VERFAHREN ZUR HERSTELLUNG VON PIPERAZINDION-DERIVATEN
    22.
    发明公开
    VERFAHREN ZUR HERSTELLUNG VON PIPERAZINDION-DERIVATEN 审中-公开
    用于生产哌嗪衍生物

    公开(公告)号:EP2318379A1

    公开(公告)日:2011-05-11

    申请号:EP09781280.4

    申请日:2009-07-30

    Applicant: BASF SE

    CPC classification number: C07D241/08

    Abstract: Method for preparation of piperazindione derivates of formula I, wherein R
    1 stands for hydrogen, alkyl, alkenyl, alkinyl and alkylcarbonyl, R
    2 stands for hydrogen, alkyl, alkenyl, C
    3 -C
    4 -alkinyl and C(=O)R
    11 , R
    3 ,R
    4 stand for hydrogen, alkyl and halogen-alkyl, wherein the groups can be substituted, characterized in that amines of formula II, in which R
    1 stands for hydrogen and alkyl, which likewise can be substituted, are reacted under basic conditions in an aqueous solvent with N-acylated amino acid derivates of formula II, wherein X stands for halogen, Y halogen, alkoxy or phenyloxy, which can be substituted, and R
    2 , R
    3 and R
    4 have the meaning above.

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