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148 条记录 (耗时 0.036 秒)

    DNA encoding chondroitin synthase from Pasteurella multocida and methods of use
    21.
    发明公开
    DNA encoding chondroitin synthase from Pasteurella multocida and methods of use 有权
    软骨素合成酶科尔德氏菌多巴氏杆菌和Verwendungsverfahren

    公开(公告)号：EP1832662A2

    公开(公告)日：2007-09-12

    申请号：EP07007453.9

    申请日：1999-04-01

    申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA

    发明人： DeAngelis, Paul ,  Weigel, Paul H. ,  Kumari, Kshama

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/689 ,  A61K39/102 ,  C12N9/1051 ,  C12P19/04 ,  Y02A50/52

    摘要： The present invention relates to a nucleic acid segment having a coding region segment encoding enzymatically active bacterial multocida hyaluronate synthase (PmHAS), and to the use of this nucleic acid segment in the preparation of recombinant cells which produce hyaluronate synthase and its hyaluronic acid product. Hyaluronate is also known as hyaluronic acid or hyaluronan. The present invention also relates to the use of the PmHAS in constructing "knock-out" mutant strains of P. multocida for use in vaccinations. The present invention further relates to the use of the PmHAS in diagnostic tests in the field determinations of livestock P. multocida infection.

    摘要翻译： 本发明涉及具有编码酶活性细菌多病毒的编码区段的核酸片段，以及该核酸片段在制备产生软骨素合成酶和软骨素聚合物的重组细胞中的用途。

    Functionally active selectin-derived peptides and ligand for GMP140
    27.
    发明公开
    Functionally active selectin-derived peptides and ligand for GMP140 失效
    Selektinderivierte功能活性肽和配体GMP140

    公开(公告)号：EP1245575A3

    公开(公告)日：2002-11-20

    申请号：EP01204837.7

    申请日：1991-07-17

    申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA

    发明人： McEver, Rodger P.

    IPC分类号： C07K16/28 ,  C07K16/18

    CPC分类号： C07K16/2854 ,  A61K2039/505

    摘要： Peptides derived from three regions of the lectin binding region of GMP-140 have been found to selectively interact with "selectins", including GMP-140, ELAM-1, and lymphocyte homing receptor. The three regions include amino acids 19-34, 54-72, and 66-89, based on the numbers of the residues contained in the peptide, with residue 1 defined as the N terminus of the mature protein after cleavage of the signal peptide. Fucosylated sialyated lactosamine structures that bind to GMP-140 have also been discovered. The structure is created by expression of α(1,3) fucosyltransferases capable of modifying acceptors containing α(2,3) sialic acid-substituted lactosaminoglycans. Le x , Galβ1,4(Fucα1,3)GlcNAcβ1-R (where R is a protein or other carbohydrate structure) forms the core of this sialyated structure. The peptides and carbohydrate structures are useful as diagnostics and for clinical applications in the modulation or inhibition of coagulation processes or inflammatory processes.

    Functionally active selectin-derived peptides and ligand for GMP140
    28.
    发明公开
    Functionally active selectin-derived peptides and ligand for GMP140 失效
    Funktionell aktive selektinderivierte Peptide und LigandfürGMP140

    公开(公告)号：EP1245575A2

    公开(公告)日：2002-10-02

    申请号：EP01204837.7

    申请日：1991-07-17

    申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA

    发明人： McEver, Rodger P.

    IPC分类号： C07K16/28 ,  C07K16/18

    CPC分类号： C07K16/2854 ,  A61K2039/505

    摘要： Peptides derived from three regions of the lectin binding region of GMP-140 have been found to selectively interact with "selectins", including GMP-140, ELAM-1, and lymphocyte homing receptor. The three regions include amino acids 19-34, 54-72, and 66-89, based on the numbers of the residues contained in the peptide, with residue 1 defined as the N terminus of the mature protein after cleavage of the signal peptide. Fucosylated sialyated lactosamine structures that bind to GMP-140 have also been discovered. The structure is created by expression of α(1,3) fucosyltransferases capable of modifying acceptors containing α(2,3) sialic acid-substituted lactosaminoglycans. Le x , Galβ1,4(Fucα1,3)GlcNAcβ1-R (where R is a protein or other carbohydrate structure) forms the core of this sialyated structure. The peptides and carbohydrate structures are useful as diagnostics and for clinical applications in the modulation or inhibition of coagulation processes or inflammatory processes.

    摘要翻译： 已经发现衍生自GMP-140的凝集素结合区域的三个区域的肽选择性地与“选择素”相互作用，包括GMP-140，ELAM-1和淋巴细胞归巢受体。 三个区域包括氨基酸19-34,54-72和66-89，基于肽中包含的残基数目，残基1定义为信号肽切割后成熟蛋白的N末端。 也发现了与GMP-140结合的岩藻糖化的唾液酸化的乳糖胺结构。 该结构通过能够修饰含有α（2,3）唾液酸取代的乳糖胺聚糖的受体的α（1,3）岩藻糖基转移酶的表达产生。 Le x，Galβ1,4（Fuc alpha 1,3）GlcNAcβ1-R（其中R是蛋白质或其他碳水化合物结构）形成该唾液酸化结构的核心。 肽和碳水化合物结构可用作诊断和用于调节或抑制凝血过程或炎症过程的临床应用。