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    POTASSIUM-BINDING AGENTS FOR TREATING HYPERTENSION AND HYPERKALEMIA
    13.
    发明公开
    POTASSIUM-BINDING AGENTS FOR TREATING HYPERTENSION AND HYPERKALEMIA 审中-公开
    钾结合剂高血压和高血钾症的治疗

    公开(公告)号：EP2916851A2

    公开(公告)日：2015-09-16

    申请号：EP13779499.6

    申请日：2013-10-08

    申请人： Relypsa, Inc.

    发明人： KLAERNER, Gerrit ,  BERMAN, Lance

    IPC分类号： A61K31/78 ,  A61K31/7004 ,  A61K33/06 ,  A61P9/12 ,  A61P13/12

    CPC分类号： A61K31/78 ,  A61K9/14 ,  A61K31/7004 ,  A61K33/06 ,  A61K33/24 ,  B01J39/20

    摘要： The present invention generally relates to methods of treating hypertension (HTN) in patients in need thereof wherein the patient optionally further suffers from chronic kidney disease (CKD) or Type II diabetes mellitus (T2DM). The invention also relates to methods of treating hyperkalemia in a patient in need thereof, wherein the patient suffers from CKD, T2DM or HTN and are optionally being treated with an effective amount of a renin-angiotensin-aldosterone system (RAAS) agent. The invention also relates to methods of treating kidney disease in a patient in need thereof, wherein the patient is optionally being treated with an effective amount of a renin-angiotensin-aldosterone system (RAAS) agent. The methods can comprise administering an effective amount of a potassium-binding agent to the patient to lower the patient's blood pressure and/or increase or stabilize the patient's kidney function.

    ADHESIVE HYDROUS GEL SHEET
    14.
    发明公开
    ADHESIVE HYDROUS GEL SHEET 审中-公开
    水凝胶HAFTFOLIE

    公开(公告)号：EP2543350A4

    公开(公告)日：2014-04-23

    申请号：EP10849901

    申请日：2010-09-17

    申请人： KIM BONGJO

    发明人： KIM BONGJO

    IPC分类号： A61F13/02 ,  A61K31/78 ,  A61L15/22 ,  B23B27/00 ,  C08F20/06

    CPC分类号： A61L15/60 ,  A61F13/0213 ,  C08F20/06

    摘要： The present invention relates to a hydrous gel sheet including at least two laminated layers of a body-side surface layer and an environment-side surface layer, each of which is made of a hydrogel obtained from the reaction of polyacrylic acid or a salt thereof and multivalent metal ions, wherein the polyacrylic acid or the salt thereof used for forming a gel matrix of the environment-side surface layer is greater in weight-average molecular weight than the polyacrylic acid or the salt thereof used for forming a gel matrix of the body-side surface layer. Since a support body such as a nonwoven fabric is not used for the environment-side surface, but rather a support body made of hydrous gel is formed on the environment-side surface, the adhesive hydrous gel sheet according to the present invention, which is used for adhering to the human body, has excellent wear and handling properties as well as excellent stretching and deformation-absorbing properties, and also exhibits an improved appearance, aging stability, and durability.

    Water-absorbent polymers and their use as a medicament
    19.
    发明公开
    Water-absorbent polymers and their use as a medicament 审中-公开
    Wasser-absorptionierende Polymere und ihre Verwendung als Arzneimittel

    公开(公告)号：EP1847271A2

    公开(公告)日：2007-10-24

    申请号：EP07015451.3

    申请日：2001-11-06

    申请人： Sorbent Therapeutics, Inc.

    发明人： Simon, Jaime ,  Strickland, Alan D.

    IPC分类号： A61K31/715 ,  A61K9/16 ,  A61K9/50 ,  A61P7/10 ,  A61K47/30 ,  A61K47/38 ,  A61P7/00 ,  A61K31/78 ,  A61K31/74 ,  A61K47/32

    CPC分类号： A61K9/1635 ,  A61K9/5073 ,  A61K31/715 ,  A61K31/74 ,  A61K31/78 ,  A61K47/32

    摘要： The subject invention is a method and material for removing fluid from the intestinal tract of a host and may be useful in treating animals or human patients suffering from fluid overload states. In one embodiment, the subject method involves ingesting an enterically coated non-systemic, non-toxic, non-digestible, water absorbing polymer which absorbs fluid while passing through the intestinal tract. The polymer is excreted in the feces wherein the polymer and absorbed fluid is removed from the body. Preferred polymers include super absorbent acrylic acid polymers, preferably provided in bead form. The polymers may include functional groups for selectively removing blood borne waste products, e.g. urea, from the G.I. tract.

    摘要翻译： 本发明是用于从宿主的肠道中除去流体的方法和材料，并且可用于治疗患有流体过载状态的动物或人类患者。 在一个实施方案中，本发明方法涉及摄取肠道内涂覆的非全身性，无毒性，不可消化的吸水聚合物，其在通过肠道时吸收流体。 聚合物在粪便中排出，其中聚合物和吸收的流体从身体移除。 优选的聚合物包括优选以珠粒形式提供的超级吸收性丙烯酸聚合物。 聚合物可以包括用于选择性除去血液传播的废物的官能团，例如， 尿素，来自G.I. 道。