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公开(公告)号：EP1527078A2
公开(公告)日：2005-05-04
申请号：EP03732752.5
申请日：2003-06-25
IPC分类号： C07F9/38 , C02F5/14 , E21B37/06 , C10L3/00 , C23F11/167
CPC分类号： C23F11/1676 , C02F5/14 , C07F9/3808 , C07F9/3869 , C09K8/52 , C09K8/524 , C11D3/365 , C23F11/167
摘要： Phosphono or phosphino acids, in which at least one carboxyl group is esterified with a C6-25 alkyl, alkaryl or alkenyl group, are effective as oil-soluble scale inhibitors, and as wax or asphaltene inhibitors or dispersants. A method for making and the use of the aforesaid esters is also disclosed.
摘要翻译： 其中至少一个羧基被C6-25烷基，烷芳基或链烯基酯化的膦酰基或膦基酸作为油溶性结垢抑制剂和蜡或沥青质抑制剂或分散剂是有效的。 还公开了制造和使用上述酯的方法。
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12.发明公开PHOSPHONIC ACID DERIVATIVES AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B (PTP-1B) 审中-公开膦酸衍生物作为蛋白酪氨酸磷酸酶1B（PTP-1B）抑制剂
公开(公告)号：EP1242432A1
公开(公告)日：2002-09-25
申请号：EP00986934.8
申请日：2000-12-21
发明人： LEBLANC, Yves , LAU, Cheuk, Kun , DUFRESNE, Claude , LI, Chun, Sing , ROY, Patrick , WANG, Zhaoyin , SCHEIGETZ, John , BOYD, Michael
CPC分类号： C07F9/65318 , C07F9/3856 , C07F9/3869 , C07F9/3873 , C07F9/3882 , C07F9/4037 , C07F9/4056 , C07F9/4075 , C07F9/582 , C07F9/65188
摘要： The invention encompasses the novel class of compounds represented by formula (I), which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and diabetes-related diseases.
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13.发明授权
公开(公告)号：EP0971939B1
公开(公告)日：2002-09-11
申请号：EP98917062.6
申请日：1998-03-24
申请人： Novuspharma S.p.A.
CPC分类号： C07F9/3869 , C07F9/4046
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公开(公告)号：EP1131327A1
公开(公告)日：2001-09-12
申请号：EP99955618.6
申请日：1999-11-18
发明人： GIL, Laurent , HAN, Yongxin , RUEL, Rejean , YOUNG, Robert, N.
IPC分类号： C07F9/38 , A61K31/663
CPC分类号： C07F9/3869 , A61K47/54 , C07F9/3865
摘要： This invention relates to prostaglandin-bisphosphonate conjugates. These conjugates are effective for treating or preventing bone diseases such as osteoporosis. These conjugates simultaneously deliver a prostaglandin agent for increasing bone formation and a bisphosphonate agent for inhibiting bone resorption.
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公开(公告)号：EP0831845A1
公开(公告)日：1998-04-01
申请号：EP96918247.0
申请日：1996-06-06
发明人： HARTMANN, John, F. , FARCASIU, Dan
CPC分类号： A61B5/0422 , A61B5/4504 , A61B5/4547 , C07D499/00 , C07D501/00 , C07F9/3869 , C07F9/3873 , C07F9/404 , C07F9/60 , C07F9/650958 , C07F9/65335 , C07F9/6539 , C07F9/65583 , C07F9/6561 , C07F9/65613
摘要： Novel chemotherapeutic agents having utility in treating infectious diseases such as periodontal disease, certain urinary tract infections, infectious urinary tract stones, and bone cancer, are obtained by combining chemically a diphosphonate compound with a therapeutic agent effective against the foregoing diseases.
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16.发明公开Derivatives of diphosphonic acids, and pharmaceutical preparations containing them 失效二磷酸的衍生物和含有它们的药物制剂
公开(公告)号：EP0098567A3
公开(公告)日：1984-02-22
申请号：EP83106511
申请日：1983-07-04
CPC分类号： C07F9/3873 , C07F9/3869 , C07F9/4025
摘要： Diphosphonsäure-Derivate der allgemeinen Formel I worin
X eine Cyanogruppe, eine 2-Cyanoethylgruppe, eine Dimethyl aminomethylengruppe oder eine 3-Aminopropylgruppe und R ein Wasserstoffatom, ein Alkalimetallatom oder eine 1 bis 4 Kohlenstoffatome enthaltende Alkylgruppe bedeuten, mit Aus nahme des Cyanomethan-bis(phosphonsäure-diethyl-esters), sind pharmakologisch wirksame Substanzen.-
17.发明授权Phosphorhaltige Carbonsäure-Derivate, Verfahren zu deren Herstellung, sowie ihre Verwendung 失效含有磷酸的羧酸衍生物，其制备方法及其利用
公开(公告)号：EP0000061B1
公开(公告)日：1980-10-15
申请号：EP78100104.5
申请日：1978-06-06
CPC分类号： C07F9/4046 , C02F5/14 , C07F9/305 , C07F9/3235 , C07F9/3869 , C07F9/5312 , C07F9/5329 , C08K5/5393 , D06M13/288
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公开(公告)号：EP2691402A1
公开(公告)日：2014-02-05
申请号：EP12711632.5
申请日：2012-03-28
申请人： Atlanthera
发明人： EGOROV, Maxim , GOUJON, Jean-Yves , LE BOT, Ronan
IPC分类号： C07F9/38 , A61K31/662 , A61P35/00
CPC分类号： C07F9/650952 , A61K31/662 , A61K47/548 , A61K49/0052 , C07F9/3869 , C07F9/3873 , C07F9/65517 , C07F9/6552 , C07F9/65522 , C07F9/6561
摘要： The invention relates to a bifunctional hydroxy-bisphosphonic acid derivative of formula (I) or a pharmaceutically acceptable salt thereof, a method for producing the same, pharmaceutical compositions containing the same, and the use thereof as a medicament, as well as a compound of formula (II) or a pharmaceutically acceptable salt thereof, and the use thereof for producing a target molecule for therapeutic or diagnostic purposes.
摘要翻译： 本发明涉及以下式（I）的双功能羟基 - 双膦酸衍生物：其药学上可接受的盐，其制备方法，含有该化合物的药物组合物及其作为药物的用途 作为下式（II）的化合物或其药学上可接受的盐，以及其用于制备治疗或诊断目的的载体化分子的用途。
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公开(公告)号：EP2001486A2
公开(公告)日：2008-12-17
申请号：EP07758756.6
申请日：2007-03-16
IPC分类号： A61K31/663
CPC分类号： C07F9/4037 , C07F9/3843 , C07F9/3856 , C07F9/3865 , C07F9/3869 , C07F9/3873 , C07F9/4028 , C07F9/404 , C07F9/4046 , C07F9/5414 , C07F9/5728 , C07F9/581 , C07F9/65061 , C07F9/655345 , C07F9/655363 , C07F9/723
摘要： The invention provides, inter alia, novel bisphosphonate compounds and methods of making and using. In embodiments, the invention provides compounds and methods in connection with research and therapeutic applications, e.g., for tumor cell growth inhibition, activation of gammadelta T cells, inhibition of farnesyldiphosphate (FPPS) and/or undecaprenyldiphosphate synthase enzymes, bone resorption diseases, cancer, immune disorders, immunotherapy, and infectious diseases. In regards to certain embodiments, a surprising advance has been the recognition that certain structural features can significantly enhance the activity of the compounds. For example, the presence of particular cationic species e.g., phosphonium, sulfonium, and arsonium moieties can contribute to desirable functional activity when positioned near a bisphosphonate moiety. In other embodiments of non-nitrogen containing bisphosphonates, terphenyl and benzyl bisphosphonate compounds and methods are provided. Further variations are also provided.
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公开(公告)号：EP1131327B1
公开(公告)日：2003-02-19
申请号：EP99955618.6
申请日：1999-11-18
发明人： GIL, Laurent , HAN, Yongxin , RUEL, Rejean , YOUNG, Robert, N.
IPC分类号： C07F9/38 , A61K31/663
CPC分类号： C07F9/3869 , A61K47/54 , C07F9/3865
摘要： This invention relates to prostaglandin-bisphosphonate conjugates. These conjugates are effective for treating or preventing bone diseases such as osteoporosis. These conjugates simultaneously deliver a prostaglandin agent for increasing bone formation and a bisphosphonate agent for inhibiting bone resorption.
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