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公开(公告)号：EP4347558A1
公开(公告)日：2024-04-10
申请号：EP22732146.0
申请日：2022-06-03
发明人： PERICOLLE, Vincent , VANHERCK, Jean-Christophe , MARCHAND, Arnaud Didier Marie , DUVEY, Guillaume Albert Jacques , PINTO, Rui Miguel Garcia Costa
IPC分类号： C07D207/36 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/06 , C07D417/04 , A61K31/40 , A61K31/4439 , A61P25/00
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公开(公告)号：EP4298908A3
公开(公告)日：2024-03-20
申请号：EP23204176.4
申请日：2018-03-26
发明人： HARSCHNECK, Tobias , ARLT, Alexander , VELTEN, Robert , MAUE, Michael , ILG, Kerstin , HALLENBACH, Werner , GÖRGENS, Ulrich , HORSTMANN, Sebastian , LÖSEL, Peter , TURBERG, Andreas
IPC分类号： C07D417/04 , C07D403/04 , C07D409/04 , A01N43/56 , A01N43/78
摘要： Die Erfindung umfasst unter anderem Verbindungen der allgemeinen Formel (I). Ferner werden Verfahren zur Herstellung der Verbindungen der Formel (I) beschrieben. Die erfindungsgemäßen Verbindungen eignen sich insbesondere zur Bekämpfung von Insekten, Spinnentieren und Nematoden in der Landwirtschaft sowie von Ektoparasiten in der Veterinärmedizin.
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13.发明公开
公开(公告)号：EP4313971A1
公开(公告)日：2024-02-07
申请号：EP22716947.1
申请日：2022-03-22
IPC分类号： C07D403/04 , C07D417/04 , C07D471/04 , A61P35/00 , A61K31/4155 , A61K31/427 , A61K31/437 , A61K31/506
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公开(公告)号：EP4298093A1
公开(公告)日：2024-01-03
申请号：EP22758892.8
申请日：2022-02-23
IPC分类号： C07D405/04 , C07D405/14 , C07D409/04 , C07D403/04 , C07D417/04 , C07D413/04 , C07D401/14 , A61K31/4164 , A61P35/00
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公开(公告)号：EP3212636B1
公开(公告)日：2023-11-29
申请号：EP15785140.3
申请日：2015-10-28
发明人： AEBI, Johannes , AMREIN, Kurt , HORNSPERGER, Benoit , KUHN, Bernd , LI, Dongbo , LIU, Yongfu , MAERKI, Hans P. , MARTIN, Rainer E. , MAYWEG, Alexander V. , TAN, Xuefei , WANG, Lisha , WU, Jun
IPC分类号： C07D403/12 , C07D401/14 , C07D405/14 , C07D231/18 , C07D401/04 , C07D401/12 , C07D405/04 , C07D413/12 , C07D417/04 , A61K31/4155 , A61P13/12 , A61P9/00
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公开(公告)号：EP4269392A1
公开(公告)日：2023-11-01
申请号：EP21911025.1
申请日：2021-12-24
发明人： ASABA, Ken Nunettsu , TAKAHASHI,Takehiro , YAMAMOTO, Masashi , TAKAGAKI, Kozue , NOGAMI, Marina , TSUJI, Riichiro , MEGURO, Hiroyuki , UKEGAWA, Naoya
IPC分类号： C07D215/04 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61P25/00 , A61P25/28 , A61P43/00 , C07D215/12 , C07D215/14 , C07D215/18 , C07D215/20 , C07D215/227 , C07D215/38 , C07D215/48 , C07D401/04 , C07D401/06 , C07D405/04 , C07D413/04 , C07D417/04
摘要： The purpose of the present invention is to provide a compound having a tetrahydroquinoline skeleton, the compound having inhibitory action against ferroptosis, and exerting therapeutic or preventive effect on diseases, disorders or syndromes related to ferroptosis inhibition, such as multiple sclerosis. The present invention provides a tetrahydroquinoline derivative represented by the following formula or a pharmaceutically acceptable salt thereof.
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公开(公告)号：EP3878841B1
公开(公告)日：2023-10-18
申请号：EP18938587.5
申请日：2018-11-12
发明人： LIU, Jing , LIU, Qingsong , LIU, Xuesong , WANG, Beilei , CHEN, Cheng , QI, Ziping , WANG, Wenchao , WANG, Junjie , JIANG, Zongru , WANG, Wenliang , QI, Shuang , WANG, Li
IPC分类号： C07D417/04 , C07D417/14 , A61P35/00 , A61P1/00 , A61P19/02 , A61K31/427 , A61K31/496 , A61K31/4439 , A61K31/444
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公开(公告)号：EP3860975B1
公开(公告)日：2023-10-18
申请号：EP19787545.3
申请日：2019-09-30
发明人： METCALF, Brian W. , LI, Zhe , XU, Qing , DUFU, Kobina N. , PARTRIDGE, James , SHAM, Hing , YU, Ming
IPC分类号： C07D207/08 , C07D207/26 , C07D211/22 , C07D211/76 , C07D213/48 , C07D223/04 , C07D265/30 , C07D279/12 , C07D307/46 , C07D401/04 , C07D401/06 , C07D405/04 , C07D405/12 , C07D413/04 , C07D417/04 , A61P7/06 , A61K31/40
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公开(公告)号：EP3601279B1
公开(公告)日：2023-10-18
申请号：EP18711973.0
申请日：2018-03-26
发明人： HARSCHNECK, Tobias , ARLT, Alexander , VELTEN, Robert , MAUE, Michael , ILG, Kerstin , HALLENBACH, Werner , GÖRGENS, Ulrich , HORSTMANN, Sebastian , LÖSEL, Peter , TURBERG, Andreas
IPC分类号： C07D417/04 , C07D403/04 , C07D409/04 , A01N43/56 , A01N43/78
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公开(公告)号：EP4253374A1
公开(公告)日：2023-10-04
申请号：EP21897208.1
申请日：2021-11-29
发明人： LV, Binhua , CUI, Dawei , LIU, Lianjun , PANG, Xudong , CHAI, Chuanke
IPC分类号： C07D401/14 , C07D417/04 , A61K31/501 , A61P35/00
摘要： The present invention relates to a deuterated 3-oxo-2,3-dihydropyridazine-4-carboxamide inhibitor, a preparation method therefor, and an application thereof. Specifically, the compound of the present invention has the structure shown in formula (I); also disclosed in the present invention are a preparation method for said compound and the use thereof as an AhR inhibitor; the compound of the present invention has a good selective inhibitory effect on AhR, and has better pharmacodynamics, pharmacokinetic properties, and lower toxic and side effects.
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