公开(公告)号：EP3377865A1

公开(公告)日：2018-09-26

申请号：EP16867078.4

申请日：2016-11-16

Applicant: ChemImage Corporation

Inventor： TREADO, Patrick ,  STEWART, Shona ,  SMITH, Aaron ,  GOMER, Heather

IPC: G01J3/44 ,  A61B6/00 ,  G01N21/17 ,  G01N21/65 ,  G01N33/53

CPC classification number: G01N21/65 ,  G01J3/0218 ,  G01J3/0291 ,  G01J3/2823 ,  G01J3/44 ,  G01N21/17 ,  G01N33/53 ,  G01N2201/0833 ,  G01N2800/50 ,  G01N2800/52 ,  G01N2800/56 ,  G01N2800/60 ,  G16H50/20

Abstract: This disclosure is directed to systems and methods for fusing Raman data with biomarker data to identify a disease and/or the progression of the disease. The system disclosed herein may include an illumination source for generating interacted photons from a biological sample and a detector for detecting the interacted photons to generate a Raman data set. A processor is included to fuse the Raman data set with a biomarker data set to identify a disease and/or a disease progression. The instant disclosure further includes a method comprising illuminating a biological sample to generate interacted photons, and detecting the interacted photons to generate a Raman data set. A biomarker data set is obtained from the biological sample, and the Raman data set is fused with the biomarker data set to generate an index score. The index score correlates with one or more of a disease and a disease progression.

公开(公告)号：EP3237944A1

公开(公告)日：2017-11-01

申请号：EP15873925.0

申请日：2015-11-18

Applicant: Zolo Technologies, Inc.

Inventor： SAPPEY, Andrew D. ,  MASTERSON, Bernard Patrick

IPC: G02B6/00

CPC classification number: G01N21/39 ,  B01D53/30 ,  F23N5/00 ,  G01N2021/399 ,  G01N2201/0833 ,  G02B6/04 ,  G02B6/3598 ,  G02B6/3624 ,  G02B6/3672 ,  G02B6/40 ,  G02B6/4292

Abstract: A system for widely spaced wavelength tunable diode laser absorption spectroscopy includes at least a first and second tunable diode laser generating laser light at a first and second wavelength, wherein laser light of the first and second wavelengths cannot co-propagate efficiently on the same single-mode fiber. A first fiber may be configured to carry light in the first wavelength, and a second fiber configured to carry light in the second wavelength. A fiber bundle may be formed from the distal ends of the first and second fibers stripped of their respective coatings, and arranged with their claddings adjacent to each other. One or more pitch heads are configured to project respective beams of laser light from the fiber bundle through a measurement zone. One or more catch heads located across the measurement zone receive the respective beams and direct the respective beams onto at least one sensor.

Abstract translation: 用于宽间隔波长可调谐二极管激光吸收光谱的系统包括至少第一和第二可调谐二极管激光器，其产生第一和第二波长的激光，其中第一和第二波长的激光不能有效地在同一个单一波长上共同传播， 模式光纤。 第一光纤可以被配置为承载第一波长的光，而第二光纤被配置成承载第二波长的光。 纤维束可以由剥离其各自涂层的第一和第二纤维的远端形成，并且它们的包层彼此相邻布置。 一个或多个俯仰头被配置为将来自光纤束的相应激光束投射通过测量区域。 位于测量区域上的一个或多个抓取头接收相应的射束并将相应的射束引导到至少一个传感器上。

公开(公告)号：EP3136086A1

公开(公告)日：2017-03-01

申请号：EP16180465.3

申请日：2016-07-21

Applicant: Otsuka Electronics Co., Ltd.

Inventor： SHIRAIWA, Hisashi

IPC: G01N21/64 ,  G02B21/00 ,  G01N21/65 ,  G01J3/02 ,  G01J3/44

CPC classification number: G01J3/28 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/18 ,  G01J3/2803 ,  G01J3/44 ,  G01J3/4406 ,  G01N21/6452 ,  G01N21/6458 ,  G01N21/65 ,  G01N2021/6484 ,  G01N2201/0833 ,  G01N2201/0846 ,  G02B21/0032 ,  G02B21/004 ,  G02B21/0064

Abstract: A microspectroscope (101) includes: a light source (11, 17); a plurality of light projecting optical fibers (12) that receive light from the light source (11, 17); a spectroscope (1); a plurality of light receiving optical fibers (22) for guiding received light to the spectroscope (1); and a confocal optical system (5) for causing each of a plurality of beams from the plurality of light projecting optical fibers (12) to be condensed and irradiated onto a sample, and forming images of a plurality of beams from a plurality of condensing points on the sample, respectively on the plurality of light receiving optical fibers (22).

Abstract translation: 显微光谱仪（101）包括：光源（11,17）; 多个从所述光源（11,17）接收光的投光光纤（12）; 分光仪（1）; 多个光接收光纤（22），用于将接收的光引导到所述分光器（1）; 以及共焦光学系统（5），用于使来自所述多个投光光纤（12）的多个光束中的每一个被聚集并照射到样本上，并且从多个聚光点形成多个光束的图像 分别在多个受光光纤（22）上。

公开(公告)号：EP3091351A1

公开(公告)日：2016-11-09

申请号：EP16154743.5

申请日：2016-02-08

Applicant: Honeywell International Inc.

Inventor： JUNGWIRTH, Matthew Edward Lewis ,  GOEDERS, James E. ,  FRITZ, Bernard S. ,  OHNSTEIN, Thomas R. ,  FREDRICK, Kris ,  YOUNGNER, Daniel

IPC: G01N21/64 ,  G02B6/36

CPC classification number: G01N21/645 ,  G01N2021/6478 ,  G01N2021/6484 ,  G01N2201/0639 ,  G01N2201/0826 ,  G01N2201/0833 ,  G02B6/3644 ,  G02B6/3672

Abstract: An apparatus (100) and method for an alignment cell (108) are described herein. One apparatus includes a delivery fiber (112, 212, 312) and a delivery lens (232, 332) coupled to an optical bench (104), a mirror (234, 334) to receive light from the delivery fiber (112, 212, 312) through the delivery lens (232, 332) , wherein the received light is directed by the mirror (234, 334) to an ion trap (236, 336) on the trap surface, and a collection fiber (116, 216, 316) coupled to the optical bench (104) to receive light fluoresced from an ion in the ion trap (236, 336).

Abstract translation: 本文描述了用于对准单元（108）的装置（100）和方法。 一种装置包括传送光纤（112,212,312）和耦合到光学平台（104）的传送透镜（232,332），反射镜（234,334），用于接收来自传送光纤（112,212,312）的光， 312）通过传送透镜（232,332），其中所接收的光被反射镜（234,334）引导到捕获表面上的离子阱（236,336），以及收集光纤（116,216,316） ）耦合到光学台（104）以接收从离子阱（236,336）中的离子发出的光。

公开(公告)号：EP3084306A1

公开(公告)日：2016-10-26

申请号：EP14872360.4

申请日：2014-12-22

Applicant: Zolo Technologies, Inc.

Inventor： MASTERSON, Bernard P. ,  ESTES, Michael John ,  SAPPEY, AndrewD.

IPC: F23N5/08

CPC classification number: F23N5/082 ,  F23M11/042 ,  F23N5/24 ,  F23N2031/00 ,  G01N21/15 ,  G01N21/39 ,  G01N21/716 ,  G01N2021/151 ,  G01N2021/152 ,  G01N2021/399 ,  G01N2021/8416 ,  G01N2201/066 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: A method of monitoring blockage of a sight tube attached to a wall of a process chamber, the sight tube being operatively associated with a TDLAS optical head with a window between the sight tube and the TDLAS optical head. The method includes the steps of providing a photo sensor in the TDLAS optical head, the photo sensor being positioned to receive light emitted by a light emitting process within the process chamber. An emission signal produced by light emitted by the light emitting process within the process chamber being received by the photo sensor is monitored. A determination is made if the emission signal is degrading.

公开(公告)号：EP2904380A1

公开(公告)日：2015-08-12

申请号：EP13848232.8

申请日：2013-10-25

Applicant: COLORADO STATE UNIVERSITY RESEARCH FOUNDATION

Inventor： LEAR, Kevin ,  ERICKSON, Timothy

IPC: G01N21/41 ,  H01L27/14

CPC classification number: G01N21/4133 ,  G01N21/7703 ,  G01N2021/7793 ,  G01N2201/0833 ,  H01L31/105 ,  H01L31/1085

Abstract: An analyte-detection system has an optical waveguide with first and second cladding layers adjacent a core; a light source coupled to provide light to the waveguide; a photodetector such as a metal- semiconductor- metal, vertical PIN, or horizontal PIN photodetectors, the photodetector having an absorber configured to detect light escaping from the waveguide through the first cladding layer; multiple, separate, photocurrent collectors, where each photocurrent collector collects current from a separate portion of the photodetector absorber; and at least one current-sensing amplifier for receiving photocurrent. The photodetector absorber is an undivided absorber region for multiple photocurrent collectors. Either separate amplifiers are provided for each of the multiple photocurrent collection lines, or multiplexing logic couples selected photocurrent collectors to amplifiers, while coupling unselected photocurrent collectors to a bias generator.

Abstract translation: 分析物检测系统具有光波导，其中第一和第二包覆层与芯相邻; 耦合以向所述波导提供光的光源; 诸如金属 - 半导体 - 金属，垂直PIN或水平PIN光电检测器的光电检测器，所述光电检测器具有被配置为检测从所述波导通过所述第一包层逸出的光的吸收体; 多个独立的光电流集电器，其中每个光电流集电器从光电检测器吸收器的分开的部分收集电流; 以及用于接收光电流的至少一个电流感测放大器。 光电检测器吸收器是用于多个光电流收集器的不分开的吸收区域。 为多个光电流收集线中的每一个提供单独的放大器，或者将选择的光电流收集器耦合到放大器，同时将未选择的光电流收集器耦合到偏置发生器。

公开(公告)号：EP2893320A2

公开(公告)日：2015-07-15

申请号：EP13830276.5

申请日：2013-08-06

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： COHEN, Beri

IPC: G01N21/05

CPC classification number: G01N21/76 ,  G01N21/253 ,  G01N33/5302 ,  G01N2201/0221 ,  G01N2201/064 ,  G01N2201/08 ,  G01N2201/0833 ,  G01N2201/084

Abstract: A clam-shell luminometer that, when closed, completely encloses an assay reaction mixture-containing reaction vessel and some portion of a reaction carousel or ring. The luminometer includes first and second portions that are coupled to each other, a photomultiplier tube, and plural fiber optic bundles that are optically coupled to the photomultiplier tube. First ends of the fiber optic bundles are disposed adjacent to the reaction vessel in the second portion so that the fiber optic bundles completely surround the perimeter or periphery of the reaction vessel.

Abstract translation: 蛤壳式发光计，当关闭时，完全包含含有测定反应混合物的反应容器和一部分反应转盘或环。 光度计包括彼此耦合的第一和第二部分，光电倍增管和光学耦合到光电倍增管的多个光纤束。 光纤束的第一端与第二部分中的反应容器相邻设置，使得光纤束完全包围反应容器的周边或周边。

公开(公告)号：EP2491366A4

公开(公告)日：2014-04-09

申请号：EP10825529

申请日：2010-10-19

Applicant: UNIV CALIFORNIA

Inventor： OZCAN AYDOGAN ,  ISIKMAN SERHAN OMER ,  OZTOPRAK CHETIN

IPC: G01N1/28

CPC classification number: G03H1/06 ,  G01N15/1475 ,  G01N15/1484 ,  G01N21/6456 ,  G01N2015/1006 ,  G01N2015/1454 ,  G01N2021/6471 ,  G01N2021/6482 ,  G01N2021/6484 ,  G01N2201/0833 ,  G03H1/041 ,  G03H1/0443 ,  G03H1/0866 ,  G03H2001/0447 ,  G03H2001/0454 ,  G03H2001/0816 ,  G03H2001/0825 ,  G03H2001/2284 ,  G03H2222/13 ,  G03H2222/22 ,  G03H2222/24 ,  G03H2222/34 ,  G03H2223/18 ,  G03H2226/11 ,  G03H2227/02 ,  G03H2240/62

公开(公告)号：EP2584344A2

公开(公告)日：2013-04-24

申请号：EP13151696.5

申请日：2010-01-08

Applicant: IT-IS International Limited

Inventor： HOWELL, James Richard ,  WEBSTER, Benjamin Masterman ,  CLARK, Mark Quentin ,  HOWELL, Richard Alfred

IPC: G01N21/64 ,  G01N21/25

CPC classification number: B01J19/0046 ,  G01N21/253 ,  G01N21/6452 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: An apparatus for detecting spectra in light emanating from chemical or biochemical reactions occurring in at least one reaction vessel (3) of a plurality of reaction vessels is disclosed. Each reaction vessel (3) has a receptacle portion having an emitting area from which light can emanate. The apparatus may include a masking element (5) having an array of apertures (6) through which light from each reaction vessel (3) can escape. A plurality of light waveguides (7) are arranged to guide light from the apertures (6) in the masking element (5) to a light detecting device (10) for detecting the spectra of light substantially simultaneously. One or more further light waveguides (31) may be provided for each reaction vessel (3) for directing excitation light from one or more excitation light sources (32, 33) to the reaction vessels (3).

Abstract translation: 公开了一种用于检测在多个反应容器（3）中发生的化学或生物化学反应产生的光中的光谱的装置。 每个反应容器（3）具有容纳部分，该容器部分具有能够发出光的发射区域。 该装置可以包括具有孔阵列（6）的掩模元件（5），来自每个反应容器（3）的光可通过该孔排出。 多个光波导（7）布置成将来自掩模元件（5）中的孔（6）的光引导到光检测装置（10），用于基本上同时检测光的光谱。 可以为每个反应容器（3）提供一个或多个另外的光波导（31），用于将来自一个或多个激发光源（32,33）的激发光引导到反应容器（3）。

公开(公告)号：EP2385362A1

公开(公告)日：2011-11-09

申请号：EP10192451.2

申请日：2010-11-24

Applicant: Brightview Systems Ltd.

Inventor： Finarov, Moshe

IPC: G01N21/65

CPC classification number: G01B11/06 ,  G01B11/0625 ,  G01N21/31 ,  G01N21/6489 ,  G01N21/65 ,  G01N21/8422 ,  G01N21/8901 ,  G01N2021/3568 ,  G01N2021/8908 ,  G01N2201/0826 ,  G01N2201/0833 ,  G01N2201/1085

Abstract: Photovoltaic thin film quality control is obtained where the thin film is supported by a support and a section of the film is illuminated by a polychromatic or monochromatic illumination source. The source forms on the thin film an illuminated line. The light collected from discrete sampled points located on the illuminated line is transferred to a photo-sensitive sensor through an optical switch. The spectral signal of the light reflected, transmitted or scattered by the sampled points is collected by the sensor, processed and photovoltaic thin film parameters applicable to the quality control are derived e.g. thin film thickness, index of refraction, extinction coefficient, absorption coefficient, energy gap, conductivity, crystallinity, surface roughness, crystal phase, material composition and photoluminescence spectrum and intensity. Manufacturing equipment parameters influencing the material properties may be changed to provide a uniform thin film layer with pre-defined properties.

Abstract translation: 获得光电薄膜质量控制，其中薄膜由支撑体支撑并且膜的一部分被多色或单色照明源照射。 源在薄膜上形成一条照明线。 从位于照明线上的离散采样点收集的光通过光学开关转移到光敏传感器。 由采样点反射，传播或散射的光的光谱信号由传感器收集，处理和适用于质量控制的光伏薄膜参数例如被导出。 薄膜厚度，折射率，消光系数，吸收系数，能隙，导电率，结晶度，表面粗糙度，结晶相，材料组成和光致发光光谱和强度。 可以改变影响材料性能的制造设备参数，以提供具有预定特性的均匀薄膜层。