公开(公告)号：EP2375273A1

公开(公告)日：2011-10-12

申请号：EP11156504.0

申请日：2011-03-02

Applicant: Leica Microsystems CMS GmbH

Inventor： Knebel, Werner

IPC: G02B21/00 ,  G01N21/64

CPC classification number: G01N21/6458 ,  G01N21/6452 ,  G01N2021/6463 ,  G01N2201/0833 ,  G02B21/16

Abstract: Ein Fluoreszenzmikroskop (20) zum Untersuchen mindestens einer Probe (42) umfasst eine Lichtquelle (22), die Anregungslicht (24) erzeugt, mehrere Detektorelemente zur Detektion von Fluoreszenzlicht (44) und mehrere Lichtleiter (41), die das Anregungslicht (24) als Teilstrahlen (30) zu der Probe (42) leiten. Das Anregungslicht (24) regt Farbstoffpartikel der Probe (42) zum Fluoreszieren an. Die Lichtleiter (41) leiten von der Probe (42) emittiertes Fluoreszenzlicht zu den Detektorelementen. Eine Fokussieroptik ist in Richtung der Teilstrahlen (30) zwischen den Lichtleitern (41) und der Probe (42) angeordnet. Jedem Lichtleiter (41) ist mindestens ein Detektorelement zugeordnet.

Abstract translation: 显微镜（20）具有光源（22） 用于产生激发光（24）的LED阵列和用于检测荧光的检测器元件。 光纤将激发光引导到样品（42）作为部分光束（30），并将样品发射的荧光引导到检测器元件。 在光纤和样品之间的部分光束的方向上布置聚焦透镜，其中光纤附着到检测器元件。 透镜具有用于将部分光束耦合到光纤的微透镜系统（36）。 对于通过使用荧光显微镜检查样品的方法，还包括独立权利要求。

公开(公告)号：EP2021777A2

公开(公告)日：2009-02-11

申请号：EP07761766.0

申请日：2007-05-02

Applicant: Ocela Technologies

Inventor： HEANUE, John F. ,  HEANUE, Joseph A. ,  WILFLEY, Brian P. ,  LOWELL, Augustus P.

IPC: G01N21/76

CPC classification number: G01N21/6408 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/415 ,  A61B5/418 ,  A61B5/6848 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/10 ,  G01J3/2823 ,  G01J3/4406 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: A system and method for measuring fluorescence lifetimes utilizing a light source modulated with a code sequence to interrogate a sample of interest. The system is useful for studying the interaction of chemicals, biomolecules, and other substances. The fluorescence lifetime is used as an indicator of chemical binding and chemical environment. A system and method for measuring photons. The system produces an estimate of the distribution of flight times for photons traveling from the source to the detector. A system and method for optical lymph node mapping. A correlation of a photo-detector signal and a digital code sequence, used to modulated light signal, is calculated to produce an estimate of the distribution of flight times for photons traveling from a given source to a given detector. These distributions are used along with the measured amplitudes to reconstruct a map of contrast agent location within the tissue.

公开(公告)号：EP1999444A1

公开(公告)日：2008-12-10

申请号：EP07771726.2

申请日：2007-03-02

Applicant: Chemimage Corporation

Inventor： NELSON, Matthew, P. ,  TREADO, Patrick, J.

IPC: G01J3/44

CPC classification number: G01J3/2803 ,  G01J3/0221 ,  G01J3/44 ,  G01N21/474 ,  G01N21/55 ,  G01N21/645 ,  G01N21/6456 ,  G01N21/65 ,  G01N2021/6423 ,  G01N2021/6484 ,  G01N2201/0833 ,  G01N2201/0846 ,  G02B6/06

Abstract: The disclosure relates generally to methods and apparatus for using a fiber array spectral translator-based ('FAST') spectroscopic system for improved imaging, spectral analysis, and interactive probing of a sample. In an embodiment, the confocality of a fiber array spectral translator-based spectroscopic system is improved through the use of structured illumination and/or structured collection of photons. User input may be received and acted upon to allow a user to interactively in real time and/or near real time view and analyze specific regions of the sample.

公开(公告)号：EP1775577A1

公开(公告)日：2007-04-18

申请号：EP06021069.7

申请日：2006-10-06

Applicant: Taiwan Unison Biotech Inc.

Inventor： Yao, Wen Fa ,  Liu, Yung Chuan ,  Wang, Chih Ming ,  Lo, Shih Yang ,  Lin, Hsiu Min ,  Hsiung, Kuang Pin

IPC: G01N21/78 ,  G01N21/86 ,  G01N33/551

CPC classification number: G01N21/8483 ,  G01N21/274 ,  G01N21/78 ,  G01N2021/6419 ,  G01N2021/6441 ,  G01N2021/8645 ,  G01N2021/8654 ,  G01N2201/0221 ,  G01N2201/0626 ,  G01N2201/0627 ,  G01N2201/064 ,  G01N2201/0833

Abstract: A portable, scanning and analyzing apparatus (100) that uses an integrated scan probe for the scanning operation is described. The integrated scanning probe is formed with a light emitting diode array light source and a photodiode detector array. After a test sample finishes the reaction in test strip paper, a scanner device (110) scans the test paper to collect the optical signals at variable, consecutive intervals along the scanning path to obtain the test signal accordingly. Then, the scanner device (110) outputs the test signal (16) for amplification. The amplified test signals are sent to an analog/digital converter (140) such that the amplified test signals are converted into digital signals, which are then output to a computing unit (170) for analyzing for subjective analytical results. The computing unit (170) couples with the controller device (160), wherein the controller device (160) controls a driver device (130) that drives the scanner device (110) to perform the scanning operation on the test paper.

Abstract translation: 描述了使用集成扫描探针进行扫描操作的便携式扫描和分析装置（100）。 集成扫描探针由发光二极管阵列光源和光电二极管检测器阵列形成。 在测试样品在测试条纸中完成反应之后，扫描仪装置（110）扫描测试纸以沿着扫描路径以可变的连续间隔收集光学信号，从而相应地获得测试信号。 然后，扫描器装置（110）输出用于放大的测试信号（16）。 放大的测试信号被发送到模拟/数字转换器（140），使得放大的测试信号被转换成数字信号，然后输出到计算单元（170）以分析主观分析结果。 计算单元（170）与控制器设备（160）耦合，其中控制器设备（160）控制驱动扫描仪设备（110）以对测试纸执行扫描操作的驱动器设备（130）。

公开(公告)号：EP1659391A2

公开(公告)日：2006-05-24

申请号：EP05380243.5

申请日：2005-10-31

Applicant: Grifols, S.A.

Inventor： Pagés Pinyol, Josep

IPC: G01N21/03 ,  G01N21/27 ,  G01J3/28

CPC classification number: G01J3/02 ,  G01J3/0213 ,  G01J3/0218 ,  G01J3/12 ,  G01J3/2803 ,  G01N21/03 ,  G01N21/13 ,  G01N21/253 ,  G01N21/272 ,  G01N21/274 ,  G01N2201/0461 ,  G01N2201/082 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: The apparatus comprises a receiving body (1) for receiving the reaction containers (3) carrying the samples to be analyzed, with means (4,4',4'',5,5',5'',6,6') for causing each of the reaction containers to be passed through by a luminous signal of controlled wavelength, having means for conducting it to a scanning head where the luminous signals are picked up by a single CCD sensor (12), constituting a digital processing system for evaluating the absorbency of the corresponding sample.

Abstract translation: 所述装置包括：接收体（1），用于接收反应容器（3）承载所述样本以进行分析，有装置（4,4“ 4' ，5,5”，5' ”，6.6' ） 用于使每个反应容器要通过控制波长的发光信号通过的，具有用于将其导通的扫描头，其中发光信号由单个CCD传感器（12）拾取，构成数字处理系统，用于 评估样本对应的一种吸收性。

公开(公告)号：EP1348120B1

公开(公告)日：2006-03-08

申请号：EP01272703.8

申请日：2001-12-18

Applicant: Packard Instrument Company, Inc.

Inventor： RUSHBROOKE, John, Gordon ,  HOOPER, Claire, Elizabeth

IPC: G01N21/64

CPC classification number: G01N21/6452 ,  G01N21/6456 ,  G01N21/76 ,  G01N2021/6484 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: A fibre optic epi-fluorescence imaging system in which the optical fibres are rearranged so that the system can be used for measuring luminescence samples. The system comprises at least two optical fibres (32, 46) or bundles of fibres which lead to a CCD camera (74), the fibres or bundles of fibres from all samples being arranged in two sets, a first set which are formed from a non-fluorescing material and a second set which are formed from a material which may fluoresce but enables the fibres formed therefrom to have a higher numerical aperature than those of the first set.

公开(公告)号：EP1431750A2

公开(公告)日：2004-06-23

申请号：EP03078526.5

申请日：2001-12-18

Applicant: Packard Instrument Company, Inc.

Inventor： Rushbrooke, John Gordon ,  Hooper, Claire Elizabeth

IPC: G01N21/64

CPC classification number: G01N21/6452 ,  G01N21/6456 ,  G01N21/76 ,  G01N2021/6484 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: A fibre optic epi-fluorescence imaging system in which the optical fibres are rearranged so that the system can be used for measuring luminescence samples.

Abstract translation: 光纤外延荧光成像系统，其中光纤被重新排列，使得该系统可用于测量发光样品。

公开(公告)号：EP0411042B1

公开(公告)日：1996-09-04

申请号：EP89905570.1

申请日：1989-04-28

Applicant: IGEN, INC.

Inventor： LEVENTIS, Nicholas ,  MORRIS, Susan, E.

IPC: G01N21/76

CPC classification number: G01N27/305 ,  G01N21/05 ,  G01N21/76 ,  G01N2201/0833

Abstract: An apparatus for conducting two or more simultaneous measurements of electrochemiluminescent (ECL) phenomena includes a cell (12'')in which a sample including an ECL moiety may be induced to repeatedly emit light in response to electrochemical energy applied, by, for example, a working voltametric electrode (44, 44'). Two or more light detectors, such as, photomultiplier tubes (12'', 16'') receive the emitted light at respective wavelengths which are indicative of respective analytes of interest in the sample.

公开(公告)号：EP0452403A4

公开(公告)日：1992-06-17

申请号：EP90902079

申请日：1989-12-26

Applicant: GUIDED WAVE, INC.

Inventor： LEFEBRE, DAVID, A.

IPC: G01J1/18 ,  G01J3/06 ,  G01J3/08 ,  G01J3/42 ,  G01J3/433

CPC classification number: G01J3/08 ,  G01J3/42 ,  G01J2001/182 ,  G01J2003/068 ,  G01N2201/04 ,  G01N2201/0833

公开(公告)号：EP0452403A1

公开(公告)日：1991-10-23

申请号：EP90902079.0

申请日：1989-12-26

Applicant: GUIDED WAVE, INC.

Inventor： LEFEBRE, David, A.

IPC: G01J3 ,  G01J1

CPC classification number: G01J3/08 ,  G01J3/42 ,  G01J2001/182 ,  G01J2003/068 ,  G01N2201/04 ,  G01N2201/0833

Abstract: Procédé et appareil spectrophotométrique approprié à une utilisation continue et à long terme. L'appareil comprend un monochromateur (13) envoyant une lumière monochromatique prédispersée aux entrées optiques d'une paire de câbles à fibre optique (34-37) et un dispositif de translation (43) pour positionner alternativement les câbles à fibre optique (34-37) au même emplacement par rapport à la sortie du monochromateur. L'un des câbles (61) conduit la lumière vers un échantillon à analyser tandis que l'autre câble (35b) établit une référence pour des mesures d'intensité de lumière. La méthode consiste à effectuer deux balayages avec la sortie du monochromateur pour chaque mesure sur l'échantillon. Les câbles à fibre optique sont déplacés entre les balayages de sorte que le câble utilisé dans le dernier balayage occupe la première position du câble utilisé dans le balayage antérieur.