公开(公告)号：EP3117208A1

公开(公告)日：2017-01-18

申请号：EP15762208.5

申请日：2015-03-13

申请人： Halaka, Folim G.

发明人： Halaka, Folim G.

IPC分类号： G01N30/02 ,  G01N30/60 ,  B01J20/22 ,  B01J20/24 ,  B01J20/26 ,  B01J20/28 ,  B01J20/30

CPC分类号： B01J20/286 ,  B01J20/3204 ,  B01J20/321 ,  B01J20/3274 ,  B01J20/3282 ,  B01J2220/82 ,  B01J2220/825 ,  G01N30/52 ,  G01N30/6043 ,  G01N2030/524 ,  G01N2030/525 ,  G01N2030/527 ,  G01N2030/528

摘要： Devices and associated processes suitable for small and large scale purification of molecules in a fluid, and provides embodiments that overcome the difficulties of transitioning purification from research stages to production scale-up. The invention relates to the formation and characteristics of substantially uniform, continuous, and homogeneous porous separation matrices. The matrices are in the form of a polymeric layer with substantially uniform thickness and porosity. The polymeric layer is formed for the purpose of providing convective flow through the separation matrix.

摘要翻译： 适用于流体中分子的小型和大规​​模纯化的装置和相关方法，并且提供了克服从研究阶段向生产放大转移纯化困难的实施例。 本发明涉及基本上均匀的，连续的和均匀的多孔分离基质的形成和特征。 基质是具有基本均匀的厚度和孔隙率的聚合物层的形式。 形成聚合物层用于提供通过分离基质的对流流动。

公开(公告)号：EP2762876A4

公开(公告)日：2015-05-06

申请号：EP12835058

申请日：2012-09-26

申请人： SEKISUI MEDICAL CO LTD

发明人： OISHI KAZUYUKI

IPC分类号： G01N30/88 ,  G01N30/32 ,  G01N30/56

CPC分类号： G01N30/32 ,  G01N30/14 ,  G01N30/52 ,  G01N33/721 ,  G01N2030/328 ,  G01N2030/525 ,  G01N2030/527 ,  G01N2030/567 ,  G01N2030/8831

公开(公告)号：EP2762876A1

公开(公告)日：2014-08-06

申请号：EP12835058.4

申请日：2012-09-26

申请人： Sekisui Medical Co., Ltd.

发明人： OISHI, Kazuyuki

IPC分类号： G01N30/88 ,  G01N30/32 ,  G01N30/56

CPC分类号： G01N30/32 ,  G01N30/14 ,  G01N30/52 ,  G01N33/721 ,  G01N2030/328 ,  G01N2030/525 ,  G01N2030/527 ,  G01N2030/567 ,  G01N2030/8831

摘要： An object of the present invention is to provide a method capable of measuring stable hemoglobin A1c using liquid chromatography in a short time with good reproducibility.
The present invention is a method for measuring stable hemoglobin A1c using liquid chromatography, installing on a flow path of a liquid chromatograph a filter whose surface is treated with a solution containing 1 to 50% by weight of a silicone oil or a solution containing 1 to 50% by weight of a silicone resin,; and setting a pressure value generated in a measurement system of the liquid chromatograph to 9.8 × 10 3 Pa or more and 19.6 × 10 5 Pa or less.

摘要翻译： 本发明的一个目的是提供一种能够在短时间内以良好的再现利用液相色谱法测定稳定型血红蛋白A1c的方法。 本发明是用于利用液相色谱法测定稳定型血红蛋白A1c的方法，安装的液相色谱仪的过滤器，其表面被处理用溶液（重量）的硅油或含有1至溶液含有1至50％的流动路径上 50重量％的有机硅树脂，的; 并在液相色谱仪的测量系统所产生的压力值设定为9.8×10 3 Pa以上且19.6×10 5 Pa以下。

公开(公告)号：EP1154828A1

公开(公告)日：2001-11-21

申请号：EP00913609.4

申请日：2000-02-25

申请人： Pall Corporation

发明人： HURWITZ, Mark, F. ,  SORENSEN, Thomas ,  STREMPEL, John ,  FENDYA, Thomas

IPC分类号： B01D15/08 ,  G01N30/60 ,  B01D53/04

CPC分类号： B01D15/14 ,  B01D15/22 ,  B01D53/025 ,  G01N30/6017 ,  G01N2030/025 ,  G01N2030/527

摘要： A chromatography device includes an inlet, an outlet, a porous medium module and a flow distributor arrangement disposed in the flow path between the porous media and one of the inlet and the outlet.

公开(公告)号：EP1078254A1

公开(公告)日：2001-02-28

申请号：EP99923534.4

申请日：1999-05-05

申请人： MERCK PATENT GmbH

发明人： MÜLLER, Egbert ,  REGENER, Jürgen ,  WOLLBECK, Rudi

IPC分类号： G01N30/60 ,  B01D15/08

CPC分类号： G01N30/6073 ,  C07K1/16 ,  G01N30/6004 ,  G01N30/74 ,  G01N2030/527 ,  G01N2030/6013 ,  G01N21/33

摘要： The invention relates to miniaturized separating columns whose separating means are formed from an individual porous hollow fibrous membrane which has undergone a derivatization with separation effectors. In addition, the separating columns are provided with connections for admitting and discharging eluting agents.

公开(公告)号：EP1033572A4

公开(公告)日：2001-02-07

申请号：EP99943401

申请日：1999-09-17

申请人： EISAI CO LTD

发明人： MURATA KAORU ,  MANO NARIYASU ,  ASAKAWA NAOKI

IPC分类号： G01N30/08 ,  G01N30/20 ,  G01N30/34 ,  G01N30/46 ,  G01N30/52 ,  G01N30/60

CPC分类号： G01N30/603 ,  G01N30/468 ,  G01N30/6017 ,  G01N2030/085 ,  G01N2030/201 ,  G01N2030/347 ,  G01N2030/527

摘要： A column for concentrating a component in a sample is used for high performance liquid chromatography and comprises a membrane for diffusing an object component and a membrane for absorbing an object component. The column is useful especially for microcolumn liquid chromatography.

公开(公告)号：EP0483143B1

公开(公告)日：1994-06-01

申请号：EP89912702.1

申请日：1989-10-30

申请人： HEMASURE INC

发明人： GOFFE, Randal, A. ,  ZALE, Stephen, E. ,  O'CONNOR, James, L. ,  KESSLER, Stephen, B. ,  COHEN, Charles, M.

IPC分类号： B01D63/02 ,  B01D63/04 ,  B01D63/08

CPC分类号： B01D15/08 ,  B01D15/3804 ,  B01D61/00 ,  B01D63/02 ,  B01D63/043 ,  B01D67/0009 ,  B01D67/0093 ,  B01D69/08 ,  B01D69/085 ,  B01D69/141 ,  B01D2313/243 ,  B01D2323/38 ,  B01D2325/36 ,  B01D2325/38 ,  C07K1/22 ,  C07K14/745 ,  C07K14/755 ,  C07K14/78 ,  C07K16/00 ,  C07K16/065 ,  C07K16/36 ,  C07K16/40 ,  C07K16/44 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/50 ,  C07K2319/705 ,  C12N9/644 ,  C12Y304/21022 ,  G01N2030/527 ,  G01N2030/528

摘要： The invention relates to an apparatus useful for the separation of at least one preselected ligate present in a fluid. The invention also features an easily scaled-up membrane affinity separation process which is highly reliable, highly selective, provides a high yield of product, and is further characterized by a high volumetric throughput. The invention utilizes a substantially isotropic porous membrane, to which is associated a preselected ligand, which provides an optimum loading capacity and low dead volume while allowing high filtrate flow rates. Methods for isolating macromolecules having therapeutic value are described.

公开(公告)号：EP0588564A1

公开(公告)日：1994-03-23

申请号：EP93307141.7

申请日：1993-09-10

申请人： AMERSHAM INTERNATIONAL plc

发明人： Raybuck, Margaret Patricia ,  Kenrick, Michael Kenneth ,  Parry, David Alun

IPC分类号： B01D15/00 ,  G01N30/00 ,  G01N33/543

CPC分类号： B01L3/0275 ,  B01D15/00 ,  B01D15/3804 ,  B01J2220/54 ,  G01N1/405 ,  G01N30/48 ,  G01N30/6065 ,  G01N33/54366 ,  G01N2030/527 ,  G01N2035/0434 ,  G01N2035/1055

摘要： A device for capturing a component present in a fluid comprises a pipette tip having a rearward end 15 adapted to be fitted on a micro-pipette, and a forward end 12 with a membrane 17, adapted to bind the component, extending across the pipette tip.

摘要翻译： 用于捕获存在于流体中的组分的装置包括移液管末端，其具有适于装配在微量移液管上的后端15，以及具有膜17的前端12，其适于粘合部件，延伸穿过移液管尖端 。

公开(公告)号：EP0289755B1

公开(公告)日：1991-09-04

申请号：EP88104232.9

申请日：1988-03-17

申请人： GEBRÜDER SULZER AKTIENGESELLSCHAFT

发明人： Brändli, Ernst, Dr.

IPC分类号： B01D15/08 ,  G01N30/56

CPC分类号： G01N30/56 ,  B01D15/1871 ,  G01N30/38 ,  G01N30/6069 ,  G01N2030/527 ,  G01N2030/8881

公开(公告)号：EP0483143A4

公开(公告)日：1991-07-24

申请号：EP89912702

申请日：1989-10-30

申请人： SEPRACOR INC

发明人： GOFFE RANDAL A ,  ZALE STEPHEN E ,  O'CONNOR JAMES L ,  KESSLER STEPHEN B ,  COHEN CHARLES M

IPC分类号： B01D15/08 ,  B01D61/00 ,  B01D63/02 ,  B01D63/04 ,  B01D63/08 ,  B01D67/00 ,  B01D69/08 ,  B01D69/14 ,  B01J16/00 ,  C07K1/00 ,  C07K1/22 ,  C07K14/745 ,  C07K14/755 ,  C07K14/78 ,  C07K16/00 ,  C07K16/06 ,  C07K16/36 ,  C07K16/40 ,  C12N9/64 ,  D01D5/24 ,  G01N30/52

CPC分类号： B01D15/08 ,  B01D15/3804 ,  B01D61/00 ,  B01D63/02 ,  B01D63/043 ,  B01D67/0009 ,  B01D67/0093 ,  B01D69/08 ,  B01D69/085 ,  B01D69/141 ,  B01D2313/243 ,  B01D2323/38 ,  B01D2325/36 ,  B01D2325/38 ,  C07K1/22 ,  C07K14/745 ,  C07K14/755 ,  C07K14/78 ,  C07K16/00 ,  C07K16/065 ,  C07K16/36 ,  C07K16/40 ,  C07K16/44 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/50 ,  C07K2319/705 ,  C12N9/644 ,  C12Y304/21022 ,  G01N2030/527 ,  G01N2030/528

摘要： The invention relates to an apparatus useful for the separation of at least one preselected ligate present in a fluid. The invention also features an easily scaled-up membrane affinity separation process which is highly reliable, highly selective, provides a high yield of product, and is further characterized by a high volumetric throughput. The invention utilizes a substantially isotropic porous membrane, to which is associated a preselected ligand, which provides an optimum loading capacity and low dead volume while allowing high filtrate flow rates. Methods for isolating macromolecules having therapeutic value are described.