公开(公告)号：EP1928827A2

公开(公告)日：2008-06-11

申请号：EP06804229.0

申请日：2006-09-27

申请人： MYRIAD GENETICS, INC.

发明人： WEINER, Warren, S. ,  SLADE, Rachel, M. ,  KLIMOVA, Yevgeniya, I. ,  WALTON, Ruth, J. ,  ANDERSON, Mark, B.

IPC分类号： C07D209/00

CPC分类号： C07D207/327 ,  C07D207/325 ,  C07D207/33 ,  C07D207/34

摘要： Novel pyrrole derivatives are disclosed as Aβ42-lowering agents for the treatment and prevention of neurodegenerative disorders characterized by the formation or accumulation of amyloid plaques comprising the Aβ42 peptide.

公开(公告)号：EP1893629A1

公开(公告)日：2008-03-05

申请号：EP06773841.9

申请日：2006-06-22

申请人： MYRIAD GENETICS, INC.

发明人： ARRANZ PLAZA, Esther ,  YAGER, Kraig, M. ,  GERRISH, David Allen ,  ANDERSON, Mark, B. ,  KIM, In Chul ,  KUMAR, Dange, Vijay

IPC分类号： C07J53/00 ,  A61K31/56

CPC分类号： C07J63/008

摘要： The invention relates to compounds, pharmaceutical compositions and methods useful for treating viral infection.

摘要翻译： 本发明涉及用于治疗病毒感染的化合物，药物组合物和方法。

公开(公告)号：EP1843752A2

公开(公告)日：2007-10-17

申请号：EP05855810.7

申请日：2005-12-27

申请人： MYRIAD GENETICS, INC.

发明人： ROTH, Bruce ,  BAICHWAL, Vijay ,  PLEIMAN, Chris

IPC分类号： A61K9/127

CPC分类号： A61K31/167

摘要： The present invention provides therapeutic compounds and methods for the treatment of refractory and multidrug resistant cancers in patients in need of such treatment.

公开(公告)号：EP1833803A2

公开(公告)日：2007-09-19

申请号：EP06733603.2

申请日：2006-01-03

申请人： MYRIAD GENETICS, INC. ,  Cytovia, Inc.

发明人： CAI, Sui Xiong ,  ANDERSON, Mark B. ,  WILLARDSEN, Adam ,  JIANG, Songchun ,  HALTER, Robert J. ,  SLADE, Rachel ,  KLIMOVA, Yevgeniya

IPC分类号： C07D253/08 ,  C07D237/28 ,  C07D237/30 ,  C07D217/22 ,  A61K31/53 ,  A61K31/502 ,  A61K31/472 ,  A61P35/00

CPC分类号： C07D237/34 ,  C07D253/08

摘要： Disclosed are 1-arylamino-phthalazines, 4-arylamino-benzo[d][1,2,3]triazines, and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

公开(公告)号：EP1833511A2

公开(公告)日：2007-09-19

申请号：EP06717342.7

申请日：2006-01-03

申请人： MYRIAD GENETICS, INC. ,  Cytovia, Inc.

发明人： CAI, Sui Xiong ,  ANDERSON, Mark B. ,  WILLARDSEN, Adam ,  SIRISOMA, Nilantha Sudath

IPC分类号： A61K39/395

CPC分类号： C07D239/94 ,  A61K31/395 ,  C07D239/95 ,  C07D401/12

摘要： Disclosed are 4-arylamino-quinazolines and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs, and in particular to the use of these compounds in treating brain cancer.

公开(公告)号：EP1661566A2

公开(公告)日：2006-05-31

申请号：EP06000130.2

申请日：1997-08-05

申请人： MYRIAD GENETICS, INC.

发明人： Kahn, Michael ,  Ogbu, Cyprian Okwara ,  Qabar, Maher Nicola ,  Eguchi, Masakatsu ,  McMillan, Michael Kim ,  Kim, Hwa-Ok ,  Boatman, Patrick Douglas, Jr. ,  Babu, Suresh ,  Lum, Christopher Todd ,  Meara, Joseph Patrick ,  Ferguson, Mark D. ,  Urban, Jan.

IPC分类号： A61K31/4035 ,  A61K31/407 ,  A61K31/4152 ,  A61K31/428 ,  A61K31/437 ,  A61K31/5025 ,  A61K38/00 ,  A61K38/04 ,  A61K38/55 ,  C07K1/04 ,  C07K5/02 ,  C07K5/06 ,  C07K5/08 ,  C07K5/10 ,  C07K7/06

CPC分类号： C07K14/81 ,  C07K14/4703

摘要： β-sheet mimetics and methods relating to the same are disclosed. The β-sheet mimetics have utility as protease and kinase inhibitors, as well as inhibitors of transcription factors. Methods of the invention include administration of a β-sheet mimetic, or use of the same for the manufacture of a medicament for treatment of a variety of conditions associated with the targeted protease, kinase and/or transcription factor.

摘要翻译： 公开了2页模拟物及其相关方法。 2片模拟物可用作蛋白酶和激酶抑制剂，以及转录因子抑制剂。 本发明的方法包括施用2页模拟物，或者使用它们来制备用于治疗与靶向的蛋白酶，激酶和/或转录因子相关的多种病症的药物。

公开(公告)号：EP1651195A2

公开(公告)日：2006-05-03

申请号：EP04821024.9

申请日：2004-07-12

申请人： MYRIAD GENETICS, INC.

发明人： HOBDEN, Adrian ,  ZAVITZ, Kenton ,  MATHER, Gary ,  HENDRIX, Suzanne

IPC分类号： A61K9/48 ,  A61K31/19

CPC分类号： A61K31/192 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2054 ,  A61K9/2813 ,  A61K9/282 ,  A61K9/2866

摘要： In general, the invention relates to a pharmaceutical dose having R-flurbiprofen as the active ingredient that upon oral administration of a single dose to a fasting subject provides a Cmax of about 30-95 µg per mL. When the dose is administered to an individual having mild-to-moderate Alzheimer's disease (or desiring protection against Alzheimer's disease) twice daily for at least 4 months according to the described guidelines, an improvement or lessening in decline of cognitive function as characterized by cognition tests is observed in the patient. The composition of the invention is formulated with one or more pharmaceutically acceptable excipients, salts or carriers.

公开(公告)号：EP0915700B1

公开(公告)日：2006-03-22

申请号：EP97936371.0

申请日：1997-08-05

申请人： MYRIAD GENETICS, INC.

发明人： KAHN, Michael ,  QABAR, Maher, Nicola ,  McMILLAN, Michael, Kim ,  OGBU, Cyprian, Okwara ,  EGUCHI, Masakatsu ,  KIM, Hwa-Ok ,  BOATMAN, Patrick, Douglas, Jr. ,  URBAN, Jan ,  MEARA, Joseph, Patrick ,  BABU, Suresh ,  FERGUSON, Mark, D. ,  LUM, Christopher, Todd

IPC分类号： A61K31/50 ,  A61K31/435 ,  A61K31/415 ,  A61K31/40 ,  A61K38/00

CPC分类号： C07K7/06 ,  A61K31/4035 ,  A61K31/407 ,  A61K31/4152 ,  A61K31/428 ,  A61K31/437 ,  A61K31/5025 ,  A61K38/005 ,  A61K38/04 ,  A61K38/55 ,  C07K1/047 ,  C07K5/021 ,  C07K5/06139 ,  C07K5/06191 ,  C07K5/0821 ,  C07K5/1024

摘要： β-sheet mimetics and methods relating to the same are disclosed. The β-sheet mimetics have utility as protease and kinase inhibitors, as well as inhibitors of transcription factors. Methods of the invention include administration of a β-sheet mimetic, or use of the same for the manufacture of a medicament for treatment of a variety of conditions associated with the targeted protease, kinase and/or transcription factor.

公开(公告)号：EP1377165A4

公开(公告)日：2005-04-20

申请号：EP02726648

申请日：2002-03-14

申请人： MYRIAD GENETICS INC

发明人： WETTSTEIN DANIEL ALBERT ,  MORHAM SCOTT ,  ZAVITZ KENTON

IPC分类号： G01N33/50 ,  A61K31/7088 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P31/18 ,  C07K14/155 ,  C07K14/16 ,  C07K14/47 ,  C07K16/10 ,  C07K16/18 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/10 ,  C12Q1/02 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  G01N37/00 ,  A01N43/04 ,  A61K31/70 ,  C07H21/04 ,  C07K1/00

CPC分类号： C07K14/005 ,  C07K14/4703 ,  C07K2319/00 ,  C12N15/1055 ,  C12N2740/16222 ,  Y02P20/582

公开(公告)号：EP0785216A1

公开(公告)日：1997-07-23

申请号：EP96309211.9

申请日：1996-12-17

申请人： MYRIAD GENETICS, INC. ,  Endo Recherche Inc. ,  THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ,  HSC Research and Development Limited Partnership

发明人： Tavtigian, Sean V. ,  Kamb, Alexander ,  Simard, Jacques ,  Couch, Fergus ,  Rommens, Johanna M. ,  Weber, Barbara L.

IPC分类号： C07K14/82 ,  C12Q1/68 ,  G01N33/53 ,  A01K67/027

CPC分类号： C07K14/4703 ,  A61K48/00 ,  Y10S530/828

摘要： The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human breast cancer predisposing gene (BRCA2), some mutant alleles of which cause susceptibility to cancer, in particular breast cancer. More specifically, the invention relates to germline mutations in the BRCA2 gene and their use in the diagnosis of predisposition to breast cancer. The present invention further relates to somatic mutations in the BRCA2 gene in human breast cancer and their use in the diagnosis and prognosis of human breast cancer. Additionally, the invention relates to somatic mutations in the BRCA2 gene in other human cancers and their use in the diagnosis and prognosis of human cancers. The invention also relates to the therapy of human cancers which have a mutation in the BRCA2 gene, including gene therapy, protein replacement therapy and protein mimetics. The invention further relates to the screening of drugs for cancer therapy. Finally, the invention relates to the screening of the BRCA2 gene for mutations, which are useful for diagnosing the predisposition to breast cancer.

摘要翻译： 本发明一般涉及人类遗传学领域。 具体而言，本发明涉及用于分离和检测人乳腺癌易感基因（BRCA2）的方法和材料，其中一些突变等位基因引起对癌症尤其是乳腺癌的易感性。 更具体地说，本发明涉及BRCA2基因中的种系突变及其在诊断乳腺癌易感性中的用途。 本发明进一步涉及人乳腺癌中BRCA2基因的体细胞突变及其在人乳腺癌的诊断和预后中的用途。 此外，本发明涉及其他人类癌症中BRCA2基因的体细胞突变及其在人类癌症的诊断和预后中的用途。 本发明还涉及在BRCA2基因中具有突变的人类癌症的治疗，包括基因治疗，蛋白质替代疗法和蛋白质模拟物。 本发明还涉及用于癌症治疗的药物的筛选。 最后，本发明涉及BRCA2基因突变的筛选，其可用于诊断乳腺癌倾向。