公开(公告)号：EP2575764A2

公开(公告)日：2013-04-10

申请号：EP11726579.3

申请日：2011-06-03

申请人： Alnylam Pharmaceuticals, Inc.

发明人： MANOHARAN, Muthiah ,  MAIER, Martin ,  JAYARAMAN, Muthusamy ,  MATSUDA, Shigeo ,  JAYAPRAKASH, Narayanannair, K. ,  RAJEEV, Kallanthottathil, G. ,  AKINC, Akin ,  BAILLIE, Thomas, A.

IPC分类号： A61K9/10 ,  A61K39/00 ,  A61K48/00 ,  C07C69/02 ,  C07C211/62 ,  C07C211/63 ,  C12N15/87 ,  A61K47/48

CPC分类号： C07C229/12 ,  A61K31/713 ,  A61K39/0005 ,  A61K47/44 ,  C12N15/113 ,  C12N15/88 ,  C12N2310/14 ,  C12N2320/30

摘要： The present invention relates to a cationic lipid having one or more biodegradable groups located in the mid- or distal section of a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

公开(公告)号：EP2512449A1

公开(公告)日：2012-10-24

申请号：EP10838298.7

申请日：2010-12-17

申请人： The University of British Columbia ,  Alnylam Pharmaceuticals, Inc.

发明人： HOPE, Michael, J. ,  MADDEN, Thomas, D. ,  CULLIS, Pieter ,  MAIER, Martin, A. ,  JAYARAMAN, Muthusamy ,  RAJEEV, Kallanthottathil, G. ,  AKINC, Akin ,  MANOHARAN, Muthiah

IPC分类号： A61K9/127 ,  A61K9/133

CPC分类号： A61K47/543 ,  A61K9/1272 ,  A61K47/6911 ,  C12N15/88

摘要： A lipid particle can include a plurality of cationic lipids, such as a first cationic lipid and a second cationic lipid. The first cationic lipid can be selected on the basis of a first property and the second cationic can be selected on the basis of a second property. The first and second properties are complementary. The attributes of the lipid particle can reflect the selected properties of the cationic lipids, and the complementary nature of those properties.

公开(公告)号：EP2440183A1

公开(公告)日：2012-04-18

申请号：EP10786869.7

申请日：2010-06-10

申请人： Alnylam Pharmaceuticals, Inc.

发明人： AKINC, Akin ,  DORKIN, Joseph, R. ,  QIN, Xiaojun ,  CANTLEY, William ,  MANOHARAN, Muthiah ,  RAJEEV, Kallanthottathil, G. ,  NARAYANANNAIR, Jayaprakash, K. ,  JAYARAMAN, Muthusamy ,  CHEN, Jianxin ,  ANSELL, Steven

IPC分类号： A61K9/127 ,  C07C211/00 ,  A61K31/20

CPC分类号： A61K9/1272 ,  A61K9/1278 ,  A61K31/22 ,  A61K31/7088 ,  A61K31/712 ,  A61K31/713 ,  A61K38/1709 ,  A61K38/4846 ,  A61K47/14 ,  A61K47/549 ,  A61K47/551 ,  A61K47/6911 ,  A61K48/0033 ,  C07C29/58 ,  C07C227/18 ,  C07C227/40 ,  C07C229/12 ,  C07D475/04 ,  C12N15/113 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/351 ,  C12N2310/3515 ,  C12N2320/32 ,  Y02A50/463 ,  A61K2300/00 ,  C12N2310/3521 ,  C12N2310/3533

摘要： The invention features a cationic lipid of formula I, an improved lipid formulation comprising a cationic lipid of formula I and corresponding methods of use. Also disclosed are targeting lipids, and specific lipid formulations comprising such targeting lipids.

公开(公告)号：EP2406376A1

公开(公告)日：2012-01-18

申请号：EP10708686.0

申请日：2010-03-12

申请人： Alnylam Pharmaceuticals, Inc.

发明人： BUMCROT, David ,  AKINC, Akin ,  SAH, Dinah ,  NOVOBRANTSEVA, Tatiana

IPC分类号： C12N15/113 ,  C12N15/88

CPC分类号： C12N15/1136 ,  A61K31/44 ,  A61K31/713 ,  C12N15/111 ,  C12N15/113 ,  C12N15/88 ,  C12N2310/14 ,  C12N2310/3515 ,  C12N2320/32 ,  C12N2799/04

摘要： This invention relates to compositions containing double-stranded ribonucleic acid (dsRNA) in a lipid formulation, and methods of using the compositions to inhibit the expression of the Human kinesin family member 11 (Eg5) and Vascular Endothelial Growth Factor (VEGF), and methods of using the compositions to treat pathological processes mediated by Eg5 and VEGF expression, such as cancer.

公开(公告)号：EP1765847A2

公开(公告)日：2007-03-28

申请号：EP05780090.6

申请日：2005-05-27

申请人： Alnylam Pharmaceuticals Inc.

发明人： VORNLOCHER, Hans-Peter ,  HADWIGER, Philipp ,  ZIMMERMANN, Tracy, Stage ,  MANOHARAN, Muthiah ,  RAJEEV, Kallanthottathil G. ,  ROEHL, Ingo ,  AKINC, Akin

IPC分类号： C07H21/04 ,  A01N43/04

CPC分类号： C07H21/02 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/318 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/323 ,  C12N2310/3231 ,  C12N2310/53 ,  C12N2320/51 ,  C12N2310/3521 ,  C12N2310/3525 ,  C12N2310/3527

摘要： This invention relates to modified double-stranded oligoribonucleic acid (dsRNA) having improved stability in cells and biological fluids, and methods of making and identifying dsRNA having improved stability, and of using the dsRNA to inhibit the expression or function of a target gene.

公开(公告)号：EP4133076A1

公开(公告)日：2023-02-15

申请号：EP21719420.8

申请日：2021-03-25

申请人： Alnylam Pharmaceuticals, Inc.

发明人： AKINC, Akin ,  MCININCH, James D. ,  ANGLERO-RODRIGUEZ, Yesseinia ,  SCHLEGEL, Mark K.

IPC分类号： C12N15/113

公开(公告)号：EP3324980A1

公开(公告)日：2018-05-30

申请号：EP16828302.6

申请日：2016-07-15

申请人： Alnylam Pharmaceuticals, Inc.

发明人： JADHAV, Vasant ,  MAIER, Martin ,  ZLATEV, Ivan ,  AKINC, Akin ,  RAJEEV, Kallanthottathil G. ,  NAIR, Jayaprakash K. ,  KANDASAMY, Pachamuthu ,  MANOHARAN, Muthiah

IPC分类号： A61K31/713 ,  C07H21/02 ,  C12N15/11 ,  C12N15/113

CPC分类号： C12N15/113 ,  A61K47/549 ,  A61K47/55 ,  C07H21/00 ,  C12N15/111 ,  C12N2310/20 ,  C12N2310/3519 ,  C12N2310/51 ,  C12N2320/31

摘要： The present invention relates, in general to, compounds, compositions and methods useful for modulating gene expression of multiple target nucleic acids by a single chemical entity.

公开(公告)号：EP3234141A1

公开(公告)日：2017-10-25

申请号：EP15871104.4

申请日：2015-12-17

申请人： Alnylam Pharmaceuticals, Inc.

发明人： JADHAV, Vasant ,  MARAGANORE, John ,  MAIER, Martin ,  RAJEEV, Kallanthottathil G. ,  MANOHARAN, Muthiah ,  AKINC, Akin ,  ZLATEV, Ivan

IPC分类号： C12N15/113

CPC分类号： C12N15/111 ,  C12N15/113 ,  C12N2310/113 ,  C12N2310/315 ,  C12N2310/3183 ,  C12N2310/319 ,  C12N2310/3231 ,  C12N2310/3341 ,  C12N2310/346 ,  C12N2310/351 ,  C12N2310/322 ,  C12N2310/3533 ,  C12N2310/321 ,  C12N2310/3527 ,  C12N2310/3525 ,  C12N2310/3521

摘要： The present invention relates, in general to agents that modulate the pharmacological activity of conjugated siRNAs.

摘要翻译： 本发明一般涉及调节缀合的siRNA的药理学活性的药剂。

公开(公告)号：EP2841443A2

公开(公告)日：2015-03-04

申请号：EP13782531.1

申请日：2013-04-25

申请人： Alnylam Pharmaceuticals Inc.

发明人： AKINC, Akin ,  SEHGAL, Alfica ,  TOUDJARSKA, Ivanka ,  FOSTER, Donald ,  MILSTEIN, Stuart ,  BETTENCOURT, Brian ,  MAIER, Martin ,  CHARISSE, Klaus ,  KUCHIMANCHI, Satyanarayana ,  RAJEEV, Kallanthottathil, G. ,  MANOHARAN, Muthiah

IPC分类号： C07H21/04 ,  C12N15/113

CPC分类号： C12N15/113 ,  A61K31/713 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/335 ,  C12N2310/351 ,  C12N2310/3515 ,  C12N2310/3521 ,  C12N2310/3533 ,  C12N2320/30 ,  C12N2310/3525 ,  C12N2310/3523

摘要： The invention relates to iRNA, e.g., double- stranded ribonucleic acid (dsRNA), compositions targeting the Serpinc1 gene, and methods of using such iRNA, e.g., dsRNA, compositions to inhibit expression of Serpinc1 and methods of treating subjects having a bleeding disorder, such as a hemophilia.

公开(公告)号：EP2442792A2

公开(公告)日：2012-04-25

申请号：EP10790072.2

申请日：2010-06-15

申请人： Alnylam Pharmaceuticals, Inc.

发明人： FITZGERALD, Kevin ,  HINKLE, Gregory ,  AKINC, Akin ,  MILSTEIN, Stuart

IPC分类号： A61K9/127 ,  C12N15/11

CPC分类号： A61K31/713 ,  A61K9/0019 ,  A61K9/1272 ,  A61K9/1273 ,  A61K38/1709 ,  A61K47/545 ,  A61K47/55 ,  A61K47/6911 ,  C12N15/1137 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/3515

摘要： This invention relates to composition and methods using lipid formulated siRNA targeted to a PCSK9 gene.