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公开(公告)号：EP0844236A4
公开(公告)日：1999-04-14
申请号：EP96925075
申请日：1996-07-25
申请人： SHIONOGI & CO
发明人： KOIKE HARUO , UEDA YASUFUMI , MATSUDA KOJI , KABAKI MIKIO
IPC分类号： C07C225/22 , C07C229/18 , C07C273/18 , C07C275/42 , C07C275/28 , C07C237/04
CPC分类号： C07C225/22 , C07C229/18 , C07C273/1827 , C07C275/42
摘要： A process for producing carbamoylmethylurea derivatives represented by general formula (I), characterized by reacting a compound represented by general formula (II) with a compound represented by general formula (III).
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公开(公告)号：EP0488756B1
公开(公告)日：1997-02-26
申请号：EP91311060.7
申请日：1991-11-28
发明人： Hashizume, Kazunari, c/o Osaka Kenkyusho , Sugiyama, Haruhiko, c/o Osaka Kenkyusho , Date, Mutsuhiro, c/o Osaka Kenkyusho
IPC分类号： C12Q1/28 , C07C215/16 , C07C309/14 , C07C229/18 , C07C233/36
CPC分类号： C07C229/18 , C07C215/16 , C07C233/36 , C07C309/14 , C12Q1/28 , C12Q2326/96
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公开(公告)号：EP0752465A1
公开(公告)日：1997-01-08
申请号：EP95308269.0
申请日：1995-11-17
IPC分类号： C11D1/62 , C11D3/50 , C11D1/90 , C11D1/88 , C07C229/12 , C07C229/14 , C07C229/18 , C07C229/16
CPC分类号： C07D213/74 , A23L27/75 , C07C229/12 , C07C229/16 , C07C2601/14 , C07C2601/16 , C11D3/26 , C11D9/30
摘要： The invention concerns compositions comprising a compound of general formula selected from:
Said compositions show an excellent deposition to a surface followed by delayed release of the R-group.
More in particular, the invention relates to betaine-ester quaternary ammonium derivatives having an odoriferous alcohol as releasable R-group such as geraniol.摘要翻译： 本发明涉及包含选自以下的通式化合物的组合物：所述组合物显示出优异的表面沉积，随后延迟释放R-基团。 更具体地，本发明涉及具有气味醇作为可释放R基团的甜菜碱酯季铵衍生物，例如香叶醇。
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公开(公告)号：EP0499206A3
公开(公告)日：1993-03-03
申请号：EP92102265.3
申请日：1992-02-11
IPC分类号： C08G65/32 , C07C229/18
CPC分类号： C07C227/06 , C08G18/3228 , C08G18/325 , C08G18/5024 , C08G65/331 , C08G65/332 , C08G65/3332 , C08G65/3344 , C08G73/024 , C08G2120/00
摘要： Polyoxyalkylene polyamine or aromatic diamines or xylylenediamines are modified by subjecting to the Michael reaction with an ethylenically unsaturated monomer having an electron-withdrawing group to convert the primarary amino groups at least in part to a secondary amino group of the formula:
-NH-CH₂-CH(R)-Y
wherein R is a hydrogen atom or methyl, and Y is an electron-withdrawing group. The modified amines find use in the manufacture of plastics such as polyurea elastomers or polyurea RIM.摘要翻译： 聚氧化烯多胺或芳族二胺或二甲苯二胺通过与具有吸电子基团的烯属不饱和单体进行迈克尔反应而被改性，以将初级氨基至少部分转化为下式的仲氨基：-NH-CH 2 - CH（R）-Y其中R是氢原子或甲基，Y是吸电子基团。 改性胺可用于制造塑料如聚脲弹性体或聚脲RIM。
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公开(公告)号：EP2632452B1
公开(公告)日：2018-09-26
申请号：EP11856486.3
申请日：2011-10-26
发明人： GAGNON, Lyne , GROUIX, Brigitte , GEERTS, Lilianne , LAURIN, Pierre , PENNEY, Christopher , ZACHARIE, Boulos
IPC分类号： A61K31/192 , A61K31/196 , A61K31/22 , A61P35/00 , C07C217/84 , C07C229/18 , C07C229/42 , C07C229/60 , C07C323/20 , C07C323/52 , C07C323/62 , C07C57/30 , C07C59/52 , C07C59/64 , C07C59/76
CPC分类号： A61K31/192 , A61K31/196 , A61K31/22 , A61K31/513 , A61K31/675 , A61K31/7068 , C07C57/46 , C07C57/48 , C07C59/54 , C07C59/84 , C07C62/20 , C07C229/18 , C07C229/42 , C07C323/52
摘要： New uses for phenylketone carboxylate compounds and substituted aromatic compounds of Formula I, Formula I.1, Formula I.2, Formula IA, Formula IB, Formula IC and Formula II and their pharmaceutical acceptable salts for the treatment of cancer. The use of a combination of two of these compounds is described and the use of the combination of one of these compounds with an anticancer agent such as decarbazine, doxorubicin, daunorubicin, cyclophosphamide, busulfex, busulfan, vinblastine, vincristine, bleomycin, etoposide, topotecan, irinotecan, taxotere, taxol, 5-fluorouracil, methotrexate, gemcitabine, cisplatin, carboplatin and chlorambucil.
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公开(公告)号：EP2632452A1
公开(公告)日：2013-09-04
申请号：EP11856486.3
申请日：2011-10-26
发明人： GAGNON, Lyne , GROUIX, Brigitte , GEERTS, Lilianne , LAURIN, Pierre , PENNEY, Christopher , ZACHARIE, Boulos
IPC分类号： A61K31/192 , A61K31/196 , A61K31/22 , A61P35/00 , C07C217/84 , C07C229/18 , C07C229/42 , C07C229/60 , C07C323/20 , C07C323/52 , C07C323/62 , C07C57/30 , C07C59/52 , C07C59/64 , C07C59/76
CPC分类号： A61K31/192 , A61K31/196 , A61K31/22 , A61K31/513 , A61K31/675 , A61K31/7068 , C07C57/46 , C07C57/48 , C07C59/54 , C07C59/84 , C07C62/20 , C07C229/18 , C07C229/42 , C07C323/52
摘要： New uses for phenylketone carboxylate compounds and substituted aromatic compounds of Formula I, Formula I.1, Formula I.2, Formula IA, Formula IB, Formula IC and Formula II and their pharmaceutical acceptable salts for the treatment of cancer. The use of a combination of two of these compounds is described and the use of the combination of one of these compounds with an anticancer agent such as decarbazine, doxorubicin, daunorubicin, cyclophosphamide, busulfex, busulfan, vinblastine, vincristine, bleomycin, etoposide, topotecan, irinotecan, taxotere, taxol, 5-fluorouracil, methotrexate, gemcitabine, cisplatin, carboplatin and chlorambucil.
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公开(公告)号：EP2360160B1
公开(公告)日：2013-07-24
申请号：EP11166796.0
申请日：2000-09-07
发明人： SATO, Kouji , TAKAYANAGI, Yoshihiro , OKANO, Katsuhiko , NAKAYAMA, Keiji , IMURA, Akihiro , ITOH, Mikihiro , YAGI, Tsutomu , KOBAYASHI, Yukinari , NAGAI, Tomoyuki
IPC分类号： C07D498/06 , C07D265/36 , C07C229/18 , C07C229/30 , C07C227/06 , C07C227/34 , C07C215/16 , C07C213/00 , C12P13/00 , A61K31/5383 , A61P31/04 , C07B57/00
CPC分类号： C07D498/06 , C07B57/00 , C07B2200/07 , C07C213/00 , C07C227/08 , C07C227/34 , C07C227/36 , C07C229/18 , C07C229/30 , C07D265/36 , C12P13/001 , C12P13/02 , C12P13/04 , C12P41/005 , Y02P20/55 , C07C215/16
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18.发明授权Two-photon probe for real-time monitoring of intracellular free zinc ions, method for preparing the probe and method for real-time monitoring of intracellular free zinc ions using the probe 有权对于细胞内游离锌离子的实时监控双光子探测器，处理用于使用探针制备探针和方法，用于细胞内游离锌离子的实时监控
公开(公告)号：EP2119456B1
公开(公告)日：2011-07-20
申请号：EP09159851.6
申请日：2009-05-11
发明人： Cho, Bong-Rae
IPC分类号： A61K49/00 , C07C229/18 , C07D211/00
CPC分类号： A61K49/0021 , C07D213/38
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19.发明公开INTERMEDIATES FOR THE PREPARATION OF BENZOXAZINE DERIVATIVES AND PROCESS FOR THEIR PREPARATION 有权中间体，用于制备苯并恶嗪的衍生物和方法的用于其制备
公开(公告)号：EP2284174A1
公开(公告)日：2011-02-16
申请号：EP10191758.1
申请日：2000-09-07
发明人： Sato, Kouji , Takyanagi, Yoshihiro , Okano, Katsuhiko , Nakayama, Keiji , Imura, Akihiro , Itoh, Mikihiro , Yagi, Tsutomu , Kobayashi, Yukinari , Nagai, Tomoyuki
IPC分类号： C07D498/06 , C07D265/36 , C07C229/18 , C07C229/30 , C07C227/06 , C07C227/34 , C07C215/16 , C07C213/00 , C12P13/00 , A61K31/5383 , A61P31/04
CPC分类号： C07D498/06 , C07B57/00 , C07B2200/07 , C07C213/00 , C07C227/08 , C07C227/34 , C07C227/36 , C07C229/18 , C07C229/30 , C07D265/36 , C12P13/001 , C12P13/02 , C12P13/04 , C12P41/005 , Y02P20/55 , C07C215/16
摘要： A processes which is industrially advantageous in producing antibacterial agents. An industrially advantageous process for producing an intermediate useful in producing antibactrial agents is provided by producing compound (VI-a) in accordance with the following reaction schema.
A process for producing the compound represented by the above formulae and production intermediates thereof.摘要翻译： 甲工序全部是在制造抗菌剂在工业上是有利的。 用于在生产antibactrial剂中间体有用生产工业上有利的方法是通过产生在雅舞蹈化合物（VI-a）用下列反应方案提供。 一种用于生产由上述式餐饮和生产其中间体表示的化合物的过程。
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20.发明公开Two-photon probe for real-time monitoring of intracellular free zinc ions, method for preparing the probe and method for real-time monitoring of intracellular free zinc ions using the probe 有权对于细胞内游离锌离子的实时监控双光子探测器，处理用于使用探针制备探针和方法，用于细胞内游离锌离子的实时监控
公开(公告)号：EP2119456A1
公开(公告)日：2009-11-18
申请号：EP09159851.6
申请日：2009-05-11
发明人： Cho, Bong-Rae
IPC分类号： A61K49/00 , C07C229/18 , C07D211/00
CPC分类号： A61K49/0021 , C07D213/38
摘要： A two-photon probe for real-time monitoring of intracellular free zinc ions is provided. The two-photon probe is represented by Formula 1:
wherein R is H or OCH 3 . The two-photon probe has high selectivity for Zn 2+ and enables very effective and long-term monitoring of intracellular free Zn 2+ present in the deep tissue. Further provided are a method for preparing the two-photon probe and a method for real-time monitoring of intracellular free zinc ions using the two-photon probe.摘要翻译： 提供了一种用于细胞内游离锌离子的实时监测的双光子探测器。 双光子探针由式1表示：其中R是H或OCH 3。 双光子探测器具有用于锌离子的高选择性，使非常有效的和细胞内游离的Zn 2+存在于深部组织的长期监测。 进一步提供的是一种用于制备双光子探针和探针用于使用双光子细胞内游离锌离子的实时监测的方法。
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