)日：2000-11-22

申请号：EP99116292.6

申请日：1999-08-18

申请人： TOKAI UNIVERSITY EDUCATIONAL SYSTEM ,  Nippon Infrared Industries Co., Ltd.

发明人： Matsumae, Mitsunori, Dept. of Neurosurgery Tokai U ,  Kaneda, Michihiro, c/o Nippon Infrared Industries

IPC分类号： A61N5/06

CPC分类号： A61N5/0601 ,  A61B90/10 ,  A61B2017/00084 ,  A61B2018/2211

摘要： A device for heating a biotissue employing strong light, characterized in that, in thermotherapy comprising leading a biotissue to necrosis by heating the biotissue by strong light from a light source, in order to lead a predetermined biotissue to necrosis at a temperature region before reaching tissue transpiration during raising the temperature of said biotissue, temperature measurement is performed by a temperature meter measuring the spatial temperature distribution of the biotissue at a real time, and that the light output of the light source, the on-time of intermittent irradiation and the off-time of intermittent irradiation are controlled on the basis of the information at a real time to accomplish remedial conditions.

公开(公告)号：EP3859754B1

公开(公告)日：2024-06-12

申请号：EP19865613.4

申请日：2019-09-20

IPC分类号： H01B12/10 ,  H01B13/00 ,  H10N60/20 ,  H10N60/01 ,  H01F41/04

CPC分类号： Y02E40/60 ,  H01B12/10 ,  H01F41/048 ,  H10N60/20 ,  H10N60/0184

公开(公告)号：EP2218669B1

公开(公告)日：2018-12-26

申请号：EP07832722.8

申请日：2007-11-21

申请人： TOYOTA JIDOSHA KABUSHIKI KAISHA ,  TOKAI UNIVERSITY EDUCATIONAL SYSTEM

发明人： HASHIMOTO, Hiromu

IPC分类号： B65H23/188 ,  B65H23/04

CPC分类号： B65H23/048 ,  B65H23/1888 ,  B65H2404/15212 ,  B65H2515/842 ,  B65H2553/42 ,  B65H2557/266 ,  B65H2601/25 ,  B65H2220/03 ,  B65H2220/01 ,  B65H2220/02

摘要： Provided is a web carrier which can prevent creasing of a web by detecting a sign of creasing of a web during carriage of the web. The web carrier (1) for carrying a sheetlike web (10) by means of a plurality of rollers (2) detects the linear pattern of a waveform generated on the web (10) from an image picked up by means of a camera (imaging means) (3) using an image analysis means (73) in a controller (7), recognizes a state becoming the sign of creasing with the aid of the image and simultaneously analyzes the entering direction of the linear pattern into a guide roller (2c), drives the shaft (20c) of the guide roller (angle adjusting roller) (2c) in the direction of canceling the waveform (so that the web is not creased), and controls an alignment adjusting means (5) such that the web is not creased.

公开(公告)号：EP3000444B1

公开(公告)日：2018-10-31

申请号：EP14800612.5

申请日：2014-05-12

申请人： Tokai University Educational System ,  Nipro Corporation

发明人： IKARI, Yuji ,  MATSUMOTO, Kuniaki

IPC分类号： A61F2/915

CPC分类号： A61F2/89 ,  A61F2/915 ,  A61F2002/825 ,  A61F2002/91558 ,  A61F2002/91575 ,  A61F2002/91583 ,  A61F2230/0054 ,  A61F2250/0018

摘要： Provided is a stent having a novel structure, the stent simultaneously having both the stability of shape against the action of external force, such as compression force, tensile force, or torsional force, and high flexibility in the direction of twisting of the stent. Connection groups (20) are provided at three or more positions set at circumferentially equally-spaced intervals, the connection groups (20) each comprising connection sections (14) which are disposed circumferentially close to each other between axially adjacent tubular divided bodies (12c). The connection groups on both sides axially of each of the tubular divided bodies (12c) are provided at positions circumferentially offset from each other while at least one turning portion (18) is present between the connection groups.

公开(公告)号：EP3062134A1

公开(公告)日：2016-08-31

申请号：EP14856282.0

申请日：2014-10-16

申请人： Tokai University Educational System ,  Nissan Chemical Industries, Ltd.

发明人： MIKAMI, Osamu ,  OHMORI, Kentaro ,  NAWATA, Hideyuki

IPC分类号： G02B6/138 ,  C09D183/04 ,  G02B1/11 ,  G02B6/12 ,  G02B6/122 ,  G03F7/11 ,  G03F7/20 ,  H01L21/027

CPC分类号： G03F7/091 ,  B29D11/00663 ,  C08F290/148 ,  C08G77/20 ,  C08G77/80 ,  C09D183/04 ,  G02B1/111 ,  G02B6/1221 ,  G02B6/138 ,  G03F7/0005 ,  G03F7/0755 ,  G03F7/16 ,  G03F7/20 ,  G03F7/32 ,  C08K5/0025

摘要： There is a method for producing an optical waveguide composing an optical path conversion component having an extremely low signal loss, allowing a high surface packaging density and high speed operation, and allowing high productivity. A method for producing an optical waveguide that propagates light from a surface of a support to an oblique direction not vertical to the surface, the method for producing an optical waveguide comprising the steps of: (1) providing an anti-reflective coating on the support; (2) placing a photosensitive resin composition on the anti-reflective coating, and exposing the photosensitive resin composition to a light ray entering from a direction non-vertical to the surface of the support through a photomask for curing the composition; and (3) removing the unexposed photosensitive resin composition by development; and an optical waveguide obtained by the method.

摘要翻译： 具有构成具有极低信号损失的光路转换部件的光波导的制造方法，能够实现高的表面封装密度和高速运转，能够实现高生产率。 一种用于制造将光从支撑体的表面传播到不垂直于表面的倾斜方向的光波导的方法，所述光波导的制造方法包括以下步骤：（1）在支撑体上设置抗反射涂层 ; （2）将光敏树脂组合物放置在抗反射涂层上，并将感光性树脂组合物通过用于固化组合物的光掩模从不垂直于载体表面的方向进入的光线曝光; 和（3）通过显影除去未曝光的感光性树脂组合物; 以及通过该方法获得的光波导。

公开(公告)号：EP2902483A1

公开(公告)日：2015-08-05

申请号：EP13842351.2

申请日：2013-09-30

申请人： Foundation for Biomedical Research and Innovation ,  Tokai University Educational System ,  Stemmed Inc. ,  Juntendo Educational Foundation

发明人： ASAHARA, Takayuki ,  MASUDA, Haruchika ,  TANAKA, Rika

IPC分类号： C12N5/077 ,  A61K35/14 ,  A61K35/28 ,  A61P3/10 ,  A61P9/10 ,  A61P17/02 ,  C12N5/078

摘要： Simplification of a preparation step of a cell population used for the treatment of ischemic diseases, and provision of a cell population that shows more effect by the treatment.
A method of producing a cell population wherein a vascular endothelial progenitor cell and/or an anti-inflammatory macrophage are/is enriched, including cultivating a mononuclear cell derived from bone marrow, cord blood or peripheral blood in a serum-free medium containing stem cell factor, interleukin-6, FMS-like tyrosine kinase 3 ligand, thrombopoietin and vascular endothelial cell growth factor, and proliferating vascular endothelial progenitor cell from the cell; and a cell population obtained by the method, etc.

摘要翻译： 简化用于治疗缺血性疾病的细胞群的制备步骤，以及提供通过治疗显示更多效果的细胞群。 一种生产细胞群的方法，其中富含血管内皮祖细胞和/或抗炎巨噬细胞，包括在含有干细胞的无血清培养基中培养源自骨髓，脐带血或外周血的单核细胞 因子，白介素-6，FMS样酪氨酸激酶3配体，血小板生成素和血管内皮细胞生长因子，以及来自细胞的增殖性血管内皮祖细胞; 和通过该方法得到的细胞群等