公开(公告)号：EP1935983A2

公开(公告)日：2008-06-25

申请号：EP08101755.0

申请日：1998-05-05

申请人： ChemoMetec A/S

发明人： Hansen, Frans Ejner Ravn ,  Glensbjerg, Martin ,  Arnvidarson, Börkur ,  Jeppesen, Jesper Myron

IPC分类号： C12Q1/06 ,  G01N33/483 ,  G01N33/04 ,  G01N24/00 ,  G01N21/00 ,  G01N15/06 ,  G06M11/00

CPC分类号： G01N15/1459 ,  B01L3/5027 ,  G01N15/1463 ,  G01N21/31 ,  G01N21/59 ,  G01N21/6428 ,  G01N21/6458 ,  G01N21/76 ,  G01N33/04 ,  G01N2015/025 ,  G01N2015/1452 ,  G01N2015/1486 ,  G01N2021/5957 ,  G01N2021/6491

摘要： The present invention relates to a method for the assessment of quantity and quality parameters of biological particles in blood or blood product. The method comprises applying a volume of a liquid sample to an exposing domain from which exposing domain electromagnetic signals from the sample in the domain can pass to the exterior, and exposing, onto an array of active detection elements such as CCD-elements, a spatial representation of electromagnetic signals having passed from the domain, the representation being detectable as an intensity by individual active detection elements, under conditions permitting processing of the intensities detected by the array of detection elements during the exposure in such a manner that representation of electromagnetic signals from the biological particles are identified as distinct from representations of electromagnetic signals from background signals. The enlargement of an image on the array of detection elements is smaller than 10:1.

摘要翻译： 本发明涉及一种评估血液或血液制品中生物颗粒的数量和质量参数的方法。 该方法包括将一定体积的液体样本施加到曝光区域，从该区域中的来自样品的区域电磁信号可以从该域暴露于外部，并将其暴露于诸如CCD元件的主动检测元件的阵列上， 在从曝光期间通过检测元件阵列检测到的强度处理的条件下，可以通过单独的有源检测元件作为强度检测该表示作为强度的表示， 生物颗粒被识别为不同于来自背景信号的电磁信号的表示。 检测元件阵列上的图像的放大小于10：1。

公开(公告)号：EP1558934A1

公开(公告)日：2005-08-03

申请号：EP03809704.4

申请日：2003-10-31

申请人： ChemoMetec A/S

发明人： LARSEN, Rasmus, Dines ,  HANSEN, Frans, Ejner, Ravn

IPC分类号： G01N33/58

CPC分类号： G01N33/54313

摘要： The invention relates to imaging methods for assessing quality or quantity parameters of particles in a sample, wherein the particles contain less than 106 analyte detectable positions. The method comprises 1) mixing the sample with a targeting species capable of binding an analyte position and a labelling agent, 2) arranging the sample in an exposing domain, allowing electromagnetic signals from the sample to pass to the exterior, 3) exposing a representation of said signals onto an array of detection elements, wherein the representation is subject to a linear enlargement, so that the ratio of the image of a linear dimension on the array of detection elements to the original linear dimension in the exposing domain is smaller than 20:1, 4) detecting the representation as intensities by said detection elements, 5) processing the intensities to identify the particles, and 6) obtaining the quality or quantity parameter.

公开(公告)号：EP1404875A1

公开(公告)日：2004-04-07

申请号：EP02747248.9

申请日：2002-06-10

申请人： ChemoMetec A/S

发明人： SKYGGEBJERG, Ole ,  GLENSBJERG, Martin

IPC分类号： C12Q1/68 ,  G01N15/14

CPC分类号： G01N15/147 ,  G01N2015/1006 ,  G01N2015/1477

摘要： The present invention relates to a method and a system for the assessment cells in a liquid sample. The present method provides individual counts of substantially all the cells in the sample which are susceptible to the method of making cells distinguishable, in a manner whereby it is not necessary to conduct calibrations between assessments of samples with cells from different species within one taxonomic group. This is provided by measuring a part of the cells having substantially identical spatially confined identifiable substances, such as DNA. This makes the method less sensitive to variations in cell size and morphology than prior art methods for cell counting, such as Coulter counting.

公开(公告)号：EP1180675A3

公开(公告)日：2003-05-21

申请号：EP01203530.9

申请日：1998-05-05

申请人： ChemoMetec A/S

发明人： Hansen, Frans Ejner Ravn ,  Glensbjerg, Martin ,  Arnvidarsson, Börkur ,  Jeppesen, Jesper Myron

IPC分类号： G01N15/02 ,  G01N15/14

CPC分类号： G01N15/1459 ,  B01L3/5027 ,  G01N15/1463 ,  G01N21/31 ,  G01N21/59 ,  G01N21/6428 ,  G01N21/6458 ,  G01N21/76 ,  G01N33/04 ,  G01N2015/025 ,  G01N2015/1452 ,  G01N2015/1486 ,  G01N2021/5957 ,  G01N2021/6491

摘要： The present invention relates to a method for the assessment of quantity and quality parameters of biological particles in a liquid analyte material. The method comprises applying a volume of a liquid sample to an exposing domain from which exposing domain electromagnetic signals from the sample in the domain can pass to the exterior, and exposing, onto an array of active detection elements such as CCD-elements, a spatial representation of electromagnetic signals having passed from the domain, the representation being detectable as an intensity by individual active detection elements, under conditions permitting processing of the intensities detected by the array of detection elements during the exposure in such a manner that representation of electromagnetic signals from the biological particles are identified as distinct from representations of electromagnetic signals from background signals. The size of the volume of the liquid sample is sufficiently large to permit the assessment of the quantity and quality parameters to fullfil a predetermined requirement to the statistical quality of the assessment based on substantially one exposure.

公开(公告)号：EP1290427A1

公开(公告)日：2003-03-12

申请号：EP01923535.7

申请日：2001-04-11

申请人： ChemoMetec A/S

发明人： HANSEN,Frans Ejner Ravn

IPC分类号： G01N21/64

CPC分类号： G01N21/645 ,  G01N15/1468 ,  G02B21/0076 ,  G02B21/16 ,  G02B21/361

摘要： The present invention relates to an apparatus and a method for detecting the fluorescence of a sample, wherein the apparatus comprises excitation light source located on the same side of the sample as the detecting means. The apparatus may be constructed as a single-sided as well as a double-sided system, wherein the double-sided system comprises double-sided excitation system and/or double-sided detecting system. The double-sided system may also be a combination of fluorescence system and conventional microscopy. The apparatus may be used for analysis of various types of biological material, liquid as well as solid material, and various other types of material suitable being analysed through fluorescence studies.

摘要翻译： 本发明涉及一种用于检测样品荧光的装置和方法，其中该装置包括位于与检测装置相同侧的样品的激发光源。 该装置可以构造为单面和双面系统，其中双面系统包括双面激励系统和/或双面检测系统。 双面系统也可以是荧光系统和常规显微镜的组合。 该装置可用于分析各种类型的生物材料，液体和固体材料，以及适用于通过荧光研究分析的各种其他类型的材料。

公开(公告)号：EP3571488A1

公开(公告)日：2019-11-27

申请号：EP18701712.4

申请日：2018-01-22

申请人： ChemoMetec A/S

发明人： PEDERSEN, Rune, Troelsgaard ,  KJÆRULFF, Søren

IPC分类号： G01N15/14 ,  G01N21/64

公开(公告)号：EP2350617B1

公开(公告)日：2018-01-10

申请号：EP09744320.4

申请日：2009-10-21

申请人： ChemoMetec A/S

发明人： KJÆRULFF, Søren ,  SKINDERSØ, Mette Elena ,  SØRENSEN, Helle Frobøse ,  RAVN, Frans ,  GLENSBJERG, Martin

IPC分类号： G01N21/64 ,  C12N15/00 ,  G01N33/50 ,  G02B21/06 ,  G02B27/09 ,  G01N1/30 ,  G01N33/58

CPC分类号： G01N21/64 ,  G01N21/6458 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2021/6478 ,  G01N2201/0631 ,  G02B27/0905 ,  G02B27/0961

摘要： According to an embodiment of the invention, an apparatus to detect fluorescence from a sample is disclosed. The apparatus comprises a sample plane onto which the sample is arranged, an excitation light unit including at least a light source to illuminate the sample, and a detection unit comprising at least a detector having at least 100,000 active detection elements to detect a fluorescence signal from the sample.

公开(公告)号：EP1947443A2

公开(公告)日：2008-07-23

申请号：EP08101764.2

申请日：1998-05-05

申请人： ChemoMetec A/S

发明人： Hansen, Frans Ejner Ravn ,  Glensbjerg, Martin ,  Arnvidarson, Börkur ,  Jeppesen, Jesper Myron

IPC分类号： G01N15/14 ,  G01N33/04

CPC分类号： G01N15/1459 ,  B01L3/5027 ,  G01N15/1463 ,  G01N21/31 ,  G01N21/59 ,  G01N21/6428 ,  G01N21/6458 ,  G01N21/76 ,  G01N33/04 ,  G01N2015/025 ,  G01N2015/1452 ,  G01N2015/1486 ,  G01N2021/5957 ,  G01N2021/6491

摘要： The present invention relates to a method for the assessment of quantity and quality parameters of biological particles in a liquid analyte material. The method comprises applying a volume of a liquid sample to an exposing domain from which exposing domain electromagnetic signals from the sample in the domain can pass to the exterior, and exposing, onto an array of active detection elements such as CCD-elements, a spatial representation of electromagnetic signals having passed from the domain, the representation being detectable as an intensity by individual active detection elements, under conditions permitting processing of the intensities detected by the array of detection elements during the exposure in such a manner that representation of electromagnetic signals from the biological particles are identified as distinct from representations of electromagnetic signals from background signals. The exposing domain has an average interior thickness of between 20 μm and 200 μm.

摘要翻译： 本发明涉及一种用于评估液体分析物质中生物颗粒的数量和质量参数的方法。 该方法包括将一定体积的液体样本施加到曝光区域，从该区域中的来自样品的区域电磁信号可以从该域暴露于外部，并将其暴露于诸如CCD元件的主动检测元件的阵列上， 在从曝光期间通过检测元件阵列检测到的强度处理的条件下，可以通过单独的有源检测元件作为强度检测该表示作为强度的表示，从而以这种方式表示电磁信号， 生物颗粒被识别为不同于来自背景信号的电磁信号的表示。 曝光区域的平均内部厚度在20¼m至200¼m之间。

公开(公告)号：EP1936351A2

公开(公告)日：2008-06-25

申请号：EP08101761.8

申请日：1998-05-05

申请人： ChemoMetec A/S

发明人： Hansen, Frans Ejner Ravn ,  Glensbjerg, Martin ,  Arnvidarson, Börkur ,  Jeppesen, Jesper Myron

IPC分类号： G01N15/02 ,  G01N15/14

CPC分类号： G01N15/1459 ,  B01L3/5027 ,  G01N15/1463 ,  G01N21/31 ,  G01N21/59 ,  G01N21/6428 ,  G01N21/6458 ,  G01N21/76 ,  G01N33/04 ,  G01N2015/025 ,  G01N2015/1452 ,  G01N2015/1486 ,  G01N2021/5957 ,  G01N2021/6491

摘要： The present invention relates to a method for the assessment of quantity and quality parameters of biological particles in a liquid analyte material. The method comprises applying a volume of a liquid sample to an exposing domain from which exposing domain electromagnetic signals from the sample in the domain can pass to the exterior, and exposing, onto an array of active detection elements such as CCD-elements, a spatial representation of electromagnetic signals having passed from the domain, the representation being detectable as an intensity by individual active detection elements, under conditions permitting processing of the intensities detected by the array of detection elements during the exposure in such a manner that representation of electromagnetic signals from the biological particles are identified as distinct from representations of electromagnetic signals from background signals. The light source is a thermal light source, such as a halogen lamp.

摘要翻译： 本发明涉及用于评估液体分析物材料中生物颗粒的数量和质量参数的方法。 该方法包括将一定体积的液体样品施加到曝光区域，从该区域中的样品暴露域电磁信号可以将该液体样品传递到外部，并且将活性检测元件阵列（例如CCD元件）暴露在曝光区域的空间 在允许在曝光期间处理由检测元件阵列检测到的强度的条件下，从该域通过的电磁信号的表示可以作为单个有源检测元件的强度来检测， 生物粒子被识别为不同于来自背景信号的电磁信号的表示。 光源是热光源，例如卤素灯。

公开(公告)号：EP1933128A3

公开(公告)日：2008-06-25

申请号：EP08101757.6

申请日：1998-05-05

申请人： ChemoMetec A/S

发明人： Hansen, Frans Ejner Ravn ,  Glensbjerg, Martin ,  Arnvidarson, Börkur ,  Jeppesen, Jesper Myron

IPC分类号： G01N15/02 ,  G01N15/14

CPC分类号： G01N15/1459 ,  B01L3/5027 ,  G01N15/1463 ,  G01N21/31 ,  G01N21/59 ,  G01N21/6428 ,  G01N21/6458 ,  G01N21/76 ,  G01N33/04 ,  G01N2015/025 ,  G01N2015/1452 ,  G01N2015/1486 ,  G01N2021/5957 ,  G01N2021/6491

摘要： The present invention relates to a method and a device for the assessment of quantity and quality parameters of biological particles in a liquid analyte material. The method comprises applying a volume of a liquid sample to an exposing domain from which exposing domain electromagnetic signals from the sample in the domain can pass to the exterior, and exposing, onto an array of active detection elements such as CCD-elements, a spatial representation of electromagnetic signals having passed from the domain, the representation being detectable as an intensity by individual active detection elements, under conditions permitting processing of the intensities detected by the array of detection elements during the exposure in such a manner that representation of electromagnetic signals from the biological particles are identified as distinct from representations of electromagnetic signals from background signals. The light source is a LED and/or a laser diode, arranged to transmit light onto the sample.