公开(公告)号：EP1027351A1

公开(公告)日：2000-08-16

申请号：EP98967153.2

申请日：1998-10-26

申请人： FIBROGEN, INC. ,  ZENECA LIMITED

发明人： EDWARDS, Philip Neil ,  LARGE, Michael Stewart ,  HALES, Neil, James ,  MARTIN, George, R. ,  HUANG, Xinfan

IPC分类号： C07D471/04

CPC分类号： C07D471/04 ,  A61K31/4745

摘要： The present invention provides a phenanthroline derivative of formula (I) wherein, for example, R1 is hydrogen, carboxy, cyano, nitro, (1-4C)alkyl, (1-6C)alkoxycarbonyl, (1-4C)alkylamino, (2-4C)alkanoyl, (1-4C)alkoxy-(2-4C)alkoxy-(2-4C)alkoxycarbonyl or N-[amino-(2-8C)alkyl]carbamoyl; R2 is, for example, hydrogen, carboxy, (1-6C)alkoxycarbonyl, carbamoyl, N-(1-8C)alkylcarbamoyl, N,N-di-(1-8C)alkylcarbamoyl, N-(1-4C)alkylcyclohexylcarbamoyl, 1,2,3,4,-tetrahydro-isoquinolin-2-ylcarbonyl or N,N-[di-(1-4C)alkyl]thiocarbamoyl; R?3 and R4¿, which may be the same or different, are, for example, hydrogen or halo; and R5 is, for example, hydrogen, di-(1-4C)alkylamino or halo; or a pharmaceutically-acceptable salt thereof. The invention further provides pharmaceutical compositions comprising phenanthroline derivatives, processes for making the same and their use in producing an anti-fibroproliferative effect.

公开(公告)号：EP2324834B1

公开(公告)日：2019-05-08

申请号：EP10181843.3

申请日：2002-12-06

申请人： Fibrogen, Inc.

发明人： Klaus, Stephen J. ,  Lin, Al Y. ,  Neff, Thomas B. ,  Wang, Qingjian ,  Guenzler-Pukall, Volkmar ,  Arend, Michael P. ,  Flippin, Lee A.

IPC分类号： A61K31/47 ,  A61K31/4738 ,  A61K31/63 ,  A61K31/00 ,  A61K38/38 ,  C12N15/09 ,  C12Q1/56 ,  C12Q1/34 ,  A61P7/06 ,  A61K31/17 ,  C07K14/47 ,  C07K14/505 ,  G01N33/74 ,  A61K31/472 ,  A61K31/4745 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/496 ,  A61K38/17

公开(公告)号：EP3470397A1

公开(公告)日：2019-04-17

申请号：EP18189607.7

申请日：2013-07-15

申请人： Fibrogen, Inc.

发明人： WITSCHI, Claudia ,  PARK, Jung Min ,  THOMPSON, Michael, D. ,  MARTINELLI, Michael, John ,  YEOWELL, David, A. ,  AREND, Michael, P.

IPC分类号： C07D217/26

摘要： The present disclosure relates to crystalline solid forms of [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid, the process of preparing the forms, and pharmaceutical compositions and methods of use thereof.

公开(公告)号：EP2872488B1

公开(公告)日：2018-08-22

申请号：EP13740185.7

申请日：2013-07-15

申请人： Fibrogen, Inc.

发明人： WITSCHI, Claudia ,  PARK, Jung Min ,  THOMPSON, Michael, D. ,  MARTINELLI, Michael, John ,  YEOWELL, David, A. ,  AREND, Michael, P.

IPC分类号： C07D217/26 ,  A61K31/47

CPC分类号： C07D217/26 ,  A61K31/47 ,  C07B2200/13

摘要： The present disclosure relates to crystalline solid forms of [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid, the process of preparing the forms, and pharmaceutical compositions and methods of use thereof.

公开(公告)号：EP3219706A1

公开(公告)日：2017-09-20

申请号：EP17155678.0

申请日：2013-07-15

申请人： Fibrogen, Inc.

发明人： THOMPSON, Michael D. ,  PARK, Jung Min ,  AREND, Michael P.

IPC分类号： C07D217/26

CPC分类号： C07D217/26

摘要： The present invention relates to methods for making isoquinoline compounds and the intermediate compounds achieved thereby. Such compounds can be used to prepare compounds and compositions capable of decreasing HIF hydroxylase enzyme activity, thereby increasing the stability and/or activity of hypoxia inducible factor (HIF).

公开(公告)号：EP1814606B1

公开(公告)日：2015-07-22

申请号：EP05821230.9

申请日：2005-10-25

申请人： Fibrogen, Inc.

发明人： OLSEN, David R. ,  POLAREK, James W. ,  YANG, Chunlin

IPC分类号： A61L24/10 ,  A61L27/24 ,  A61L31/04 ,  A61K6/02

CPC分类号： C07K14/78 ,  A61K6/08 ,  A61L24/102 ,  A61L27/24 ,  A61L31/044

公开(公告)号：EP2872487A1

公开(公告)日：2015-05-20

申请号：EP13740184.0

申请日：2013-07-15

申请人： Fibrogen, Inc.

发明人： THOMPSON, Michael D. ,  PARK, Jung Min ,  AREND, Michael P.

IPC分类号： C07D217/26

CPC分类号： C07D217/26

摘要： The present invention relates to methods for making isoquinoline compounds and the intermediate compounds achieved thereby. Such compounds can be used to prepare compounds and compositions capable of decreasing HIF hydroxylase enzyme activity, thereby increasing the stability and/or activity of hypoxia inducible factor (HIF).

公开(公告)号：EP2834220A1

公开(公告)日：2015-02-11

申请号：EP13712970.6

申请日：2013-03-08

申请人： Fibrogen, Inc.

发明人： HO, Wen-Bin ,  ZHAO, Hongda ,  DENG, Shaojiang ,  NG, Danny ,  WRIGHT, Lee R. ,  WU, Min ,  ZHOU, Xiaoti ,  AREND, Michael P. ,  FLIPPIN, Lee A.

IPC分类号： C07D217/26 ,  C07D401/12 ,  C07D407/12 ,  C07D409/12 ,  A61K31/4725 ,  A61P21/00 ,  A61P9/10 ,  A61P1/00

CPC分类号： C07D409/12 ,  C07D217/26 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12

摘要： The present invention relates to novel compounds of formula (I), and compositions capable of inhibiting PHD1 enzyme activity selectively over other isoforms, for example, PHD2 and/or PHD3 enzymes. The invention also relates to compounds of formula (I) for use in disorders such as muscle degeneration, colitis, IBD, and certain ischemias.

公开(公告)号：EP2370422A1

公开(公告)日：2011-10-05

申请号：EP09756097.3

申请日：2009-11-11

申请人： Fibrogen, Inc.

发明人： HO, Wen-Bin ,  WRIGHT, Lee R. ,  TURTLE, Eric D. ,  MOSSMAN, Craig ,  FLIPPIN, Lee A.

IPC分类号： C07D335/06 ,  C07D409/04 ,  A61K31/382 ,  A61K31/4436 ,  A61K31/4155 ,  A61P9/10

CPC分类号： A61K31/506 ,  A61K31/382 ,  A61K31/4155 ,  A61K31/4436 ,  A61K45/06 ,  C07D335/06 ,  C07D409/04

摘要： The present invention relates to novel compounds, methods, and compositions capable of decreasing HIF hydroxylase enzyme activity, thereby increasing the stability and/or activity of hypoxia inducible factor (HIF).

公开(公告)号：EP2337797A2

公开(公告)日：2011-06-29

申请号：EP09789183.2

申请日：2009-08-21

申请人： Fibrogen, Inc.

发明人： CHANG, Robert, C. ,  OLSEN, David, R. ,  POLAREK, James, W. ,  WILLIAMS, Kim, E.

IPC分类号： C07K14/78 ,  A61K6/08 ,  A61L27/24

CPC分类号： A61L27/24 ,  A61L27/50 ,  C07K14/78

摘要： The present invention relates to double-crosslinked collagen materials, methods for preparing double- crosslinked collagen materials, and methods of using double-crosslinked collagen materials