利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

64 条记录 (耗时 0.016 秒)

    Production of dobutamine compounds
    16.
    发明公开
    Production of dobutamine compounds 失效
    Herstellung von Dobutamin Verbindungen。

    公开(公告)号：EP0620208A1

    公开(公告)日：1994-10-19

    申请号：EP94200889.7

    申请日：1994-04-07

    申请人： DUPHAR INTERNATIONAL RESEARCH B.V

    发明人： van der Meij, Paulus F. C. ,  de Jong, Paulus P. G.

    IPC分类号： C07C213/02 ,  C07C215/52 ,  C07C215/54

    CPC分类号： C07C213/02 ,  C07C215/52 ,  C07C215/54

    摘要： The invention relates to a process for the production of an acid addition salt of a dobutamine compound of the general formula

    wherein

    R is a hydrogen atom or a methyl group, and
    n is 1 or 2,
    by reacting a mineral acid - addition salt of a dopamine compound of the general formula

    with a ketone of the general formula

    under the influence of a catalytic amount of a base, and in the presence of hydrogen and a hydrogenation catalyst,
    after which the pH of the reaction mixture is adjusted to approx. 6 at most and the product is isolated.

    摘要翻译： 本发明涉及一种制备通式为CHEM的多巴酚丁胺化合物的酸加成盐的方法，其中R为氢原子或甲基，n为1或2，通过使无机酸添加 在催化量的碱的影响下，在氢和氢化催化剂的存在下，通式为CHEM的多巴胺化合物的盐与通式为CHEM的酮在氢气和氢化催化剂的存在下反应， 将反应混合物调节至约 最多6个，产品是隔离的。

    Process for the preparation of arylalkylamines and substituted arylalkylamines
    17.
    发明公开
    Process for the preparation of arylalkylamines and substituted arylalkylamines 失效
    Verfahren zur Herstellung von芳基烷基胺和取代的芳基烷基胺。

    公开(公告)号：EP0491557A1

    公开(公告)日：1992-06-24

    申请号：EP91311727.1

    申请日：1991-12-18

    申请人： HOECHST CELANESE CORPORATION

    发明人： Tafesh, Ahmed M. ,  McDonough, Joseph A. ,  Mott, Graham N.

    IPC分类号： C07C215/52 ,  C07C213/02

    CPC分类号： C07C215/52 ,  C07C213/02

    摘要： Arylalkylamines (as the hydrochloride salt), e.g. tyramine hydrochloride, are prepared by hydrogenating substituted or unsubstituted aryl-α-oximinoalkyl ketones, e.g. p-hydroxyisonitroacetophenone, in either in an aqueous reaction medium comprising hydrochloric acid, essentially without the presence of a lower alkyl alcohol in said reaction medium, or in an aqueous reaction medium comprising water, hydrochloric acid, and a lower alkyl alcohol, wherein the alcohol comprises less than about 90% by volume of the reaction medium. A substituent on the aryl portion of the aryl-α-oximinoalkyl ketone must be on a position which activates the aromatic ring.

    摘要翻译： 芳烷基胺（作为盐酸盐），例如 通过氢化取代或未取代的芳基-α-肟基烷基酮来制备盐酸酪胺。 在包含盐酸的水性反应介质中，在所述反应介质中基本上不存在低级烷基醇，或者在包含水，盐酸和低级烷基醇的水性反应介质中，其中所述醇与对羟基硝基苯乙酮 包含少于约90体积％的反应介质。 芳基-α-肟基烷基酮的芳基部分上的取代基必须在活化芳环的位置。